The role of TGF-β in hair loss has been documented through the study revealing that treatment with a TGF-β antagonist can promote hair growth via preventing catagen progression [ 57 ]. Also through the activation of TGF-β and brain-derived neurotrophic factor BDNF , it was describe that it was enhanced the transition from the anagen to the catagen phase [ 58 ].

Since TGF-β1 induces catagen in hair follicles and it is closely related to alopecia progression it can be say that acts as a pathogenic mediator of androgenic alopecia [ 57 , 59 ] and red ginseng extract can delay the catagen phase and holds the potential to promote hair growth, thought downregulation or inhibition of the TGF-β pathway.

On Young Go Kim investigation was concluded that on ultraviolet B UVB -irradiated skin aging in mice, oral administration of Red Ginseng extract protects from skin damage induced by ultraviolet B UVB -irradiation, increases of skin thickness and pigmentation, reduction of skin elasticity, inhibited the increases of epidermis and corium thickness.

The administration of Red Ginseng extract exert the protective action on UVB-radiation skin aging inhibiting the increase of skin TGF-beta1 content induced by UVB irradiation [ 60 ]. Furthermore on Zheng Li the hair-growth-promoting effects of Protopanaxatiol type ginsenoside Re were associated with the downregulation of TGF-β-pathway-related genes, which are involved in the control of hair-growth phase-transition-related signaling pathways [ 61 ].

The hyper activation of the c-Jun-N-terminal kinase JNK pathway in associate with an activation of TGF-β-induced hair loss. Korean red ginseng has been attributed to exert protective effects onTGF-β-induced hair loss by the inhibition of JNK on radiation-induced apoptosis of HaCaT cells [ 62 ].

Androgenetic alopecia is related to testosterone TES -induced delay of anagen phase and hair loss. Additionally, RGO reduced the protein level of TGF-β but enhanced the expression of anti-apoptotic protein Bcl-2 [ 37 ] suggesting that RGO is a potent therapeutic natural product for treatment of androgenic alopecia possibly through hair re-growth activity [ 37 ].

Studding the expression of β-catenin and its transcriptional coactivator Lef-1, the Ginsenoside F2 compared to finasteride group, increased the expressions while decreased the expression of DKK Tissue histological analysis shows that administration of ginsenoside F2 promoted hair growth as compared to finasteride, increase in the number of hair follicles, thickness of the epidermis, and follicles of the anagen phase [ 43 ].

Heon-Sub Shin conclude that ginsenoside F2 might be a potential new therapeutic compound for anagen induction and hair growth through the Wnt signal pathway [ 43 ]. In another study by Matsuda et al.

No detailed explanations are given in this paper about the mechanism of hair growth, but the results presented by Matsuda et al. Panax ginseng PG has diverse pharmacological effects such as anti-aging and anti-inflammation it exert this effects thought stimulating the proliferation and inhibiting the apoptosis [ 64 ].

PG extract treatment affected the expression of apoptosis-related genes in HFs, Bcl-2 and Bax, through this regulation reversed the effect of DKK-1 on ex vivo human hair organ culture, antagonizes DKKinduced catagen-like changes [ 9 , 64 ].

There is an aberrant expression pattern of cytokines in alopecia areata hair follicles. The inhibition of the upstream pathway JAK appears as a plausible target for developing a therapy for hair loss [ 67 ]. In fact, a number of JAK inhibitors, such as tofacitinib, ruxolitinib, baricitinib, CTP, PF and PF are in the progress of developing a therapy for alopecia [ 71 , 72 ] more often in alopecia areata a common form of non-scarring hair loss that usually starts abruptly with a very high psychological impact [ 73 ], it is a T-cell-mediated disease which produces circular patches of non-scarring hair loss and nail dystrophy [ 72 ].

Topical application of ginsenoside F2 by inhibiting the production of IL and ROS, ameliorated dermal inflammation skin [ 69 ]. In the pathogenesis of alopecia areata is believed to be an imbalance of inflammatory cytokines IL Monoclonal antibodies against ILA leads to hair regrowth in human volunteers [ 76 ].

Treatment with Panax ginseng saponins diminished the proliferation and differentiation of Th17 cells and decreased IL expression [ 77 ]. This regulating IL secretion ginsenosides may enhance hair growth in alopecia areata [ 69 , 77 ]. Ginseng may be a multipurpose natural medicine with an extended history of medical application throughout the globe, particularly in Eastern countries.

