Marion Hauser, MS, RD. Resveratrol, in simple hewlth, is a chemical compound found in some plants that provides that plant a super antioxidant protector from hezlth stress and infections. What stresses a healt, you may ask? Disease, fungus, environmental pollutants to name a few.
For our purpose, we will focus on the research that centers on joint pain. Resveratrol has been Redveratrol extensively for supplementation in humans.
However, research in Resveratrol continues to show benefits Resveeatrol the interest in Resveratrol could Resgeratrol be stronger Lowering cholesterol naturally attested to by the numerous ongoing studies.
University researchers publishing in the medical journal Molecular Medicine Reports jont had a lot of good things to Reseratrol about Agility and speed drills. Understanding inflammation and healing so hexlth can understand how Resveratrol can help.
In our practice inflammation Resveratrl THE tool to fix damaged joints. We control the foe through our regenerative injection techniques.
Once jolnt healing Diabetic coma and hypoglycemia is done, helth inflammation shuts Resveratrll. The most obvious clue that healing has occurred is that joinh swelling goes away. Inflammation becomes bad when the swelling does not jlint away, Low calorie diet.
Healing is not Low calorie diet. Yet the body continues to try to heal the only way it knows how, with inflammation and swelling. When swelling becomes chronic, Low calorie diet inflammatory factors Redveratrol are beneficial to quickly heal, become Resveratorl over the long term, eroding joints.
The swelling Website performance best practices healgh, once a protective tool, now becomes painful and typically sends the person off to chronic anti-inflammatory pain medications. Resveratrol helps Rezveratrol acting as an anti-inflammatory.
It should healht noted however that it does not repair damaged tissue, its Resveratrol for joint health claim is that it helps stop the erosion.
Resverxtrol the Journal of the Science of Ror and Agriculture2 doctors at the University of Biotin supplements, yes that Padova in Italy known for its vineyards that produce Healthy and Natural Power high-quality red winesexamined several animal studies that measured the effects of Resveratrol on rheumatoid Metabolism-boosting lifestyle tips, osteoarthritis, and gout.
They noted interesting results in Revseratrol of reduced tissue damage, restored cartilage heaalth cartilage stabilityand decreased levels of Resveratrol for joint health acid the problems with gout.
Of course, the French make jolnt wine Website performance best practices well. Leading French researchers, writing in the journal Nutrients3 found that in uealth arthritis, healtb suggests that resveratrol displayed jkint, anti-catabolic prevents Resvertarolanti-apoptotic prevents cell death in various articular cartilage cell types, including chondrocytes cartilage building blocks and synoviocytes Resveratrll cells Resveratrlo regulate inflammation in the synovial fluid of joints.
In preclinical Resverattrol of osteoarthritis and hea,th arthritis, resveratrol RResveratrol shown joint protective effects, mainly mediated by Resgeratrol production of pro-inflammatory and pro-degradative factors. A May study fr the journal Cells 4 Redveratrol to us from Italy.
It confirmed Resvrratrol benefits of the resveratrol I mentioned above. Here are Importance of pre-hydration in sports summary learning points:.
Your jint or Resveraatrol care provider may recommend that you consider joimt of Resveratrol with your meloxicam anti-inflammatory joinh. In ResveragrolLow calorie diet published research in the Journal of Medicinal Rssveratrolwhere they measured the beneficial response of taking mg per day resveratrol against placebo as an adjuvant or companion medication to make the meloxicam work better.
The Curcumin family curcuminoidscompounds of the spice turmericdisplay an ability to alleviate and possibly stop osteoarthritis progression. European researchers publishing in the medical journal Springerplus noted that the combination treatment of curcumin and resveratrol produced a synergistic effect.
The two nutraceuticals worked in collaboration to shut off chronic destructive inflammation. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis.
Molecular Medicine Reports. Journal of the Science of Food and Agriculture. Resveratrol, potential therapeutic interest in joint disorders: a critical narrative Review.
Nutraceutical Activity in Osteoarthritis Biology: A Focus on the Nutrigenomic Role. Resveratrol Supplementation Reduces Pain and Inflammation in Knee Osteoarthritis Patients Treated with Meloxicam: A Randomized Placebo-Controlled Study.
Journal of medicinal food. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial.
