Video
Flavonoid-rich apples and nitrate-rich green leafy vegetables improve heart health Thank you for visiting nature. You are Flabonoids a browser version Caloric restriction and exercise performance limited support for CSS. Flavonpids obtain Flavonooids best experience, we recommend Well-beinng use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. We evaluated the association between vegetable and fruit consumption — particularly flavonoid-rich fruits — in mid-life and major depressive disorder MDD in later life.Flavonoids and overall well-being -
The role of inflammation in depression and fatigue. Front Immunol. Miller AH, Raison CL. The role of inflammation in depression: from evolutionary imperative to modern treatment target.
Nat Rev Immunol. Vafeiadou K, Vauzour D, Lee HY, Rodriguez-Mateos A, Williams RJ, Spencer JPE. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch Biochem Biophys. Jia S, Hou Y, Wang D, Zhao X.
Flavonoids for depression and anxiety: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. Dietary flavonoid intake and risk of incident depression in midlife and older women. Tsugane S, Sawada N. The JPHC study: design and some findings on the typical Japanese diet. Jpn J Clin Oncol.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Muramatsu K, Miyaoka H, Kamijima K, Muramatsu Y, Tanaka Y, Hosaka M, et al.
Performance of the Japanese version of the Patient Health Questionnaire-9 J-PHQ-9 for depression in primary care. Gen Hosp Psychiatry. Wada K, Tanaka K, Theriault G, Satoh T, Mimura M, Miyaoka H, et al.
Validity of the Center for Epidemiologic Studies Depression Scale as a screening instrument of major depressive disorder among Japanese workers. Am J Ind Med. Ishihara J, Sobue T, Yamamoto S, Yoshimi I, Sasaki S, Kobayashi M, et al. Validity and reproducibility of a self-administered food frequency questionnaire in the JPHC Study Cohort II: study design, participant profile and results in comparison with Cohort I.
J Epidemiol. Sasaki S, Kobayashi M, Tsugane S, JPHC. Validity of a self-administered food frequency questionnaire used in the 5-year follow-up survey of the JPHC Study Cohort I: comparison with dietary records for food groups.
Nozaki S, Sawada N, Matsuoka YJ, Shikimoto R, Mimura M, Tsugane S. Association between dietary fish and PUFA intake in midlife and dementia in later life: the JPHC Saku Mental Health Study. J Alzheimers Dis ;— McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT.
Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. The Council for Science and Technology. Standard Tables Of Food Composition in Japan, 5th Revised And Enlarged Edn. National Printing Bureau, Ishihara J, Inoue M, Kobayashi M, Tanaka S, Yamamoto S, Iso H, et al.
Impact of the revision of a nutrient database on the validity of a self-administered food frequency questionnaire FFQ. Yang Y, Dong J-Y, Cui R, Muraki I, Yamagishi K, Sawada N, et al. Consumption of flavonoid-rich fruits and risk of CHD: a prospective cohort study.
Makiuchi T, Sobue T, Kitamura T, Ishihara J, Sawada N, Iwasaki M, et al. Int J Cancer. Willett WC, Howe GR, Kushi LH. Adjustment for total energy intake in epidemiologic studies.
Am J Clin Nutr ;S—8S. Cumming G. The new statistics: why and how. Psychol Sci. Felsenstein J. Confidence limits on phylogenies: an approach using the bootstrap. Evol Int J Org Evol. Lumley T, Diehr P, Emerson S, Chen L.
The importance of the normality assumption in large public health data sets. Carpenter J, Bithell J. Bootstrap confidence intervals: when, which, what?
A practical guide for medical statisticians. Stat Med. Crowe KM, Murray E. J Acad Nutr Diet. Atkinson FS, Foster-Powell K, Brand-Miller JC.
International tables of glycemic index and glycemic load values: Diabetes Care. Meller F, de O, Manosso LM, Schäfer AA. The influence of diet quality on depression among adults and elderly: a population-based study.
J Affect Disord. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis.
J Clin Epidemiol. Download references. This study was conducted under the framework of the Collaborative Cohort Research Network Project to the Six National Centers for Advanced and Specialized Medical Care.
This study was supported by a Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 22K , MAFF Comissioned project study JPJ , the National Cancer Center Research and Development Fund since , and a Grant-Aid for Cancer Research from the Ministry of Health, Labour and Welfare of Japan from to Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, , Japan.
Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, , Japan. Department of Psychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba-city, Chiba, Japan. Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, , Japan.
National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, , Japan. You can also search for this author in PubMed Google Scholar. Initial research questions were devised by ZN. Analyses were conducted by ZN.
The manuscript was written by ZN and finalized by NS with substantial text contributions from all authors. Correspondence to Norie Sawada. Open Access This article is licensed under a Creative Commons Attribution 4. Reprints and permissions.
Narita, Z. et al. Association between vegetable, fruit, and flavonoid-rich fruit consumption in midlife and major depressive disorder in later life: the JPHC Saku Mental Health Study. Transl Psychiatry 12 , Download citation. Received : 31 May Revised : 06 September Accepted : 08 September Published : 26 September Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content Thank you for visiting nature. nature translational psychiatry articles article.
Download PDF. Subjects Depression Human behaviour. Abstract We evaluated the association between vegetable and fruit consumption — particularly flavonoid-rich fruits — in mid-life and major depressive disorder MDD in later life.
Introduction Mental illness is a significant cause of disability and a major component of the global burden of disease [ 1 , 2 ]. Methods Study population We used data for participants from one region of the Japan Public Health Center-based prospective study JPHC study [ 26 ].
We included participants in the final sample. Full size image. Results Table 1 summarizes the demographics of participants in according to the lowest and highest quintiles of total vegetable and fruit, total fruit, and flavonoid-rich fruit consumption.
