Front Pharmacol ; Cheeseman HJ, Neal M. Interaction of chlorpromazine with tea and coffee. Br J Clin Pharmacol ;12 2 Ikeda H, Tsuji E, Matsubara T, et al. Incompatibility between propericiazine oral solution and tea-based drink.

Chem Pharm Bull Tokyo ;60 9 Ohata T, Ikeda H, Inenaga M, et al. Drug-tea polyphenol interaction II complexation of piperazine derivatives with green tea polyphenol. Thermochimica Acta ; Oda K, Murakami T.

J Pharm Pharmacol ;69 12 Kim T-E, Shin K-H, Park J-E, et al. Effect of green tea catechins on the pharmacokinetics of digoxin in humans.

Fleisher B, Unum J, Shao J, An G. Ingredients in fruit juices interact with dasatinib through inhibition of BCRP: a new mechanism of beverage-drug interaction.

J Pharm Sci ; 1 Tian D-D, Kellogg JJ, Okut N, et al. Identification of intestinal UDP-glucuronosyltransferase inhibitors in green tea Camellia sinensis using a biochemometric approach: application to raloxifene as a test drug via in vitro to in vivo extrapolation.

Drug Metab Dispos ;46 5 Jang E, Choi J, Park C, Lee SK, Kim C, Park H, et al. Effects of green tea extract administration on the pharmacokinetics of clozapine in rats.

J Pharm Pharmacol ;57 3 Mizuma T, Awazu S. J Pharm Sci ;93 9 Huang S-M, Lertora JJ, Markey SP, Atkinson AJ, editors. Principles of clinical pharmacology. Third ed. Academic Press; Yuan L, Liu M, Shi Y, Yan H, Han J, Liu L. Effect of — -epicatechingallate and — -epigallocatechingallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking.

J Biomol Struct Dyn ;37 11 Satoh T, Fujisawa H, Nakamura A, Takahashi N, Watanabe K. Inhibitory effects of eight green tea catechins on cytochrome P 1A2, 2C9, 2D6, and 3A4 activities. J Pharm Pharm Sci ;19 2 Jiang X, Sun Y, Shang L, Yang C, Kong L, Zhang Z.

Green tea extract-assembled nanoclusters for combinational photothermal and chemotherapy. J Mater Chem B ;7 39 Jana S, Rastogi H. Effects of caffeic acid and quercetin on in vitro permeability, metabolism and in vivo pharmacokinetics of melatonin in rats: potential for herb-drug interaction.

Eur J Drug Metab Pharmacokinet ;42 5 Nishikawa M, Ariyoshi N, Kotani A, et al. Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. Drug Metab Pharmacokinet ;19 4 Paul D, Surendran S, Chandrakala P, Satheeshkumar N.

An assessment of the impact of green tea extract on palbociclib pharmacokinetics using a validated UHPLC—QTOF—MS method. Biomed Chromatogr ;33 4 :e Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G.

Emerging Kidney Models to Investigate Metabolism, Transport, and Toxicity of Drugs and Xenobiotics. Drug Metab Dispos. Al-Arifi MN, Wajid S, Al-Manie NK, et al. Evaluation of knowledge of Health care professionals on warfarin interactions with drug and herb medicinal in Central Saudi Arabia.

Pak J Med Sci ;32 1 Koren R, Lerner A, Tirosh A, et al. The use of complementary and alternative medicine in hospitalized patients with type 2 diabetes mellitus in Israel.

J Altern Complement Med ;21 7 Influence of green and black tea on folic acid pharmacokinetics in healthy volunteers: potential risk of diminished folic acid bioavailability. Biopharm Drug Dispos ;29 6 Lu Y, Sun J, Petrova K, et al.

Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice. Food Chem Toxicol ; How to Cite. Meyboodi M, Mohammadpour AH, Emami SA, Karbasforooshan H. Drug Interactions of Green Tea. J Pharm Care. More Citation Formats Vancouver Download Citation.

pISSN: eISSN: Editor-in-Chief: Kheirollah Gholami, Professor. We have found 24 eligible articles. Finally, the related papers are given in our review. GT is containing polyphenols that interfere with many drugs. The most important of these polyphenol compounds is epigallocatechingallate EGCG , which most of the reported interactions are due to the presence of EGCG.