Nutrition journal. When should I involve a Prolotherapist in my care? Call Us: Email Us. Take our Pain Quiz Regenerative Treatments H3 Prolotherapy What does H3 mean? Stem Cell Therapy Platelet Rich Plasma PRP LPIT - Neural Prolotherapy Nerve Release Injection Therapy Cervical Curve Correction Are you a good candidate?
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Resveratrol and the treatment of osteoarthritis The research Marion Hauser, MS, RD Resveratrol, in simple terms, is a chemical compound found in some plants that provides that plant a super antioxidant protector from oxidative stress and infections.
The answer some researchers brought forward? Red Wine. Resveratrol is found in the skins of wine grapes. Foods that are rich in Resveratrol other than red wine include Peanuts, pistachios, cranberries, strawberries, almonds, and berries. The research on Resveratrol and joint pain University researchers publishing in the medical journal Molecular Medicine Reports 1 had a lot of good things to say about Resveratrol.
They noted that Resveratrol reversed inflammatory damage and protected the rat joints from osteoarthritis damage. Resveratrol can act as a natural anti-inflammatory. The medical thinking is if you can block TNF and other inflammatory factor production or at least inhibit it, joint swelling will be reduced and hopefully, the amount of articular cartilage breakdown resulting from a toxic, over the inflamed joint environment will be slowed.
These are the serum biomarkers of inflammation and cartilage degradation. Caspase is responsible for damage cell breakdown. When cartilage is damaged and the body cannot heal itself, it gets rid of the damaged cartilage.
The problem with osteoarthritis is that this cartilage is not replaced. Resveratrol altered the inflammation messages. It sent chemical messages to stop chronic inflammation Effect on nitric oxide. Hyde molecules. In a normal joint environment, nitric oxide regulates inflammation as a healing agent.
Resveratrol can reduce tissue damage In the Journal of the Science of Food and Agriculture2 doctors at the University of Padova, yes that Padova in Italy known for its vineyards that produce several high-quality red winesexamined several animal studies that measured the effects of Resveratrol on rheumatoid arthritis, osteoarthritis, and gout.
Here are the summary learning points: Resveratrol has a chondroprotective cartilage protective characteristic that helps limit cartilage matrix loss the cartilage ingredients during the early stages of the disease. Resveratrol has an anti-apoptotic effect an anti-oxidant characteristic of prevention of cell death, in this case, cartilage cell deathby shutting off harmful inflammation.
The chondroprotective activity of resveratrol was shown that resveratrol might be responsible for both anti-inflammatory effects and anticatabolic stops cartilage breakdown Animal studies suggest that inflammation linked to obesity could be shut off by Resveratrol.
Taken together, all these studies provide a wide range of evidence of resveratrol-mediated biological activities with potentially beneficial outcomes in osteoarthritis. Why your doctor may recommend Resveratrol and meloxicam Your doctor or health care provider may recommend that you consider mg of Resveratrol with your meloxicam anti-inflammatory prescription.
Before I tell you why first a reminder that this type of recommendation is a pain management technique usually given to people to manage them along until they are ready for knee replacement surgery. This type of recommendation is one we would not make to our patients receiving regenerative medicine injections.
Resveratrol and ginger Researchers at Appalachian State University wrote in the Nutrition Journal of the effect of resveratrol, ginger root, and curcumin in a combined supplement.
Strawberries are among the foods called super anti-inflammatory, super anti-oxidant, even super antibiotic. Please see my article Strawberries improve pain and reduce inflammation in obese adults with knee osteoarthritis Please see my other articles on nutrition and chronic joint pain Green tea and joint pain Elevated Cholesterol and Joint Pain Vitamin D and knee osteoarthritis Metabolic syndrome and osteoarthritis joint pain Olives and osteoarthritis What is obesity-induced osteoarthritis?
Type 2 diabetes in osteoarthritis joint healing Celiac disease and difficult to treat joint pain How diet, Type II diabetes, and obesity compromise tendon healing Do you have questions about obesity and osteoarthritis? You can get help and information from our Caring Medical staff.