Table 1 Demographics of participants in according to lowest and highest quintiles of total vegetable and fruit, total fruit, and flavonoid-rich fruit consumption. Full size table. Table 2 Odds of major depressive disorder according to quintiles of vegetable and fruit consumption.
Table 3 Odds of major depressive disorder according to quartiles of nutrient intake. Discussion As hypothesized, we found that consumption of flavonoid-rich fruits was inversely associated with a diagnosis of MDD.
Limitations Some characteristics of the present study warrant cautious consideration. Food Funct. Bordenave N, Hamaker BR, Ferruzzi MG. Nature and consequences of non-covalent interactions between flavonoids and macronutrients in foods.
Zhang H, Yu D, Sun J, et al. Interaction of plant phenols with food macronutrients: characterisation and nutritional-physiological consequences. Nutr Res Rev. Xiao J, Mao F, Yang F, Zhao Y, Zhang C, Yamamoto K. Interaction of dietary polyphenols with bovine milk proteins: molecular structure-affinity relationship and influencing bioactivity aspects.
Lorenz M, Jochmann N, von Krosigk A, et al. Addition of milk prevents vascular protective effects of tea. Eur Heart J. Roowi S, Stalmach A, Mullen W, Lean ME, Edwards CA, Crozier A.
Green tea flavanols: colonic degradation and urinary excretion of catabolites by humans. J Agric Food Chem. Setchell KD, Brown NM, Lydeking-Olsen E. The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones.
J Nutr. Yuan JP, Wang JH, Liu X. Metabolism of dietary soy isoflavones to equol by human intestinal microflora--implications for health. Marin L, Miguelez EM, Villar CJ, Lombo F. Bioavailability of dietary polyphenols and gut microbiota metabolism: antimicrobial properties.
Biomed Res Int. Inoue-Choi M, Yuan JM, Yang CS, et al. Genetic Association Between the COMT Genotype and Urinary Levels of Tea Polyphenols and Their Metabolites among Daily Green Tea Drinkers. Int J Mol Epidemiol Genet. Wu AH, Tseng CC, Van Den Berg D, Yu MC.
Tea intake, COMT genotype, and breast cancer in Asian-American women. Cancer Res. Jiang W, Hu M. Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways. RSC Adv. Xiao J, Kai G.
A review of dietary polyphenol-plasma protein interactions: characterization, influence on the bioactivity, and structure-affinity relationship. Manach C, Williamson G, Morand C, Scalbert A, Remesy C.
Bioavailability and bioefficacy of polyphenols in humans. Review of 97 bioavailability studies. Kroon PA, Clifford MN, Crozier A, et al. How should we assess the effects of exposure to dietary polyphenols in vitro? Heijnen CG, Haenen GR, van Acker FA, van der Vijgh WJ, Bast A.
Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol In Vitro. Chun OK, Kim DO, Lee CY. Superoxide radical scavenging activity of the major polyphenols in fresh plums. Frei B, Higdon JV. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies.
Williams RJ, Spencer JP, Rice-Evans C. Flavonoids: antioxidants or signalling molecules? Lotito SB, Frei B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon?
Mira L, Fernandez MT, Santos M, Rocha R, Florencio MH, Jennings KR. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic Res. Cheng IF, Breen K. On the ability of four flavonoids, baicilein, luteolin, naringenin, and quercetin, to suppress the Fenton reaction of the iron-ATP complex.
Spencer JP, Rice-Evans C, Williams RJ. J Biol Chem. Spencer JP, Schroeter H, Crossthwaithe AJ, Kuhnle G, Williams RJ, Rice-Evans C. Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts.
Hou Z, Lambert JD, Chin KV, Yang CS. Effects of tea polyphenols on signal transduction pathways related to cancer chemoprevention. Mutat Res. Lambert JD, Yang CS. Mechanisms of cancer prevention by tea constituents. Espley RV, Butts CA, Laing WA, et al. Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice.
Kim MC, Kim SJ, Kim DS, et al. Vanillic acid inhibits inflammatory mediators by suppressing NF-kappaB in lipopolysaccharide-stimulated mouse peritoneal macrophages. Immunopharmacol Immunotoxicol. Lee SG, Kim B, Yang Y, et al.
Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-kappaB independent of NRF2-mediated mechanism.
J Nutr Biochem. Mauray A, Felgines C, Morand C, Mazur A, Scalbert A, Milenkovic D. Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice.
Nutr Metab Cardiovasc Dis. Wang D, Wei X, Yan X, Jin T, Ling W. Protocatechuic acid, a metabolite of anthocyanins, inhibits monocyte adhesion and reduces atherosclerosis in apolipoprotein E-deficient mice.
Edirisinghe I, Banaszewski K, Cappozzo J, McCarthy D, Burton-Freeman BM. Effect of black currant anthocyanins on the activation of endothelial nitric oxide synthase eNOS in vitro in human endothelial cells.
Hidalgo M, Martin-Santamaria S, Recio I, et al. Genes Nutr. Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea - -epigallocatechin EGC in mice. Ahmad A, Khan RM, Alkharfy KM.
Effects of selected bioactive natural products on the vascular endothelium. J Cardiovasc Pharmacol. Hanhineva K, Torronen R, Bondia-Pons I, et al. Impact of dietary polyphenols on carbohydrate metabolism. Int J Mol Sci. Babu PV, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids.
Delgado ME, Haza AI, Arranz N, Garcia A, Morales P. Erba D, Casiraghi MC, Martinez-Conesa C, Goi G, Massaccesi L. Isoflavone supplementation reduces DNA oxidative damage and increases O-β-N-acetyl-D-glucosaminidase activity in healthy women. Nutr Res. Moon YJ, Wang X, Morris ME.
