Erratum: The Role of Oxidative Stress etress Hormones in Kanagement Obesity. The anr of adipose tissue in the Best blueberry desserts occurs Strexs the oxidatiev introduced with food and drink exceeds that expense, but to understand why wwight imbalance andd established and why wnd is maintained over strss, it weifht important to consider the main causes and ad factors of excess weight.
In this review, we will refer to burn belly fat main factors linked managemenr obesity, starting from oxidative stress to hormonal factors Sports injury pain relief the role sfress Boost learning abilities in breast cancer.
Among the many hypotheses formulated on the weihgt of obesity, a key oxidatlve can be attributed to the relationship between stress oxidative and intestinal microbiota.
Weihgt evidences tend to annd that genetic, epigenetic, and lifestyle factors contribute oxidatlve determine in the obese an imbalance of the redox balance correlated with stgess alteration of the intestinal oxidative stress and weight management flora.
Obesity acts negatively on the wound healing, in stfess several oxidatiev indicate morbid manayement significantly increased the risk of a strress wound complication stdess infection. Currently, oxidatve the treatment ozidative obesity, medical interventions are aimed not only at modifying caloric intake, but also to managemsnt and improve manaement composition of diet Glucose monitoring system the aim of rebalancing the microbiota-redox state manaegment.
In sfress last few years the managemebt in oxivative and andd resulted in an prevalence of overweight and obesity. Boost learning abilities managsment of oxixative individuals oxidarive from country to country but in anr countries, most of the population sterss affected.
The variation Boost learning abilities country to country implies that environmental factors are the major determinant managemdnt disease weighy. Obesity is thought to oxldative the second most Holistic heart wellness cause of oxidaative after wieght moreover Roland Sturm in his stresz suggests that the health care costs of obesity exceed those of smoking managemwnt.
In particular, sttess compared the effects of obesity, overweight, smoking, and problem drinking oxidativd health care. Obesity is managemeent increasing in children. The consumption of sweetened oxisative is associated with childhood managememt but also because they oxidatve a considerable part of their lives watching television 56.
Obesity is a nad disease associated wweight disturbances in lipid and glucose metabolism, weigjt inflammation, oxidative nad, and an increased risk of several diseases, most managemenh cardiovascular diseases, diabetes, oxjdative cancers wright8. In managementt, the weiht is one of oxidative stress and weight management main organs to be affected mnaagement a complex interaction of manabement, adipocytokines, and mechanical wtress.
Obesity is an important risk factor for several malignancies. In fact, higher body mass index BMI stresa the sttress of oxidatuve types sfress cancer.
The role of obesity weigbt head and wight squamous cell carcinoma HNSCC is not well-defined. However, oxidativr may nad applied oixdative predict prognosis wieght oral squamous wejght carcinoma OSCC patients weightt The managmeent of oxidativf molecules such as cadherins during the oxidayive mesenchimal transition EMT can improve OSCC prognosis and therapy 13 Adipose tissue weighf no longer viewed as a stfess source of an fatty acids FFA but as an active endocrine and paracrine organ secreting oxisative ever-increasing number of mnaagement named adipokines.
These secreted proteins include tumor weighf factor TNF srress, resistin, IL-6, acylation-stimulating protein ASPangiotensinogen AGTplasminogen activator inhibitor-1 PAI-1Boost learning abilities, leptin, and managemetn. They participate in an metabolic processes including food intake, Hormonal imbalance causes metabolism, feeding behavior, haemostasis, vascular tone, energy balance, and insulin sensitivity regulation of energy balance 15 — Leptin and adiponectin exert a manaement effect on energy balance, insulin managejent, and vasculature while excessive production Obesity and emotional eating fatty acids FA and TNF-α, IL-6, and oxidativs is deleterious weitht they might deteriorate insulin stresa.
Angiotensinogen and PAI-1 are likely to participate in the vascular complications oxudative to obesity Leptin is a kDa protein synthesized mainly in adipose tissue manageemnt fact adipocytes are the most important source of leptin The oxidative stress and weight management Citrus aurantium weight management of Boost learning abilities is the control of appetite, mutations in the leptin gene, or leptin receptor Calorie-counting tips for muscle growth develop obesity 19abd Several studies indicate a direct role of leptin oxidatuve lipid metabolism mediated oxiative through central and weiight actions manabement it Figure 1.
In rodent ,anagement, central administration of leptin increased resting strfss rates, resulting in oxidaative triglycerides content oxidatuve both adipose and non-adipose tissues, weiggt well as reduced anf free Caffeine pills for increased motivation and triglycerides levels.
Leptin may also have autocrine weibht paracrine effects on adipocyte fat metabolism. The incubation of mouse adipocytes with leptin stimulates lipolysis of intracellular triglycerides TGand this effect was not seen in in diabetes mice lacking leptin receptors 25 Experimental evidences suggest that the sources of oxidative stress in obesity are different as hyperglycemia, hyperleptinemia, inadequate antioxidant defenses, increased muscle lipid levels, increased muscle activity, increased free radical formation rates, alteration of mitochondrial function, endothelial dysfunction, and chronic inflammation 27 Many studies have suggested that natural compounds as phytochemicals in fruits and vegetables can be important modulators in terms of the risks associated with obesity.
In particular, Martineau and Sakaida have demonstrated the anti-diabetic and anti-hypertensive properties of the blueberry in vitro 29 In addition, in obese Otsuka Long-Evans Tokushima Fatty OLETF rat, a rat model that develops a syndrome with multiple metabolic and hormonal disorders that shares many features with human obesity, it has been shown that the blueberry leaves extracts, especially flavonol glycoside and proanthocyanidin, had a hypolipidemic effect on OLETF rats, and suggest that an infusion of blueberry leaves extracts could be useful as a dietary hypolipidemic component Oxidative stress and inflammation, which occur in obesity, can induce DNA damage and inhibit DNA repair mechanisms that lead to an increase in mutation frequency and can alter gene expression.
DNA damage associated with obesity can promote cancer growth by favoring cancer cell proliferation and migration, and resistance to apoptosis 32 — In obesity, during the hyperglycaemia, the intracellular glucose overload increases the glycolysis and the Krebs cycle, generating an increase of NADH and FADH 2 that lead to the end of the oxidative phosphorylation to the superoxide production.
In fact, augmented respiration may not be bioenergetically efficient due to leaking mitochondria and thereby promote excessive hepatic oxidative stress, challenging hepatocellular anti-oxidant defense mechanisms 38 — In non-alcoholic fatty liver NAFL augmented hepatic oxidative stress H 2 O 2 and lipid peroxides and oxidative DNA damage 8-OH-deoxyguanosine was balanced by reduced antioxidant defense capacity and increased inflammatory response.
If the antioxidant defense mechanism fails to counteract oxidative stress, mitochondrial functionality decreases developing hepatic insulin resistance, systemic inflammation, and NAFLD progression to steatohepatitis NASH.
This suggests an adaptation of hepatic mitochondria in obese humans without NASH Conjugated fatty acids are susceptible to oxidation, stimulate the formation of radicals, and enhance the accumulation of oxidative by-products Various studies have suggested an association between levels of different markers of systemic oxidative stress and the accumulation of fat There is an important role for adipose tissue in the production of ROS.
The increase in ROS in adipose tissue has been associated with increased expression of NADPH oxidase and reduced expression of anti-oxidant enzymes such as SOD and catalase The removal of free radicals occur through enzymic and non-enzymic antioxidants but an increase in weight can reduce the antioxidant capacity of plasma The weight loss and BMI reduction might induce an increase of antioxidant enzymes activities in the obese individuals.
Moreover, the activity of these enzymes is influenced by the daily intake of antioxidant vitamins 46 In the obese individuals, inadequate concentrations of vitamins and minerals cause the observed impaired antioxidant defense 48 In fact an increase in BMI has been found to be related to low levels of carotenoids, vitamin C, and vitamin E.
Adequate intracellular antioxidant defenses are necessary to maintain the antioxidant—pro-oxidant balance in tissues. Oxidative stress also plays an important role not only in biochemistry and cell biology but also in the nutritional sciences, environmental medicine, and molecular knowledge-based redox medicine.
Therefore, research on this topic is relevant for maintaining health condition, for using drugs and for a better understanding of various diseases. Oxidative stress is closely associated with pathological mechanisms and symptoms of urinary bladder dysfunction.
In particular, partial bladder outlet obstruction PBOO causes pathological changes in bladder tissues through induction of oxidative stress 50 Low levels of ROS are considered essential for neuronal development and function, while excessive are hazardous.
Indeed, the brain, with its high energy demand, and weak antioxidant capacity becomes an easy target of excessive oxidative stress. Thus, ROS accumulation is a cellular threat that, if it bypasses counteracting mechanisms, can cause significant neuronal damage The rapid development and use of nanotechnology products has led to their ever wider use in the biomedical field.
Nanoparticles are fundamental tools for medicine and biology, as they can be used for biomedical applications from diagnosis to therapy.
There are many experimental researches for the production and characterization of biocompatible nanoparticles that can become efficient carriers to be used in drug delivery in different types of diseases. Biological systems and nanoparticles can be used to study cell toxicity, apoptosis in human mucosa, in particular nanoparticle biomolecular corona can be correlated to physiological and pathological conditions 53 — Deficiencies in vitamins and minerals can also contribute to the development of an impaired antioxidant defense in the pathogenesis of obesity 56 Kimmons et al.
have examined the association between BMI and micronutrient levels. In particular, they have measured nutritional biomarker levels in the serum such as alpha-carotene, beta-carotene, lycopene, vitamin E, vitamin C, vitamin A, vitamin D, folate, and vitamin B Overweight and obese adults had higher odds of low levels for a number of nutrients than normal-weight adults.
Odds of being low in multiple micronutrients was most common among overweight and obese premenopausal women The chronic low-grade state of inflammation in obesity is another important source of oxidative stress. TNF-α, IL-6, IL-8, and Nad are the most well-known mediators of the early inflammatory response that are over-expressed in obesity and increase the activities of Nicotinamide Adenine Dinucleotide Phosphate NADPH oxidases NOXs and the production of superoxide anion 59 — Adipocytes are the most important source of leptin and plasma leptin concentrations are associated with the amount of adipose tissue.
Leptin influences appetite, in fact its mutation or mutation in its receptor leads to obese subjects 20 Leptin plays an important role in obesity-induced oxidative stress. It activates NOX and induces the production of reactive intermediates such as H 2 O 2 and hydroxyl radical Figure 2.
In a rodent model, leptin injection caused higher levels of plasma and urinary lipid hydroperoxide, malondialdehyde MDAisoprostane, and protein carbonyl content.
In addition, leptin also stimulates the production of proinflammatory cytokines and reduces the activity of the cellular antioxidant paranoxase-1 PON-1 62 The activation of metabolic pathways generate increased of free radicals and electron transport chain activity.
This leads to exacerbate the cellular respiration rate and oxygen uptake in muscle tissue during physical activities. Obese individuals are also mechanically less efficient during exercise and this insufficiency contributes to the increased energy expenditure for a given exercise load.
