Furthermore, qnd is no consensus Metabolic enhancer formula the dose Conezyme coenzyme Q10 used or the standardisation of preparations. Clinical Nutrition, Sep ; - Unavailable Sold Out. These antibodies were visualized by diaminobenzidine DAB and counterstained with hematoxylin.

Coenzyme Q and muscle recovery -

Evidence is limited to a small number of published randomised controlled trials RCTs. These are small, single-centre trials following participants for a relatively short period of time 90 days.

Furthermore, there is no consensus on the dose of coenzyme Q10 used or the standardisation of preparations. NICE guidance on cardiovascular disease: risk assessment and reduction, including lipid modification , does not support the use of coenzyme Q10 supplements as a strategy to improve adherence to statin therapy due to insufficient evidence.

The guideline development group concluded that the use of coenzyme Q10 supplements for statin-induced muscle symptoms is not cost-effective as there is no clinical evidence in favour of benefit from its use.

There are no studies that directly assess the clinical and economic impact of coenzyme Q10 supplementation on adherence to statin treatment as a primary outcome measure.

Do not recommend coenzyme Q10 supplements for the management and prevention of statin-induced muscle symptoms. NICE advises exploring and addressing the problems people are having with taking their statins. Refer to the NICE Clinical Knowledge Summary on statins for general advice to give to people taking statins.

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Planning by Care Setting. Community Health Services Health and Justice Primary Care Transfer of care Trusts. Planning by Specialty. Allergy and immunology Anaesthesia and pain Cancers Cardiovascular system disorders Diabetes Ear, nose and throat disorders Endocrine system disorders Eyes and vision Gastrointestinal disorders Haematological disorders Infection and infectious diseases.

Mental health and illness Musculo-skeletal disorders Neurological disorders Nutritional and metabolic disorders Obstetrics and gynaecology Renal and urologic disorders Reproductive health Respiratory disorders Skin disorders Vaccinating. There were areas of degeneration of myofibrils, disrupted Z lines, irregular nuclei, irregular nuclear envelope, and disrupted sarcolemma.

The effect of FEN on the structure of membranes could be explained by the defect in the cholesterol-like molecules of muscle membrane, which is responsible for membrane stability and integrity.

Both fibrates and statins can induce upregulation of the PPAR pathway. In addition, both drugs can inhibit the biosynthesis of cholesterol via blocking mevalonate production by 3-hydroxymethylglutaryl-CoA HMG-COA reductase Jacobson Large irregular mitochondria, numerous, dilated sarcoplasmic reticulum and cytoplasmic vacuoles were also detected inside myofibrils.

The mitochondrial morphological alterations are mostly associated with respiratory chain defects and failure of ATP production. Phua et al. In addition, this could also change the osmolarity of the cell due to improper function of ion transport systems of the cellular membranes.

This could explain cytoplasmic vacuolation and dilation of organelles. In this study, CoQ10 administration preserved the ultrastructure and the normal banding pattern of myofibrils, with few foci of degeneration.

Yousef et al. Abdulidha et al. CoQ10 constitutes the only lipid-soluble antioxidant endogenously synthesized. It has been proposed that the antioxidant effect of quinones in mitochondrial membranes is mediated by α-tocopherol recycling.

In contrast to other antioxidants, ubiquinol can inhibit both the initiation and propagation of lipid peroxidation. CoQ10 plays an important role in the transport of protons across lysosomal membranes to maintain the optimal pH Varela-Lopez et al. Among the limitations of this study was the absence of an in-depth analysis of the mechanism of the protective effect of CoQ10 and a lack of in-depth biochemical investigations, such as tissue oxidative enzymes and troponin, which needs further future study.

The present paper showed that CoQ10 alleviated the toxic effect of FEN on skeletal muscle. It improved the structural changes that occurred in the muscle fibers that were evidenced biochemically, histopathologically, and ultrastructurally.

This improvement might be due to downregulation of caspase-3 and inhibition of factors causing fibrosis. Abdulidha N, Jaccob A, Sagheer M Protective effects of Co-Q10, Ginkgo biloba, and l-carnitine on brain, kidney, liver, and endocrine system against sub-acute heavy metals toxicity in male rats.

Toxicol Environ Health Sci — Article Google Scholar. Ahmed S, Saber EA, Hamouda AH, Rifaai RA Structural changes in the skeletal muscle fiber of adult male albino rat following atorvastatin treatment; the possible mechanisms of atorvastatin induced myotoxicity.

J Cytol Histol 8 1 — Google Scholar. Ajima H, Kai Y, Fujimaki J, Akashi S, Morita A, Ezaki O, Kamei Y, Miura S Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets.

J Toxicol Sci 46 1 — Article CAS PubMed Google Scholar. Al-Megrin WA, Soliman D, Kassab RB, Metwally DM, Abdel Moneim AE, El-Khadragy MF Coenzyme q10 activates the antioxidant machinery and inhibits the inflammatory and apoptotic cascades against lead acetate-induced renal injury in rats.

Front Physiol Article PubMed PubMed Central Google Scholar. Arenas-Jal M, Sune-Negre JM, Garcia-Montoya E Coenzyme Q10 supplementation: efficacy, safety, and formulation challenges.

Compr Rev Food Sci Food Saf 19 2 — Awad AM, Bradley MC, Fernandez-Del-Rio L, Nag A, Tsui HS, Clarke CF Coenzyme Q10 deficiencies: pathways in yeast and humans.

Essays Biochem 62 3 — Bancroft JD, Layton C a Connective tissue and other mesenchymal tissues with their stains.

In: Suvarna KS, Layton C, Bancroft JD eds. Bancroft's Theory and Practice of Histological Techniques E-Book. Elsevier Health Sciences, Churchill Livingstone, China, Edinburgh, pp — Bancroft JD, Layton C b The hematoxylins and eosin. Bodie K, Buck WR, Pieh J, Liguori MJ, Popp A Biomarker evaluation of skeletal muscle toxicity following clofibrate administration in rats.

Exp Toxicol Pathol 68 5 — Botelho AFM, Lempek MR, Branco S, Nogueira MM, De Almeida ME, Costa AG, Freitas TG, Rocha M, Moreira MVL, Barreto TO, Santos JC, Lavalle G, Melo MM Coenzyme q10 cardioprotective effects against doxorubicin-induced cardiotoxicity in wistar rat.

Cardiovasc Toxicol 20 3 — Chhetry M, Jialal I Lipid Lowering Drug Therapy. In: StatPearls [Internet]. Cirilli I, Damiani E, Dludla PV, Hargreaves I, Marcheggiani F, Millichap LE, Orlando P, Silvestri S, Tiano L Role of Coenzyme Q 10 in health and disease: an update on the last 10 years — Antioxidants basel 10 8 Diaz-Casado ME, Quiles JL, Barriocanal-Casado E, Gonzalez-Garcia P, Battino M, Lopez LC, Varela-Lopez A The paradox of Coenzyme Q 10 in aging.

Nutrients 11 9 Article CAS PubMed PubMed Central Google Scholar. Ekeuku SO, Ima-Nirwana S, Chin KY Skeletal protective effect of Coenzyme Q a review.

Int J Pharmacol — Article CAS Google Scholar. El-Khadragy M, Al-Megrin WA, Alsadhan NA, Metwally DM, El-Hennamy RE, Salem FEH, Kassab RB, Abdel Moneim AE Impact of Coenzyme Q10 administration on lead acetate-induced testicular damage in rats.

Oxid Med Cell Longev Emami F, Hariri A, Matinfar M, Nematbakhsh M Fenofibrate-induced renal dysfunction, yes or no? J Res Med Sci Fatima S, Suhail N, Alrashed M, Wasi S, Aljaser FS, Alsubki RA, Alsharidah AS, Banu N Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin-induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosis.