Interaction of GT with different drugs occurs in the context of both pharmacodynamics and pharmacokinetics that includes drug absorption, metabolism, and renal excretion. The mechanisms of these interactions consist of increase in the concentration included several medications such as melatonin, midazolam, and amlodipine consuming after GT; these interactions can be toxic.

Additionally, it has been reported that serum levels of several drugs such as nadolol, digoxin, amoxicillin, and clozapine are decreased and their efficacy are reduced when they simultaneously administer with GT. The serum concentration of rhodamin , quinidine, and doxorubicin have increased when these drugs were co-administered with GT.

GT has pharmacodynamics interactions with a few drugs such as a hydrochlorothiazide.

EGCG is most prevalent in green tea but also found in smaller quantities in other types of tea, fruit, and some nuts. Other health-promoting catechins are plentiful in red wine, dark chocolate, legumes, and most fruit.

Test-tube, animal, and a few human studies indicate that EGCG provides numerous health benefits, including reduced inflammation, weight loss, and improved heart and brain health.

Ultimately, more research is needed to better understand how EGCG may be used as a preventative tool or treatment for disease, though current data is promising.

Free radicals are highly reactive particles that can cause damage to your cells. Excessive free radical production leads to oxidative stress. As an antioxidant, EGCG protects your cells from damage associated with oxidative stress and suppresses the activity of pro-inflammatory chemicals produced in your body, such as tumor necrosis factor-alpha TNF-alpha 6.

Stress and inflammation are linked to a variety of chronic illnesses, including cancer, diabetes, and heart disease. Thus, the anti-inflammatory and antioxidant effects of EGCG are thought to be one of the main reasons for its broad disease-preventing applications 1.

Research suggests that EGCG in green tea may support heart health by reducing blood pressure, cholesterol, and the accumulation of plaque in blood vessels — all major risk factors for heart disease 7 , 8. In an 8-week study in 33 people, taking mg of EGCG-containing green tea extract daily resulted in a significant 4.

A separate study in 56 people found significant reductions in blood pressure, cholesterol, and inflammatory markers in those taking a daily dose of mg of green tea extract over 3 months Though these results are encouraging, more research is needed to better understand how EGCG in green tea may reduce heart disease risk.

EGCG may also promote weight loss , especially when taken alongside the caffeine naturally found in green tea. Additional human studies have collectively found that taking — mg of EGCG together with 80— mg of caffeine for at least 12 weeks is linked to significant weight loss and reduction of body fat Still, changes in weight or body composition are not consistently seen when EGCG is taken without caffeine.

Early research suggests that EGCG in green tea may play a role in improving neurological cell function and preventing degenerative brain diseases. In some studies, EGCG injections significantly improved inflammation, as well as recovery and regeneration of neural cells in mice with spinal cord injuries 13 , However, the available data is inconsistent More research is needed to better understand whether EGCG may effectively prevent or treat degenerative brain diseases in humans.

EGCG in green tea may offer a variety of health benefits, such as reduced inflammation, weight loss, and the prevention of heart and brain diseases.

Still, more research on its effectiveness is needed. The reason for this is not completely understood, but it may be related to the fact that a lot of EGCG bypasses the small intestine too quickly and ends up being degraded by bacteria in the large intestine A single cup 8 ounces or ml of brewed green tea typically contains about 50— mg of EGCG.

Dosages used in scientific studies are often much higher, but exact amounts have been inconsistent 11 , Daily intakes equal to or above mg of EGCG per day increases the blood levels of transaminases, an indicator of liver damage One group of researchers suggested a safe intake level of mg of EGCG per day when ingested in solid supplemental form In fact, EGCG supplements have been associated with serious side effects, such as 16 :.