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism. Schwarz D, Kisselev P, Roots I. CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin. Eur J Cancer. Suh Y, Afaq F, Johnson JJ, Mukhtar H. Ravishankar D, Watson KA, Boateng SY, Green RJ, Greco F, Osborn HM.
Exploring quercetin and luteolin derivatives as antiangiogenic agents. Eur J Med Chem. Santos BL, Oliveira MN, Coelho PC, et al. Flavonoids suppress human glioblastoma cell growth by inhibiting cell metabolism, migration, and by regulating extracellular matrix proteins and metalloproteinases expression.
Chem Biol Interact. Sokolov AN, Pavlova MA, Klosterhalfen S, Enck P. Chocolate and the brain: neurobiological impact of cocoa flavanols on cognition and behavior.
Neurosci Biobehav Rev. Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP. The neuroprotective potential of flavonoids: a multiplicity of effects. Wang X, Ouyang YY, Liu J, Zhao G.
Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies. Br J Nutr. Wang ZM, Zhao D, Nie ZL, et al.
Flavonol intake and stroke risk: a meta-analysis of cohort studies. Jacques PF, Cassidy A, Rogers G, Peterson JJ, Dwyer JT. Dietary flavonoid intakes and CVD incidence in the Framingham Offspring Cohort.
US Department of Agriculture. USDA Database for the Proanthocyanidin Content of Selected Foods. August, USDA Database for the Isoflavone Content of Selected Foods, release 2.
September USDA Database for the Flavonoid Content of Selected Foods, release 3. May Vogiatzoglou A, Mulligan AA, Bhaniani A, et al. Associations between flavanol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer EPIC-Norfolk.
Cassidy A, Rogers G, Peterson JJ, Dwyer JT, Lin H, Jacques PF. Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults. Grassi D, Desideri G, Ferri C.
Protective effects of dark chocolate on endothelial function and diabetes. Curr Opin Clin Nutr Metab Care. Sansone R, Rodriguez-Mateos A, Heuel J, et al.
Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study.
Basu A, Fu DX, Wilkinson M, et al. Strawberries decrease atherosclerotic markers in subjects with metabolic syndrome.
Kelley DS, Rasooly R, Jacob RA, Kader AA, Mackey BE. Consumption of Bing sweet cherries lowers circulating concentrations of inflammation markers in healthy men and women. Moazen S, Amani R, Homayouni Rad A, Shahbazian H, Ahmadi K, Taha Jalali M. Effects of freeze-dried strawberry supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes: a randomized double-blind controlled trial.
Ann Nutr Metab. Edirisinghe I, Banaszewski K, Cappozzo J, et al. Strawberry anthocyanin and its association with postprandial inflammation and insulin.
Karlsen A, Retterstol L, Laake P, et al. Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults.
Basu A, Lyons TJ. Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. Zhu Y, Ling W, Guo H, et al. Anti-inflammatory effect of purified dietary anthocyanin in adults with hypercholesterolemia: a randomized controlled trial. Qin Y, Xia M, Ma J, et al.
Anthocyanin supplementation improves serum LDL- and HDL-cholesterol concentrations associated with the inhibition of cholesteryl ester transfer protein in dyslipidemic subjects. Zhu Y, Huang X, Zhang Y, et al. Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia.
J Clin Endocrinol Metab. Curtis PJ, Kroon PA, Hollands WJ, et al. Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks.
Grassi D, Desideri G, Di Giosia P, et al. Tea, flavonoids, and cardiovascular health: endothelial protection. Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function.
Ras RT, Streppel MT, Draijer R, Zock PL. Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis. Int J Cardiol. Liu Y, Li D, Zhang Y, Sun R, Xia M.
Anthocyanin increases adiponectin secretion and protects against diabetes-related endothelial dysfunction. Am J Physiol Endocrinol Metab. Zhu Y, Xia M, Yang Y, et al. Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals.
Clin Chem. Ras RT, Zock PL, Draijer R. Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. PLoS One. Hooper L, Kay C, Abdelhamid A, et al. Effects of chocolate, cocoa, and flavanols on cardiovascular health: a systematic review and meta-analysis of randomized trials.
Grassi D, Necozione S, Lippi C, et al. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Grassi D, Desideri G, Necozione S, et al. Protective effects of flavanol-rich dark chocolate on endothelial function and wave reflection during acute hyperglycemia.
Davison K, Coates AM, Buckley JD, Howe PR. Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects.
Int J Obes Lond. West SG, McIntyre MD, Piotrowski MJ, et al. Effects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adults. Flammer AJ, Sudano I, Wolfrum M, et al. Cardiovascular effects of flavanol-rich chocolate in patients with heart failure.
Schroeter H, Heiss C, Balzer J, et al. Proc Natl Acad Sci U S A. Gomez-Guzman M, Jimenez R, Sanchez M, et al. Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension.
Bachmair EM, Ostertag LM, Zhang X, de Roos B. Dietary manipulation of platelet function. Pharmacol Ther. Pearson DA, Paglieroni TG, Rein D, et al. The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function.
Thromb Res. Ried K, Sullivan TR, Fakler P, Frank OR, Stocks NP. Effect of cocoa on blood pressure. Cochrane Database Syst Rev. Khalesi S, Sun J, Buys N, Jamshidi A, Nikbakht-Nasrabadi E, Khosravi-Boroujeni H.
Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. Guerrero L, Castillo J, Quinones M, et al.
Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies. Egert S, Bosy-Westphal A, Seiberl J, et al. Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study.
Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. Zahedi M, Ghiasvand R, Feizi A, Asgari G, Darvish L.
Does Quercetin Improve Cardiovascular Risk factors and Inflammatory Biomarkers in Women with Type 2 Diabetes: A Double-blind Randomized Controlled Clinical Trial. Int J Prev Med. Brull V, Burak C, Stoffel-Wagner B, et al. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with pre- hypertension: a randomised double-blinded placebo-controlled cross-over trial.