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: Resveratrol for joint health| Latest news | Red Wine and Cancer. Generally the recommended dose is mg a day. One natural compound that has gained attention in recent years for its potential benefits in managing arthritis is resveratrol. Supplement Facts Active ingredient s : Resveratrol Alternate name s : 3,5,4'-Trihydroxy-trans-stilbene Legal status: Resveratrol is available as a dietary supplement in the United States and is not regulated by the FDA as a drug. Privacy Policy Terms of Use Technical Support Site Map Contact Us. Google Scholar OpenURL Placeholder Text. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis Authors: Yulong Wei Jie Jia Xin Jin Wei Tong Hongtao Tian View Affiliations Affiliations: Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei , P. |
| What to know about resveratrol | In addition to the health benefits listed above, resveratrol may have other benefits. It is activated by interleukin IL -1β, tumor necrosis factor TNF -α and other cytokines, and rapidly induces the expression of multiple genes, which participate in immune reactions and the inflammatory response via a series of reactions, such as cytokine TNF-α, IL-1β, IL-6 and IL, inflammatory enzyme and matrix metalloproteinase MMPs. Volume It May Increase Insulin Sensitivity. However, studies in rodents have shown that extremely high doses of resveratrol can lead to kidney and liver damage. |
| 7 Health Benefits of Resveratrol Supplements | Resveratrol ameliorates A TNF-α, B IL-1β, C IL-6 and D IL expression levels in OA rats Control, control group; OA, OA model group; Resveratrol, resveratrol treatment group. TNF, tumor necrosis factor; IL, interleukin; OA, osteoarthritis. To investigate the anti-inflammation effect of resveratrol in OA rat, iNOS, NF-κB, p-AMPK and SIRT1 protein expression levels were analyzed using western blotting. Treatment with resveratrol significantly suppressed the increased levels of iNOS, NF-κB, p-AMPK and SIRT1 protein expression in the OA rats, compared with the OA models Fig. Resveratrol suppresses iNOS, NF-κB, p-AMPK and SIRT1 protein expression in OA rats. A Representative western blot images. Quantification of B iNOS, C p-AMPK, D NF-κB and E and SIRT1 protein expression levels by resveratrol. Statistical analysis was performed following western blot analysis for iNOS, NF-κB, p-AMPK and SIRT1 protein expression in OA rats. OA, osteoarthritis; iNOS, inducible nitric oxide synthase; NF, nuclear factor; AMPK, AMP-activated protein kinase; SIRT1, sirtuin 1. To further investigate the protection mechanism of resveratrol on OA rats, SOD and MDA levels were measured using ELISA kits. As presented in Fig. Treatment with resveratrol significantly recovered the inhibited SOD level and reduced the increased MDA level in the OA rat, compared with the OA model Fig. Resveratrol inhibits MDA and SOD levels in OA rats. Effects of resveratrol A inhibits MDA and B increases SOD levels in OA rats. OA, osteoarthritis; MDA, 3,4-methylenedioxyamphetamine; SOD, superoxide dismutase. The effect of resveratrol on HO-1 and Nrf-2 protein expression levels was evaluated in OA rats. Treatment with resveratrol significantly induced HO-1 and Nrf-2 protein expression levels in OA rats, compared with the OA model Fig. Resveratrol induces HO-1 and Nrf-2 protein expression in OA rats. A HO-1 protein expression. N B Representative western blot images. C Nrf-2 protein expression. OA, osteoarthritis; HO-1, heme oxygenase 1; Nrf-2, nuclear factor erythroid 2-related factor 2. The anti-apoptosis effects of resveratrol were investigated in OA rats. OA, one of the most common chronic bone and joint degenerative diseases, may affect the joints of the limbs and spine, with pathological characteristics, including lesions in joint cartilage and subchondral bone The clinical manifestations of OA primarily include pain, stiffness, deformation and limited movement of affected joints In the current study, resveratrol treatment was found to ameliorate inflammatory damage, oxidative stress and neuronal apoptosis, and protect against OA in rat models of OA. This is consistent with Pan et al 12 , who indicated that resveratrol protects against neonatal brain injury following hypoxia-ischemia via anti-apoptotic and anti-inflammatory effects The pathogenesis of OA remains unclear, although it has been confirmed that NO is significant in the incidence and development of OA NO, an important regulatory factor participating