EGCG may also interfere with the absorption of some prescription medications, including certain types of cholesterol-lowering and antipsychotic drugs To ensure safety, always consult with your healthcare provider prior to starting a new dietary supplement.

There is currently no clear dosage recommendation for EGCG, though mg daily for up to 4 weeks has been used safely in studies.

EGCG supplements have been linked to serious side effects and may interfere with medication absorption. EGCG is a powerful compound that may benefit health by reducing inflammation , aiding weight loss, and preventing certain chronic diseases.

When taken as a supplement, EGCG has occasionally been associated with serious side effects. The safest route is to consult with your healthcare provider prior to adding EGCG to your routine to ensure this supplement is right for you. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Here is a detailed look at 10 evidence-based natural appetite suppressants that can help you lose weight. Whether you dislike the taste, are trying to cut back on caffeine or just want something new, here are 9 delicious alternatives to coffee you should….

Both green and black tea are incredibly popular and associated with many health benefits. This article tells you whether green or black tea may be….

Green tea extract is a concentrated supplemental form of green tea. Here are 10 science-based benefits of green tea extract. Many studies show that green tea can help you lose weight. It contains bioactive substances that can make you burn more calories, even at rest.

It's easy to make a quick and healthy breakfast from wholesome, nutritious foods. Recipients Name:. Recipients address:. If you are being treated with any of the following medications, you should not drink green tea or take green tea extract without first talking to your health care provider:.

Adenosine -- Green tea may inhibit the actions of adenosine, a medication given in the hospital for an irregular and usually unstable heart rhythm. Antibiotics, Beta-lactam -- Green tea may increase the effectiveness of beta-lactam antibiotics by reducing bacterial resistance to treatment.

Benzodiazepines -- Caffeine including caffeine from green tea has been shown to reduce the sedative effects of benzodiazepines medications commonly used to treat anxiety, such as diazepam and lorazepam. Beta-blockers, Propranolol, and Metoprolol -- Caffeine including caffeine from green tea may increase blood pressure in people taking propranolol and metoprolol medications used to treat high blood pressure and heart disease.

Blood Thinning Medications Including Aspirin -- People who take warfarin, a blood thinning medication, should not drink green tea. Since green tea contains vitamin K, it can make warfarin ineffective. Meanwhile, you should not mix green tea and aspirin because they both prevent platelets from clotting.

Using the two together may increase your risk of bleeding. Chemotherapy -- The combination of green tea and chemotherapy medications, specifically doxorubicin and tamoxifen, increased the effectiveness of these medications in laboratory tests.

However, these results have not yet been demonstrated in studies on people. On the other hand, there have been reports of both green and black tea extracts stimulating a gene in prostate cancer cells that may cause them to be less sensitive to chemotherapy drugs.

Given this potential interaction, people should not drink black and green tea as well as extracts of these teas while receiving chemotherapy for prostate cancer in particular. Clozapine -- The anti-psychotic effects of the medication clozapine may be reduced if taken fewer than 40 minutes after drinking green tea.

Ephedrine -- When taken together with ephedrine, green tea may cause agitation, tremors, insomnia, and weight loss.

Monoamine Oxidase Inhibitors MAOIs -- Green tea may cause a severe increase in blood pressure called a "hypertensive crisis" when taken together with MAOIs, which are used to treat depression. Examples of MAOIs include phenelzine and tranylcypromine. Oral Contraceptives -- Oral contraceptives can prolong the amount of time caffeine stays in the body and may increase its stimulating effects.

Phenylpropanolamine -- A combination of caffeine including caffeine from green tea and phenylpropanolamine an ingredient used in many over-the-counter and prescription cough and cold medications and weight loss products can cause mania and a severe increase in blood pressure.

The FDA issued a public health advisory in November to warn people of the risk of bleeding in the brain from use of this medication and has strongly urged all manufacturers of this drug to remove it from the market.

Reviewed By: Ernest B. Hawkins, MS, BSPharm, RPh, Health Education Resources; and Steven D.