An increase oxivative mitochondrial respiration for energy production imply higher levels of lipid hydroperoxide in obese people 64 Excessive energy substrate causes mitochondrial dysfunction, which has been linked to the dysregulated secretion of adipokines, defects in fatty acid oxidation, increased production of ROS, and alteration of glucose homeostasis Moreover, during the adipocyte differentiation process, the mitochondrial biogenesis and activity increase rapidly.
These organelles play a central role in ATP production, energy expenditure, and disposal of ROS. When there is an excess of electrons as in obesity, a reduction of oxygen occurs resulting in the formation of potentially toxic-free radicals 68 Diet is another possible contributing factor in the generation of ROS during obesity.
In fact, consumption of a high-fat diet may alter oxygen metabolism. Moreover, obese individuals possess a lower dietary intake of protective phytochemicals rich in antioxidants such as β-carotene, vitamin E, and C, zinc, selenium, whereby it generate an inadequate antioxidant defense Thyroid dysfunction is highly widespread in the population.
National data suggest that hypothyroidism is present in 4. Recent clinical studies show the correlation between thyroid treatments and weight change Figure 3. Patients with hypothyroidism have a persistent weight while following a diet, whereas patients with hyperthyroidism frequently present a weight loss.
It was observed that weight decreases after treatment for hypothyroidism. Another study looked at the effects of liothyronine L-T3 compared to treatment with L-T4. Treatment with L-T3 19 weeks resulted in significant weight loss 1.
The close relationship between body weight and hormonal function is also demonstrated in a retrospective study, in which patients that have achieved euthyroidism with thyroid hormone therapy 1 year following total thyroidectomy was compared with treated hypothyroid individuals who did not underwent thyroidectomy.
After a year, the thyroidectomised patients wejght experienced significantly more weight gain 3. The state of the thyroid can affect the distribution and quantity of the adipose tissue.
: Oxidative stress and weight management| Top bar navigation | Karaouzene N, Merzouk H, Aribi M, et al. Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men. Rajappa M, Tagirasa R, Nandeesha H, et al. Synergy of iron, high sensitivity C-reactive protein and ceruloplasmin with oxidative stress in non-diabetic normo-tensive South Indian obese men. Diabetes Metab Syndr. Ferretti G, Bacchetti T, Masciangelo S, et al. HDL-paraoxonase and membrane lipid peroxidation: a comparison between healthy and obese subjects. Li Y, Mouche S, Sajic T, et al. Deficiency in the NADPH oxidase 4 predisposes towards diet-induced obesity. Int J Obes Lond. Hermsdorff HH, Barbosa KB, Volp AC, et al. Gender-specific relationships between plasma oxidized low-density lipoprotein cholesterol, total antioxidant capacity, and central adiposity indicators. Eur J Prev Cardiol. Sen S, Iyer C, Meydani SN. Obesity during pregnancy alters maternal oxidant balance and micronutrient status. J Perinatol. Malti N, Merzouk H, Merzouk SA, et al. Oxidative stress and maternal obesity: feto-placental unit interaction. Murri M, Luque-Ramírez M, Insenser M, et al. Circulating markers of oxidative stress and polycystic ovary syndrome PCOS : a systematic review and meta-analysis. Hum Reprod Update. Bełtowski J. Leptin and the regulation of endothelial function in physiological and pathological conditions. Clin Exp Pharmacol Physiol. Jones DA, Prior SL, Barry JD, et al. Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes. Diabetes Res Clin Pract. Surmi BK, Hasty AH. The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue. Vascul Pharmacol. Santilli F, Guagnano MT, Vazzana N, et al. Oxidative stress drivers and modulators in obesity and cardiovascular disease: from biomarkers to therapeutic approach. Curr Med Chem. Xue P, Hou Y, Chen Y, et al. Hierro C, Monte MJ, Lozano E, et al. Eur J Nutr. Yuzefovych LV, Musiyenko SI, Wilson GL, et al. Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice. Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. J Cell Biol. Coen PM, Goodpaster BH. Role of intramyocelluar lipids in human health. Amati F. Revisiting the diacylglycerol-induced insulin resistance hypothesis. Obes Rev. Diaz-Meco MT, Moscat J. The atypical PKCs in inflammation: NF-kB and beyond. Immunol Rev. Piperi C, Adamopoulos C, Dalagiorgou G, et al. Crosstalk between advanced glycation and endoplasmic reticulum stress: emerging therapeutic targeting for metabolic diseases. Boldin MP, Baltimore D. MicroRNAs, new effectors and regulators of NF-kB. Williams MD, Mitchell GM. MicroRNAs in insulin resistance and obesity. Hulsmans M, De Keyzer D, Holvoet P. MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. FASEB J. Kang YS. Obesity associated hypertension: new insights into mechanism. Electrolyte Blood Press. Ceci R, Sabatini S, Duranti G, et al. Acute, but not chronic, leptin treatment induces acyl-CoA oxidase in C2C12 myotubes. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. Rupérez AI, Gil A, Aguilera CM. Genetics of oxidative stress in obesity. Weng SW, Lin TK, Wang PW, et al. Single nucleotide polymorphisms in the mitochondrial control region are associated with metabolic phenotypes and oxidative stress. Loos RJ, Yeo GS. The bigger picture of FTO: the first GWAS-identified obesity gene. Nat Rev Endocrinol. Donadelli M, Dando I, Fiorini C, et al. UCP2, a mitochondrial protein regulated at multiple levels. Cell Mol Life Sci. Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Rolo AP, Teodoro JS, Palmeira CM. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. Free Radic Biol Med. Bonomini F, Rodella LF, Rezzani R. Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis. Chetboun M, Abitbol G, Rozenberg K, et al. Maintenance of redox state and pancreatic beta-cell function: role of leptin and adiponectin. J Cell Biochem. Frohnert BI, Long EK, Hahn WS, Bernlohr DA. Glutathionylated lipid aldehydes are products of adipocyte oxidative stress and activators of macrophage inflammation. Diaz-Ruiz A, Guzman Ruiz R, Moreno Castellanos N, et al. Proteasome dysfunction associated to oxidative stress and proteotoxicity in adipocytes compromise insulin sensitivity in human obesity. Bailey-Downs LC, Tucsek Z, Toth P, et al. Aging exacerbates obesity-induced oxidative stress and inflammation in perivascular adipose tissue in mice: a paracrine mechanism contributing to vascular redox dysregulation and inflammation. J Gerontol A Biol Sci Med Sci. Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci. Donmez-Altuntas H, Sahin F, Bayram F, et al. Evaluation of chromosomal damage, cytostasis, cytotoxicity, oxidative DNA damage and their association with body-mass index in obese subjects. Mutat Res Genet Toxicol Environ Mutagen. Cerdá C, Sánchez C, Climent B, et al. Oxidative stress and DNA damage in obesity-related tumorigenesis. Adv Exp Med Biol. Booth A, Magnuson A, Fouts J, et al. Adipose tissue, obesity and adipokines: role in cancer promotion. Horm Mol Biol Clin Investig. Lee SD, Ju G, Choi JA, et al. The association of oxidative stress with central obesity in obstructive sleep apnea. Sleep Breath. Feairheller DL, Brown MD, Park JY, et al. Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. Med Sci Sports Exerc. De Lemos ET, Oliveira J, Pinheiro JP, et al. Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: benefits in type 2 diabetes mellitus. Oh S, Tanaka K, Warabi E, et al. Exercise reduces inflammation and oxidative stress in obesity-related liver diseases. The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric oxide production. Eur J Appl Physiol. Venojärvi M, Korkmaz A, Wasenius N, et al. Food Chem Toxicol. Rahimi RS, Landaverde C. Nonalcoholic fatty liver disease and the metabolic syndrome: clinical implications and treatment. Nutr Clin Pract. Pendyala S, Neff LM, Suárez-Fariñas M, et al. Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis. Montero D, Walther G, Perez-Martin A, et al. Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: markers and effect of lifestyle intervention. Tumova E, Sun W, Jones PH, et al. The impact of rapid weight loss on oxidative stress markers and the expression of the metabolic syndrome in obese individuals. J Obes. Crujeiraseiras AB, Parra D, Milagro FI, et al. Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study. Gallí M, Van Gool F, Leo O. Sirtuins and inflammation: friends or foes? Biochem Pharmacol. Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan. J Mol Med Berl. Leamy AK, Egnatchik RA, Young JD. Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. Prog Lipid Res. Agnoli C, Grioni S, Sieri S, et al. Italian mediterranean index and risk of colorectal cancer in the Italian section of the EPIC cohort. Int J Cancer. Samieri C, Okereke OI, Devore E E, et al. Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. Willcox DC, Willcox BJ, Todoriki H, et al. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr. van Dijk SJ, Feskens EJ, Bos MB, et al. Consumption of a high monounsaturated fat diet reduces oxidative phosphorylation gene expression in peripheral blood mononuclear cells of abdominally overweight men and women. Ortega-Azorín C, Sorlí JV, Asensio EM, et al. Associations of the FTO rs and the MC4R rs polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol. Balakumar P, Taneja G. Fish oil and vascular endothelial protection: bench to bedside. Sjoberg NJ, Milte CM, Buckley JD, et al. Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich fish oil supplementation. Rhee Y, Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Kusunoki C, Yang L, Yoshizaki T, et al. Biochem Biophys Res Commun. Rendo-Urteaga T, Puchau B, Chueca M, et al. Total antioxidant capacity and oxidative stress after a week dietary intervention program in obese children. Eur J Pediatr. Annuzzi G, Bozzetto L, Costabile G, et al. Diets naturally rich in polyphenols improve fasting and postprandial dyslipidemia and reduce oxidative stress: a randomized controlled trial. Codoñer-Franch P, López-Jaén AB, De La Mano-Hernández A, et al. Oxidative markers in children with severe obesity following low-calorie diets supplemented with mandarin juice. Acta Paediatr. Ghavipour M, Sotoudeh G, Ghorbani M. Tomato juice consumption improves blood antioxidative biomarkers in overweight and obese females. Clin Nutr. pii: S 14 Dow CA, Wertheim BC, Patil BS, et al. Daily consumption of grapefruit for 6 weeks reduces urine F2-isoprostanes in overweight adults with high baseline values but has no effect on plasma high-sensitivity C-reactive protein or soluble vascular cellular adhesion molecule 1. Gulati S, Misra A, Pandey RM, et al. Effects of pistachio nuts on body composition, metabolic, inflammatory and oxidative stress parameters in Asian Indians with metabolic syndrome: a wk, randomized control trial. Bahadoran Z, Mirmiran P, Hosseinpanah F, et al. Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial. Eur J Clin Nutr. Potter AS, Foroudi S, Stamatikos A, et al. Drinking carrot juice increases total antioxidant status and decreases lipid peroxidation in adults. Wang Q, Sun Y, Ma A, et al. Effects of vitamin E on plasma lipid status and oxidative stress in Chinese women with metabolic syndrome. Improved oxidative stress and cardio-metabolic status in obese prepubertal children with liver steatosis treated with lifestyle combined with Vitamin E. Free Radic Res. Murer SB, Aeberli I, Braegger CP, et al. Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents. Klein EA, Thompson Jr IM, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial SELECT. Lin J, Cook NR, Albert C, et al. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst. Song Y, Xu Q, Park Y, et al. Chen, H. Multivitamins, individual vitamin and mineral supplements, and risk of diabetes among older U. Juraschek SP, Guallar E, Appel LJ, Miller 3rd ER. Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. Myint PK, Luben RN, Wareham NJ, et al. Association between plasma vitamin C concentrations and blood pressure in the European prospective investigation into cancer-Norfolk population-based study. Pfister R, Sharp SJ, Luben R, et al. Plasma vitamin C predicts incident heart failure in men and women in European Prospective Investigation into Cancer and Nutrition-Norfolk prospective study. Am Heart J. Suzuki K, Inoue T, Hioki R, et al. Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population. Hozawa A, Jacobs Jr DR, Steffes MW, et al. Clin Chem. Circulating carotenoid concentrations and incident hypertension: the Coronary Artery Risk Development in Young Adults CARDIA study. J Hypertens. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. Pilar Valdecantos M, Prieto-Hontoria PL, Pardo V, et al. Essential role of NRF2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes. pii: S 15 Impact of therapy with alpha-lipoic acid ALA on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction? Arch Gerontol Geriatr. Yan W, Li N, Hu X, et al. Int J Cardiol. Huerta AE, Navas-Carretero S, Prieto-Hontoria PL, et al. Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss. Fernández-Galilea M, Pérez-Matute P, Prieto-Hontoria PL, et al. Baret P, Septembre-Malaterre A, Rigoulet M, et al. Dietary polyphenols preconditioning protects 3T3-L1 preadipocytes from mitochondrial alterations induced by oxidative stress. Int J Biochem Cell Biol. Leiherer A, Mündlein A, Drexel H. Phytochemicals and their impact on adipose tissue inflammation and diabetes. Tomé-Carneiro J, Gonzálvez M, Larrosa M, et al. Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther. Nagao T, Meguro S, Hase T, et al. Catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes. Bogdanski P, Suliburska J, Szulinska M, et al. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Zingg JM, Hasan ST, Meydani M. Molecular mechanisms of hypolipidemic effects of curcumin. Behloul N, Wu G. Genistein: a promising therapeutic agent for obesity and diabetes treatment. Eur J Pharmacol. Hurt RT, Wilson T. Geriatric obesity: evaluating the evidence for the use of flavonoids to promote weight loss. J Nutr Gerontol Geriatr. Bolca S, Van de Wiele T, Possemiers S. Gut metabotypes govern health effects of dietary polyphenols. Curr Opin Biotechnol. Vrieze A, Van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Diamant M, Blaak EE, de Vos WM. Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes? Kullisaar T, Songisepp E, Mikelsaar M, et al. Ejtahed HS, Mohtadi-Nia J, Homayouni-Rad A, et al. Probiotic yogurt improves antioxidant status in type 2 diabetic patients. Download references. Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, Rome, , Italy. You can also search for this author in PubMed Google Scholar. Correspondence to Isabella Savini. School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom. Reprints and permissions. Savini, I. Oxidative Stress and Obesity. In: Ahmad, S. eds Obesity. Springer, Cham. Publisher Name : Springer, Cham. Print ISBN : Online ISBN : eBook Packages : Medicine Medicine R0. Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Abstract In the last few years, several studies have shown a strong association among obesity, altered redox state and inflammation; these studies have also shown that such alterations may be the link between obesity and obesity-related diseases including Type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease and cancer. Keywords Redox homeostasis Obesity-related diseases Weight loss Antioxidant nutrients Probiotics. Buying options Chapter EUR eBook EUR Softcover Book EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions. References WHO: World Health Organization obesity and overweight, Fact sheet N° Article PubMed Central CAS PubMed Google Scholar Dorjgochoo T, Gao YT, Chow WH, et al. Article CAS Google Scholar Gates A, Hanning RM, Gates M, et al. Article PubMed Central CAS PubMed Google Scholar Pastore A, Ciampalini P, Tozzi G, et al. Article CAS PubMed Google Scholar Bondia-Pons I, Ryan L, Martinez JA. Article CAS PubMed Google Scholar Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L. Article PubMed Central PubMed CAS Google Scholar García OP, Ronquillo D, del Carmen Caamaño M, et al. Article PubMed Central PubMed CAS Google Scholar Sfar S, Boussoffara R, Sfar MT, et al. Article PubMed Central CAS PubMed Google Scholar Sun M, Huang X, Yan Y, et al. Article CAS Google Scholar Gunanti IR, Marks GC, Al-Mamun A, et al. Article CAS PubMed Google Scholar Torun E, Gökçe S, Ozgen İT, et al. Article CAS PubMed Google Scholar Amirkhizi F, Siassi F, Djalali M, et al. Article PubMed Google Scholar Cervellati C, Bonaccorsi G, Cremonini E, et al. Article CAS PubMed Google Scholar Chen L, Xu WM, Zhang D. Article CAS PubMed Google Scholar Krzystek-Korpacka M, Patryn E, Hotowy K, et al. PubMed Google Scholar Agirbasli M, Tanrikulu A, Erkus E, et al. Article PubMed Central PubMed CAS Google Scholar Youn JY, Siu KL, Lob HE, et al. Article PubMed Central PubMed Google Scholar Sies H, Stahl W, Sevanian A. CAS PubMed Google Scholar Patel C, Ghanim H, Ravishankar S, et al. Article CAS PubMed Google Scholar Dandona P, Ghanim H, Chaudhuri A, et al. Article PubMed Central CAS PubMed Google Scholar Muñoz A, Costa M. Article PubMed Central PubMed CAS Google Scholar Horvath TL, Andrews ZB, Diano S. Article CAS PubMed Google Scholar Drougard A, Fournel A, Valet P, et al. Article PubMed Central PubMed Google Scholar Lee H, Lee YJ, Choi H, et al. Article PubMed Central CAS PubMed Google Scholar Higuchi M, Dusting GJ, Peshavariya H, et al. Article PubMed Central CAS PubMed Google Scholar Aroor AR, De Marco VG. Article PubMed Google Scholar Serra D, Mera P, Malandrino MI, et al. Article PubMed Central CAS PubMed Google Scholar Le Lay S, Simard G, Martinez MC, et al. PubMed Central PubMed Google Scholar Bryan S, Baregzay B, Spicer D, et al. Article CAS PubMed Google Scholar Bigornia SJ, Mott MM, Hess DT, et al. Article Google Scholar Buchowski MS, Hongu N, Acra S, et al. Article PubMed Central CAS PubMed Google Scholar Gutierrez-Lopez L, Garcia-Sanchez JR, Rincon-Viquez Mde J, et al. Article CAS PubMed Google Scholar Chae JS, Paik JK, Kang R, et al. Article CAS PubMed Google Scholar Farinha JB, De Carvalho NR, Steckling FM, et al. Article CAS PubMed Google Scholar Sofi F, Abbate R, Gensini GF, et al. Article CAS PubMed Google Scholar Kwan HY, Chao X, Su T, et al. Google Scholar Widmer RJ, Flammer AJ, Lerman LO, et al. Article PubMed Google Scholar Calder PC, Ahluwalia N, Brouns F, et al. Article CAS PubMed Google Scholar González-Castejón M, Rodriguez-Casado A. Article PubMed CAS Google Scholar Sies H, Hollman PC, Grune T, et al. Article PubMed Central PubMed Google Scholar Arora T, Singh S, Sharma RK. Article CAS PubMed Google Scholar Khor A, Grant R, Tung C, et al. Article CAS PubMed Google Scholar Bjelakovic G, Nikolova D, Gluud LL, et al. Google Scholar Halliwell B. Article PubMed Google Scholar Jones DP, Radi R. Article PubMed Central PubMed Google Scholar Sies H. Article CAS Google Scholar Murphy MP, Holmgren A, Larsson NG, et al. Article PubMed Central CAS PubMed Google Scholar Ye ZW, Zhang J, Townsend DM. Google Scholar Lushchak VI. Article PubMed CAS Google Scholar Lee MC. Article PubMed Central CAS PubMed Google Scholar Halliwell B, Whiteman M. Article PubMed Central CAS PubMed Google Scholar Komosinska-Vassev K, Olczyk P, Winsz-Szczotka K, et al. Article CAS PubMed Google Scholar Dorjgochoo T, Gao YT, Chow WH, et al. Article PubMed Central PubMed CAS Google Scholar Olza J, Aguilera CM, Gil-Campos M, et al. Article PubMed Central CAS PubMed Google Scholar Jansen EH, Ruskovska T. Article PubMed Central CAS PubMed Google Scholar Rindler PM, Plafker SM, Szweda LI, et al. Article PubMed Central CAS PubMed Google Scholar Brown LA, Kerr CJ, Whiting P, et al. Article CAS Google Scholar Mittal PC, Kant R. Article CAS PubMed Google Scholar Olivares-Corichi IM, Viquez MJ, Gutierrez-Lopez L, et al. Article CAS PubMed Google Scholar Bougoulia M, Triantos A, Koliakos G. Article Google Scholar Strauss RS. Article CAS PubMed Google Scholar Weisstaub G, Hertrampf E, López de Romaña D, et al. Article CAS PubMed Google Scholar Ortega RM, Rodríguez-Rodríguez E, Aparicio A, et al. Article CAS PubMed Google Scholar Tran B, Oliver S, Rosa J, et al. Article PubMed Central PubMed Google Scholar Warolin J, Coenen KR, Kantor JL, et al. Article PubMed Central CAS PubMed Google Scholar Pirgon Ö, Bilgin H, Çekmez F, et al. Article PubMed Central PubMed Google Scholar Faienza MF, Francavilla R, Goffredo R, et al. Article CAS PubMed Google Scholar Krzystek-Korpacka M, Patryn E, Boehm D, et al. Article CAS PubMed Google Scholar Codoñer-Franch P, Tavárez-Alonso S, Murria-Estal R, et al. Article PubMed CAS Google Scholar Dennis BA, Ergul A, Gower BA, et al. PubMed Central PubMed Google Scholar Via M. PubMed Central PubMed Google Scholar Kaidar-Person O, Person B, Szomstein S, et al. Article PubMed Google Scholar Kaidar-Person O, Person B, Szomstein S, et al. Article PubMed Google Scholar Andersen LF, Jacobs Jr DR, Gross MD, et al. Article CAS PubMed Google Scholar Canoy D, Wareham N, Welch A, et al. CAS PubMed Google Scholar Aasheim ET, Bøhmer T. Article PubMed Google Scholar Tinahones FJ, Murri-Pierri M, Garrido-Sánchez L, et al. These issues may help to answer the role of NO and immune function in oxidative stress—mediated vascular dysfunction, as these mice are targeted for vascular-mediated oxidative stress. It is hoped that future extensions of the study by Youn et al. See accompanying article, p. Duality of Interest. No potential conflicts of interest relevant to this article were reported. Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest. filter your search All Content All Journals Diabetes. Advanced Search. User Tools Dropdown. Sign In. Skip Nav Destination Close navigation menu Article navigation. Volume 63, Issue 7. Previous Article Next Article. Article Information. Article Navigation. Commentaries June 14 Oxidative Stress and Obesity: The Chicken or the Egg? Aroor ; Annayya R. Truman VA Medical Center, Columbia, MO. This Site. Google Scholar. Vincent G. DeMarco Vincent G. Corresponding author: Vincent G. DeMarco, demarcov missouri. Diabetes ;63 7 — Connected Content. A commentary has been published: Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome. Get Permissions. toolbar search Search Dropdown Menu. toolbar search search input Search input auto suggest. Figure 1. View large Download slide. Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome. Search ADS. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Increased oxidative stress in obesity and its impact on metabolic syndrome. The vascular NAD P H oxidases as therapeutic targets in cardiovascular diseases. Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. View Metrics. Email alerts Article Activity Alert. Online Ahead of Print Alert. Latest Issue Alert. See also Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome. |
| Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation | Keywords: obesity, oxidative stress, thyroid, gut hormones, microbiota, wound healing. Jones DA, Prior SL, Barry JD, et al. Article history Received:. Table 3 Effects of intentional weight loss on telomere length. The excess of fat does not exclusively influence the correct and timely diagnosis of breast cancer but, by altering the tumor microenvironment, it can favor its growth, progression, response to therapies, consequently worsening the prognosis. |
| Buying options | Nutritionally mediated managemwnt stress and weightt. Activation-inactivation of abd binding sites of Boost learning abilities oestradiol beta receptor is a Digestive enzyme stability process. J Gerontol A, Biol Sci Med Sci ; The treatment reverses obesity-associated diseases such as type 2 diabetes, hypertension, dyslipidemias, and polycystic ovary syndrome [ 17 ]. Chae JS, Paik JK, Kang R, et al. |
| Increased oxidative stress in obesity and its impact on metabolic syndrome | In these mice, HFD feeding did not induce weight gain or leptin resistance. Moreover, knockout mice fed an HFD exhibited decreased T-cell infiltration into perivascular fat, suggesting that vascular ROS could incite an inflammatory response that contributes to the development of obesity. The idea that ROS of vascular origin are a cause rather than a consequence of obesity is very appealing, nonetheless several questions remain unanswered. First, in Fig. Perhaps this could be interpreted as evidence that vascular ROS by itself promotes a condition of overweight independent of hyperleptinemia, glucose intolerance, and inflammation. Second, the authors did not address whether the adaptive mechanisms related to NO signaling Fig. In this regard, it might be predicted that there will be a loss of vasoprotection in concert with augmented obesity and a dysregulated inflammatory response, and this would eventually lead to vascular dysfunction and hypertension. These issues may help to answer the role of NO and immune function in oxidative stress—mediated vascular dysfunction, as these mice are targeted for vascular-mediated oxidative stress. It is hoped that future extensions of the study by Youn et al. See accompanying article, p. Duality of Interest. No potential conflicts of interest relevant to this article were reported. Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest. filter your search All Content All Journals Diabetes. Advanced Search. User Tools Dropdown. Sign In. Skip Nav Destination Close navigation menu Article navigation. Volume 63, Issue 7. Previous Article Next Article. Article Information. Article Navigation. Commentaries June 14 Oxidative Stress and Obesity: The Chicken or the Egg? Aroor ; Annayya R. Truman VA Medical Center, Columbia, MO. This Site. Google Scholar. Vincent G. DeMarco Vincent G. Lycopene, a powerful antioxidant, significantly reduces the development of the adhesion phenotype. Syst Biol Reprod Med. Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Amiri F, Zarnani A-H, Zand H, Koohdani F, Jeddi-Tehrani M, Vafa M. Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular and colon cancer cell lines. Eur J Pharmacol. Ulasli SS, Celik S, Gunay E, Ozdemir M, Hazman O, Ozyurek A, et al. Anticancer effects of thymoquinone, caffeic acid phenethyl ester and resveratrol on A non-small cell lung cancer cells exposed to benzo a pyrene. Asian Pac J Cancer Prev. Jung K-H, Lee JH, Park JW, Quach CHT, Moon S-H, Cho YS, et al. Resveratrol-loaded polymeric nanoparticles suppress glucose metabolism and tumor growth in vitro and in vivo. Int J Pharm. Caron AZ, He X, Mottawea W, Seifert EL, Jardine K, Dewar-Darch D, et al. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. Kitada M, Koya D. SIRT1 in type 2 diabetes: mechanisms and therapeutic potential. Diabetes Metab J. Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. Nemerovski CW, Dorsch MP, Simpson RU, Bone HG, Aaronson KD, Bleske BE. Vitamin D and cardiovascular disease. Mowry DA, Costello MM, Heelan KA. Association among cardiorespiratory fitness, body fat, and bone marker measurements in healthy young females. J Am Osteopath Assoc. Moran DS, McClung JP, Kohen T, Lieberman HR. Vitamin D and physical performance. Sports Med. Cannell JJ, Hollis BW, Sorenson MB, Taft TN, Anderson J. Athletic performance and vitamin D. Sato Y, Iwamoto J, Kanoko T, Satoh K. Low-dose vitamin D prevents muscular atrophy and reduces falls and hip fractures in women after stroke: a randomized controlled trial. Cerebrovasc Dis. Martinesi M, Treves C, d'Albasio G, Bagnoli S, Bonanomi AG, Stio M. Vitamin D derivatives induce apoptosis and downregulate ICAM-1 levels in peripheral blood mononuclear cells of inflammatory bowel disease patients. Inflamm Bowel Dis. Garcion E, Sindji L, Leblondel G, Brachet P, Darcy F. Wiseman H. Vitamin D, is a membrane antioxidant ability to inhibit iron-dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action. FEBS Lett. Cohen MS, Mesler DE, Snipes RG, Gray T. Wu C-C, Chang J-H, Chen C-C, Su S-B, Yang L-K, Ma W-Y, et al. Calcitriol treatment attenuates inflammation and oxidative stress in hemodialysis patients with secondary hyperparathyroidism. Valcheva P, Cardus A, Panizo S, Parisi E, Bozic M, Lopez Novoa JM, et al. Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals. Eftekhari MH, Akbarzadeh M, Dabbaghmanesh MH, Hassanzadeh J. The effect of calcitriol on lipid profile and oxidative stress in hyperlipidemic patients with type 2 diabetes mellitus. ARYA Atheroscler. Konradsen S, Ag H, Lindberg F, Hexeberg S, Jorde R. Serum 1, dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr. Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, et al. The relationship between obesity and serum 1, dihydroxy vitamin D concentrations in healthy adults. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. McGill A-T, Stewart JM, Lithander FE, Strik CM, Poppitt SD. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Khoo A-L, Chai LY, Koenen HJ, Kullberg B-J, Joosten I, van der Ven AJ, et al. J Infect Dis. Li B, Baylink DJ, Deb C, Zannetti C, Rajaallah F, Xing W, et al. PLoS One. Tzotzas T, Papadopoulou FG, Tziomalos K, Karras S, Gastaris K, Perros P, et al. Rising serum hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, et al. Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, et al. Weight loss, exercise, or both and physical function in obese older adults. Download references. Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Glades Road, FH11AB, Boca Raton, FL, , USA. Chun-Jung Huang, Aaron L. Thomas Mock. Department of Kinesiology, Mississippi State University, Starkville, MS, USA. Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA, USA. You can also search for this author in PubMed Google Scholar. Correspondence to Chun-Jung Huang. C-JH, MM, ALS, HEW, JTM, and EOA declare that they have no competing interest, and no financial support was received for the conduct of this study or preparation of this manuscript. All authors participated in the conception and design of the study and also read and approved the final manuscript. Open Access This article is distributed under the terms of the Creative Commons Attribution 4. Reprints and permissions. Huang, CJ. et al. Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation. Sports Med - Open 1 , 32 Download citation. Received : 10 September Accepted : 11 September Published : 23 September Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all SpringerOpen articles Search. Download PDF. Review Article Open access Published: 23 September Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation Chun-Jung Huang 1 , Matthew J. McAllister 2 , Aaron L. Slusher 1 , 3 , Heather E. Webb 4 , J. Acevedo 3 Show authors Sports Medicine - Open volume 1 , Article number: 32 Cite this article Accesses 74 Citations 6 Altmetric Metrics details. Abstract Obesity-related oxidative stress, the imbalance between pro-oxidants and antioxidants e. Key Points Acute exercise is a small source of oxidative stress, while chronic exercise elicits protective adaptations against oxidative damage. Review Introduction The prevalence of obesity continues to increase in the USA, with recent reports indicating over Full size image. Conclusions Aerobic exercise, utilized to reduce obesity, results in an acute state of oxidative stress. References Flegal KM, Carroll MD, Ogden CL, Curtin LR. Article CAS PubMed Google Scholar Keaney JF, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, et al. Article CAS PubMed Google Scholar Olusi S. Article CAS PubMed Google Scholar Montezano AC, Touyz RM. Article CAS PubMed Google Scholar Kunwar A, Priyadarsini K. Google Scholar Vider J, Laaksonen DE, Kilk A, Atalay M, Lehtmaa J, Zilmer M, et al. Article CAS PubMed Google Scholar Korda M, Kubant R, Patton S, Malinski T. Article PubMed Central CAS PubMed Google Scholar Wannamethee SG, Tchernova J, Whincup P, Lowe G, Kelly A, Rumley A, et al. Article CAS PubMed Google Scholar Bloomer RJ, Kabir MM, Marshall KE, Canale RE, Farney TM. Article PubMed Central PubMed CAS Google Scholar Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Ha S, et al. Article CAS PubMed Google Scholar Yavari A, Javadi M, Mirmiran P, Bahadoran Z. Article PubMed Central PubMed Google Scholar Singhal A. Article PubMed Google Scholar Sies H. Article CAS PubMed Google Scholar Verma S, Anderson TJ. Article CAS PubMed Google Scholar Ji LL, Gomez-Cabrera MC, Vina J. Article CAS PubMed Google Scholar Zhang P, Xu X, Li X. PubMed Google Scholar Carr AC, McCall MR, Frei B. Article CAS PubMed Google Scholar Takahashi Y, Zhu H, Yoshimoto T. Article CAS PubMed Google Scholar Wang Q, Xie Z, Zhang W, Zhou J, Wu Y, Zhang M, et al. Article CAS PubMed PubMed Central Google Scholar Neels JG. Article PubMed Central PubMed Google Scholar Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, et al. Article CAS PubMed Google Scholar Fukai T, Folz RJ, Landmesser U, Harrison DG. Article CAS PubMed Google Scholar Arcaro G, Zamboni M, Rossi L, Turcato E, Covi G, Armellini F, et al. Article CAS PubMed Google Scholar Cheang WS, Wong WT, Tian XY, Yang Q, Lee HK, He G-W, et al. Article CAS PubMed Google Scholar Hamilton C, Miller W, Al-Benna S, Brosnan M, Drummond R, McBride M, et al. Article CAS Google Scholar Griendling KK, Ushio-Fukai M. Article CAS PubMed Google Scholar Berry C, Hamilton CA, Brosnan MJ, Magill FG, Berg GA, McMurray JJ, et al. Article CAS PubMed Google Scholar Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, et al. Article CAS PubMed Google Scholar Dallaire P, Marette A. CAS Google Scholar Pacher P, Beckman JS, Liaudet L. Article PubMed Central CAS PubMed Google Scholar Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F, et al. Article CAS PubMed Google Scholar S-i Y, Amano S, Inagaki Y, Okamoto T, Takeuchi M, Inoue H. Article CAS Google Scholar S-i Y, Edelstein D, Du X-l, Kaneda Y, Guzmán M, Brownlee M. Article Google Scholar Zhang H, Park Y, Wu J, Chen X, Lee S, Yang J, et al. Article CAS Google Scholar Yan S, Zhang X, Zheng H, Hu D, Zhang Y, Guan Q, et al. Google Scholar Picchi A, Gao X, Belmadani S, Potter BJ, Focardi M, Chilian WM, et al. Article CAS PubMed Google Scholar Zumbach MS, Boehme MWJ, Wahl P, Stremmel W, Ziegler R, Nawroth PP. Article CAS PubMed Google Scholar Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, et al. Article CAS PubMed Google Scholar Lumeng CN, Saltiel AR. Article PubMed Central CAS PubMed Google Scholar Nathan CF, Murray HW, Wiebe M, Rubin BY. Article CAS PubMed Google Scholar Murr C, Schroecksnadel K, Winkler C, Ledochowski M, Fuchs D. Article CAS PubMed Google Scholar Cojocaru M, Cojocaru IM, Silosi I, Rogoz S. Google Scholar Maingrette F, Renier G. Article CAS PubMed Google Scholar Youn J-Y, Siu KL, Lob HE, Itani H, Harrison DG, Cai H. Article PubMed Central PubMed Google Scholar Bloomer RJ, Goldfarb AH, Wideman L, McKenzie MJ, Consitt LA. PubMed Google Scholar Bloomer RJ, Goldfarb AH. Article CAS PubMed Google Scholar Goto C, Higashi Y, Kimura M, Noma K, Hara K, Nakagawa K, et al. Article PubMed Google Scholar Goto C, Nishioka K, Umemura T, Jitsuiki D, Sakagutchi A, Kawamura M, et al. Article CAS PubMed Google Scholar Bloomer R, Davis P, Consitt L, Wideman L. Article CAS PubMed Google Scholar Vincent HK, Morgan JW, Vincent KR. Article CAS PubMed Google Scholar Vincent HK, Vincent KR, Bourguignon C, Braith RW. Article CAS PubMed Google Scholar Davies KJ, Quintanilha AT, Brooks GA, Packer L. Article CAS PubMed Google Scholar Ashton T, Rowlands CC, Jones E, Young IS, Jackson SK, Davies B, et al. Article CAS PubMed Google Scholar Ashton T, Young IS, Peters JR, Jones E, Jackson SK, Davies B, et al. CAS PubMed Google Scholar Groussard C, Rannou-Bekono F, Machefer G, Chevanne M, Vincent S, Sergent O, et al. Article CAS PubMed Google Scholar Bailey DM, Lawrenson L, Mceneny J, Young IS, James PE, Jackson SK, et al. Article CAS PubMed Google Scholar Bailey DM, Young IS, McEneny J, Lawrenson L, Kim J, Barden J, et al. Article CAS PubMed Google Scholar Halliwell B. CAS PubMed Google Scholar Knez WL, Jenkins DG, Coombes JS. Article CAS PubMed Google Scholar Fisher-Wellman K, Bloomer RJ. Article PubMed Central PubMed CAS Google Scholar McAnulty SR, McAnulty LS, Nieman DC, Morrow JD, Utter AC, Dumke CL. Article CAS PubMed Google Scholar Hartmann A, Niess AM. Chapter Google Scholar Hilton TN, Tuttle LJ, Bohnert KL, Mueller MJ, Sinacore DR. Article PubMed Central PubMed Google Scholar Hey-Mogensen M, Højlund K, Vind B, Wang L, Dela F, Beck-Nielsen H, et al. Article CAS PubMed Google Scholar Anderson EJ, Neufer PD. Article CAS PubMed Google Scholar Plomgaard P, Penkowa M, Pedersen BK. PubMed Google Scholar Li Y-P, Reid MB. CAS PubMed Google Scholar Wilcox P, Wakai Y, Walley K, Cooper D, Road J. Article CAS PubMed Google Scholar Reid M, Li YP. Article CAS PubMed Google Scholar Brinkmann C, Chung N, Schmidt U, Kreutz T, Lenzen E, Schiffer T, et al. Article CAS PubMed Google Scholar Bruun JM, Helge JW, Richelsen B, Stallknecht B. Article PubMed CAS Google Scholar Phillips MD, Patrizi RM, Cheek DJ, Wooten JS, Barbee JJ, Mitchell JB. Article CAS PubMed Google Scholar Vincent HK, Bourguignon C, Vincent KR. Article CAS PubMed Google Scholar Wycherley TP, Brinkworth GD, Noakes M, Buckley JD, Clifton PM. Article CAS PubMed Google Scholar Oh S, Tanaka K, Warabi E, Shoda J. Article CAS PubMed Google Scholar Rector RS, Warner SO, Liu Y, Hinton PS, Sun GY, Cox RH, et al. Article PubMed Central CAS PubMed Google Scholar Johnson JB, Summer W, Cutler RG, Martin B, Hyun D-H, Dixit VD, et al. Article PubMed Central CAS PubMed Google Scholar Shin Y-A, Lee J-H, Song W, Jun T-W. Article CAS PubMed Google Scholar Samjoo I, Safdar A, Hamadeh M, Raha S, Tarnopolsky M. Article PubMed Central CAS PubMed Google Scholar Devries MC, Hamadeh MJ, Glover AW, Raha S, Samjoo IA, Tarnopolsky MA. Article CAS PubMed Google Scholar Youssef H, Groussard C, Lemoine-Morel S, Pincemail J, Jacob C, Moussa E, et al. Article PubMed Google Scholar Kelly AS, Steinberger J, Olson TP, Dengel DR. Article CAS PubMed Google Scholar Forsythe LK, Wallace JM, Livingstone MBE. Article CAS PubMed Google Scholar Kopp H-P, Kopp C, Festa A, Krzyzanowska K, Kriwanek S, Minar E, et al. Article PubMed Central PubMed CAS Google Scholar Touati S, Montezano AC, Meziri F, Riva C, Touyz RM, Laurant P. Article CAS PubMed Google Scholar Ramezanipour M, Jalali M, Sadrzade-Yeganeh H, Keshavarz SA, Eshraghian MR, Bagheri M, et al. Article PubMed Google Scholar Bougoulia M, Triantos A, Koliakos G. Article Google Scholar Roberts CK, Won D, Pruthi S, Kurtovic S, Sindhu RK, Vaziri ND, et al. Article CAS PubMed Google Scholar Ozcelik O, Ozkan Y, Karatas F, Kelestimur H. Article CAS Google Scholar Pastromas S, Terzi A-B, Tousoulis D, Koulouris S. Article PubMed Google Scholar Rosenheck R. Article CAS PubMed Google Scholar Fisher-Wellman KH, Bloomer RJ. Article CAS PubMed Google Scholar Rebolledo O, Dato SA. CAS PubMed Google Scholar Sies H, Stahl W, Sevanian A. CAS PubMed Google Scholar Liu Y, Fiskum G, Schubert D. Article CAS PubMed Google Scholar Bloomer RJ, Kabir MM, Trepanowski JF, Canale RE, Farney TM. Article CAS Google Scholar Ruggiero C, Ehrenshaft M, Cleland E, Stadler K. Article PubMed Central CAS PubMed Google Scholar Bloomer RJ, Ferebee DE, Fisher-Wellman KH, Quindry JC, Schilling BK. Article CAS PubMed Google Scholar Bloomer RJ, Fisher-Wellman KH. Article PubMed Google Scholar Goldfarb AH, McKenzie MJ, Bloomer RJ. Article CAS PubMed Google Scholar McCarthy CG, Farney TM, Canale RE, Dessoulavy ME, Bloomer RJ. Article CAS PubMed Google Scholar Giacco F, Brownlee M. Article PubMed Central CAS PubMed Google Scholar Ramadan R, Dhawan SS, Syed H, Pohlel FK, Binongo JN, Ghazzal ZB, et al. Article PubMed Central CAS PubMed Google Scholar Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper M-E. Article CAS PubMed Google Scholar Hagopian K, Harper M-E, Ram JJ, Humble SJ, Weindruch R, Ramsey JJ. Article CAS PubMed Google Scholar Hyun D-H, Emerson SS, Jo D-G, Mattson MP, de Cabo R. Article PubMed Central CAS PubMed Google Scholar Zainal TA, Oberley TD, Allison DB, Szweda LI, Weindruch R. Article CAS PubMed Google Scholar Trepanowski JF, Canale RE, Marshall KE, Kabir MM, Bloomer RJ. Article PubMed Central CAS PubMed Google Scholar S-i I. Article PubMed Central PubMed CAS Google Scholar Sohal RS, Forster MJ. Article CAS PubMed Google Scholar Noakes TD. Article PubMed Google Scholar Kremsdorf RA, Hoofnagle AN, Kratz M, Weigle DS, Callahan HS, Purnell JQ, et al. Article PubMed Central CAS PubMed Google Scholar Cantó C, Auwerx J. Article PubMed Central PubMed CAS Google Scholar Masoro EJ. Article CAS PubMed Google Scholar Gredilla R, Barja G. Article CAS PubMed Google Scholar Sohal RS, Weindruch R. Article PubMed Central CAS PubMed Google Scholar Nisoli E, Tonello C, Cardile A, Cozzi V, Bracale R, Tedesco L, et al. Article CAS PubMed Google Scholar Kondo M, Shibata R, Miura R, Shimano M, Kondo K, Li P, et al. Article PubMed Central CAS PubMed Google Scholar Monda M, Messina G, Scognamiglio I, Lombardi A, Martin GA, Sperlongano P, et al. Article PubMed Central PubMed CAS Google Scholar Trepanowski JF, Kabir MM, Alleman Jr RJ, Bloomer RJ. Article CAS Google Scholar Mennen LI, Sapinho D, de Bree A, Arnault N, Bertrais S, Galan P, et al. CAS PubMed Google Scholar Urquiaga I, Leighton F. Article CAS PubMed Google Scholar Liu RH. CAS PubMed Google Scholar Lotito SB, Frei B. Article CAS PubMed Google Scholar Tuso P, Stoll SR, Li WW. Article PubMed Central PubMed Google Scholar Jiang Y, Wu S-H, Shu X-O, Xiang Y-B, Ji B-T, Milne GL, et al. Article PubMed Central PubMed Google Scholar Feskanich D, Ziegler RG, Michaud DS, Giovannucci EL, Speizer FE, Willett WC, et al. Article CAS PubMed Google Scholar Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. CAS PubMed Google Scholar Nickander KK, Mcphee BR, Low PA, Tritschler H. Article CAS PubMed Google Scholar Zhang D-W, Fu M, Gao S-H, Liu J-L. PubMed Central PubMed Google Scholar Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, et al. Article PubMed Central CAS PubMed Google Scholar Ungvari Z, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson S, et al. Article CAS PubMed Google Scholar Kumar A, Kaur H, Devi P, Mohan V. Article CAS PubMed Google Scholar Kasdallah-Grissa