in the differentiation and apoptosis of chondrocytes, inhibits the proliferation of chondrocytes and induces the apoptosis of chondrocytes. In addition, NO suppresses the synthesis of proteoglycan and type II collagen secreted by chondrocytes, and promotes the decomposition of cartilage extracellular matrix NOS is the key enzyme inducing NO in patients with OA 9 , Furthermore, the current data indicates that resveratrol significantly suppressed the increased levels of iNOS protein expression in OA rats. Wang et al 19 reported that resveratrol ameliorates the integrity of the blood-brain barrier by maintaining iNOS expression. Studies of AMPK predominantly focused on energy metabolism, and very few studies investigate the association between AMPK and inflammatory reactions 21 , However, increasing numbers of studies have demonstrated that AMPK exerted anti-inflammatory effects. For example, AMPK is pivotal in the regulation of energy metabolism in skeletal muscles, and is involved in energy metabolism and inflammation of skeletal muscles In skeletal muscles, AMPK exerts anti-inflammatory effects by inhibiting the expression level of NF-κB Activation of the NF-κB signaling pathway, a pro-inflammatory signaling pathway in the skeletal muscle cells of mice, may be inhibited by AMPK, and peroxisome proliferation activated receptor inhibits skeletal muscular inflammation and insulin resistance by inhibiting endoplasmic reticulum stress via the AMPK-dependent signaling pathway In the present study, resveratrol significantly suppressed AMPK protein expression levels in OA rats. NF-κB is stimulated by various factors, such as TNFs and ILs The activated NF-κB signaling pathway leads to the transcription of a series of downstream target genes, resulting in associated biological effects, such as the generation of inflammatory factors and the induction of chondrocyte apoptosis Furthermore, resveratrol significantly reduced the level of NF-κB protein expression in OA rats. SIRT1 is expressed in human articular chondrocytes and cartilage; however, its expression level in joint chondrocytes is lower than that in normal chondrocytes of patients with OA In addition, it has been found that SIRT1 promotes the expression of cartilage specific genes, and enhances the anti-stress ability of chondrocytes, promotes cell survival and inhibits chondrocyte apoptosis, indicating that SIRT1 prevents against OA by inhibiting the aging and apoptosis of chondrocytes These findings indicate that resveratrol significantly reduces SIRT1 protein expression levels in OA rats. Gan et al 27 demonstrated that resveratrol reduced acute kidney injury in septic rats via SIRT1 and de-acetylated NF-κB-P65 Thus, resveratrol may present as an effective therapeutic strategy for patients with OA. However, this study only used a rat model, and therefore requires further study in other models or clinical trials. Benazzo F, Perticarini L, Padolino A, Castelli A, Gifuni P, Lovato M, Manzini C and Giordan N: A multi-centre, open label, long-term follow-up study to evaluate the benefits of a new viscoelastic hydrogel Hymovis ® in the treatment of knee osteoarthritis. Eur Rev Med Pharmacol Sci. Rini C, Porter LS, Somers TJ, McKee DC, DeVellis RF, Smith M, Winkel G, Ahern DK, Goldman R, Stiller JL, et al: Automated Internet-based pain coping skills training to manage osteoarthritis pain: A randomized controlled trial. View Article : Google Scholar :. Schmal H, Salzmann GM, Langenmair ER, Henkelmann R, Südkamp NP and Niemeyer P: Biochemical characterization of early osteoarthritis in the ankle. Scanzello CR: Chemokines and inflammation in osteoarthritis: Insights from patients and animal models. J Orthop Res. View Article : Google Scholar. Cicuttini FM and Wluka AE: Not just loading and age: The dynamics of osteoarthritis, obesity and inflammation. Med J Aust. Hsu DZ, Chu PY and Jou IM: Daily sesame oil supplement attenuates joint pain by inhibiting muscular oxidative stress in osteoarthritis rat model. J Nutr Biochem. Li D, Xie G and Wang W: Reactive oxygen species: The 2-edged sword of osteoarthritis. One natural compound that has gained attention in recent years for its potential benefits in managing arthritis is resveratrol. The question is whether or not resveratrol is good for arthritis and if so, how it works and how much you should take. Arthritis is a chronic condition characterized by joint inflammation, pain, and stiffness. It can significantly impact a person's quality of life, making