A single cup 8 ounces or ml of brewed green tea typically contains about 50— mg of EGCG. Dosages used in scientific studies are often much higher, but exact amounts have been inconsistent 11 , Daily intakes equal to or above mg of EGCG per day increases the blood levels of transaminases, an indicator of liver damage One group of researchers suggested a safe intake level of mg of EGCG per day when ingested in solid supplemental form In fact, EGCG supplements have been associated with serious side effects, such as 16 :.

EGCG may also interfere with the absorption of some prescription medications, including certain types of cholesterol-lowering and antipsychotic drugs To ensure safety, always consult with your healthcare provider prior to starting a new dietary supplement.

There is currently no clear dosage recommendation for EGCG, though mg daily for up to 4 weeks has been used safely in studies. EGCG supplements have been linked to serious side effects and may interfere with medication absorption. EGCG is a powerful compound that may benefit health by reducing inflammation , aiding weight loss, and preventing certain chronic diseases.

When taken as a supplement, EGCG has occasionally been associated with serious side effects. The safest route is to consult with your healthcare provider prior to adding EGCG to your routine to ensure this supplement is right for you.

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

Here is a detailed look at 10 evidence-based natural appetite suppressants that can help you lose weight. Whether you dislike the taste, are trying to cut back on caffeine or just want something new, here are 9 delicious alternatives to coffee you should….

Both green and black tea are incredibly popular and associated with many health benefits. This article tells you whether green or black tea may be…. Green tea extract is a concentrated supplemental form of green tea. Here are 10 science-based benefits of green tea extract. Many studies show that green tea can help you lose weight.

It contains bioactive substances that can make you burn more calories, even at rest. It's easy to make a quick and healthy breakfast from wholesome, nutritious foods. Here are the 12 healthiest foods to eat in the morning. Matcha is a type of powdered green tea. It is very high in antioxidants and has numerous health benefits for your body and brain.

Phosphatidylcholine is known to boost cognition, but its potential benefits don't stop there. Here's what you should know about this herbal remedy. A Quiz for Teens Are You a Workaholic?

How Well Do You Sleep? Health Conditions Discover Plan Connect. BMC Pharmacol Toxicol ;20 1 Maher HM, Alzoman NZ, Shehata SM, Abahussain AO.

J Chromatogr B Analyt Technol Biomed Life Sci ; Misaka S, Miyazaki N, Fukushima T, Yamada S, Kimura J. Phytomedicine ;20 14 Abe O, Ono T, Sato H, et al. Eur J Clin Pharmacol ;74 6 Shan Y, Zhang M, Wang T, et al. Oxidative tea polyphenols greatly inhibit the absorption of atenolol.

Front Pharmacol ; Cheeseman HJ, Neal M. Interaction of chlorpromazine with tea and coffee. Br J Clin Pharmacol ;12 2 Ikeda H, Tsuji E, Matsubara T, et al. Incompatibility between propericiazine oral solution and tea-based drink. Chem Pharm Bull Tokyo ;60 9 Ohata T, Ikeda H, Inenaga M, et al.

Drug-tea polyphenol interaction II complexation of piperazine derivatives with green tea polyphenol. Thermochimica Acta ; Oda K, Murakami T. J Pharm Pharmacol ;69 12 Kim T-E, Shin K-H, Park J-E, et al. Effect of green tea catechins on the pharmacokinetics of digoxin in humans.

Fleisher B, Unum J, Shao J, An G. Ingredients in fruit juices interact with dasatinib through inhibition of BCRP: a new mechanism of beverage-drug interaction. J Pharm Sci ; 1 Tian D-D, Kellogg JJ, Okut N, et al.

Identification of intestinal UDP-glucuronosyltransferase inhibitors in green tea Camellia sinensis using a biochemometric approach: application to raloxifene as a test drug via in vitro to in vivo extrapolation.

Drug Metab Dispos ;46 5 Jang E, Choi J, Park C, Lee SK, Kim C, Park H, et al. Effects of green tea extract administration on the pharmacokinetics of clozapine in rats. J Pharm Pharmacol ;57 3 Mizuma T, Awazu S.