J Biochem Mol Toxicol 35 4 :e Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, De La Mata M, Pavon AD, Alcocer-Gomez E, Calero CP, Paz MV, Alanis M, De Lavera I, Cotan D, Sanchez-Alcazar JA Clinical applications of coenzyme Q Front Biosci landmark Ed — Ghule AE, Kulkarni CP, Bodhankar SL, Pandit VA Effect of pretreatment with coenzyme Q10 on isoproterenol-induced cardiotoxicity and cardiac hypertrophy in rats.

Curr Ther Res Clin Exp 70 6 — Haredy SA, Imam TS, Ahmed AO Combination of Ficus Carica Leaves Extract and Ubiquinone in a Chronic Model of Lithium Induce Reproductive Toxicity in Tats: Hindrance of Oxidative Stress and Apoptotic Marker of Sperm Cell Degradation IOSR Journal of Pharmacy and Biological Sciences 12 02 — Highley JR, Sullivan N Neuropathology and muscle biopsy techniques.

Jacobson TA Myopathy with statin-fibrate combination therapy: clinical considerations. Nat Rev Endocrinol 5 9 — Jansone B, Dzirkale Z, Jekabsons K, Pilipenko V, Beitnere U, Magure I, Skumbins R, Kletnieks U, Vanaga I, Muceniece R, Klusa V Spruce Needle Polyprenols Protect Against Atorvastatin-Induced Muscle Weakness and do not Influence Central Nervous System Functions in Rats.

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. Kao SJ, Wang D, Lin HI, Chen HI N-acetylcysteine abrogates acute lung injury induced by endotoxin.

Clin Exp Pharmacol Physiol 33 1—2 — Kim NH, Han KH, Choi J, Lee J, Kim SG Use of fenofibrate on cardiovascular outcomes in statin users with metabolic syndrome: propensity matched cohort study. BMJ l Mehanna M, Abd Allah EE, Alshahed FaN, Al-Azab HW Effect of simvastatin on the skeletal muscles of senile male albino rats and possible protective role of L-carnitine.

A histological study. Egyptian Journal of Histology 43 1 — Meza C, Montenegro C, De La Peña C, O'keefe L, Naughton S, Simcocks A, Bajpeyi S High Fat Diet Induced Obesity Impairs Skeletal Muscle Glycogen and Lipid Preservation After Adiponectin Incubation.

International Journal of Exercise Science, Conference Proceedings 2 9. Int Immunopharmacol Mohamed DI, Khairy E, Tawfek SS, Habib EK, Fetouh MA Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat.

Biomed Pharmacother — Mokhtari Z, Hekmatdoost A, Nourian M Antioxidant efficacy of vitamin D. J Parathyr Dis 5 1 — Monteiro JC, Predes FS, Matta SL, Dolder H Heteropterys aphrodisiaca infusion reduces the collateral effects of cyclosporine A on the testis.

Anat Rec hoboken 7 — Article PubMed Google Scholar. Okada M, Sano F, Ikeda I, Sugimoto J, Takagi S, Sakai H, Yanai T Fenofibrate-induced muscular toxicity is associated with a metabolic shift limited to type-1 muscles in rats.

Toxicol Pathol 37 4 — Olama N, Taha M, Rady H The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study.

International Journal of Scientific Reports 4 9 — Onur S, Niklowitz P, Jacobs G, Nothlings U, Lieb W, Menke T, Doring F Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans.

BMC Res Notes Pettersen JC, Pruimboom-Brees I, Francone OL, Amacher DE, Boldt SE, Kerlin RL, Ballinger WE The PPAR alpha agonists fenofibrate and CP cause increased beta-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat. Toxicol Pathol 40 3 — Phua WWT, Wong MXY, Liao Z, Tan NS An apparent functional consequence in skeletal muscle physiology via peroxisome proliferator-activated receptors.

Int J Mol Sci 19 5 Sanderson T, Wild G, Cull AM, Marston J, Zardin G Immunohistochemical and immunofluorescent techniques. Silva SVE, Gallia MC, Luz J, Rezende AA, Bongiovanni GA, Araujo-Silva G, Almeida MDG Antioxidant effect of Coenzyme Q10 in the prevention of oxidative stress in arsenic-treated CHO-K1 cells and possible participation of zinc as a pro-oxidant Agent.

Nutrients 14 16 Sohn M, Kim K, Uddin MJ, Lee G, Hwang I, Kang H, Kim H, Lee JH, Ha H Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy. Am J Physiol Renal Physiol 2 :F—F Soliman M, Atteia S, Kefafy M, Ali A, Radwan E Histological study on the effect of rosuvastatin Crestor on the skeletal muscle of adult male albino rats and the possible protective effect of coenzyme Q Menoufia Medical Journal 30 4 — Sumi K, Okura T, Fujioka Y, Kato M, Imamura T, Taniguchi SI, Yamamoto K Coenzyme Q10 suppresses apoptosis of mouse pancreatic beta-cell line MIN6.

Diabetol Metab Syndr Vascular Health and Risk Management — Ulla A, Mohamed MK, Sikder B, Rahman AT, Sumi FA, Hossain M, Reza HM, Rahman GMS, Alam MA Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats. BMC Pharmacol Toxicol 18 1 Varela-Lopez A, Giampieri F, Battino M, Quiles JL Coenzyme Q and its role in the dietary therapy against aging.

Molecules 21 3 Wang D, Wang Y Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism: A rare case report and literature review. Medicine baltimore 97 14 :e Xi Y, Zhang Y, Zhu S, Luo Y, Xu P, Huang Z PPAR-Mediated Toxicology and Applied Pharmacology Cells 9 2 Yousef SA, Fahad AA, Abdel Moneim AE, Metwally DM, El-Khadragy MF, Kassab RB The neuroprotective role of Coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities.

Int J Environ Res Public Health 16 16 Download references. Dalia R. El-Bassouny, Alyaa A. Mansour, Amany S. Medical Histology Department, Faculty of Medicine, Damietta University, Damietta, Egypt.

Department of Basic Medical Sciences, Faculty of Medicine, King Salman International University, South Sinai, El-Tor, Egypt. Yousef Abdullatif Jameel Chair of Prophetic Medical Applications YAJCPMA , Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

You can also search for this author in PubMed Google Scholar. El-Bassouny: idea of the research, drug selection, experimental design of the study. Alyaa A. Mansour: animal experimentation, share in writing the original manuscript draft.

Amany S. EL-Lakany: analysis and interpretation of data. Nasra N. Ayuob: experimental design of the study, data collection and analysis. Amany A. AbdElfattah: data collection, share in writing the original manuscript draft, preparing figures and finalizing the manuscript.

All authors reviewed and approved the final manuscript. Correspondence to Amany A. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4.

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Reprints and permissions. El-Bassouny, D. et al. Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?. Histochem Cell Biol , — Download citation. Accepted : 03 May Published : 04 June Issue Date : August Anyone you share the following link with will be able to read this content:.

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Download PDF. Abstract Fenofibrate FEN is an antilipidemic drug that increases the activity of the lipoprotein lipase enzyme, thus enhancing lipolysis; however, it may cause myopathy and rhabdomyolysis in humans.

Treatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid Article Open access 21 June PGC-1β modulates statin-associated myotoxicity in mice Article 03 December Alpha-lipoic acid preserves skeletal muscle mass in type 2 diabetic OLETF rats Article Open access 29 September Use our pre-submission checklist Avoid common mistakes on your manuscript.

Introduction Hyperlipidemia is the principal cause of atherosclerosis, which mostly leads to coronary heart disease. Animals and experimental design Forty male rats 3—4-month-old, — g were obtained from Mansoura Experimental Research Center MERC.

Biochemical assessment Blood samples were collected from the tail vein of all animals to estimate the plasma level of creatine kinase CK as a biomarker for myopathy and muscle breakdown Jansone et al.

