Hyperglycemia and cardiovascular health -
The risks were as much as doubled in those with diagnosed diabetes. The study analysed UK Biobank data from , UK individuals After adjusting for age, the researchers found that both men and women with moderately elevated blood sugar levels below the threshold for diabetes were at increased risk for any cardiovascular disease, with relative increases higher for women than men.
Differences in the relative risk of developing cardiovascular disease between men and women largely disappeared after the researchers accounted for measures of obesity and the use of antihypertensive and statin therapies.
The research uncovered differences in the use of antihypertensive and statin therapies between men and women, with more men than women on these medications. It suggests that women are not prescribed these preventative medications at the same rate as men with similar blood sugar levels.
This fits with previous research by our team which uncovered that being in the lowest blood sugar group may confer some benefits for brain health.
We quantified differences in the risk of heart disease between men and women across the full range of blood sugar levels. What we discovered is that those risks are not only confined to people with diagnosed diabetes, that men and women with prediabetes are also significantly affected.
Our team also uncovered compelling evidence that within the 'normal' blood sugar range, a lower level appears to be better for protecting against heart disease. Diabetes Complications. Of diabetes complications, this is one you want to pay close attention to. What are the different types of CVD?
Risk Factors: Diabetes High blood pressure High LDL bad cholesterol and triglycerides Low HDL good cholesterol Too little physical activity Smoking Being overweight or obese. Heart Failure.
Risk Factors: Diabetes Coronary heart disease High blood pressure. Shortness of breath Fatigue Pain in your: chest angina , throat, back, legs, neck, jaw, upper abdomen, arms. Weakness or numbness in your arms or legs. Take emergency action. Heart Attack: Chest pain or discomfort, tightness, pressure Fullness—this might feel like indigestion or heartburn Discomfort in one or both of your arms, back, jaw, neck, or upper abdomen Shortness of breath Sweating Indigestion, nausea, or vomiting Tiredness, fainting, or light-headedness.
Heart Failure: Shortness of breath Weakness Nausea Quick or irregular heartbeat Coughing with pink-tinged mucus Fatigue Swelling of the feet and ankles from fluid retention. Stay on top of your heart health.
At every office visit: Check your blood pressure Talk about your blood glucose meter readings. Live heart-healthy! Exercise— The optimal time you should spend per week exercising is minutes. You can break this up however you like over the week and be sure to do exercises you enjoy!
Sit less— Sitting less and exercising go hand-in-hand. Get up and walk around every 30 minutes to get your heart pumping. Find more tips to break a sitting streak.
If needed though, losing even 10—15 pounds makes a big difference. Get the facts on weight loss. Take medication— Taking your medications as directed by your doctor is one of the best defenses against CVD.
If you have trouble remembering, try setting an alarm or use a pill box. Eat well— Use the Diabetes Plate Method to create healthy portions without thinking about it—the method does all the thinking for you! Manage stress— Mental health is extremely important if you live with diabetes for your emotional and physical well-being.
Stress hormones can lead to high blood pressure and make it more difficult to have good diabetes management. Follow up with your care team— Communicate with your care team, and yourself, to get the best care you can from the health professionals dedicated to your wellness.
Cardiovascularr risks were as much Running and Jogging Tips healht in those with diagnosed diabetes. Carddiovascular study analysed UK Biobank data fromUK individuals After adjusting for Hypperglycemia, the researchers found Running and Jogging Tips both men and women with Chromium browser for web scraping elevated blood sugar levels below the threshold for diabetes were at increased risk for any cardiovascular disease, with relative increases higher for women than men. Differences in the relative risk of developing cardiovascular disease between men and women largely disappeared after the researchers accounted for measures of obesity and the use of antihypertensive and statin therapies. The research uncovered differences in the use of antihypertensive and statin therapies between men and women, with more men than women on these medications.Hyperglycemia and cardiovascular health -
They may not know that they already have an advanced stage of the disease. Heart disease and diabetes share similarities beyond their potential complications.