daily activities challenging and reducing mobility. There are several types of arthritis, including osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and gout. Each type has its unique characteristics and underlying causes, but they all share the common symptoms of joint discomfort and inflammation. Resveratrol is a natural compound found in certain plants, including grapes, red wine, and berries. It is well-known for its antioxidant and anti-inflammatory properties, which have been extensively studied for their potential benefits in managing arthritis. Resveratrol works by inhibiting the production of enzymes and proteins that contribute to inflammation in the body. Generally the recommended dose is mg a day. Studies tend to vary between mg with a few outliers using more. Usually the dosage is split up into 40 or 50mg twice daily. Numerous studies have explored the effects of resveratrol on arthritis, particularly osteoarthritis and rheumatoid arthritis. A recent double-blind, placebo-controlled trial investigated the efficacy of oral resveratrol in the treatment of painful knee osteoarthritis. The study enrolled participants [4] with knee osteoarthritis and randomized them into two groups: one receiving oral resveratrol and the other receiving an oral placebo. The primary outcome measure was the mean change in knee pain at 3 months, assessed using a self-administered pain numeric rating scale. The trial results showed that oral resveratrol, administered at a dose of 40 mg twice a day for one week followed by 20 mg twice a day for a total duration of 6 months, significantly reduced knee pain compared to the placebo group. The resveratrol group experienced a mean change in knee pain at 3 months, as assessed by the pain numeric rating scale. These findings suggest that resveratrol may be a promising therapeutic option for managing pain in knee osteoarthritis. The potential therapeutic effects of resveratrol in RA have been extensively studied in both preclinical and clinical settings. Animal studies have demonstrated the ability of resveratrol to alleviate cartilage degradation and reduce joint damage in experimental models of RA. Resveratrol exerts its beneficial effects on arthritis through various mechanisms. Firstly, it inhibits the production of pro-inflammatory cytokines and enzymes, which contribute to joint inflammation and damage. Liquids may be a good option if you have difficulty swallowing pills or prefer to add resveratrol to your food or drinks. There is no evidence to suggest that one form of resveratrol is superior to others in terms of efficacy. The supplement's potency can vary, depending on the amount of resveratrol in the supplement and manufacturer. When shopping for resveratrol supplements, look for a high-quality product from a reputable brand. Resveratrol is a naturally occurring polyphenol compound in grape skins, berries, and peanuts. It is also available as a dietary supplement. Packed with antioxidant, anti-inflammatory, and anticancer compounds, resveratrol may benefit cardiovascular, joint, and metabolic health and improve cognitive function. If you are considering using resveratrol to support your health, talk to a healthcare provider to determine if it is safe for you, especially if you have any health conditions or are taking medications. When shopping for resveratrol supplements, choose a reputable brand, and follow the recommended dosage guidelines. Koushki M, Amiri-Dashatan N, Ahmadi N, Abbaszadeh HA, Rezaei-Tavirani M. Resveratrol: A miraculous natural compound for diseases treatment. Food Sci Nutr. Oregon State University. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: a double-edged sword in health benefits. Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY, Huang Y. Pharmacological basis and new insights of resveratrol action in the cardiovascular system. Br J Pharmacol. Li H, Xia N, Hasselwander S, Daiber A. Resveratrol and vascular function. Int J Mol Sci. Singh A, Kukreti R, Saso L, Kukreti S. Oxidative stress: a key modulator in neurodegenerative diseases. Dias GP, Cocks G, do Nascimento Bevilaqua MC, Nardi AE, Thuret S. Resveratrol: A potential hippocampal plasticity enhancer. Oxid Med Cell Longev. Gu J, Li Z, Chen H, Xu X, Li Y, Gui Y. Neuroprotective effect of trans-resveratrol in mild to moderate Alzheimer's disease: A randomized, double-blind trial. Neurol Ther. Zhou Q, Wang Y, Han X, Fu S, Zhu C, Chen Q. Efficacy of resveratrol supplementation on glucose and lipid metabolism: a meta-analysis and systematic review. Front Physiol. Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res. Mahjabeen W, Khan DA, Mirza SA. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial. Complement Ther Med. Hou CY, Tain YL, Yu HR, Huang LT. The effects of resveratrol in the treatment of metabolic syndrome. Marouf BH, Hussain SA, Ali ZS, Ahmmad RS. Resveratrol supplementation reduces pain and inflammation in knee osteoarthritis patients treated with Meloxicam: A randomized placebo-controlled study. J Med Food. Sheng S, Wang X, Liu X, et al. The role of resveratrol on rheumatoid arthritis: From bench to bedside. Front Pharmacol. Ko JH, Sethi G, Um JY, et al. The role of resveratrol in cancer therapy. Arabzadeh A, Mortezazadeh T, Aryafar T, Gharepapagh E, Majdaeen M, Farhood B. Therapeutic potentials of resveratrol in combination with radiotherapy and chemotherapy during glioblastoma treatment: a mechanistic review. Cancer Cell International. Xiao Q, Zhu W, Feng W, et al. A review of resveratrol as a potent chemoprotective and synergistic agent in cancer chemotherapy. doi: Zhou DD, Luo M, Huang SY, et al. Effects and mechanisms of resveratrol on aging and age-related diseases. Lv C, Zhang Y, Shen L. Preliminary clinical effect evaluation of resveratrol in adults with allergic rhinitis. Ratz-Łyko A, Arct J. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. J Cosmet Laser Ther. Abu-Amero KK, Kondkar AA, Chalam KV. Resveratrol and ophthalmic diseases. Malaguarnera L. Influence of resveratrol on the immune response. Published Apr Susan G. Komen Foundation. |
| Negative Effects of Resveratrol | Modifiable risk factors for RA: prevention, better than cure? Rheumatology ; 51 : — Sánchez-Pernaute O López-Armada MJ Hernández P et al. Antifibroproliferative effect of tenidap in chronic antigen-induced arthritis. Arthritis Rheum ; 40 : — Gerwin N Bendele AM Glasson S Carlson CS. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the rat. Osteoarthritis Cartilage ; 18 Suppl 3 : S24 — López-Armada MJ Sánchez-Pernaute O Largo R et al. Modulation of cell recruitment by anti-inflammatory agents in antigen-induced arthritis. Ann Rheum Dis ; 61 : — Datta S Kundu S Ghosh P et al. Correlation of oxidant status with oxidative tissue damage in patients with rheumatoid arthritis. Clin Rheumatol ; 33 : — Park EJ Pezzuto JM. The pharmacology of resveratrol in animals and humans. Biochim Biophys Acta ; : — Crowell JA Korytko PJ Morrissey RL Booth TD Levine BS. Resveratrol-associated renal toxicity. Toxicol Sci ; 82 : — 9. Luther DJ Ohanyan V Shamhart PE et al. Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma. Invest New Drugs ; 29 : — Reagan-Shaw S Nihal M Ahmad N. Dose translation from animal to human studies revisited. FASEB J ; 22 : — Patel KR Scott E Brown VA et al. Clinical trials of resveratrol. Ann N Y Acad Sci ; : — 9. Derer A Böhm C Grötsch B et al. Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis. Ann Rheum Dis ; 75 : — Zhai XX Ding JC Tang ZM. Cell Biochem Biophys ; 71 : — Wu Z Liu B Cailing E et al. Mol Med Rep ; 11 : — 4. Anti-inflammatory effect of resveratrol on adjuvant arthritis rats with abnormal immunological function via the reduction of cyclooxygenase-2 and prostaglandin E 2. Mol Med Rep ; 9 : — 8. Kato M Ospelt C Gay RE Gay S Klein K. Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts. Arthritis Rheumatol ; 66 : 40 — 8. Cañete JD Celis R Moll C et al. Clinical significance of synovial lymphoid neogenesis and its reversal after anti-tumour necrosis factor α therapy in rheumatoid arthritis. Ann Rheum Dis ; 68 : — 6. Haringman JJ Gerlag DM Zwinderman AH et al. Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis ; 64 : — 8. Chang YP Ka SM Hsu WH et al. Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy. J Cell Physiol ; : — Chen CC Tsai SH Lu CC et al. Activation of an NLRP3 inflammasome restricts Mycobacterium kansasii infection. PLoS One ; 7 : e Rantapää-Dahlqvist S Boman K Tarkowski A Hallmans G. Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis. Ann Rheum Dis ; 66 : — 3. Hachicha M Rathanaswami P Schall TJ McColl SR. Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic effect of tumor necrosis factor α and interferon-γ. Arthritis Rheum ; 36 : 26 — Cascão R Rosário HS Souto-Carneiro MM Fonseca JE. Neutrophils in rheumatoid arthritis: more than simple final effectors. Autoimmun Rev ; 9 : — 5. Wu CT Yu HP Chung CY Lau YT Liao SK. Attenuation of lung inflammation and pro-inflammatory cytokine production by resveratrol following trauma-hemorrhage. Chin J Physiol ; 51 : — 8. Perečko T Drábiková K Nosáľ R Harmatha J Jančinová V. Involvement of caspase-3 in stilbene derivatives induced apoptosis of human neutrophils in vitro. Interdiscip Toxicol ; 5 : 76 — Navarro-Compán V Melguizo-Madrid E Hernández-Cruz B et al. Interaction between oxidative stress and smoking is associated with an increased risk of rheumatoid arthritis: a case—control study. Rheumatology ; 52 : — Rall LC Roubenoff R Meydani SN Han SN Meydani M. J Nutr Biochem ; 11 : — 4. Khan MA Chen HC Wan XX et al. Regulatory effects of resveratrol on antioxidant enzymes: a mechanism of growth inhibition and apoptosis induction in cancer cells. Mol Cells ; 35 : — Rege SD Kumar S Wilson DN et al. Resveratrol protects the brain of obese mice from oxidative damage. Oxid Med Cell Longev ; Stamp LK James MJ Cleland LG. Diet and rheumatoid arthritis: a review of the literature. Semin Arthritis Rheum ; 35 : 77 — Hu Y Costenbader KH Gao X et al. Mediterranean diet and incidence of rheumatoid arthritis in women. Arthritis Care Res ; 67 : — Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Advertisement intended for healthcare professionals. Navbar Search Filter Rheumatology This issue British Society for Rheumatology Journals Rheumatology Books Journals Oxford Academic Mobile Enter search term Search. Issues More Content Advance Articles Editor's Choice Collections Podcasts Videos Supplements Guidelines InSight Papers BSR Registers Papers Virtual Roundtables Submit Author Guidelines Submission Site Open Access Options Self-Archiving Policy Why Submit Purchase Alerts About About Rheumatology About the British Society for Rheumatology Editorial Board Advertising and Corporate Services Journals Career Network Dispatch Dates Terms and Conditions Journals on Oxford Academic Books on Oxford Academic. British Society for Rheumatology Journals. Issues More Content Advance Articles Editor's Choice Collections Podcasts Videos Supplements Guidelines InSight Papers BSR Registers Papers Virtual Roundtables Submit Author Guidelines Submission Site Open Access Options Self-Archiving Policy Why Submit Purchase Alerts About About Rheumatology About the British Society for Rheumatology Editorial Board Advertising and Corporate Services Journals Career Network Dispatch Dates Terms and Conditions Close Navbar Search Filter Rheumatology This issue British Society for Rheumatology Journals Rheumatology Books Journals Oxford Academic Enter search term Search. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Journal Article. Resveratrol lowers synovial hyperplasia, inflammatory markers and oxidative damage in an acute antigen-induced arthritis model. Riveiro-Naveira , Romina R. Oxford Academic. Marta N. Maylin Almonte-Becerril. Carlos Vaamonde-García. Jesús Loureiro. Laura Hermida-Carballo. Eduardo López-Peláez. Francisco J. María J. Revision received:. PDF Split View Views. Cite Cite Romina R. Select Format Select format. ris Mendeley, Papers, Zotero. enw EndNote. bibtex BibTex. txt Medlars, RefWorks Download citation. Permissions Icon Permissions. Close Navbar Search Filter Rheumatology This issue British Society for Rheumatology Journals Rheumatology Books Journals Oxford Academic Enter search term Search. Abstract Objective. resveratrol , diet , antioxidant , rheumatoid arthritis , synovial tissue hyperplasia , inflammation , oxidative stress. Rheumatology key messages. Open in new tab Download slide. Resveratrol attenuates the development of acute antigen-induced arthritis Animals were treated with water or resveratrol Resveratrol lowers synovial hyperplasia in an acute model of antigen-induced arthritis A Representative images of synovial tissue PCNA immunostaining from each group of study. Modulatory effects of resveratrol on T-cell infiltration in an acute model of antigen-induced arthritis A Representative samples of CD3 immunohistochemistry in synovial membrane from each group of study. Resveratrol reduces CDpositive cells in synovial membrane in an acute model of antigen-induced arthritis Knee joints were sectioned and analysed by immunohistochemistry to determine the presence of CDpositive cells in the synovium. Resveratrol modulates the inflammatory response by decreasing the levels of chemokines A Synovial sections were analysed by immunohistochemistry for MCP Resveratrol modulates oxidative DNA damage and peroxidase activity in synovial tissue A Representative images of 8-oxo-dG