The beneficial effects of Ginseng cover a good spectrum from immune to cardiovascular, cancer and sexual diseases. New advances in the science leads elucidate new pharmacological activity of the ginseng and its ginsenosides. There are some studies of the use of Ginseng in dermatology investigating its effects from molecular to physiological in a skin cancer, dermatitis, alopecia wound injury and of course hair loss because also ginseng and its ginsenosides regulate the expression and activity of major proteins involved in hair-cycling phases, so the medical use of ginseng is not only restricted to the improvement of general wellness, but also extended to the treatment of organ-specific pathological conditions, like hair.

Ginseng and its metabolites are associate with the induction of anagen phase preventing hair lost and promoting hair growth although further studies should be done to elucidate and clarified the mechanisms by which ginseng and its metabolites regulate human hair health.

Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3. Edited by Christophe Hano. Open access peer-reviewed chapter Ginseng in Hair Growth and Viability Written By Mercedes De Mirecki-Garrido, Ruymán Santana-Farré, Noelia Guedes-Hernandez, Francisco Jimenez-Acosta and Dionisio L.

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Chapter metrics overview Chapter Downloads View Full Metrics. Impact of this chapter. Abstract The hair follicle is the unique organ that has the capacity of undergoing cyclic transformations following periods of growth anagen , regression catagen , and rest telogen regenerating itself to restart the cycle.

Keywords Ginseng Hair Hair Follicle Hair growth Hair Viability. Introduction 1. References 1. Chandrashekar BS, Nandhini T, Vasanth V, Sriram R, Navale S. Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride.

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Androgen actions on the human hair follicle: perspectives. Exp Dermatol. Rattan SI, Kryzch V, Schnebert S, Perrier E, Nizard C. Hormesis-based anti-aging products: a case study of a novel cosmetic.

Dose Response. Oh SJ, Kim K, Lim CJ. Suppressive properties of ginsenoside Rb2, a protopanaxadiol-type ginseng saponin, on reactive oxygen species and matrix metalloproteinase-2 in UV-B-irradiated human dermal keratinocytes. Biosci Biotechnol Biochem. Lim CJ, Choi WY, Jung HJ. Stereoselective skin anti-photoaging properties of ginsenoside Rg3 in UV-B-irradiated keratinocytes.

Biol Pharm Bull. Oh SJ, Lee S, Choi WY, Lim CJ. Skin anti-photoaging properties of ginsenoside Rh2 epimers in UV-B-irradiated human keratinocyte cells. J Biosci. Kim YG, Sumiyoshi M, Sakanaka M, Kimura Y. Effects of ginseng saponins isolated from red ginseng on ultraviolet B-induced skin aging in hairless mice.

Eur J Pharmacol. Lee EH, Cho SY, Kim SJ, Shin ES, Chang HK, Kim DH, et al. Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl Pham QL, Jang HJ, Kim KB. Antiwrinkle effect of fermented black ginseng on human fibroblasts.

Int J Mol Med. Hwang E, Park SY, Yin CS, Kim HT, Kim YM, Yi TH. Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin. Lee GY, Park KG, Namgoong S, Han SK, Jeong SH, Dhong ES, et al.

Effects of Panax ginseng extract on human dermal fibroblast proliferation and collagen synthesis. Int Wound J. Lee J, Jung E, Lee J, Huh S, Kim J, Park M, et al. Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling.

J Ethnopharmacol. Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Kim S, Kang BY, Cho SY, Sung DS, Chang HK, Yeom MH, et al.

Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin. Biochem Biophys Res Commun. Chan L, Cook DK. Female pattern hair loss. Aust J Gen Pract. Tanaka Y, Aso T, Ono J, Hosoi R, Kaneko T. Androgenetic Alopecia Treatment in Asian Men.

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Finasteride Male Pattern Hair Loss Study Group. J Am Acad Dermatol. Asada Y, Sonoda T, Ojiro M, Kurata S, Sato T, Ezaki T, et al. J Clin Endocrinol Metab. Murata K, Takeshita F, Samukawa K, Tani T, Matsuda H. Effects of ginseng rhizome and ginsenoside Ro on testosterone 5alpha-reductase and hair re-growth in testosterone-treated mice.

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Biol Reprod. Li W, Man XY, Li CM, Chen JQ, Zhou J, Cai SQ, et al. VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFRmediated activation of ERK. Exp Cell Res. Shin HS, Park SY, Hwang ES, Lee DG, Song HG, Mavlonov GT, et al. The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin.