J Pharm Sci ;93 9 Huang S-M, Lertora JJ, Markey SP, Atkinson AJ, editors. Principles of clinical pharmacology. Third ed. Academic Press; Yuan L, Liu M, Shi Y, Yan H, Han J, Liu L. Effect of — -epicatechingallate and — -epigallocatechingallate on the binding of tegafur to human serum albumin as determined by spectroscopy, isothermal titration calorimetry, and molecular docking.

J Biomol Struct Dyn ;37 11 Satoh T, Fujisawa H, Nakamura A, Takahashi N, Watanabe K. Inhibitory effects of eight green tea catechins on cytochrome P 1A2, 2C9, 2D6, and 3A4 activities. J Pharm Pharm Sci ;19 2 The most likely mechanisms appear to be inhibition of intestinal uptake by OAPT1A2 or activation of liver uptake by induction of OATP1B3 or OATP1B1.

The former might be expected to reduce the lipid lowering effect of rosuvastatin whereas the latter might increase it. This study has several limitations that need to be considered. Firstly, this study only assessed one dosage for each herb product e. It is known that interactions between herbs and drugs may be dose-dependent.

Evaluating a higher dose or a lower dose may help to provide a better understanding of the interaction between statins and green tea or soy isoflavones.

Secondly, it has been shown that taking EGCG 8 or 4 h before sunitinib administration had no effect on the pharmacokinetics of sunitinib in rats, whereas taking the two together reduced the bioavailability of sunitinib probably because of a physical reaction between the two compounds 49 , suggesting separation of dosing of green tea and drugs may reduce any herb-drug interaction.

To maximize the possibility of finding an interaction between statins and green tea, subjects were taking green tea extract and statins simultaneously on the dosing day, so that a physical interaction between the two substances cannot be excluded.

It would be useful to assess whether the separation of dosing has different effects. During the study, we instructed the study participants to take the study product on an empty stomach at least 1 h before breakfast after overnight fasting to enhance the bioavailability of EGCG and to reduce the variations in EGCG bioavailability caused by food.

They were requested not to take alcohol, tea, grapefruit juice, caffeine, soybean milk or dietary supplements and herbal products 2 weeks before and throughout the study. Subjects were educated about the importance of their compliance to the herbs and dietary restrictions for this research at the beginning of the study and they were reminded frequently of these requirements.

The compliance to instructions on EGCG and soy isoflavones intake or dietary restrictions was monitored by using a food diary. This approach inevitably relied on the subjects' cooperation and honesty and may not be objective, but it was a practical way to conduct the study.

It would be important to further evaluate the mechanisms responsible for the observed interactions and to assess whether these pharmacokinetic interactions have any impact on the lipid-lowering effect of statins in patients requiring long-term statin therapy.

There was no significant effect of soy isoflavones on rosuvastatin pharmacokinetics. Further studies should be performed to investigate the underlying mechanisms responsible for this observed interaction and to assess the clinical relevance in patients receiving long-term statins.

The studies involving human participants were reviewed and approved by the Joint Chinese University of Hong Kong-New Territories East Cluster Clinical Research Ethics Committee with reference number CRE Written informed consent was obtained from the individual s for the publication of any potentially identifiable images or data included in this article.

WZ and MH analyzed the data and wrote this manuscript. BT designed the research project. HL, EW, CL, CW, and CH performed the experiments. BT and CH revised this manuscript. All authors contributed to the article and approved the submitted version.

This study was supported by the Health and Health Services Research Fund of the Food and Health Bureau, Hong Kong Special Administrative Region Government The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

We thank the other member of the research team, especially Ms. Swen Ip, Ms. Eliza Choy, and Dr. Benny Fok, for their excellent assistance and Ms.

Emily Poon for her help with the genotyping. We are also very grateful to the healthy volunteers for their participation in this research. Khan J, Deb PK, Priya S, Medina KD, Devi R, Walode SG et al.

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