Zamora-Ros R, Forouhi NG, Sharp SJ, et al. The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study.
Diabetes Care. Dietary intakes of individual flavanols and flavonols are inversely associated with incident type 2 diabetes in European populations. Wang X, Tian J, Jiang J, et al. Effects of green tea or green tea extract on insulin sensitivity and glycaemic control in populations at risk of type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials.
J Hum Nutr Diet. Liu K, Zhou R, Wang B, et al. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Zheng XX, Xu YL, Li SH, Hui R, Wu YJ, Huang XH. Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials.
Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. Curtis PJ, Sampson M, Potter J, Dhatariya K, Kroon PA, Cassidy A. Chronic ingestion of flavanols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial.
Wedick NM, Pan A, Cassidy A, et al. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Hokayem M, Blond E, Vidal H, et al.
Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients. Soltani R, Gorji A, Asgary S, Sarrafzadegan N, Siavash M.
Evaluation of the Effects of Cornus mas L. Fruit Extract on Glycemic Control and Insulin Level in Type 2 Diabetic Adult Patients: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
Na HK, Surh YJ Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Download references. First Faculty of Medicine, Department of Social Medicine and Public Health, Medical University of Warsaw, Warsaw, Poland.
Faculty of Health Science, Department of Clinical Dietetics, Medical University of Warsaw, Warsaw, Poland. You can also search for this author in PubMed Google Scholar.
Correspondence to Aleksandra Kozłowska. d'Etude Subst. à Act. Biol, Institut des Sciences de la Vigne e Gr. Biol, Villenave d'Ornon, France. Sukhadia University , Badgaon, Rajasthan, India.
Reprints and permissions. Kozłowska, A. Flavonoids — Food Sources, Health Benefits, and Mechanisms Involved. In: Mérillon, JM. eds Bioactive Molecules in Food.
Reference Series in Phytochemistry. Springer, Cham. Received : 09 October Accepted : 03 November Published : 10 November Publisher Name : Springer, Cham. Print ISBN : Online ISBN : eBook Packages : Springer Reference Chemistry and Mat.
Science Reference Module Physical and Materials Science Reference Module Chemistry, Materials and Physics. Policies and ethics. Skip to main content. Abstract In recent years, growing attention has been focused on the use of natural sources of antioxidants in the prevention of chronic diseases.
Keywords Flavonoids Antioxidants Bioactive compounds Chronic diseases Prevention Neurodegenerative diseases Cataract Erectile dysfunction Inflammatory bowel disease Type 2 diabetes. References Middleton E Jr Effect of plant flavonoids on immune and inflammatory cell function.
Adv Exp Med Biol — Article CAS Google Scholar Kumar S, Pandey AK Chemistry and biological activities of flavonoids: an overview.
ScientificWorldJournal Google Scholar Kozłowska A, Szostak-Węgierek D Flavonoids-food sources and health benefits. Rocz Panstw Zakl Hig —85 Google Scholar Pollastri S, Tattini M Flavonols: old compounds for old roles.
Ann Bot — Article CAS Google Scholar Csepregi K, Neugart S, Schreiner M, Hideg E Comparative evaluation of total antioxidant capacities of plant polyphenols.
Molecules Article CAS Google Scholar Panche AN, Diwan AD, Chandra SR Flavonoids: an overview. Department of Agriculture, 1— Google Scholar Zakaryan H, Arabyan E, Oo A, Zandi K Flavonoids: promising natural compounds against viral infections.
Pharmacol Res — Article CAS Google Scholar Kim K, Vance TM, Chun OK Estimated intake and major food sources of flavonoids among US adults: changes between — and — in NHANES. Eur J Nutr — Article CAS Google Scholar Witkowska AM, Zujko ME, Waskiewicz A, Terlikowska KM, Piotrowski W Comparison of various databases for estimation of dietary polyphenol intake in the population of Polish adults.
Forum Nutr — CAS Google Scholar Kozłowska A, Przekop D, Szostak-Węgierek D Flavonoids intake among Polish and Spanish students. Rocz Panstw Zakl Hig 66 4 — Google Scholar Wang Y, Qian J, Cao J, Wang D, Liu C, Yang R, Li X, Sun C Antioxidant capacity, anticancer ability and flavonoids composition of 35 citrus Citrus reticulata Blanco varieties.
Free Radic Biol Med — Article CAS Google Scholar Wen L, Jiang Y, Yang J, Zhao Y, Tian M, Yang B Structure, bioactivity, and synthesis of methylated flavonoids. Ann N Y Acad Sci — Article CAS Google Scholar Marunaka Y Actions of quercetin, a flavonoid, on ion transporters: its physiological roles.
Ann N Y Acad Sci — Article CAS Google Scholar Jurikova T, Mlcek J, Skrovankova S, Sumczynski D, Sochor J, Hlavacova I, Snopek L, Orsavova J Fruits of Black Chokeberry Aronia melanocarpa in the prevention of chronic diseases.
Pol Merkur Lekarski —54 Google Scholar Faggio C, Sureda A, Morabito S, Sanches-Silva A, Mocan A, Nabavi SF, Nabavi SM Flavonoids and platelet aggregation: a brief review.
Eur J Pharmacol — Article CAS Google Scholar Lin SH, Huang KJ, Weng CF, Shiuan D Exploration of natural product ingredients as inhibitors of human HMG-CoA reductase through structure-based virtual screening.
Drug Des Devel Ther — Google Scholar Li D, Zhang Y, Liu Y, Sun R, Xia M Purified anthocyanin supplementation reduces dyslipidemia, enhances antioxidant capacity, and prevents insulin resistance in diabetic patients. J Nutr — Article CAS Google Scholar Zhu Y, Huang X, Zhang Y, Wang Y, Liu Y, Sun R, Xia M Anthocyanin supplementation improves HDL-associated paraoxonase 1 activity and enhances cholesterol efflux capacity in subjects with hypercholesterolemia.