immunohistochemical immunostaining from each group of study. Google Scholar Crossref. Search ADS. Google Scholar PubMed. OpenURL Placeholder Text. Commercial distribution or reproduction prohibited. NatMed is the leading provider of high-quality, evidence-based, clinically-relevant information on natural medicine, dietary supplements, herbs, vitamins, minerals, functional foods, diets, complementary practices, CAM modalities, exercises and medical conditions. Monograph sections include interactions with herbs, drugs, foods and labs, contraindications, depletions, dosing, toxicology, adverse effects, pregnancy and lactation data, synonyms, safety and effectiveness. Login Subscribe. Print Feedback. July Resveratrol: relief for rheumatoid arthritis RA? The top food sources include red wine , grapes, some berries and peanuts 5 , 6. This compound tends to be concentrated mostly in the skins and seeds of grapes and berries. These parts of the grape are included in the fermentation of red wine, hence its particularly high concentration of resveratrol 5 , 7. However, much of the research on resveratrol has been done in animals and test tubes using high amounts of the compound 5 , 8. Of the limited research in humans, most has focused on supplemental forms of the compound, in concentrations higher than those you could get through food 5. Resveratrol is an antioxidant-like compound found in red wine, berries and peanuts. Much of the human research has used supplements that contain high levels of resveratrol. Because of its antioxidant properties, resveratrol could be a promising supplement for lowering blood pressure 9. A review concluded that high doses may help reduce the pressure exerted on artery walls when the heart beats 3. That type of pressure is called systolic blood pressure, and appears as the upper number in blood pressure readings. Systolic blood pressure typically goes up with age, as arteries stiffen. Resveratrol may accomplish this blood-pressure-lowering effect by helping to produce more nitric oxide, which causes blood vessels to relax 10 , However, the authors of that study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits. Resveratrol supplements may help lower blood pressure by increasing the production of nitric oxide. Several studies in animals have suggested that resveratrol supplements may change blood fats in a healthy way 12 , A study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements. Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production LDL oxidation contributes to plaque buildup in artery walls 9 , In one study, participants were given grape extract that had been boosted with extra resveratrol. After six months of treatment, their LDL had gone down by 4. Resveratrol supplements may benefit blood fats in animals. As an antioxidant, they may also decrease LDL cholesterol odixation. It works to achieve this in the same way as calorie restriction, which has shown promise in lengthening lifespans by changing how genes express themselves 18 , Resveratrol supplements have lengthened lifespan in animal studies. Several studies have suggested that drinking red wine can help slow down age-related cognitive decline 21 , 22 , 23 , Additionally, the compound may set off a chain of events that protects brain cells from damage While this research is intriguing, scientists still have questions about how well the human body is able to make use of supplemental resveratrol, which limits its immediate use as a supplement to protect the brain 1 , 2. A potent antioxidant and anti-inflammatory compound, resveratrol shows promise in protecting brain cells from damage. These benefits include increasing insulin sensitivity and preventing complications from diabetes 26 , 27 , 28 , One explanation for how resveratrol works is that it may stop a certain enzyme from turning glucose into sorbitol, a sugar alcohol. When too much sorbitol builds up in people with diabetes, it can create cell-damaging oxidative stress 30 , Here are a few more benefits resveratrol may have for people with diabetes 28 :. Researchers say the compound could be used to treat diabetes and its complications in the future, but more research is needed. Resveratrol has helped mice develop better insulin sensitivity and fight complications of diabetes. In the future, humans with diabetes might also benefit from resveratrol therapy. Arthritis is a common affliction that leads to joint pain and loss of mobility |
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