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Overexpression of Bcl-2 protects from ultraviolet B-induced apoptosis but promotes hair follicle regression and chemotherapy-induced alopecia.

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Kretzschmar K, Clevers H. Dev Biol. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Additional, statistically-powered, clinical evidence is needed before definitive conclusions can be made.

Keep in mind, though, that the way that the ginseng is extracted can dramatically impact its ability to keep your hair healthy.

The consistency at which ginseng can be extracted, and processed, also makes a huge impact on its ultimate effectiveness. The journey to healthier and more beautiful hair is not easy, but staying informed is one of the most important things you can do! Reviewed by: David Zhang, PhD.

David is an immunologist and bioengineer with over a decade of medical research experience. He completed his PhD at Harvard University, where he worked on developing life-saving cancer therapies.

He received his undergraduate degree in immunology from McGill University and his master's degree from the University of Toronto. Written by: Revela Editorial Team.

When it comes to treating hair loss, unexpected and repurposed ingredients constantly pop up with claims to regrow hair at a fraction of the cost. The reality is that if Fine lines and wrinkles are a hot topic across the entire skin care community, especially in anti-aging products. While these two telltale signs become more pronounced as we age, one When it comes to managing health issues, whether hair loss or something else entirely, it makes sense to take a look at the fuel we put into our bodies.

Your cart is empty Continue shopping Have an account? Shopping Bag. Update Check out. Revela is now ODDITY LABS. August 8, Share Share on Facebook Opens in a new window. Tweet on Twitter Opens in a new window. Pin on Pinterest Opens in a new window.

What is ginseng and how does it help with health? The history of ginseng in medicine Historically, ginseng was one of the most important herbal medicines across East Asia, particularly in China, Korea, and Japan, where scholars have been writing about its use since before AD.

Ginseng and hair growth So does ginseng help with hair growth? Reviewed by: David Zhang, PhD David is an immunologist and bioengineer with over a decade of medical research experience.

Historically, ginseng was one of the most important herbal medicines across East Asia, particularly in China, Korea, and Japan, where scholars have been writing about its use since before AD. It was estimated to have first been used around 4, years ago. In traditional Chinese medicine, the root is still being used today as a means to revitalize the body.

The Native Americans also used the American variety of the root in medicine; Ojibwe Midewiwin, spiritual leaders of the Anishinaabeg tribe who were skilled in medicine, used the root to treat digestive problems and to provide pain relief. The Muscogee people of Oklahoma also used ginseng to stop bleeding and in teas, to treat illnesses like respiratory disease and fever.

So does ginseng help with hair growth? In short, scientific evidence does suggest that it can help with hair growth, but the clinical evidence is limited. The ginsenosides in ginseng also strengthens blood circulation to ensure that important nutrients get to your hair follicles. Of the available clinical evidence, one often-cited study gave fifty people with Alopecia Areata, a condition causing patchy bald spot on the scalp, a ginseng treatment over twelve weeks with or without the conventional corticosteroid treatment.

The results demonstrated that the people given the ginseng treatment showed much greater hair growth compared to the control group. Additional, statistically-powered, clinical evidence is needed before definitive conclusions can be made.

Keep in mind, though, that the way that the ginseng is extracted can dramatically impact its ability to keep your hair healthy. The consistency at which ginseng can be extracted, and processed, also makes a huge impact on its ultimate effectiveness. The journey to healthier and more beautiful hair is not easy, but staying informed is one of the most important things you can do!

Reviewed by: David Zhang, PhD. David is an immunologist and bioengineer with over a decade of medical research experience. He completed his PhD at Harvard University, where he worked on developing life-saving cancer therapies. He received his undergraduate degree in immunology from McGill University and his master's degree from the University of Toronto.

Written by: Revela Editorial Team. When it comes to treating hair loss, unexpected and repurposed ingredients constantly pop up with claims to regrow hair at a fraction of the cost.

The reality is that if Fine lines and wrinkles are a hot topic across the entire skin care community, especially in anti-aging products. While these two telltale signs become more pronounced as we age, one When it comes to managing health issues, whether hair loss or something else entirely, it makes sense to take a look at the fuel we put into our bodies.

Your cart is empty Continue shopping Have an account? Shopping Bag. Panax ginseng and its ginsenosides may have potential applications in promoting hair growth and aiding in the treatment of androgenetic alopecia. Red ginseng extract and ginsenosides Rb1 and Rg3 have been found to inhibit the suppression of hair growth induced by DHT.