J Clin Endocrinol Metab — Article CAS Google Scholar Kianbakht S, Abasi B, Hashem Dabaghian F Improved lipid profile in hyperlipidemic patients taking Vaccinium arctostaphylos fruit hydroalcoholic extract: a randomized double-blind placebo-controlled clinical trial.
Phytother Res — Article CAS Google Scholar Cassidy A, Bertoia M, Chiuve S, Flint A, Forman J, Rimm EB Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men.
Am J Clin Nutr — Article CAS Google Scholar Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation — Google Scholar McCullough ML, Peterson JJ, Patel R, Jacques PF, Shah R, Dwyer JT Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults.
Am J Clin Nutr — Article CAS Google Scholar Goetz ME, Judd SE, Safford MM, Hartman TJ, McClellan WM, Vaccarino V Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke REGARDS study.
Am J Clin Nutr — Article CAS Google Scholar Jacques PF, Cassidy A, Rogers G, Peterson JJ, Dwyer JT Dietary flavonoid intakes and CVD incidence in the Framingham Offspring Cohort. Br J Nutr — Article CAS Google Scholar Matsuyama T, Tanaka Y, Kamimaki I, Nagao T, Tokimitsu I Catechin safely improved higher levels of fatness, blood pressure, and cholesterol in children.
Obesity Silver Spring — Article Google Scholar Li B, Yang M, Liu JW, Yin GT Protective mechanism of quercetin on acute myocardial infarction in rats.
Br J Nutr — Article CAS Google Scholar Larson AJ, Symons JD, Jalili T Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms.
Adv Nutr —46 Article CAS Google Scholar Czank C, Cassidy A, Zhang Q, Morrison DJ, Preston T, Kroon PA, Botting NP, Kay CD Human metabolism and elimination of the anthocyanin, cyanidinglucoside: a 13 C-tracer study. Am J Clin Nutr — Article CAS Google Scholar Cassidy A Berry anthocyanin intake and cardiovascular health.
Am J Clin Nutr —22 Article CAS Google Scholar Babu PVA, Liu D, Gilbert ER Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem — Article CAS Google Scholar Liu Y-J, Zhan J, Liu X-L, Wang Y, Ji J, He Q-Q Dietary flavonoids intake and risk of type 2 diabetes: a meta-analysis of prospective cohort studies.
Clin Nutr —63 Article CAS Google Scholar Tresserra-Rimbau A, Guasch-Ferre M, Salas-Salvado J, Toledo E, Corella D, Castaner O, Guo X, Gomez-Gracia E, Lapetra J, Aros F, Fiol M, Ros E, Serra-Majem L, Pinto X, Fito M, Babio N, Martinez-Gonzalez MA, Sorli JV, Lopez-Sabater MC, Estruch R, Lamuela-Raventos RM Intake of total polyphenols and some classes of polyphenols is inversely associated with diabetes in elderly people at high cardiovascular disease risk.
Maturitas —52 Article CAS Google Scholar de Koning Gans JM, Uiterwaal CS, van der Schouw YT, Boer JM, Grobbee DE, Verschuren WM, Beulens JW Tea and coffee consumption and cardiovascular morbidity and mortality.
Arterioscler Thromb Vasc Biol — Article CAS Google Scholar Wallace TC, Slavin M, Frankenfeld CL Systematic review of anthocyanins and markers of cardiovascular disease.
Endocrinology — Article CAS Google Scholar Priscilla DH, Roy D, Suresh A, Kumar V, Thirumurugan K Naringenin inhibits α-glucosidase activity: a promising strategy for the regulation of postprandial hyperglycemia in high fat diet fed streptozotocin induced diabetic rats.
Chem Biol Interact —85 Article CAS Google Scholar Jennings A, Welch AA, Spector T, Macgregor A, Cassidy A Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women. J Nutr — Article CAS Google Scholar Chahar MK, Sharma N, Dobhal MP, Joshi YC Flavonoids: a versatile source of anticancer drugs.
Pharmacogn Rev —12 Article CAS Google Scholar Liao W, Chen L, Ma X, Jiao R, Li X, Wang Y Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells.
Eur J Med Chem —32 Article CAS Google Scholar LY T, Bai HH, Cai JY, Deng SP The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: from macro to nano.
Oncol Rep — Article CAS Google Scholar Kim SH, Hwang KA, Choi KC Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. J Nutr Biochem —82 Article CAS Google Scholar Qin Y, Cui W, Yang X, Tong B Kaempferol inhibits the growth and metastasis of cholangiocarcinoma in vitro and in vivo.
Acta Biochim Biophys Sin Shanghai — Article Google Scholar Dang Q, Song W, Xu D, Ma Y, Li F, Zeng J, Zhu G, Wang X, Chang LS, He D, Li L Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis.
Mol Carcinog — Article CAS Google Scholar Li C, Zhao Y, Yang D, Yu Y, Guo H, Zhao Z, Zhang B, Yin X Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase Biochem Cell Biol —27 Article CAS Google Scholar Katiyar SK Emerging phytochemicals for the prevention and treatment of head and neck cancer.
CA Cancer J Clin —90 Article Google Scholar Xie Q, Chen ML, Qin Y, Zhang QY, HX X, Zhou Y, Mi MT, Zhu JD Isoflavone consumption and risk of breast cancer: a dose-response meta-analysis of observational studies.
Asia Pac J Clin Nutr — CAS Google Scholar Wada K, Nakamura K, Tamai Y, Tsuji M, Kawachi T, Hori A, Takeyama N, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C Soy isoflavone intake and breast cancer risk in Japan: from the Takayama study.