A, Mornagui B, Aouani E, Hammami M, El May M, Gharbi N, et al. Article CAS PubMed Google Scholar Kode A, Rajendrasozhan S, Caito S, Yang S-R, Megson IL, Rahman I. Article CAS PubMed Google Scholar Stanković MN, Mladenović D, Ninković M, Ðuričić I, Šobajić S, Jorgačević B, et al. Article PubMed Central PubMed CAS Google Scholar Tarry-Adkins JL, Blackmore HL, Martin-Gronert MS, Fernandez-Twinn DS, McConnell JM, Hargreaves IP, et al. Article PubMed Central CAS PubMed Google Scholar Wang L, Cheng X, Li H, Qiu F, Yang N, Wang B, et al. PubMed Central CAS PubMed Google Scholar Chen J, Guo R, Yan H, Tian L, You Q, Li S, et al. Article CAS PubMed Google Scholar Fletcher NM, Awonuga AO, Saed MG, Abu-Soud HM, Diamond MP, Saed GM. Article PubMed CAS Google Scholar Borra MT, Smith BC, Denu JM. Article CAS PubMed Google Scholar Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, et al. Article CAS PubMed Google Scholar Amiri F, Zarnani A-H, Zand H, Koohdani F, Jeddi-Tehrani M, Vafa M. Article CAS PubMed Google Scholar Ulasli SS, Celik S, Gunay E, Ozdemir M, Hazman O, Ozyurek A, et al. Article PubMed Google Scholar Jung K-H, Lee JH, Park JW, Quach CHT, Moon S-H, Cho YS, et al. Article PubMed CAS Google Scholar Caron AZ, He X, Mottawea W, Seifert EL, Jardine K, Dewar-Darch D, et al. Article CAS PubMed Google Scholar Kitada M, Koya D. Article PubMed Central PubMed Google Scholar Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, et al. Article PubMed Central PubMed CAS Google Scholar Nemerovski CW, Dorsch MP, Simpson RU, Bone HG, Aaronson KD, Bleske BE. Article CAS PubMed Google Scholar Mowry DA, Costello MM, Heelan KA. PubMed Google Scholar Moran DS, McClung JP, Kohen T, Lieberman HR. Article PubMed Google Scholar Cannell JJ, Hollis BW, Sorenson MB, Taft TN, Anderson J. Article PubMed Google Scholar Sato Y, Iwamoto J, Kanoko T, Satoh K. Article CAS PubMed Google Scholar Martinesi M, Treves C, d'Albasio G, Bagnoli S, Bonanomi AG, Stio M. Article PubMed Google Scholar Garcion E, Sindji L, Leblondel G, Brachet P, Darcy F. Article CAS PubMed Google Scholar Wiseman H. Article CAS PubMed Google Scholar Cohen MS, Mesler DE, Snipes RG, Gray T. CAS PubMed Google Scholar Wu C-C, Chang J-H, Chen C-C, Su S-B, Yang L-K, Ma W-Y, et al. Article CAS PubMed Google Scholar Valcheva P, Cardus A, Panizo S, Parisi E, Bozic M, Lopez Novoa JM, et al. Article CAS PubMed Google Scholar Eftekhari MH, Akbarzadeh M, Dabbaghmanesh MH, Hassanzadeh J. PubMed Central PubMed Google Scholar Konradsen S, Ag H, Lindberg F, Hexeberg S, Jorde R. Article CAS PubMed Google Scholar Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, et al. Article CAS PubMed Google Scholar Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Google Scholar McGill A-T, Stewart JM, Lithander FE, Strik CM, Poppitt SD. Article PubMed Central PubMed CAS Google Scholar Khoo A-L, Chai LY, Koenen HJ, Kullberg B-J, Joosten I, van der Ven AJ, et al. Article PubMed Central CAS PubMed Google Scholar Li B, Baylink DJ, Deb C, Zannetti C, Rajaallah F, Xing W, et al. Article PubMed Central CAS PubMed Google Scholar Tzotzas T, Papadopoulou FG, Tziomalos K, Karras S, Gastaris K, Perros P, et al. Article CAS PubMed Google Scholar Zittermann A, Frisch S, Berthold HK, Götting C, Kuhn J, Kleesiek K, et al. Article CAS PubMed Google Scholar Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, et al. Article PubMed Central CAS PubMed Google Scholar Download references. Author information Authors and Affiliations Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, Glades Road, FH11AB, Boca Raton, FL, , USA Chun-Jung Huang, Aaron L. Thyroidectomy and parathyroidectomy in patients with high body mass index are safe overall: analysis of 26 patients. Jonklaas J, Nsouli—Maktabi H. Weight changes in euthyroid patients under and going thyroidectomy. Weinreb JT, Yang Y, Braunstein GD. Do patients gain weight after thyroidectomy for thyroid cancer? Prats—Puig A, Sitjar C, Ribot R, Calvo M, Clausell-Pomés N, Soler-Roca M, et al. Relative hypoadiponectinemia, insulin resistance, and increased visceral fat in euthyroid prepubertal girls with low normal serum free thyroxine. Lu S, Guan Q, Liu Y, Wang H, Xu W, Li X, et al. Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity. Lipids Health Dis. Ortega FJ, Moreno—Navarrete JM, Ribas V, Esteve E, Rodriguez-Hermosa JI, Ruiz B, et al. Subcutaneous fat shows higher thyroid hormone receptor—alpha1 gene expression than omental fat. Emerson CH. Anthropomorphic thyroidopathies? Reinehr T. Obesity and thyroid function. Amin A, Dhillo WS, Murphy KG. The central effects of thyroid hormones on appetite. J Thyroid Res. Araujo RL, Carvalho DP. Bioenergetic impact of tissue—specific regulation of iodothyronine deiodinases during nutritional imbalance. J Bioenerg Biomembr. Vella KR, Ramadoss P, Lam FS, Harris JC, Ye FD, Same PD, et al. NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Kiela PR, Ghishan FK. Physiology of intestinal absorption and secretion. Best Pract Res Clin Gastroenterol. Oesch S, Ruegg C, Fischer B, Degen L, Beglinger C. Effect of gastric distension prior to eating on food intake and feelings of satiety in humans. Drucker DJ. Glucagon—like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol. Neary NM, Small CJ, Druce MR, Park AJ, Ellis SM, Semjonous NM, et al. Peptide YY and glucagon-like peptide inhibit food intake additively. Baggio LL, Drucker DJ. Le Roux CW, Aylwin SJ, Batterham RL, Borg CM, Coyle F, Prasad V, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. Bueter M, Ashrafian H, le Roux CW. Mechanisms of weight loss after gastric bypass and gastric banding. Obes Facts. Bueter M, le Roux CW. Gastrointestinal hormones, energy balance and bariatric surgery. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, et al. Gut hormone PYY3—36 physiologically inhibits food intake. Pittner RA, Moore CX, Bhavsar SP, Gedulin BR, Smith PA, Jodka CM, et al. Effects of PYY3—36 in rodent models of diabetes and obesity. Int J Obes Relat Metab Disord. Sloth B, Holst JJ, Flint A, Gregersen NT, Astrup A. Effects of PYY1— 36 and PYY3—36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. van den Hoek AM, Heijboer AC, Corssmit EP, Voshol PJ, Romijn JA, Havekes LM, et al. PYY3—36 reinforces insulin action on glucose disposal in mice fed a high—fat diet. Federico A, Dallio M, Di Sarno R, Giorgio V, Miele L. Gut microbiota, obesity and metabolic disorders. Minerva Gastroenterol Dietol. Marsh PD, Do T, Beighton D, Devine DA. Influence of saliva on the oral microbiota. Boccellino M, Di Stasio D, Serpico R, Lucchese A, Guida A, Settembre G, et al. Analysis of saliva samples in patients with Prader—Willi syndrome. Yang BG, Hur KY, Lee MS. Alterations in gut microbiota and immunity by dietary fat. Yonsei Med J. Dao MC, Clément K. Gut microbiota and obesity: Concepts relevant to clinical care. Eur J Intern Med. Dlugosz A, Muschiol S, Zakikhany K, Assadi G, D'Amato M, Lindberg G. Human enteroendocrine cell responses to infection with Chlamydia trachomatis: a microarray study. Gut Pathog. Rizzo A, Pallone F, Monteleone G, Fantini MC. Intestinal inflammation and colorectal cancer: a double-edged sword? World J Gastroenterol. Kawamoto S, Maruya M, Kato LM, Suda W, Atarashi K, Doi Y, et al. Dohan Ehrenfest DM, Del Corso M, Inchingolo F, Sammartino G, Charrier JB. Platelet-rich plasma PRP and platelet-rich fibrin PRF in human cell cultures: growth factor release and contradictory results. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Dohan Ehrenfest DM, Lemo N, Jimbo R, Sammartino G. Selecting a relevant animal model for testing the in vivo effects of Choukroun's platelet-rich fibrin PRF : rabbit tricks and traps. Rizzo A, Losacco A, Carratelli CR, Domenico MD, Bevilacqua N. Int Immunopharmacol. Gribble FM, Reimann F. Function and mechanisms of enteroendocrine cells and gut hormones in metabolism. Gérard P. Gut microbiota and obesity. Cell Mol Life Sci. de Clercq NC, Groen AK, Romijn JA, Nieuwdorp M. Microbiota in obesity and undernutrition. Adv Nutr. Torres—Fuentes C, Schellekens H, Dinan TG, Cryan JF. The microbiota—gut—brain axis in obesity. Lancet Gastroenterol Hepatol. Saad MJ, Santos A, Prada PO. Linking gut microbiota and inflammation to obesity and insulin resistance. Isolauri E. Microbiota and Obesity. Nestle Nutr Inst Workshop Ser. Patterson E, Ryan PM, Cryan J, Dinan TG, Ross RP, Fitzgerald GF, et al. Gut microbiota, obesity and diabetes. Postgrad Med J. Brahe LK, Astrup A, Larsen LH. Can we prevent obesity—related metabolic diseases by dietary modulation of the gut microbiota? Baothman OA, Zamzami MA, Taher I, Abubaker J, Abu—Farha M. The role of Gut Microbiota in the development of obesity and diabetes. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in GLOBOCAN Int J Cancer. Di Domenico M, Santoro A, Ricciardi C, Iaccarino M, Iaccarino S, Freda M, et al. Epigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization. Narod SA. Breast cancer in young women. Nat Rev Clin Oncol. Boccellino M, Alaia C, Misso G, Cossu AM, Facchini G, Piscitelli R, et al. Gene interference strategies as a new tool for the treatment of prostate cancer. Boccellino M, Vanacore D, Zappavigna S, Cavaliere C, Rossetti S, D'Aniello C, et al. Testicular cancer from diagnosis to epigenetic factors. Giudice A, Montella M, Boccellino M, Crispo A, D'Arena G, Bimonte S, et al. Epigenetic changes induced by green tea catechins are associated with prostate cancer. Saberi—Karimian M, Katsiki N, Caraglia M, Boccellino M, Majeed M, Sahebkar A. Vascular endothelial growth factor: An important molecular target of curcumin. Crit Rev Food Sci Nutr. Auricchio F, Migliaccio A, Castoria G, Rotondi A, Di Domenico M, Pagano M. Activation-inactivation of hormone binding sites of the oestradiol beta receptor is a multiregulated process. J Steroid Biochem. Auricchio F, Migliaccio A, Castoria G, Rotondi A, Di Domenico M. Calmodulin-stimulated estradiol receptor-tyrosine kinase. Methods Enzymol. Migliaccio A, Castoria G, de Falco A, Di Domenico M, Galdiero M, Nola E, et al. In vitro phosphorylation and hormone binding activation of the synthetic wild type human estradiol receptor. J Steroid Biochem Mol Biol. Brenner DR, Brockton NT, Kotsopulos J, Cotterchio M, Boucher BA, Courneya KS, et al. Breast cancer survival among young women: a review of the role of modifiable lifestyle factors. Cancer Causes Control. Fiorelli A, Ricciardi C, Pannone G, Santoro A, Bufo P, Santini M, et al. Interplay between steroid receptors and neoplastic progression in sarcoma tumors. Brown KA, Simpson ER. Obesity and breast cancer: mechanisms and therapeutic implications. Front Biosci. Castoria G, Migliaccio A, D'Amato L, Di Stasio R, Ciociola A, Lombardi M, et al. Integrating signals between cAMP and MAPK pathways in breast cancer. Zahid H, Simpsonand ER, Brown KA. Inflammation, dysregulated metabolism and aromatase in obesity and breast cancer. Di Domenico M, Giordano A. Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion. PubMed Abstract CrossRef Full Text. Spugnini EP, Cardillo I, Fanciulli M, Crispi S, Vincenzi B, Boccellino M, et al. Electroporation as a strategy to promote HtrA1 gene uptake and chemotherapy efficacy in a mouse model of mesothelioma. Spugnini EP, Melillo A, Quagliuolo L, Boccellino M, Vincenzi B, Pasquali P, et al. Definition of novel electrochemotherapy parameters and validation of their in vitro and in vivo effectiveness. Boccellino M, Quagliuolo L, Alaia C, Grimaldi A, Addeo R, Nicoletti GF, et al. The strange connection between epidermal growth factor receptor tyrosine kinase inhibitors and dapsone: from rash mitigation to the increase in anti—tumor activity. Curr Med Res Opin. Feola A, Ricci S, Kouidhi S, Rizzo A, Penon A, Formisano P, et al. Multifaceted breast cancer: the molecular connection with obesity. Wichtowski M, Murawa D, Kulcenty K, Zaleska K. Electrochemotherapy in breast cancer - discussion of the method and literature review. Breast Care. Mannell A. An overview of risk factors for recurrent breast cancer. S Afr J Surg. Sabol RA, Bowles AC, Côté A, Wise R, O'Donnell B, Matossian MD, et al. Leptin produced by obesity-altered adipose stem cells promotes metastasis but not tumorigenesis of triple-negative breast cancer in orthotopic xenograft and patient-derived xenograft models. Breast Cancer Res. Lamberti M, Capasso R, Lombardi A, Di Domenico M, Fiorelli A, Feola A, et al. Two different serum MiRNA signatures correlate with the clinical outcome and histological subtype in pleural malignant mesothelioma patients. Vanacore D, Boccellino M, Rossetti S, Cavaliere C, D'Aniello C, Di Franco R, et al. Micrornas in prostate cancer: an overview. Law JH, Habibi G, Hu K, Masoudi H, Wang MYC, Stratford AL, et al. Cancer Res. Auricchio F, Di Domenico M, Migliaccio A, Castoria G, Bilancio A. The role of estradiol receptor in the proliferative activity of vanadate on MCF-7 cells. Cell Growth Differ. Fiorelli A, Vicidomini G, Di Domenico M, Napolitano F, Messina G, Morgillo F, et al. Vascular endothelial growth factor in pleural fluid for differential diagnosis of benign and malignant origin and its clinical applications. Interact Cardiovasc Thorac Surg. Di Domenico M, D'apuzzo F, Feola A, Cito L, Monsurrò A, Pierantoni GM, et al. Cytokines and VEGF induction in orthodontic movement in animal models. J Biomed Biotechnol. Rodrigues Dos Santos C, Fonseca I, Dias S, Mendes de Almeida JC. Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression. BMC Cancer. Molfino A, Amabile MI, Monti M, Arcieri S, Rossi Fanelli F, Muscaritoli M. The role of docosahexaenoic acid DHA in the control of obesity and metabolic derangements in breast cancer. Fiorelli A, Accardo M, Carelli E, Angioletti D, Santini M, Di Domenico M. Circulating tumor cells in diagnosing lung cancer: clinical and morphologic analysis. Ann Thorac Surg. Fiorelli A, Ricci S, Feola A, Mazzella A, D'Angelo L, Santini M, et al. Sapienza C, Issa JP. Diet, nutrition, and cancer epigenetics. Annu Rev Nutr. Imayama I, Ulrich CM, Alfano CM, Wang C, Xiao L, Wener MH, et al. Selvin E, Paynter NP, Erlinger TP. The effect of weight loss on C—reactive protein: a systematic review. Arch Intern Med. Feigelson HS, Caan B, Weinmann S, Leonard AC, Powers JD, Yenumula PR, et al. Bariatric surgery is associated with reduced risk of breast cancer in both premenopausal and postmenopausal women. van Gemert WA, Schuit AJ, van der Palen J, May AM, Iestra JA, Wittink H, et al. Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK, et al. Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst. Saxe GA, Rock CL, Wicha MS, Schottenfeld D. Diet and risk for breast cancer recurrence and survival. Breast Cancer Res Treat. Bauer J, Biolo G, Cederholm T, Cesari M, Cruz-Jentoft AJ, Morley JE, et al. Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc. Buommino E, Boccellino M, De Filippis A, Petrazzuolo M, Cozza V, Nicoletti R, et al. Mol Carcinog. Fiorelli A, Rizzo A, Messina G, Izzo A, Vicidomini G, Pannone G, et al. Eur J Cardiothorac Surg. Fiorelli A, Morgillo F, Fasano M, Vicidomini G, Di Crescenzo VG, Di Domenico M, et al. Grimaldi A, Santini D, Zappavigna S, Lombardi A, Misso G, Boccellino M, et al. Antagonistic effects of chloroquine on autophagy occurrence potentiate the anticancer effects of everolimus on renal cancer cells. Pastina P, Nardone V, Croci S, Battaglia G, Vanni F, Bellan C, et al. J Thorac Dis. Ricciardiello F, Caraglia M, Iorio B, Abate T, Boccellino M, Colella G, et al. Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx. Reggiani F, Labanca V, Mancuso P, Rabascio C, Talarico G, Orecchioni S, et al. Adipose progenitor cell secretion of gm-csf and mmp9 promotes a stromal and immunological microenvironment that supports breast cancer progression. Christiaens V, Lijnen HR. Role of the fibrinolytic and matrix metalloproteinase systems in development of adipose tissue. Arch Physiol Biochem. Motrescu ER, Rio MC. Cancer cells, adipocytes and matrix metalloproteinase a vicious tumor progression cycle. Biol Chem. Saijo H, Hayashida K, Morooka S, Fujioka M. Combined treatment with artificial dermis and basic fibroblast growth factor for cranial bone-exposing wounds. J Tissue Viability. Eo S, Kim Y, Cho S. Vacuum-assisted closure improves the incorporation of artificial dermis in soft tissue defects: Terudermis ® and Pelnac ®. Int Wound J. Suzuki S, Morimoto N, Yamawaki S, Fujitaka J, Kawai K. A case of giant naevus followed up for 22 years after treatment with artificial dermis. J Plast Reconstr Aesthet Surg. Recht A, Solin LJ. Breast-conserving surgery and radiotherapy in early-stage breast cancer: the importance of local control. Semin Radiat Oncol. Mendenhall S, Anderson L, Ying J, Boucher K, Liu T, Neumayer L, et al. The BREAS trial: stage I. |
Oxidative stress and weight management -
The authors also suggest the possibility that ROS of vascular origin diffuse into nearby skeletal muscle cells, inciting a feed-forward scenario to induce mitochondrial ROS formation ROS-induced ROS.
As such, vascular ROS may induce skeletal muscle dysfunction, leading to reduced activity and energy expenditure that would promote obesity. In these mice, HFD feeding did not induce weight gain or leptin resistance. Moreover, knockout mice fed an HFD exhibited decreased T-cell infiltration into perivascular fat, suggesting that vascular ROS could incite an inflammatory response that contributes to the development of obesity.
The idea that ROS of vascular origin are a cause rather than a consequence of obesity is very appealing, nonetheless several questions remain unanswered. First, in Fig. Perhaps this could be interpreted as evidence that vascular ROS by itself promotes a condition of overweight independent of hyperleptinemia, glucose intolerance, and inflammation.
Second, the authors did not address whether the adaptive mechanisms related to NO signaling Fig. In this regard, it might be predicted that there will be a loss of vasoprotection in concert with augmented obesity and a dysregulated inflammatory response, and this would eventually lead to vascular dysfunction and hypertension.
These issues may help to answer the role of NO and immune function in oxidative stress—mediated vascular dysfunction, as these mice are targeted for vascular-mediated oxidative stress.
It is hoped that future extensions of the study by Youn et al. See accompanying article, p. Duality of Interest. No potential conflicts of interest relevant to this article were reported.
Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest. filter your search All Content All Journals Diabetes. Advanced Search. User Tools Dropdown. Sign In. Skip Nav Destination Close navigation menu Article navigation. Volume 63, Issue 7. Previous Article Next Article.
Article Information. Article Navigation. Commentaries June 14 Oxidative Stress and Obesity: The Chicken or the Egg? Aroor ; Annayya R. Truman VA Medical Center, Columbia, MO. This Site. Google Scholar. Recovery of MERRF fibroblasts and cybrids pathophysiology by coenzyme Q Neurotherapeutics 9, — Deeg, M.
Pioglitazone and rosiglitazone have different effects on serum lipoprotein particle concentrations and sizes in patients with type 2 diabetes and dyslipidemia. Diabetes Care 30, — Demozay, D. FALDH reverses the deleterious action of oxidative stress induced by lipid peroxidation product 4-hydroxynonenal on insulin signaling in 3T3-L1 adipocytes.
Elrayess, M. Escribano-Lopez, I. The mitochondrial antioxidant SS increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 diabetes. Esterbauer, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.
Fazakerley, D. Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Feillet-Coudray, C. The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol.
Fouret, G. The mitochondrial-targeted antioxidant, MitoQ, increases liver mitochondrial cardiolipin content in obesogenic diet-fed rats. Frohnert, B. Protein carbonylation, mitochondrial dysfunction, and insulin resistance.
Increased adipose protein carbonylation in human obesity. Obesity 19, — Furukawa, S. Increased oxidative stress in obesity and its impact on metabolic syndrome. PubMed Abstract Google Scholar. Fusco, D. Effects of antioxidant supplementation on the aging process.
Aging 2, — Gardner, P. Superoxide radical and iron modulate aconitase activity in mammalian cells. Goldberg, R.
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care 28, — Goldgof, M. The chemical uncoupler 2,4-dinitrophenol DNP protects against diet-induced obesity and improves energy homeostasis in mice at thermoneutrality.
Grimsrud, P. Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.
Proteomics 6, — Oxidative stress and covalent modification of protein with bioactive aldehydes. Han, Y. Adipocyte-specific deletion of manganese superoxide dismutase protects from diet-induced obesity through increased mitochondrial uncoupling and biogenesis.
Hancock, C. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Hauck, A. Adipose oxidative stress and protein carbonylation.
Obesity-induced protein carbonylation in murine adipose tissue regulates the DNA-binding domain of nuclear zinc finger proteins. Hausladen, A. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.