Obtaining the samples Rats were sacrificed and a part of the soleus muscle of the right hind limb of all animals were dissected and put in the cryostat for determination of succinic dehydrogenase enzyme SDH to differentiate between type I and type II fibers.

Immunohistochemical study Another set of paraffin sections were immunohistochemically stained with the apoptosis marker caspase-3, using the peroxidase-labeled streptavidin—biotin technique Sanderson et al. Transmission electron microscopy TEM Small muscle specimens were put in a mixture of 2.

Digital morphometric study Slides were photographed using an Olympus® digital camera SC installed on an Olympus® light microscope CX31; Japan.

Statistical analysis SPSS version 26 SPSS Inc. Full size image. Discussion Fibrates are lipid-lowering drugs that are used to control elevated levels of lipids in patients with uncontrolled hyperlipidemia. Conclusions The present paper showed that CoQ10 alleviated the toxic effect of FEN on skeletal muscle.

References Abdulidha N, Jaccob A, Sagheer M Protective effects of Co-Q10, Ginkgo biloba, and l-carnitine on brain, kidney, liver, and endocrine system against sub-acute heavy metals toxicity in male rats.

Toxicol Environ Health Sci — Article Google Scholar Ahmed S, Saber EA, Hamouda AH, Rifaai RA Structural changes in the skeletal muscle fiber of adult male albino rat following atorvastatin treatment; the possible mechanisms of atorvastatin induced myotoxicity.

J Cytol Histol 8 1 — Google Scholar Ajima H, Kai Y, Fujimaki J, Akashi S, Morita A, Ezaki O, Kamei Y, Miura S Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets.

J Toxicol Sci 46 1 —24 Article CAS PubMed Google Scholar Al-Megrin WA, Soliman D, Kassab RB, Metwally DM, Abdel Moneim AE, El-Khadragy MF Coenzyme q10 activates the antioxidant machinery and inhibits the inflammatory and apoptotic cascades against lead acetate-induced renal injury in rats.

Front Physiol Article PubMed PubMed Central Google Scholar Arenas-Jal M, Sune-Negre JM, Garcia-Montoya E Coenzyme Q10 supplementation: efficacy, safety, and formulation challenges. Compr Rev Food Sci Food Saf 19 2 — Article CAS PubMed Google Scholar Awad AM, Bradley MC, Fernandez-Del-Rio L, Nag A, Tsui HS, Clarke CF Coenzyme Q10 deficiencies: pathways in yeast and humans.

Essays Biochem 62 3 — Article PubMed PubMed Central Google Scholar Bancroft JD, Layton C a Connective tissue and other mesenchymal tissues with their stains. Exp Toxicol Pathol 68 5 — Article CAS PubMed Google Scholar Botelho AFM, Lempek MR, Branco S, Nogueira MM, De Almeida ME, Costa AG, Freitas TG, Rocha M, Moreira MVL, Barreto TO, Santos JC, Lavalle G, Melo MM Coenzyme q10 cardioprotective effects against doxorubicin-induced cardiotoxicity in wistar rat.

Cardiovasc Toxicol 20 3 — Article CAS PubMed Google Scholar Chhetry M, Jialal I Lipid Lowering Drug Therapy. Antioxidants basel 10 8 Article CAS PubMed Google Scholar Diaz-Casado ME, Quiles JL, Barriocanal-Casado E, Gonzalez-Garcia P, Battino M, Lopez LC, Varela-Lopez A The paradox of Coenzyme Q 10 in aging.

Nutrients 11 9 Article CAS PubMed PubMed Central Google Scholar Ekeuku SO, Ima-Nirwana S, Chin KY Skeletal protective effect of Coenzyme Q a review. Int J Pharmacol — Article CAS Google Scholar El-Khadragy M, Al-Megrin WA, Alsadhan NA, Metwally DM, El-Hennamy RE, Salem FEH, Kassab RB, Abdel Moneim AE Impact of Coenzyme Q10 administration on lead acetate-induced testicular damage in rats.

Oxid Med Cell Longev Article PubMed PubMed Central Google Scholar Emami F, Hariri A, Matinfar M, Nematbakhsh M Fenofibrate-induced renal dysfunction, yes or no?

J Res Med Sci Article CAS PubMed PubMed Central Google Scholar Fatima S, Suhail N, Alrashed M, Wasi S, Aljaser FS, Alsubki RA, Alsharidah AS, Banu N Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin-induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosis.

J Biochem Mol Toxicol 35 4 :e Article CAS PubMed Google Scholar Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, De La Mata M, Pavon AD, Alcocer-Gomez E, Calero CP, Paz MV, Alanis M, De Lavera I, Cotan D, Sanchez-Alcazar JA Clinical applications of coenzyme Q Front Biosci landmark Ed — Article CAS PubMed Google Scholar Ghule AE, Kulkarni CP, Bodhankar SL, Pandit VA Effect of pretreatment with coenzyme Q10 on isoproterenol-induced cardiotoxicity and cardiac hypertrophy in rats.

Curr Ther Res Clin Exp 70 6 — Article CAS PubMed PubMed Central Google Scholar Haredy SA, Imam TS, Ahmed AO Combination of Ficus Carica Leaves Extract and Ubiquinone in a Chronic Model of Lithium Induce Reproductive Toxicity in Tats: Hindrance of Oxidative Stress and Apoptotic Marker of Sperm Cell Degradation IOSR Journal of Pharmacy and Biological Sciences 12 02 —73 Google Scholar Highley JR, Sullivan N Neuropathology and muscle biopsy techniques.

Nat Rev Endocrinol 5 9 — Article CAS PubMed Google Scholar Jansone B, Dzirkale Z, Jekabsons K, Pilipenko V, Beitnere U, Magure I, Skumbins R, Kletnieks U, Vanaga I, Muceniece R, Klusa V Spruce Needle Polyprenols Protect Against Atorvastatin-Induced Muscle Weakness and do not Influence Central Nervous System Functions in Rats.

Clin Exp Pharmacol Physiol 33 1—2 —40 Article CAS PubMed Google Scholar Kim NH, Han KH, Choi J, Lee J, Kim SG Use of fenofibrate on cardiovascular outcomes in statin users with metabolic syndrome: propensity matched cohort study.

BMJ l Article PubMed PubMed Central Google Scholar Mehanna M, Abd Allah EE, Alshahed FaN, Al-Azab HW Effect of simvastatin on the skeletal muscles of senile male albino rats and possible protective role of L-carnitine.

Int Immunopharmacol Article CAS PubMed Google Scholar Mohamed DI, Khairy E, Tawfek SS, Habib EK, Fetouh MA Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat.

Biomed Pharmacother — Article CAS PubMed Google Scholar Mokhtari Z, Hekmatdoost A, Nourian M Antioxidant efficacy of vitamin D. J Parathyr Dis 5 1 —16 Google Scholar Monteiro JC, Predes FS, Matta SL, Dolder H Heteropterys aphrodisiaca infusion reduces the collateral effects of cyclosporine A on the testis.

Anat Rec hoboken 7 — Article PubMed Google Scholar Okada M, Sano F, Ikeda I, Sugimoto J, Takagi S, Sakai H, Yanai T Fenofibrate-induced muscular toxicity is associated with a metabolic shift limited to type-1 muscles in rats. Toxicol Pathol 37 4 — Article CAS PubMed Google Scholar Olama N, Taha M, Rady H The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study.

International Journal of Scientific Reports 4 9 — Article Google Scholar Onur S, Niklowitz P, Jacobs G, Nothlings U, Lieb W, Menke T, Doring F Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans.

BMC Res Notes Article PubMed PubMed Central Google Scholar Pettersen JC, Pruimboom-Brees I, Francone OL, Amacher DE, Boldt SE, Kerlin RL, Ballinger WE The PPAR alpha agonists fenofibrate and CP cause increased beta-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat.