Int J Cancer — Article CAS Google Scholar Hua X, Yu L, You R, Yang Y, Liao J, Chen D, Yu L Association among dietary flavonoids, flavonoid subclasses and ovarian cancer risk: a meta-analysis. J Enzyme Inhib Med Chem Google Scholar George VC, Rupasinghe HPV Apple flavonoids suppress carcinogen-induced DNA damage in normal human bronchial epithelial cells.
Food Chem — Article CAS Google Scholar Jiang Y, Gong P, Madak-Erdogan Z, Martin T, Jeyakumar M, Carlson K, Khan I, Smillie TJ, Chittiboyina AG, Rotte SC, Helferich WG, Katzenellenbogen JA, Katzenellenbogen BS Mechanisms enforcing the estrogen receptor beta selectivity of botanical estrogens.
FASEB J — Article CAS Google Scholar Seo HS, Choi HS, Choi HS, Choi YK, Um JY, Choi I, Shin YC, Ko SG Phytoestrogens induce apoptosis via extrinsic pathway, inhibiting nuclear factor-kappaB signaling in HER2-overexpressing breast cancer cells.
Anticancer Res — CAS Google Scholar Prietsch RF, Monte LG, da Silva FA, Beira FT, Del Pino FA, Campos VF, Collares T, Pinto LS, Spanevello RM, Gamaro GD, Braganhol E Genistein induces apoptosis and autophagy in human breast MCF-7 cells by modulating the expression of proapoptotic factors and oxidative stress enzymes.
Mol Cell Biochem — Article CAS Google Scholar Shike M, Doane AS, Russo L, Cabal R, Reis-Filho JS, Gerald W, Cody H, Khanin R, Bromberg J, Norton L The effects of soy supplementation on gene expression in breast cancer: a randomized placebo-controlled study.
Curr Drug Metab — Article CAS Google Scholar Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P Flavonoid intake and cognitive decline over a year period. Alzheimers Dement — Article Google Scholar Tramutola A, Lanzillotta C, Perluigi M, Butterfield DA Oxidative stress, protein modification and Alzheimer disease.
Oxidative Med Cell Longev Article Google Scholar Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr — Article CAS Google Scholar Solanki I, Parihar P, Mansuri ML, Parihar MS Flavonoid-based therapies in the early management of neurodegenerative diseases.
Adv Nutr —72 Article CAS Google Scholar Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT Neuropathological alterations in Alzheimer disease. a Article CAS Google Scholar Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.
Curr Drug Targets — Article CAS Google Scholar Chesser AS, Ganeshan V, Yang J, Johnson GV Epigallocatechingallate enhances clearance of phosphorylated tau in primary neurons. Nutr Neurosci —31 Article CAS Google Scholar Magalingam KB, Radhakrishnan A, Haleagrahara N Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma PC cells against 6-hydroxydopamine 6-OHDA -induced neurotoxicity.
Int J Mol Med — Article CAS Google Scholar Magalingam KB, Radhakrishnan A, Haleagrahara N Protective effects of flavonol isoquercitrin, against 6-hydroxy dopamine 6-OHDA -induced toxicity in PC12 cells. Neuroreport — Article CAS Google Scholar Gao X, Cassidy A, Schwarzschild MA, Rimm EB, Ascherio A Habitual intake of dietary flavonoids and risk of Parkinson disease.
Neurology — Article CAS Google Scholar Socci V, Tempesta D, Desideri G, De Gennaro L, Ferrara M Enhancing human cognition with cocoa flavonoids. Front Nutr Article Google Scholar Mastroiacovo D, Kwik-Uribe C, Grassi D, Necozione S, Raffaele A, Pistacchio L, Righetti R, Bocale R, Lechiara MC, Marini C, Ferri C, Desideri G Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging CoCoA Study-a randomized controlled trial.
Am J Clin Nutr — Article CAS Google Scholar Samieri C, Sun Q, Townsend MK, Rimm EB, Grodstein F Dietary flavonoid intake at midlife and healthy aging in women. Am J Clin Nutr — Article CAS Google Scholar Eleazu C, Obianuju N, Eleazu K, Kalu W The role of dietary polyphenols in the management of erectile dysfunction-mechanisms of action.
Biomed Pharmacother — Article CAS Google Scholar Pavan V, Mucignat-Caretta C, Redaelli M, Ribaudo G, Zagotto G The old made new: natural compounds against erectile dysfunction.
Biochem Res Int Google Scholar Cassidy A, Franz M, Rimm EB Dietary flavonoid intake and incidence of erectile dysfunction. Am J Clin Nutr — Article CAS Google Scholar Patil KK, Gacche RN Inhibition of glycation and aldose reductase activity using dietary flavonoids: a lens organ culture studies.
Int J Biol Macromol — Article CAS Google Scholar Patel DK, Prasad SK, Kumar R, Hemalatha S Cataract: a major secondary complication of diabetes, its epidemiology and an overview on major medicinal plants screened for anticataract activity.
Asian Pac J Trop Dis — Article Google Scholar Bhatnagar A, Srivastava SK Aldose reductase: congenial and injurious profiles of an enigmatic enzyme. Biochem Med Metab Biol — Article CAS Google Scholar Patil KK, Meshram RJ, Dhole NA, Gacche RN Role of dietary flavonoids in amelioration of sugar induced cataractogenesis.
Arch Biochem Biophys —11 Article CAS Google Scholar Mok JW, Chang DJ, Joo CK Antiapoptotic effects of anthocyanin from the seed coat of black soybean against oxidative damage of human lens epithelial cell induced by H2O2.
Curr Eye Res — Article CAS Google Scholar Chantrill BH, Coulthard CE, Dickinson L, Inkley GW, Mrris W, Pyle AH The action of plant extracts on a bacteriophage of pseudomonas pyocyanea and on influenza a virus.