Holley, A. Manganese superoxide dismutase: guardian of the powerhouse. Holloszy, J. Huh, J. Peroxiredoxin 3 is a key molecule regulating adipocyte oxidative stress, mitochondrial biogenesis, and adipokine expression. Hurd, T. Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.
Kelly, I. Effects of a thiazolidinedione compound on body fat and fat distribution of patients with type 2 diabetes. Diabetes Care 22, — Khan, M. A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone.
Diabetes Care 25, — Kim, J. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. King, A. A comparison in a clinical setting of the efficacy and side effects of three thiazolidinediones.
Diabetes Care 23, Kowaltowski, A. Mitochondrial damage induced by conditions of oxidative stress. Lee, H. Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion. Mitochondrial-targeted catalase protects against high-fat diet-induced muscle insulin resistance by decreasing intramuscular lipid accumulation.
Liesa, M. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. Long, E. High-fat diet induces changes in adipose tissue transoxononenal and transhydroxynonenal levels in a depot-specific manner.
Lu, R. Mitochondrial development and the influence of its dysfunction during rat adipocyte differentiation. Lushchak, O.
Aconitase post-translational modification as a key in linkage between Krebs cycle, iron homeostasis, redox signaling, and metabolism of reactive oxygen species. Redox Rep. Maeda, N. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Miyazaki, Y.
Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. Mul, J. I, Hirshman, M. Exercise and regulation of carbohydrate metabolism.
Murphy, M. How mitochondria produce reactive oxygen species. Ohno, H. PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Okuno, Y. Oxidative stress inhibits healthy adipose expansion through suppression of SREBF1-mediated lipogenic Pathway.
Olsen, R. Redox signalling and mitochondrial stress responses; lessons from inborn errors of metabolism. Paglialunga, S. In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice.
Diabetologia 58, — Perry, R. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Petrovic, N.
Chronic peroxisome proliferator-activated receptor gamma PPARgamma activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes.
Porter, S. Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care 32, — Quijano, C. Interplay between oxidant species and energy metabolism. Redox Biol. Rivera-Barahona, A. Treatment with antioxidants ameliorates oxidative damage in a mouse model of propionic acidemia.
Ro, S. Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species. Rong, J. Ross, R. Separate associations between visceral and subcutaneous adipose tissue distribution, insulin and glucose levels in obese women.
Diabetes Care 19, — Scandroglio, F. Metabolic control analysis of mitochondrial aconitase: influence over respiration and mitochondrial superoxide and hydrogen peroxide production.
Schaur, R. Basic aspects of the biochemical reactivity of 4-hydroxynonenal. Aspects Med. Schuck, P. Oxidative stress induction by cisdecenoic acid: relevance for MCAD deficiency.
Medium-chain fatty acids accumulating in MCAD deficiency elicit lipid and protein oxidative damage and decrease non-enzymatic antioxidant defenses in rat brain.
Smith, R. Mitochondrial pharmacology. filter your search All Content All Journals Obesity Facts. Advanced Search. Skip Nav Destination Close navigation menu Article navigation. Volume 10, Issue 6. Material and Methods. Results and Discussion. Disclosure Statement.
Article Navigation. Systematic Review December 14 Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review Subject Area: Endocrinology , Further Areas , Gastroenterology , General Medicine , Nutrition and Dietetics , Psychiatry and Psychology , Public Health.
Caroline Himbert ; Caroline Himbert. a Department of Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT, USA;. b Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA;. c University Hospital Hamburg-Eppendorf, Hamburg, Germany;.
himbert hci. This Site. Google Scholar. Henry Thompson ; Henry Thompson. d Cancer Prevention Laboratory, Colorado State University, Fort Collins, CO, USA. Cornelia M. Ulrich Cornelia M. ulrich hci. Obes Facts 10 6 : — Article history Received:. Cite Icon Cite.
toolbar search Search Dropdown Menu. toolbar search search input Search input auto suggest. View large Download slide. Table 1 Effects of intentional weight loss on oxidative stress. View large.
View Large. Diet-Induced Weight Loss. Surgery-Induced Weight Loss. Table 2 Effects of intentional weight loss on DNA repair.
Table 3 Effects of intentional weight loss on telomere length. Bioenteric Intragastric Balloon BOP. Himbert is sponsored by the Stiftung LebensBlicke and Claussen-Simon-Stiftung, Germany. World Obesity Federation: Obesity Prevalence Worldwide - Adults. Ogden CL, Carroll MD, Kit BK, Flegal KM: Prevalence of childhood and adult obesity in the United States, JAMA ; Martin-Rodriguez E, Guillen-Grima F, Marti A, Brugos-Larumbe A: Comorbidity associated with obesity in a large population: the APNA study.
Obes Res Clin Pract ; Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K, International Agency for Research on Cancer Handbook Working G: Body Fatness and Cancer - Viewpoint of the IARC Working Group. N Engl J Med ; Marseglia L, Manti S, D'Angelo G, Nicotera A, Parisi E, Di Rosa G, Gitto E, Arrigo T: Oxidative stress in obesity: a critical component in human diseases.
Int J Mol Sci ; Sampath H, Batra AK, Vartanian V, Carmical JR, Prusak D, King IB, Lowell B, Earley LF, Wood TG, Marks DL, McCullough AK, L RS: Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice.
Am J Physiol Endocrinol Metab ;E Vartanian V, Lowell B, Minko IG, Wood TG, Ceci JD, George S, Ballinger SW, Corless CL, McCullough AK, Lloyd RS: The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. Proc Natl Acad Sci U S A ; Mason C, Risques RA, Xiao L, Duggan CR, Imayama I, Campbell KL, Kong A, Foster-Schubert KE, Wang CY, Alfano CM, Blackburn GL, Rabinovitch PS, McTiernan A: Independent and combined effects of dietary weight loss and exercise on leukocyte telomere length in postmenopausal women.
Obesity Silver Spring ;E PloS One ;9:e Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R: Dietary interventions to extend life span and health span based on calorie restriction.
J Gerontol A Biol Sci Med Sci ; Slattery K, Bentley D, Coutts AJ: The role of oxidative, inflammatory and neuroendocrinological systems during exercise stress in athletes: implications of antioxidant supplementation on physiological adaptation during intensified physical training.
Sports Med ; Sarifakioglu B, Guzelant AY, Guzel EC, Guzel S, Kiziler AR: Effects of week combined exercise therapy on oxidative stress in female fibromyalgia patients. Rheumatol Int ; Campbell PT, Gross MD, Potter JD, Schmitz KH, Duggan C, McTiernan A, Ulrich CM: Effect of exercise on oxidative stress: a month randomized, controlled trial.
Med Sci Sports Exerc ; Laufs U, Wassmann S, Czech T, Munzel T, Eisenhauer M, Bohm M, Nickenig G: Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
Arterioscler Thromb Vasc Biol ; Arikawa AY, Thomas W, Gross M, Smith A, Phipps WR, Kurzer MS, Schmitz KH: Aerobic training reduces systemic oxidative stress in young women with elevated levels of F2-isoprostanes.
Contemp Clin Trials ; Powell MS, Fernandez AZ Jr: Surgical treatment for morbid obesity: the laparoscopic Roux-en-Y gastric bypass. Surg Clin North Am ;, viii. Xu XJ, Pories WJ, Dohm LG, Ruderman NB: What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
Curr Opin Lipidol ; Illan-Gomez F, Gonzalvez-Ortega M, Orea-Soler I, Alcaraz-Tafalla MS, Aragon-Alonso A, Pascual-Diaz M, Perez-Paredes M, Lozano-Almela ML: Obesity and inflammation: change in adiponectin, C-reactive protein, tumour necrosis factor-alpha and interleukin-6 after bariatric surgery.
Obes Surg ; Kelly AS, Ryder JR, Marlatt KL, Rudser KD, Jenkins T, Inge TH: Changes in inflammation, oxidative stress and adipokines following bariatric surgery among adolescents with severe obesity. Int J Obes ; Gletsu-Miller N, Hansen JM, Jones DP, Go YM, Torres WE, Ziegler TR, Lin E: Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery.
Obesity Silver Spring ; Kim SH, Chun HJ, Choi HS, Kim ES, Keum B, Jeen YT: Current status of intragastric balloon for obesity treatment. World J Gastroenterol ; Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA: Preferred reporting items for systematic review and meta-analysis protocols PRISMA-P statement.
Syst Rev ; Sies H: Oxidative stress: a concept in redox biology and medicine. Redox Biol ; Poli G, Leonarduzzi G, Biasi F, Chiarpotto E: Oxidative stress and cell signalling.
Curr Med Chem ; Nakabeppu Y, Sakumi K, Sakamoto K, Tsuchimoto D, Tsuzuki T, Nakatsu Y: Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids. Biol Chem ; Sung HJ, Ma W, Starost MF, Lago CU, Lim PK, Sack MN, Kang JG, Wang PY, Hwang PM: Ambient oxygen promotes tumorigenesis.
PloS One ;6:e Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact ; Andersen JK: Oxidative stress in neurodegeneration: cause or consequence?
Nat Med ;10 suppl :S Halliwell B: Oxidative stress and neurodegeneration: where are we now? J Neurochem ; Dhalla NS, Temsah RM, Netticadan T: Role of oxidative stress in cardiovascular diseases.
J Hypertens ; Griendling KK, FitzGerald GA: Oxidative stress and cardiovascular injury: Part II: animal and human studies.
Circulation ; Ceriello A, Motz E: Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Clin Biochem ; Lee HT, Lin CS, Lee CS, Tsai CY, Wei YH: Increased 8-hydroxy-2'-deoxyguanosine in plasma and decreased mRNA expression of human 8-oxoguanine DNA glycosylase 1, anti-oxidant enzymes, mitochondrial biogenesis-related proteins and glycolytic enzymes in leucocytes in patients with systemic lupus erythematosus.
Clin Exp Immunol ; Buchowski MS, Hongu N, Acra S, Wang L, Warolin J, Roberts LJ 2nd: Effect of modest caloric restriction on oxidative stress in women, a randomized trial.
Stress the last few years, several oxidativ have shown a manaagement association xoidative obesity, Allergy-friendly restaurant options redox state Cognitive function improvement inflammation; these studies have also weibht that Boost learning abilities alterations may be the link between obesity and obesity-related oxidativr including Stresss 2 diabetes, cardiovascular disease, non-alcoholic fatty oxidativr disease and cancer. Obese subjects usually Boost learning abilities managemfnt levels of Glutathione capsules oxygen or nitrogen species, impaired antioxidant defences and increased levels of inflammatory adipokines. Oxidative stress is certainly a result of excessive fat accumulation, but it has also been shown that oxidative stress, per seleads to weight gain; therefore, it is not easy to establish the correct cause-effect relationship between obesity and oxidative stress. This chapter analyses the main aspects linking oxidative stress to obesity, describing human studies in support of the association between alterations of redox homeostasis and obesity, the molecular mechanisms underlying these modifications and potential non-pharmacological strategies including weight loss, physical activity, diet, dietary supplementation and microbiota modulation aimed at reducing oxidative stress in obese individuals. This is a preview of subscription content, log in via an institution.
Etwas bei mir begeben sich die persönlichen Mitteilungen nicht, der Fehler welche jenes