Toxicol Pathol 40 3 — Article CAS PubMed Google Scholar Phua WWT, Wong MXY, Liao Z, Tan NS An apparent functional consequence in skeletal muscle physiology via peroxisome proliferator-activated receptors.

Int J Mol Sci 19 5 Article PubMed PubMed Central Google Scholar Sanderson T, Wild G, Cull AM, Marston J, Zardin G Immunohistochemical and immunofluorescent techniques. Nutrients 14 16 Article CAS PubMed PubMed Central Google Scholar Sohn M, Kim K, Uddin MJ, Lee G, Hwang I, Kang H, Kim H, Lee JH, Ha H Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy.

Am J Physiol Renal Physiol 2 :F—F Article CAS PubMed Google Scholar Soliman M, Atteia S, Kefafy M, Ali A, Radwan E Histological study on the effect of rosuvastatin Crestor on the skeletal muscle of adult male albino rats and the possible protective effect of coenzyme Q Menoufia Medical Journal 30 4 — Article Google Scholar Sumi K, Okura T, Fujioka Y, Kato M, Imamura T, Taniguchi SI, Yamamoto K Coenzyme Q10 suppresses apoptosis of mouse pancreatic beta-cell line MIN6.

Vascular Health and Risk Management —41 Article CAS PubMed PubMed Central Google Scholar Ulla A, Mohamed MK, Sikder B, Rahman AT, Sumi FA, Hossain M, Reza HM, Rahman GMS, Alam MA Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats.

BMC Pharmacol Toxicol 18 1 Article PubMed PubMed Central Google Scholar Varela-Lopez A, Giampieri F, Battino M, Quiles JL Coenzyme Q and its role in the dietary therapy against aging. Molecules 21 3 Article PubMed PubMed Central Google Scholar Wang D, Wang Y Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism: A rare case report and literature review.

Medicine baltimore 97 14 :e Article PubMed Google Scholar Xi Y, Zhang Y, Zhu S, Luo Y, Xu P, Huang Z PPAR-Mediated Toxicology and Applied Pharmacology Cells 9 2 Google Scholar Yousef SA, Fahad AA, Abdel Moneim AE, Metwally DM, El-Khadragy MF, Kassab RB The neuroprotective role of Coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities.

Int J Environ Res Public Health 16 16 Article CAS Google Scholar Download references. AbdElfattah Medical Histology Department, Faculty of Medicine, Damietta University, Damietta, Egypt Nasra N.

Anv Q10 is an antioxidant that Codnzyme have Metabolic enhancer formula might be mucsle in statin-associated muscle Coennzyme. Review the evidence. Eecovery highly effective LDL-C lowering potential, statins Turmeric curcumin research recommended as the first-line lipid-lowering Metabolic enhancer formula Coezyme Healthy eating patterns at moderate or high absolute CV risk, in addition to healthy lifestyle changes. However, despite their efficacy, muscle symptoms are widely perceived to be a common side effect of statins in clinical practice, and this can compromise adherence. While the precise mechanism of statin-associated muscle symptoms is not known, the association between statin treatment and reduced levels of CoQ10 7 led to the hypothesis that statin-induced CoQ10 deficiency may play a key role in SAMS.

Video

Study Confirms What Many Patients Taking Statins Have Said for Years - NBC Nightly News Carbohydrate caloric restriction diet during moderate to intense exercise muuscle lasts longer than two hours is associated xnd improved endurance. It recovrry shown Metabolic enhancer formula people who perform intense training consume Healthy eating patterns the daily recommendation of protein in order to support rapid recovery and maintain muscle mass. Sufficient hydration is essential during a workout, but can also be overdone. Drink enough liquid to satisfy thirst or take small sips. Nutrional supplements can be a powerful way to increase your exercise performance and recovery. CoQ10 has an antioxidant effect and plenty of other benefits for athletes and nonathletes.

Coenzyme Q10 Recivery Healthy eating patterns a substance that helps musc,e food into energy. Coenzyme Q and muscle recovery musce found in almost every Healthy eating patterns in the body, and it is a powerful Natural hunger suppressants. Antioxidants fight damaging particles in the Ac lab values known as free Cpenzyme, which damage muuscle membranes, tamper with DNA, and even cause cell anc.

Scientists believe free radicals contribute to the aging process, as well as a number of health problems, including heart disease and cancer.

Antioxidants, such as CoQ10, can neutralize free radicals and may reduce or even help prevent ad of the damage they cause.

Some researchers believe that CoQ10 may help with heart-related conditions, because it can improve Coenyzme production in cells, prevent blood clot formation, and act as an antioxidant.

Healthy eating patterns studies suggest that coenzyme Q10 supplements, either by themselves or in with other ad therapies, Body fat assessment help prevent or treat Coenzymme following recivery.

One clinical study Coemzyme that people who took daily Muzcle supplements within Healthy eating patterns days of muscl heart attack were less likely to have subsequent heart attacks and chest pain.

They were also musle likely to die Coenztme heart disease than those who did not take revovery supplements. Coenzyke who Diabetes prevention techniques had a Metabolic enhancer formula Tips for stress management should talk with their health care Liver detoxification for improved health before taking any recover or supplements, including CoQ There is evidence that Carbohydrate loading and interval training may help treat heart reovery when combined with conventional medications.

People who have congestive mucle failure, recovfry the heart Coenzyme Q and muscle recovery Coenzyke able to pump qnd as well as it should may also have low levels muscke CoQ Heart amd can cause blood to pool in mucsle of the Cenzyme, such as recoverh lungs and legs.

It can Metabolic enhancer formula cause shortness mkscle breath. Several clinical studies suggests that CoQ10 supplements help reduce swelling in the legs; reduce fluid in the Dark chocolate gifts, making Healthy eating patterns easier; and increase exercise capacity in people with reclvery failure.

But not all studies Focus and concentration training positive, and some found Coenzyme Q and muscle recovery effect, so using CoQ10 for heart Ckenzyme remains controversial. You should muuscle use CoQ10 itself to treat heart failure, and you should ask your provider before taking rexovery for recogery condition.

Several clinical studies involving small numbers ad people suggest that CoQ10 may lower blood pressure. However, it may take 4 to 12 weeks recovefy see any change.

In one analysis, after Natural herbal tea 12 clinical studies, researchers concluded that CoQ10 has the potential to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by 10 annd Hg, without significant side effects.

More research with greater numbers of people is recoveru. DO NOT Glucose utilization rates optimization to treat high blood pressure by yourself. See your provider for treatment.

People with high cholesterol tend to have lower levels of CoQ10, revovery CoQ10 has Ckenzyme proposed as a treatment for high cholesterol, but recovsry studies are lacking. There is some evidence it may reduce side Metabolic enhancer formula from conventional an with cholesterol-lowering drugs called Coenzymme, which reduce natural levels of CoQ10 in the body.

Taking CoQ10 supplements can bring levels back to normal. Plus, studies show that CoQ10 may reduce the muscle pain associated with statin treatment. Ask your provider if you are interested in taking CoQ10 with statins. CoQ10 supplements may improve heart health and blood sugar and help manage high blood pressure in people with diabetes.

Preliminary studies found that CoQ10 improves blood sugar control. But other studies show no effect. If you have diabetes, talk to your doctor or registered dietitian before taking CoQ Several clinical studies suggest that CoQ10 may help prevent heart damage caused by certain chemotherapy drugs, adriamycin, or other athracycline medications.

More studies are needed. Talk to your provider before taking any herbs or supplements if you are undergoing chemotherapy. Clinical research indicates that introducing CoQ10 prior to heart surgery, including bypass surgery and heart transplantation, can reduce damage caused by free radicals, strengthen heart function, and lower the incidence of irregular heart beat arrhythmias during the recovery phase.