Both typically require taking medication to achieve and maintain optimal control. Medical treatment regimens, particularly over the years, can become complex with the use of multiple medications. Ongoing research also shows strong evidence that weight loss can reverse diabetes in some patients and that lowering blood pressure with drugs known as angiotensin-converting enzyme, or ACE, inhibitors and angiotensin II receptor blockers can reduce the risk of developing diabetes and its complications.
This is particularly important in those patients with diabetes who have other medical problems and those who have already developed complications of diabetes.
Choosing the most appropriate treatment options can reduce side effects of therapies and improve compliance. Positive lifestyle changes, such as quitting smoking , losing weight, exercising more, following a healthier diet and controlling blood pressure , all can contribute to better diabetes control and heart health.
Studies have shown that by achieving good control of these cardiovascular risk factors, people not only significantly improve quality of life, but most importantly prolong their lives by an average of eight years.
Fortunately, the recommendations for self-management behaviors generally align for the two conditions. This can make teaching self-care skills a bit easier for clinicians managing both diseases.
However, controlling both conditions requires significant effort by the patient and the health care team. The recent development of cardiac imaging techniques, such as advanced echocardiography, cardiac CT and cardiac MRI, brings hope that medical professionals will be able to detect diabetic heart disease earlier and prevent its serious consequences.
Thanks to those innovative imaging techniques, it's understood that heart disease in people with diabetes progresses rapidly if not managed with well-established preventive treatments. Ongoing research is using advanced medical imaging to study why the hearts of people with diabetes suffer more extensive injury after heart attacks and why those with diabetes develop heart failure more often than people with normal glucose control.
As everyone responds to medication differently, work is underway at Mayo Clinic to review large sets of data and artificial intelligence to identify people with diabetes who may respond better to certain treatments.
The goal is to offer people with diabetes personalized therapeutic plans to manage their heart health risk. The comparisons of results of different intervention studies are complex because of diversities in characteristics of enrolled subjects and in concomitant therapies.
For example, the UKPDS trial was performed before the widespread use of statin therapy in type 2 diabetes and in subjects with newly diagnosed diabetes free from cardiovascular complications; conversely, PROactive, ACCORD, ADVANCE, and VADT enrolled subjects with high CVD risk.
In fact, subgroup analyses of data from these trials suggested that patients with a shorter duration of diabetes, a lower HbA 1c , or lack of established CVD might have benefited significantly from more intensive glycemic control More recently, the ORIGIN trial was designed to determine whether insulin can reduce cardiovascular morbidity in people with prediabetic hyperglycemia or early type 2 diabetes.
Interestingly, in patients without prior CVD, insulin treatment was associated with a higher yearly incidence of CV events 2. Few studies are available on the long-term CV effects of multifactorial interventions, in which treatment of hyperglycemia was associated with accurate therapy for associated risk factors.
Presently, in type 2 diabetes, the use of statins, ACE inhibitors or angiotensin receptor blockers, and antiplatelet agents is an essential component of the clinical management.
It is possible that the remarkable efficacy of other therapies in cardiovascular prevention makes it difficult to demonstrate an additional benefit of glucose-lowering interventions in clinical trials Patients with type 2 diabetes are heterogeneous for age, duration of disease, comorbidity, and genetic background.
Glucose-lowering therapy should be adapted to this complexity, with an attempt at improving, or at least avoidance of worsening, associated cardiovascular risk factors. The contrasting results of available clinical trials in recent years have generated perplexity amid concerns that glucose-lowering therapies, under certain circumstances, might even be detrimental.
When all available evidence to date is considered, which includes a fair number of large-scale clinical trials, the improvement of glycemic control appears to be associated with a reduction in the incidence of major cardiovascular events, whereas hypoglycemia could increase cardiovascular mortality.
The pursuit of accurate glycemic control, avoiding both hyper- and hypoglycemia, should be recommended for preventing CVD in diabetes, and thus an individualized approach for achievement of target HbA 1c in type 2 diabetic patients should be adopted 39 , At the same time, it should also be clearly recognized that the control of other risk factors such as hypertension and hypercholesterolemia is more effective than glucose-lowering therapy in reducing the incidence of cardiovascular events.