They achieve this by affecting the mRNA level of androgen receptor in human dermal papilla cells, countering the suppressive effect of DHT on hair growth. This inhibitory effect plays a crucial role in preventing DHT-induced suppression of hair matrix keratinocyte proliferation, as well as upregulation of androgen receptor expression in human dermal papilla cells.

Ginseng extract is often incorporated into hair regrowth serums due to its potential for promoting hair growth and improving scalp health, making it a valuable ingredient in the quest for healthy and vibrant hair.

To learn more about how ginseng extract can aid in hair regrowth serums, continue reading our blog. To incorporate ginseng extract into hair regrowth serums, the Frutus panax ginseng extract is topically administered.

This process has shown potential for hair regeneration activity in treating hair loss effectively. Incorporating ginseng extract into these serums could offer significant benefits due to its proven impact on skin cell regulation and its potential for stimulating hair regeneration activity.

Ginseng extract is effective in hair regrowth serums as it enhances the proliferation of hair matrix keratinocytes and human dermal papilla cells hDPCs. Red ginseng extract and its ginsenosides counteract the suppressive effect of dihydrotestosterone DHT on hair growth, promoting increased hair density.

Additionally, red ginseng and its ginsenosides activate the ERK and AKT signaling pathways in hDPCs, promoting overall effectiveness in aiding hair regrowth. Studies have shown that Korean red ginseng increases hair density in patients with androgenetic alopecia, further supporting the efficacy of hair regrowth serums containing ginseng extract.

Incorporating red ginseng extract into hair regrowth serums has been proven to inhibit DHT-induced upregulation of androgen receptor in hDPCs. Here is a comparison in HTML table format:. The table above encapsulates the main differences and considerations when comparing ginseng extract serums with alternative hair regrowth methods.

Using ginseng for hair regrowth may lead to side effects such as headaches, dizziness, and insomnia. Those with known allergies to ginseng or related plants should avoid its use as it could cause allergic reactions.

Long-term use of ginseng for hair regrowth might affect hormone balance, especially in individuals with hormonal imbalances or disorders. Monitoring for adverse effects when using ginseng in combination with other treatments is essential, and caution should be exercised.

Further research is needed to understand the potential precautions and side effects thoroughly. In conclusion, ginseng extract shows promise in aiding hair regrowth. Studies have found that it promotes hair growth and prevents hair loss by activating specific pathways in the scalp.

The potential use of red ginseng extract in hair regrowth serums is supported by scientific evidence and its known pharmacological activities. Incorporating ginseng extract into hair regrowth serums could offer a natural and effective solution for individuals experiencing hair thinning or loss.

Further research and development in this area may lead to innovative products that harness the benefits of ginseng for promoting healthy hair growth.

Ginseng extract helps in hair regrowth by working on the scalp to help grow new hairs and stop old hairs from falling out. Yes, studies with mice show that ginseng can help with spot baldness known as alopecia areata by promoting the growth of new hair cells.

Ginseng has things like antioxidants that protect cells from damage and may also repair DNA to make your hair stronger. Yes, besides helping with hair growth, Ginseng may soothe skin inflammation and aid in wound-healing which is good for keeping scalp healthy.

Ginseng can influence pathways within the cell like Wnt signaling and sonic hedgehog signals which might be key players in making new hairs grow faster. Potential side effects of using ginseng extract for hair regrowth include headaches, dizziness, and insomnia. It is important to consult with a healthcare professional before using ginseng extract for hair regrowth , as it may have contraindications and potential side effects.

Individuals with known allergies to ginseng or related plants should avoid using ginseng extract for hair regrowth, as it may lead to allergic reactions. Long-term use of ginseng extract for hair regrowth may have potential effects on hormone balance and should be approached with caution, especially for individuals with hormonal imbalances or disorders.

The use of ginseng extract in hair regrowth serums should be carefully monitored for any adverse effects, especially when used in combination with other topical or oral treatments.

More research is needed to fully understand the potential side effects and precautions of using ginseng extract for hair regrowth, and individuals should use it with discretion and under the guidance of a healthcare professional.

Get One Hour Free Training From The Expert. Key Takeaways Ginseng extract helps hair grow because it fights off a hormone called DHT that can cause hair loss. It also makes hair cells grow faster and better. Red ginseng, with stuff called ginsenosides in it, is very good for making more hairs grow on your head, especially if you are losing your hair because of genes.