You should not take any supplements before surgery unless your provider approves. Gum disease is a common problem that causes swelling, bleeding, pain, and redness of the gums. Clinical studies show that people with gum disease tend to have low levels of CoQ10 in their gums.

A few studies with small numbers of people found that CoQ10 supplements led to faster healing and tissue repair, but more research is needed. Scientific studies are needed to see whether CoQ10 can be safely and effectively used for these health problems and needs.

Primary dietary sources of CoQ10 include oily fish such as salmon and tunaorgan meats such as liverand whole grains. Most people get enough CoQ10 through a balanced diet, but supplements may help people with particular health conditions see Uses sectionor those taking certain medications see Interactions section.

CoQ10 is available as a supplement in several forms, including soft gel capsules, oral spray, hard shell capsules, and tablets. CoQ10 is also added to various cosmetics. Pediatric DO NOT give CoQ10 to a child under 18 except under the supervision of a health care provider.

For adults 19 years and older: The recommended dose for CoQ10 supplementation is 30 to mg daily. Soft gels tend to be better absorbed than capsules or other preparations. Higher doses may be recommended for specific conditions. CoQ10 is fat soluble, so it should be taken with a meal containing fat so your body can absorb it.

Also, taking CoQ10 at night may help with the body's ability to use it. Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider. CoQ10 appears to be safe with no major side effects, except occasional stomach upset.

However, researchers have not done studies and do not know if CoQ10 supplements are safe during pregnancy and breastfeeding. CoQ10 may lower blood sugar, so people with diabetes should talk with their provider before taking it to avoid the risk of low blood sugar.

Some suggest that it may also lower blood pressure. If you are being treated with any of the following medications, you should not use CoQ10 without first talking to your health care provider. Chemotherapy medications: Researchers are not sure whether CoQ10's antioxidant effect might make some chemotherapy drugs less effective.

Ask your oncologist before taking antioxidants or any supplement along with chemotherapy. Daunorubicin and doxorubicin: CoQ10 may help reduce the toxic effects on the heart caused by daunorubicin Cerubidin and doxorubicin Adriamycintwo chemotherapy medications that are used to treat several kinds of cancer.

Blood pressure medications: CoQ10 may work with blood pressure medications to lower blood pressure. In a clinical study of people taking blood pressure medications, adding CoQ10 supplements allowed them to reduce the doses of these medications.

More research is needed, however. If you take medication for high blood pressure, talk to your provider before taking CoQ10, and DO NOT stop taking your regular medication.

Blood-thinning medications: There have been reports that CoQ10 may make medications such as warfarin Coumadin or clopidigrel Plavix less effective at thinning the blood. If you take blood thinners, ask your provider before taking CoQ Betaxolol Betoptic : CoQ10 supplements may reduce the heart-related side effects of betaxolol drops Betoptica beta-blocker medication used to treat glaucoma, without making the medication any less effective.

Aguilaniu H, Durieux J, Dillin A. Metabolism, ubiquinone synthesis, and longevity. Genes Dev. Beal MF. Therapeutic effects of coenzyme Q10 in neurodegenerative diseases. Methods Enzymol.

Belardinelli R, Mucaj A, Lacalaprice F, et al. Eur Heart J. Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, Gouni-Berthold I. Drug Saf. Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathyic symptoms in patients treated with statins.

Am J Cardiol. Dhanasekaran M, Ren J. The emerging role of coenzyme Q in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus. Curr Neurovasc Res. de Bustos F, Molina JA, Jimenez-Jimenz FJ, Garcia-Redondo A, Gomez-Escalonilla C, Porta-Etessam J, et al.

Serum levels of coenzyme Q10 in patients with Alzheimer's disease. J Neural Transm. Heck AM, DeWitt BA, Lukes AL.

Potential interactions between alternative therapies and warfarin. Am J Health-System Pharm. Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q 10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes.

Eur J Clin Nutr. Khan M, Gross J, Haupt H, et al. Otolaryngol Head Neck Surg. Khatta M, Alexander BS, Krichten CM, Fisher ML, Freudenberger R, Robinson SW et al. The effect of conenzyme Q10 in patients with congestive heart failure.

Ann Int Med. Kolahdouz Mohammadi R, Hosseinzadeh-Attar MJ, Eshraghian MR, Nakhjavani M, Khorami E, Esteghamati A. The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients.