Microbiology —84 CAS Google Scholar Li B, Guo QL, Tian Y, Liu SJ, Wang Q, Chen L, Dong JX New anti-HBV C-boivinopyranosyl flavones from Alternanthera philoxeroides.
World J Gastroenterol — Article CAS Google Scholar Zhong L, Hu J, Shu W, Gao B, Xiong S Epigallocatechingallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication.
Res Pharm Sci — CAS Google Scholar Liang G, Li N, Ma L, Qian Z, Sun Y, Shi L, Zhao L Effect of quercetin on the transport of ritonavir to the central nervous system in vitro and in vivo. Acta Pharma — Article CAS Google Scholar Cantatore A, Randall SD, Traum D, Adams SD Effect of black tea extract on herpes simplex virus-1 infection of cultured cells.
BMC Complement Altern Med Article Google Scholar de Oliveira A, Adams SD, Lee LH, Murray SR, Hsu SD, Hammond JR, Dickinson D, Chen P, Chu TC Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate.
Res Vet Sci —33 Article CAS Google Scholar Muller P, Downard KM Catechin inhibition of influenza neuraminidase and its molecular basis with mass spectrometry. Antimicrob Agents Chemother — Article CAS Google Scholar Hung PY, Ho BC, Lee SY, Chang SY, Kao CL, Lee SS, Lee CN Houttuynia cordata targets the beginning stage of herpes simplex virus infection.
Am J Chin Med — Article Google Scholar Fan FY, Sang LX, Jiang M Catechins and their therapeutic benefits to inflammatory bowel disease. J Crohns Colitis — Article Google Scholar Vasconcelos PC, Seito LN, Di Stasi LC, Akiko Hiruma-Lima C, Pellizzon CH Epicatechin used in the treatment of intestinal inflammatory disease: an analysis by experimental models.
Free Radic Biol Med —16 Article CAS Google Scholar Na HK, Surh YJ Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG.
There Flavonoids and overall well-being Flavonooids increasing interest in the research First aid for DKA flavonoids from dietary Flavnoids, due to growing evidence of the versatile health anx of flavonoids through epidemiological Flavoboids. As occurrence Flavonoids and overall well-being flavonoids is directly associated with Pre-game meal ideas daily dietary intake of antioxidants, it is important to evaluate flavonoid sources in food. Fruits and vegetables are the main dietary sources of flavonoids for humans, along with tea and wine. However, there is still difficulty in accurately measuring the daily intake of flavonoids because of the complexity of existence of flavonoids from various food sources, the diversity of dietary culture, and the occurrence of a large amount of flavonoids itself in nature. Nevertheless, research qnd the health aspects of flavonoids for humans is expanding rapidly.
Flavonoids and overall well-being -
The authors wish to thank Professor Thomas A. Gerds for his statistical advice. The Danish Diet, Cancer, and Health Study was funded by the Danish Cancer Society, Denmark. FD is funded by The Danish Heart Foundation Grant number RA and Gangstedfonden Grant number A , Denmark. NPB is funded by a National Health and Medical Research Council Early Career Fellowship Grant number APP , Australia.
The salary of JMH is supported by a National Health and Medical Research Council of Australia Senior Research Fellowship, Australia Grant number APP School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia.
Nicola P. Bondonno, Catherine P. Bondonno, Joshua R. Lewis, Kevin D. School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia.
The Danish Cancer Society Research Centre, Copenhagen, Denmark. School of Population and Global Health, University of Western Australia, Crawley, Western Australia, Australia. The National Institute of Public Health, University of Southern Denmark, Odense, Denmark.
International Agency for Research on Cancer, Lyon, France. Department of Public Health, Aarhus University, Aarhus, Denmark. You can also search for this author in PubMed Google Scholar. contributed to the study concept and design; AS calculated the flavonoid intake from FFQ data; N.
and F. conducted the data analysis; N. drafted the manuscript; N. critically reviewed the final draft of the manuscript. Correspondence to Nicola P.
Peer Review Information: Nature Communications thanks the anonymous reviewer s for their contribution to the peer review of this work.
Peer reviewer reports are available. Open Access This article is licensed under a Creative Commons Attribution 4. Reprints and permissions. Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort.
Nat Commun 10 , Download citation. Received : 23 February Accepted : 22 July Published : 13 August Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
Provided by the Springer Nature SharedIt content-sharing initiative. European Journal of Clinical Nutrition By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly. Skip to main content Thank you for visiting nature.
nature nature communications articles article. Download PDF. Subjects Cancer Cardiology Diseases. Abstract Flavonoids, plant-derived polyphenolic compounds, have been linked with health benefits.
Introduction Fruit and vegetable intakes are associated with a lower risk of cardiovascular disease CVD , cancer, and all-cause mortality, with an estimated 7.
Results Baseline characteristics In this population of 56, Danish citizens, with a median [IQR] age of 56 [52—60] years at entry, 14, died from any cause during 1,, person-years of follow-up. Table 1 Baseline characteristics of study population Full size table.
Full size image. Table 2 Hazard ratios of all-cause mortality by quintiles of flavonoid intake Full size table. Table 3 Hazard ratios of cardiovascular disease-related mortality by quintiles of flavonoid intake Full size table.
Table 4 Hazard ratios of cancer-related mortality by quintiles of flavonoid intake Full size table. Discussion There is great potential to improve population health through improved dietary behaviors, with tailored recommendations focusing on specific dietary components and population subgroups.
Methods Study population From December to May the study recruited 56, participants without cancer prior to enrollment, between the age of 50—65 years, residing in the greater area of Copenhagen and Aarhus, Denmark.