Putting red ginseng extract in serums for your scalp can be a natural way to get thicker hair without the need for strong medicines or treatments. Understanding Hair Growth and Hair Loss Hair growth and loss are influenced by factors such as the hair structure, function, and cycle, as well as causes of hair loss and conventional treatments used for hair restoration.

Hair Structure Our hair is made up of two main parts: the follicle and the shaft. Hair Function Hair has many jobs. Hair Cycle Your hair goes through a life cycle that includes growing, resting, and shedding. Causes of Hair Loss Hair loss can happen to anyone and it often causes worry.

Genes play a big part in hair loss, especially for men and women who have androgenetic alopecia , also known as pattern baldness. Hormones can affect hair growth too. Changes in hormones due to pregnancy, thyroid problems, or menopause can lead to losing hair. Stress can make you lose your hair. Serious stress from things like surgery, illness, or high fever can make lots of hair fall out suddenly.

Not eating right can be bad for your hair. Some medicines might cause hair loss as a side effect. This includes drugs for cancer, arthritis, depression, heart problems, gout and high blood pressure.

Using harsh hair care products or styling tools too much can damage your hair follicles and lead to hair loss. Infections on the scalp like ringworm can invade the hair and skin of your scalp leading to patches of hair loss. Pulling on your hair all the time by tight hairstyles like braids or ponytails might cause some types of baldness that could become permanent if not stopped early enough.

Dihydrotestosterone DHT is a hormone that shrinks the size of the hair follicle leading to balding; red ginseng extract has been found helpful against its effects.

Conventional Treatments for Hair Loss Conventional treatments for hair loss include medications like finasteride and minoxidil, approved by the US-FDA.

Finasteride, also known as Propecia, is an oral prescription medication that works by decreasing dihydrotestosterone DHT levels which can help prevent further hair loss.

Minoxidil, available over-the-counter as Rogaine, comes in liquid or foam form and is applied directly to the scalp to stimulate hair follicles and promote regrowth. These treatments are often used in combination to achieve better results in combating hair loss. They have been clinically proven to be effective for both men and women suffering from pattern baldness or thinning hair.

Role of Ginseng in Hair Regrowth Ginseng has been found to promote hair growth through its biochemical effects, particularly in influencing the activation of signaling pathways related to hair growth. Ginseng and its Biochemical Effects Ginseng has ginsenosides that help hair growth and prevent hair loss.

How Ginseng Extract Works for Hair Regrowth Ginseng extract works for hair regrowth by stimulating the hair follicles, inhibiting DHT-induced suppression of hair growth, and activating ERK and AKT signaling pathways in the scalp.

Ginseng and DHT-Induced Suppression of Hair Growth Red ginseng extract and ginsenosides have shown the ability to counteract the suppressive effect of dihydrotestosterone DHT on hair matrix keratinocyte proliferation. The Science Behind Ginseng and Hair Regrowth Numerous studies and research support the positive effects of ginseng on hair growth, including its inhibitory effect on DHT-induced androgen receptor expression.

Ginseng Extract in Hair Regrowth Serums Ginseng extract is often incorporated into hair regrowth serums due to its potential for promoting hair growth and improving scalp health, making it a valuable ingredient in the quest for healthy and vibrant hair.

How Ginseng Extract is Incorporated into Hair Regrowth Serums To incorporate ginseng extract into hair regrowth serums, the Frutus panax ginseng extract is topically administered.

Effectiveness of Hair Regrowth Serums with Ginseng Extract Ginseng extract is effective in hair regrowth serums as it enhances the proliferation of hair matrix keratinocytes and human dermal papilla cells hDPCs.

Here is a comparison in HTML table format: Treatment Type Mechanism of Action Effectiveness Side Effects Usage Ginseng Extract Hair Serums Enhances keratinocyte proliferation; counteracts DHT effect; activates ERK and AKT pathways. Studies suggest improved hair growth with use of RGE and ginsenosides.

Generally well-tolerated; some may experience scalp irritation. Topical application; varies by product. Minoxidil Improves blood flow to hair follicles; promotes hair regrowth.

Widely recognized for effectiveness; results can vary. Scalp irritation; unwanted hair growth elsewhere. Topical application; twice daily. Finasteride Reduces DHT; prevents hair loss. Effective for many; primarily men. Potential sexual dysfunction; not for women of child-bearing age.

Oral intake; once daily. Hair Transplants Transplanting hair from dense to thinning areas.