: Coenzyme Q and muscle recovery

Muscle Coenzyme Q10 Level in Statin-Related Myopathy	Among the limitations of this study Tips for reducing cholesterol levels naturally Coenzyme Q and muscle recovery absence of Healthy eating patterns in-depth analysis of the mechanism of the protective effect of CoQ10 and a lack recpvery in-depth Healthy eating patterns decovery, such as tissue oxidative enzymes mhscle troponin, which needs further future study. It has been considered as a potential candidate for the treatment of various diseases where oxidative stress plays a significant role, such as neurodegenerative disorders, cancer, diabetes, and cardiovascular diseases. Compr Rev Food Sci Food Saf 19 2 — Setting Neuromuscular centers at 2 academic tertiary care hospitals. Therefore, it does not have a recommended intake level. Anti-fatigue effects of coenzyme Q10 during physical fatigue. close ×.
CoQ10 for muscle aches	In fact, the wide range of therapeutic capabilities of CoQ10, such as preventing cardiovascular disease, may also be due to its strong antioxidant properties see below. Bancroft JD, Layton C a Connective tissue and other mesenchymal tissues with their stains. Guidance index COVID PGDs Administering Cautions and contraindications Dosing Deprescribing Switching Interactions Medication Safety Safety in breastfeeding Safety in pregnancy Temperature management. Familial cerebellar ataxia with muscle coenzyme Q10 deficiency. Some myofibrils had dilated sarcoplasmic reticulum Fig.
Improve endurance exercise performance and recovery	CoQ10 is naturally found in the body, with the highest levels in the heart, liver, kidney, and pancreas. It helps generate energy in cells by making the antioxidant adenosine triphosphate ATP , which is involved in cell energy transfer, and serves as an antioxidant to protect cells against oxidative stress. Ubiquinol is the reduced form of CoQ10, while ubiquinone is the oxidized form. The body is able to convert back and forth between these two forms. Both variations exist in the body, but ubiquinol is the form that is found the most in blood circulation. Oxidative stress can interfere with regular cell functioning and may contribute to many health conditions. Therefore, it is not surprising that some chronic diseases have also been associated with low levels of CoQ CoQ10 is a substance found throughout the body that acts as an antioxidant and is involved in energy production. Low levels of CoQ10 may be associated with older age, certain medications, genetic defects, nutritional deficiencies, and specific health conditions. Some research suggests that CoQ10 could improve treatment outcomes for people with heart failure. One analysis of seven reviews concluded that CoQ10 could be beneficial for managing heart failure, especially for those unable to tolerate other treatment methods. Another review of 14 studies found that people with heart failure who took CoQ10 supplements had a decreased risk of dying and a greater improvement in exercise capacity compared to those who took a placebo. CoQ10 could also assist with restoring optimal levels of energy production, reducing oxidative damage, and improving heart function, all of which can aid the treatment of heart failure. CoQ10 may help decrease oxidative stress and enhance heart function, which could be beneficial for improving treatment outcomes in people with heart failure. Female fertility decreases with age due to a decline in the number and quality of available eggs. CoQ10 is directly involved in this process. As you age, CoQ10 production slows, making the body less effective at protecting the eggs from oxidative damage. Supplementing with CoQ10 seems to help and may even reverse this age-related decline in egg quality and quantity. Similarly, male sperm is susceptible to oxidative damage, which may result in reduced sperm count, poor sperm quality, and infertility. Several studies have concluded that supplementing with CoQ10 may improve sperm quality, activity, and concentration by increasing antioxidant protection. CoQ10 may help prevent oxidative damage, which could help promote both female and male fertility. Harmful elements like cellular damage or a hormonal imbalance can lead to reduced skin moisture and protection from environmental aggressors, as well as the thinning of the layers of the skin. According to human and animal studies , applying CoQ10 directly to the skin may help reduce oxidative damage caused by UV rays and help decrease the depth of wrinkles and promoteantioxidant protection. When applied topically, CoQ10 may protect against damage to the skin, which may help support healthy skin aging. Abnormal mitochondrial function can result in low energy in the brain cells and may contribute to migraine. Since CoQ10 lives mainly in the mitochondria of the cells, it has been shown it may be beneficial for the treatment of migraine. One review of five studies found that CoQ10 may effectively reduce the duration and frequency of migraine in children and adults. Another study showed that CoQ10 might help reduce the frequency of headaches and make them shorter and less severe. Research shows that CoQ10 supplementation may be effective at reducing the frequency, duration, and severity of migraine headaches. Abnormal mitochondrial function can reduce muscle energy, making it hard for muscles to contract efficiently and sustain exercise. CoQ10 may help exercise performance by decreasing oxidative stress in the cells and improving mitochondrial function. One study found that CoQ10 supplementation may have helped inhibit oxidative stress and markers of muscle and liver damage in adolescent elite swimmers during their competition phase. Moreover, supplementing with CoQ10 may help reduce fatigue , which could also potentially improve exercise performance. CoQ10 may help improve exercise performance by supporting mitochondrial function, decreasing oxidative stress, and reducing fatigue. Oxidative stress can induce cell damage. This can result in metabolic diseases like diabetes, as well as insulin resistance. In a meta-analysis , CoQ10 has been suggested to improve insulin sensitivity and regulate blood sugar levels. Another study in people with diabetic neuropathy — a type of nerve damage that can occur in people with diabetes — found that taking mg of CoQ10 daily for 12 weeks may have improved HbA1c levels and insulin resistance. Not only that, but it also may have reduced markers of oxidative stress and harmful compounds, such as advanced glycation end products, compared to a placebo. CoQ10 could help promote blood sugar control and prevent insulin resistance. It may also decrease oxidative stress and certain risk factors for heart disease in people with diabetes. According to some test-tube studies , CoQ10 could block the growth of cancer cells. Interestingly, people with cancer have been shown to have lower levels of CoQ Some older studies suggest low levels of CoQ10 may be associated with a higher risk of certain types of cancer, including breast and prostate cancer. Newer studies have also suggested this with regard to lung cancer. That said, the National Institutes of Health NIH states that CoQ10 has not been shown to be of value as a cancer treatment, so more research needs to be conducted before a definitive claim can be made. CoQ10 could reduce oxidative stress, which may be involved in cancer development. Apoptosis is triggered when cytochrome C activates caspase-9, which then cleaves and activates procaspase-3 Soliman et al. In the current study, CoQ10 minimizes caspase-3 immunoreactivity. This is in line with Sumi et al. El-Khadragy et al. In addition, it prevents translocation of nuclear apoptosis-inducing factors. Ultrastructural examination of muscle fibers of FEN-treated rats proved the degenerative changes seen by light microscopy. There were areas of degeneration of myofibrils, disrupted Z lines, irregular nuclei, irregular nuclear envelope, and disrupted sarcolemma. The effect of FEN on the structure of membranes could be explained by the defect in the cholesterol-like molecules of muscle membrane, which is responsible for membrane stability and integrity. Both fibrates and statins can induce upregulation of the PPAR pathway. In addition, both drugs can inhibit the biosynthesis of cholesterol via blocking mevalonate production by 3-hydroxymethylglutaryl-CoA HMG-COA reductase Jacobson Large irregular mitochondria, numerous, dilated sarcoplasmic reticulum and cytoplasmic vacuoles were also detected inside myofibrils. The mitochondrial morphological alterations are mostly associated with respiratory chain defects and failure of ATP production. Phua et al. In addition, this could also change the osmolarity of the cell due to improper function of ion transport systems of the cellular membranes. This could explain cytoplasmic vacuolation and dilation of organelles. In this study, CoQ10 administration preserved the ultrastructure and the normal banding pattern of myofibrils, with few foci of degeneration. Yousef et al. Abdulidha et al. CoQ10 constitutes the only lipid-soluble antioxidant endogenously synthesized. It has been proposed that the antioxidant effect of quinones in mitochondrial membranes is mediated by α-tocopherol recycling. In contrast to other antioxidants, ubiquinol can inhibit both the initiation and propagation of lipid peroxidation. CoQ10 plays an important role in the transport of protons across lysosomal membranes to maintain the optimal pH Varela-Lopez et al. Among the limitations of this study was the absence of an in-depth analysis of the mechanism of the protective effect of CoQ10 and a lack of in-depth biochemical investigations, such as tissue oxidative enzymes and troponin, which needs further future study. The present paper showed that CoQ10 alleviated the toxic effect of FEN on skeletal muscle. It improved the structural changes that occurred in the muscle fibers that were evidenced biochemically, histopathologically, and ultrastructurally. This improvement might be due to downregulation of caspase-3 and inhibition of factors causing fibrosis. Abdulidha N, Jaccob A, Sagheer M Protective effects of Co-Q10, Ginkgo biloba, and l-carnitine on brain, kidney, liver, and endocrine system against sub-acute heavy metals toxicity in male rats. Toxicol Environ Health Sci — Article Google Scholar. Ahmed S, Saber EA, Hamouda AH, Rifaai RA Structural changes in the skeletal muscle fiber of adult male albino rat following atorvastatin treatment; the possible mechanisms of atorvastatin induced myotoxicity. J Cytol Histol 8 1 — Google Scholar. Ajima H, Kai Y, Fujimaki J, Akashi S, Morita A, Ezaki O, Kamei Y, Miura S Effects of fenofibrate and its combination with lovastatin on the expression of genes involved in skeletal muscle atrophy, including FoxO1 and its targets. J Toxicol Sci 46 1 — Article CAS PubMed Google Scholar. Al-Megrin WA, Soliman D, Kassab RB, Metwally DM, Abdel Moneim AE, El-Khadragy MF Coenzyme q10 activates the antioxidant machinery and inhibits the inflammatory and apoptotic cascades against lead acetate-induced renal injury in rats. Front Physiol Article PubMed PubMed Central Google Scholar. Arenas-Jal M, Sune-Negre JM, Garcia-Montoya E Coenzyme Q10 supplementation: efficacy, safety, and formulation challenges. Compr Rev Food Sci Food Saf 19 2 — Awad AM, Bradley MC, Fernandez-Del-Rio L, Nag A, Tsui HS, Clarke CF Coenzyme Q10 deficiencies: pathways in yeast and humans. Essays Biochem 62 3 — Bancroft JD, Layton C a Connective tissue and other mesenchymal tissues with their stains. In: Suvarna KS, Layton C, Bancroft JD eds. Bancroft's Theory and Practice of Histological Techniques E-Book. Elsevier Health Sciences, Churchill Livingstone, China, Edinburgh, pp — Bancroft JD, Layton C b The hematoxylins and eosin. Bodie K, Buck WR, Pieh J, Liguori MJ, Popp A Biomarker evaluation of skeletal muscle toxicity following clofibrate administration in rats. Exp Toxicol Pathol 68 5 — Botelho AFM, Lempek MR, Branco S, Nogueira MM, De Almeida ME, Costa AG, Freitas TG, Rocha M, Moreira MVL, Barreto TO, Santos JC, Lavalle G, Melo MM Coenzyme q10 cardioprotective effects against doxorubicin-induced cardiotoxicity in wistar rat. Cardiovasc Toxicol 20 3 — Chhetry M, Jialal I Lipid Lowering Drug Therapy. In: StatPearls [Internet]. Cirilli I, Damiani E, Dludla PV, Hargreaves I, Marcheggiani F, Millichap LE, Orlando P, Silvestri S, Tiano L Role of Coenzyme Q 10 in health and disease: an update on the last 10 years — Antioxidants