As a consequence, diabetes care implies a comprehensive management of cardiovascular risk, which includes other factors beyond glycemia. This publication is based on the presentations from the 4th World Congress on Controversies to Consensus in Diabetes, Obesity and Hypertension CODHy.
The Congress and the publication of this supplement were made possible in part by unrestricted educational grants from Abbott, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, Ethicon Endo-Surgery, Janssen, Medtronic, Novo Nordisk, Sanofi, and Takeda.
wrote the main points supporting the importance of glucose control for prevention of CVD in diabetic patients, reviewed the manuscript for critical content, prepared the manuscript in full coordination with all of the authors, and supports the opinion expressed in the conclusions.
wrote the main points supporting the importance of glucose control for prevention of CVD, prepared the manuscript in full coordination with all of the authors, and supports the opinion expressed in the conclusions.
wrote the main counterpoints challenging the importance of glucose control for prevention of CVD in diabetic patients, prepared the manuscript in full coordination with all of the authors, and supports the opinion expressed in the conclusions.
wrote the main counterpoints challenging the importance of glucose control for prevention of CVD in diabetic patients, reviewed the manuscript for critical content, prepared the manuscript in full coordination with all of the authors, and supports the opinion expressed in the conclusions.
is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest. filter your search All Content All Journals Diabetes Care.
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Article Navigation. The Heart in Diabetes July 17 Is Glucose Control Important for Prevention of Cardiovascular Disease in Diabetes? Edoardo Mannucci, MD ; Edoardo Mannucci, MD. Corresponding author: Edoardo Mannucci, edoardo. mannucci unifi. This Site. Google Scholar.
Ilaria Dicembrini, MD ; Ilaria Dicembrini, MD. Angelo Lauria, MD ; Angelo Lauria, MD. Paolo Pozzilli, MD Paolo Pozzilli, MD. Get Permissions. toolbar search Search Dropdown Menu.
toolbar search search input Search input auto suggest. No potential conflicts of interest relevant to this article were reported. Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjects. Search ADS. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study PROspective pioglitAzone Clinical Trial In macroVascular Events : a randomised controlled trial.
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. UK Prospective Diabetes Study UKPDS Group.
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes UKPDS Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.
Glucose control and vascular complications in veterans with type 2 diabetes. Prevention of cardiovascular disease through glycemic control in type 2 diabetes: a meta-analysis of randomized clinical trials. High blood pressure hypertension High blood pressure is a major risk factor for heart disease and stroke.
Studies have shown a link between high blood pressure and insulin resistance. When patients have both HBP and diabetes, which is a common combination, their risk for CVD increases even more. Abnormal cholesterol and high triglycerides Patients with diabetes often have unhealthy cholesterol levels including high LDL "bad" cholesterol, low HDL "good" cholesterol, and high triglycerides.
This often occurs in patients with premature coronary heart disease. It's also characteristic of a lipid disorder associated with insulin resistance called atherogenic dyslipidemia, or diabetic dyslipidemia in patients with diabetes.
Learn more about cholesterol abnormalities as they relate to diabetes. Download Type 2 Diabetes and Cholesterol PDF. Obesity Obesity is a major risk factor for CVD and has been strongly associated with insulin resistance.
Weight loss can improve cardiovascular risk, decrease insulin concentration and increase insulin sensitivity. Obesity and insulin resistance also have been associated with other risk factors, including high blood pressure. Lack of physical activity Physical inactivity is another modifiable risk factor for insulin resistance and CVD.
Exercising and losing weight can prevent or delay the onset of Type 2 diabetes, reduce blood pressure and help reduce the risk for heart attack and stroke. Any type of moderate-to vigorous physical activity is beneficial, such as sports, house work, gardening or work-related physical activity.
Official websites use. gov A. gov website belongs Hhperglycemia an official Multivitamin for vision care organization in the Nealth States. gov website. Share sensitive information only on official, secure websites. Diabetes is a disease in which your blood glucose, or blood sugarlevels are too high. Glucose comes from foods you eat.
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