Consort flow diagram. CVD cardiovascular disease. Data availability Due to restrictions related to Danish law and protecting patient privacy, the combined set of data as used in this study can only be made available through a trusted third party, Statistics Denmark. References Aune, D. Article Google Scholar US Department of Agriculture.
Article CAS Google Scholar Bondonno, C. Article Google Scholar Carocho, M. Article CAS Google Scholar Grosso, G. Article Google Scholar Bondonno, N.
Article Google Scholar Helweg-Larsen, K. Article Google Scholar Ivey, K. Article CAS Google Scholar Kim, Y. Article Google Scholar Shrime, M. Article CAS Google Scholar Williamson, G. Article ADS CAS Google Scholar Zamora-Ros, R. Article CAS Google Scholar Mink, P. Article CAS Google Scholar Ambrose, J.
Article CAS Google Scholar Roerecke, M. Article Google Scholar Tu, S. Article CAS Google Scholar Braun, K. Article CAS Google Scholar Begum, M. Article Google Scholar Woo, H.
Article ADS CAS Google Scholar Esposito, D. Article CAS Google Scholar Cassidy, A. Article Google Scholar Tilg, H.
Article CAS Google Scholar Tjønneland, A. Article Google Scholar JØNneland, A. Article Google Scholar Neveu, V. Article CAS Google Scholar Zamora-Ros, R. Article ADS CAS Google Scholar Knaze, V. Article Google Scholar Schmidt, M. Article Google Scholar Noordzij, M. Article Google Scholar Flegal, K.
Article CAS Google Scholar Willett, W. Article CAS Google Scholar Download references. Acknowledgements The authors wish to thank Professor Thomas A. Author information Author notes These authors contributed equally: Nicola P.
Bondonno, Frederik Dalgaard. Authors and Affiliations School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia Nicola P. Hodgson School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia Nicola P.
Bondonno View author publications. View author publications. Ethics declarations Competing interests The authors declare no competing interests. Additional information Peer Review Information: Nature Communications thanks the anonymous reviewer s for their contribution to the peer review of this work.
Supplementary information. Supplementary Information. Peer Review File. Reporting Summary. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.
About this article. Cite this article Bondonno, N. Copy to clipboard. This article is cited by Microbiota profiles in the saliva, cancerous tissues and its companion paracancerous tissues among Chinese patients with lung cancer Yuhan Zhou Hongfen Zeng Zhaonan Yu BMC Microbiology Change in habitual intakes of flavonoid-rich foods and mortality in US males and females Nicola P.
Bondonno Yan Lydia Liu Aedín Cassidy BMC Medicine Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders Urvi A. Shah Richa Parikh Alexander M. Lesokhin Leukemia Intake of dietary flavonoids and incidence of ischemic heart disease in the Danish Diet, Cancer, and Health cohort Benjamin H.
Parmenter Frederik Dalgaard Nicola P. Bondonno European Journal of Clinical Nutrition Partially substituting chemical NPK fertilizers and their impact on Eureka lemon trees Citrus limon L. Burm productivity and fruit quality Abdulrhman A.
Almadiy Ayman E. They include:. Flavanols: This type of flavonoid has particularly strong antioxidant properties that can help protect your body against symptoms of cardiovascular disease and other chronic conditions.
They can be found in foods such as broccoli, tomatoes, onions, lettuce, peaches, berries, grapes, and kale, as well as liquids such as tea and red wine. Flavanols: The most commonly-consumed type of flavonoid, flavanol, can lower your risk of several forms of cardiometabolic disease, including but not limited to hypertension high blood pressure , insulin resistance, and dyslipidemia high cholesterol.
Flavanols can be found in tea, chocolate, apples, pears, and berries. Flavones: Flavones are notable for their ability to help reduce inflammation in the body. They can typically be found in parsley, red peppers, celery, chamomile, and peppermint. Eat a rainbow," she said.
Trying to overhaul your entire diet can be difficult, so start by making small changes. Eating fresh, whole foods is the best way to get the flavonoids you need, she said. But it's not the only way. If fresh fruits aren't available, frozen berry mixes are a good alternative, Peterson said.
Fruits and vegetables that are flash frozen retain high levels of nutrients, store easily and can add variety to the plate even when out of season.
You can also drink flavonoids. Beverages such as red wine and tea, especially black or green tea, are good sources. Fruits and vegetables can be squeezed into juices or smoothies as well, but Petersen said juicing is less than ideal because it removes a lot of beneficial fiber.
There's no need to force yourself to eat foods you don't like in order to get your flavonoid fix. And don't be afraid to try new ones. Anyone already following the Mediterranean, DASH or MIND diets — or any high-quality plant-based diet — shouldn't have to worry.
If you have questions or comments about this story, please email [email protected]. American Heart Association News covers heart disease, stroke and related health issues.
Not all views expressed in American Heart Association News stories reflect the official position of the American Heart Association.
Flavonoidw are a welp-being family of qnd 5, hydroxylated polyphenolic compounds that carry out important functions in Flavooids, including attracting pollinating Selenium test reporting combating environmental Flzvonoids, such as microbial Flavonoids and overall well-being caloric restriction and disease prevention regulating cell growth 1. Their bioavailability and biological activities in Flavooids appear Flavonoids and overall well-being be overalk influenced by their chemical nature. Since the s, there has been a growing interest in dietary flavonoids due to their likely contribution to the health benefits of fruit- and vegetable-rich diets. This article reviews some of the scientific evidence regarding the role of dietary flavonoids in health promotion and disease prevention in humans; it is not meant to be a comprehensive review on every health topic studied. Flavonoids are classified into 12 major subclasses based on chemical structures, six of which, namely anthocyanidins, flavanols, flavonols, flavones, flavanones, and isoflavones Table 1 and Figures are of dietary significance.
Nach meiner Meinung sind Sie nicht recht. Schreiben Sie mir in PM, wir werden besprechen.