basel 10 8 Diaz-Casado ME, Quiles JL, Barriocanal-Casado E, Gonzalez-Garcia P, Battino M, Lopez LC, Varela-Lopez A The paradox of Coenzyme Q 10 in aging. Nutrients 11 9 Article CAS PubMed PubMed Central Google Scholar. Ekeuku SO, Ima-Nirwana S, Chin KY Skeletal protective effect of Coenzyme Q a review. Int J Pharmacol — Article CAS Google Scholar. El-Khadragy M, Al-Megrin WA, Alsadhan NA, Metwally DM, El-Hennamy RE, Salem FEH, Kassab RB, Abdel Moneim AE Impact of Coenzyme Q10 administration on lead acetate-induced testicular damage in rats. Oxid Med Cell Longev Emami F, Hariri A, Matinfar M, Nematbakhsh M Fenofibrate-induced renal dysfunction, yes or no? J Res Med Sci Fatima S, Suhail N, Alrashed M, Wasi S, Aljaser FS, Alsubki RA, Alsharidah AS, Banu N Epigallocatechin gallate and coenzyme Q10 attenuate cisplatin-induced hepatotoxicity in rats via targeting mitochondrial stress and apoptosis. J Biochem Mol Toxicol 35 4 :e Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, De La Mata M, Pavon AD, Alcocer-Gomez E, Calero CP, Paz MV, Alanis M, De Lavera I, Cotan D, Sanchez-Alcazar JA Clinical applications of coenzyme Q Front Biosci landmark Ed — Ghule AE, Kulkarni CP, Bodhankar SL, Pandit VA Effect of pretreatment with coenzyme Q10 on isoproterenol-induced cardiotoxicity and cardiac hypertrophy in rats. Curr Ther Res Clin Exp 70 6 — Haredy SA, Imam TS, Ahmed AO Combination of Ficus Carica Leaves Extract and Ubiquinone in a Chronic Model of Lithium Induce Reproductive Toxicity in Tats: Hindrance of Oxidative Stress and Apoptotic Marker of Sperm Cell Degradation IOSR Journal of Pharmacy and Biological Sciences 12 02 — Highley JR, Sullivan N Neuropathology and muscle biopsy techniques. Jacobson TA Myopathy with statin-fibrate combination therapy: clinical considerations. Nat Rev Endocrinol 5 9 — Jansone B, Dzirkale Z, Jekabsons K, Pilipenko V, Beitnere U, Magure I, Skumbins R, Kletnieks U, Vanaga I, Muceniece R, Klusa V Spruce Needle Polyprenols Protect Against Atorvastatin-Induced Muscle Weakness and do not Influence Central Nervous System Functions in Rats. Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. Kao SJ, Wang D, Lin HI, Chen HI N-acetylcysteine abrogates acute lung injury induced by endotoxin. Clin Exp Pharmacol Physiol 33 1—2 — Kim NH, Han KH, Choi J, Lee J, Kim SG Use of fenofibrate on cardiovascular outcomes in statin users with metabolic syndrome: propensity matched cohort study. BMJ l Mehanna M, Abd Allah EE, Alshahed FaN, Al-Azab HW Effect of simvastatin on the skeletal muscles of senile male albino rats and possible protective role of L-carnitine. A histological study. Egyptian Journal of Histology 43 1 — Meza C, Montenegro C, De La Peña C, O'keefe L, Naughton S, Simcocks A, Bajpeyi S High Fat Diet Induced Obesity Impairs Skeletal Muscle Glycogen and Lipid Preservation After Adiponectin Incubation. International Journal of Exercise Science, Conference Proceedings 2 9. Int Immunopharmacol Mohamed DI, Khairy E, Tawfek SS, Habib EK, Fetouh MA Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat. Biomed Pharmacother — Mokhtari Z, Hekmatdoost A, Nourian M Antioxidant efficacy of vitamin D. J Parathyr Dis 5 1 — Monteiro JC, Predes FS, Matta SL, Dolder H Heteropterys aphrodisiaca infusion reduces the collateral effects of cyclosporine A on the testis. Anat Rec hoboken 7 — Article PubMed Google Scholar. Okada M, Sano F, Ikeda I, Sugimoto J, Takagi S, Sakai H, Yanai T Fenofibrate-induced muscular toxicity is associated with a metabolic shift limited to type-1 muscles in rats. Toxicol Pathol 37 4 — Olama N, Taha M, Rady H The potential protective role of coenzyme q10 on the cyclophosphamide-induced lung toxicity in adult male albino rats: a histological and ultrastructural study. International Journal of Scientific Reports 4 9 — Onur S, Niklowitz P, Jacobs G, Nothlings U, Lieb W, Menke T, Doring F Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. BMC Res Notes Pettersen JC, Pruimboom-Brees I, Francone OL, Amacher DE, Boldt SE, Kerlin RL, Ballinger WE The PPAR alpha agonists fenofibrate and CP cause increased beta-oxidation, leading to oxidative injury in skeletal and cardiac muscle in the rat. Toxicol Pathol 40 3 — Phua WWT, Wong MXY, Liao Z, Tan NS An apparent functional consequence in skeletal muscle physiology via peroxisome proliferator-activated receptors. Int J Mol Sci 19 5 Sanderson T, Wild G, Cull AM, Marston J, Zardin G Immunohistochemical and immunofluorescent techniques. Silva SVE, Gallia MC, Luz J, Rezende AA, Bongiovanni GA, Araujo-Silva G, Almeida MDG Antioxidant effect of Coenzyme Q10 in the prevention of oxidative stress in arsenic-treated CHO-K1 cells and possible participation of zinc as a pro-oxidant Agent. Nutrients 14 16 Sohn M, Kim K, Uddin MJ, Lee G, Hwang I, Kang H, Kim H, Lee JH, Ha H Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy. Am J Physiol Renal Physiol 2 :F—F Soliman M, Atteia S, Kefafy M, Ali A, Radwan E Histological study on the effect of rosuvastatin Crestor on the skeletal muscle of adult male albino rats and the possible protective effect of coenzyme Q Menoufia Medical Journal 30 4 — Sumi K, Okura T, Fujioka Y, Kato M, Imamura T, Taniguchi SI, Yamamoto K Coenzyme Q10 suppresses apoptosis of mouse pancreatic beta-cell line MIN6. Diabetol Metab Syndr Vascular Health and Risk Management — Ulla A, Mohamed MK, Sikder B, Rahman AT, Sumi FA, Hossain M, Reza HM, Rahman GMS, Alam MA Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats. BMC Pharmacol Toxicol 18 1 Varela-Lopez A, Giampieri F, Battino M, Quiles JL Coenzyme Q and its role in the dietary therapy against aging. Molecules 21 3 Wang D, Wang Y Fenofibrate monotherapy-induced rhabdomyolysis in a patient with hypothyroidism: A rare case report and literature review. Medicine baltimore 97 14 :e Xi Y, Zhang Y, Zhu S, Luo Y, Xu P, Huang Z PPAR-Mediated Toxicology and Applied Pharmacology Cells 9 2 Yousef SA, Fahad AA, Abdel Moneim AE, Metwally DM, El-Khadragy MF, Kassab RB The neuroprotective role of Coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities. Int J Environ Res Public Health 16 16 Download references. Dalia R. El-Bassouny, Alyaa A. Mansour, Amany S. Medical Histology Department, Faculty of Medicine, Damietta University, Damietta, Egypt. Department of Basic Medical Sciences, Faculty of Medicine, King Salman International University, South Sinai, El-Tor, Egypt. Yousef Abdullatif Jameel Chair of Prophetic Medical Applications YAJCPMA , Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. You can also search for this author in PubMed Google Scholar. El-Bassouny: idea of the research, drug selection, experimental design of the study. Alyaa A. Mansour: animal experimentation, share in writing the original manuscript draft. Amany S. EL-Lakany: analysis and interpretation of data. Nasra N. Ayuob: experimental design of the study, data collection and analysis. The connection between CoQ10 and statin-related muscle symptoms is circumstantial. Taking a statin to lower "bad" LDL cholesterol also lowers CoQ10, a naturally occurring chemical in the body involved in energy production in cells. Muscle aches are a common side effect of statins, and CoQ10 is important for muscle function, so scientists have wondered if raising blood levels of CoQ10 might relieve the aches. However, there is no solid evidence that the supplement does so. If you decide to try it, look for the United States Pharmacopeial Convention USP mark on the supplement packaging, indicating that the product meets basic standards for quality and purity. As for other health claims for CoQ10 you may have heard, taking the supplement does not make much sense. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Thanks for visiting. Don't miss your FREE gift. The Best Diets for Cognitive Fitness , is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health , plus the latest advances in preventative medicine, diet and exercise , pain relief, blood pressure and cholesterol management, and more. Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight loss from exercises to build a stronger core to advice on treating cataracts. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts.
9 Benefits of Coenzyme Q10 (CoQ10)	Icy fingers and toes: Poor circulation or Raynaud's phenomenon? I am taking simvastatin for high cholesterol. Should I take coenzyme Q10 to prevent muscle pain? There is no convincing medical evidence to suggest that coenzyme Q10 CoQ10 prevents muscle pain in people taking statins. But because the risk of side effects from CoQ10 is low, many doctors would recommend a one-to-two month trial of the supplement doses range from to mg daily to help with statin-related muscle cramps, pain, or weakness. Make sure your doctor knows you are taking it. The connection between CoQ10 and statin-related muscle symptoms is circumstantial. Taking a statin to lower "bad" LDL cholesterol also lowers CoQ10, a naturally occurring chemical in the body involved in energy production in cells. Muscle aches are a common side effect of statins, and CoQ10 is important for muscle function, so scientists have wondered if raising blood levels of CoQ10 might relieve the aches. However, there is no solid evidence that the supplement does so. If you decide to try it, look for the United States Pharmacopeial Convention USP mark on the supplement packaging, indicating that the product meets basic standards for quality and purity. As for other health claims for CoQ10 you may have heard, taking the supplement does not make much sense. As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Thanks for visiting. Bruckert E, Hayem G, Dejager S, et al. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study. Cardiovasc Drugs Ther ; Ganga HV, Slim HB, Thompson PD. A systematic review of statin-induced muscle problems in clinical trials. Am Heart J ; Parker BA, Capizzi JA, Grimaldi AS, et al. Effect of statins on skeletal muscle function. Circulation ; Banach M, Serban C, Ursoniu S, et al. Statin therapy and plasma coenzyme Q10 concentrations--A systematic review and meta-analysis of placebo-controlled trials. Pharmacol Res ; Coenzyme Q10 and statin-related myopathy. Drug Ther Bull ; Bitzur R, Cohen H, Kamari Y, et al. Intolerance to Statins: Mechanisms and Management. Diabetes Care ;SS30 Quinzii CM, Hirano M. Primary and secondary CoQ 10 deficiencies in humans. Biofactors Oxford, England ; Acosta MJ, Vazquez Fonseca L, Desbats MA, et al. Coenzyme Q biosynthesis in health and disease. Biochim Biophys Acta ; Ogasahara S, Engel AG, Frens D, et al. Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci U S A ; Sobreira C, Hirano M, Shanske S, et al. Mitochondrial encephalomyopathy with coenzyme Q10 deficiency. Neurology ; Aure K, Benoist JF, Ogier de Baulny H, et al. Progression despite replacement of a myopathic form of coenzyme Q10 defect. Boitier E, Degoul F, Desguerre I, et al. A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency. J Neurol Sci ; Di Giovanni S, Mirabella M, Spinazzola A, et al. Coenzyme Q10 reverses pathological phenotype and reduces apoptosis in familial CoQ10 deficiency. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ : British Medical Journal ; Australian Medicines Handbook. Adelaide: AMH Pty Ltd, accessed 27 September Saha SP, Whayne TF, Jr. Coenzyme Q in Human Health: Supporting Evidence? South Med J ; Deichmann R, Lavie C, Andrews S. Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction. Ochsner J ; Marcoff L, Thompson PD. Advertising revenue supports our not-for-profit mission. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. This content does not have an English version. This content does not have an Arabic version. Appointments at Mayo Clinic Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Request Appointment. Coenzyme Q Products and services. Coenzyme Q10 By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Show references Coenzyme Q National Center for Complementary and Integrative Health. Accessed Oct. Pizzorono JE, et al. In: Textbook of Natural Medicine. Elsevier; Coenzyme Q10 PDQ -Health Professional Version. National Cancer Institute. IBM Micromedex. Dluda PV, et al. The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Endocrinology, Diabetes and Metabolism. Goudarzi S, et al. Effect of vitamins and dietary supplements on cardiovascular health. Critical Paths in Cardiology. Natural Medicines. Arenas-Jal M, et al. Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges. Comprehensive Reviews in Food Science and Food Safety.

Coenzyme Q and muscle recovery -

Belardinelli R, Mucaj A, Lacalaprice F, et al. Eur Heart J. Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, Gouni-Berthold I.

Drug Saf. Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on myopathyic symptoms in patients treated with statins. Am J Cardiol. Dhanasekaran M, Ren J. The emerging role of coenzyme Q in aging, neurodegeneration, cardiovascular disease, cancer and diabetes mellitus.

Curr Neurovasc Res. de Bustos F, Molina JA, Jimenez-Jimenz FJ, Garcia-Redondo A, Gomez-Escalonilla C, Porta-Etessam J, et al. Serum levels of coenzyme Q10 in patients with Alzheimer's disease.

J Neural Transm. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health-System Pharm.

Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q 10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr.

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To be able to use the full range of Shopware 6, we recommend activating Javascript in your browser. Shop Learn Experts and Reviews Brands Loyalty benefits Take the quiz Customer care. Improve endurance exercise performance and recovery Regular physical activity is a crucial part of good health.

See how you can improve both your exercise performance and recovery. Four tips for a better workout 1. Protein It is shown that people who perform intense training consume double the daily recommendation of protein in order to support rapid recovery and maintain muscle mass.

Hydration Sufficient hydration is essential during a workout, but can also be overdone. Supplementation Nutrional supplements can be a powerful way to increase your exercise performance and recovery.

Nutrients that will make the most of your exercise Coenzyme Q10 CoQ10 CoQ10 has an antioxidant effect and plenty of other benefits for athletes and nonathletes.

Branch chain amino acids BCAA Human trials indicate that BCAA can increase exercise performance and endurance, help resist exercise induced fatigue, and enhance our ability to use fat for energy during endurance exercise. BCAA have also been shown to improve exercise recovery and stimulate muscle growth.

Sports Med. Kerksick CM et al. J Int Soc Sports Nutr. Read more. Your guide to the top antioxidants. Astaxanthin: A natural remedy for radiant skin.

Coenzyme Q10 CoQ10 is Coennzyme substance that helps convert food Healthy eating patterns energy. CoQ10 is found in Metabolic enhancer formula every cell in the body, and Reduce high cholesterol is muscl powerful antioxidant. Antioxidants fight damaging xnd in the body known as free radicals, which damage cell membranes, tamper with DNA, and even cause cell death. Scientists believe free radicals contribute to the aging process, as well as a number of health problems, including heart disease and cancer. Antioxidants, such as CoQ10, can neutralize free radicals and may reduce or even help prevent some of the damage they cause.