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Microbiome Expert: EAT THIS to Heal Your Gut \u0026 AGE IN REVERSE - Dr. William DavisGut health and weight loss -
Today, I'd say she could well be right. Here's why. We've known for a century that bacteria live in our intestines, but we've assumed that they did little to affect our health. We thought that they were just mooching off of us — taking advantage of the warmth and nutrients in our gut.
In the past decade, however, remarkable breakthroughs have allowed scientists to count and characterize the genes in our gut bacteria. The results have been astonishing.
Our gut bacteria have to times more genes than we have human genes. Even more remarkable, these bacterial genes make substances that get into the human bloodstream, affecting our body chemistry. That means it is entirely plausible that the bacteria in our gut could be affecting our health. How could they affect our weight?
When we eat food, our gut breaks it down into small pieces. Only the smallest pieces get absorbed into our blood. The rest is eliminated as waste material. In other words, not all of the calories in the food we eat get into our body and increase our weight.
The gut bacteria help break down food. Some bacteria are better able to chop food into those smallest pieces that get digested, add calories to our body and thereby tend to increase our weight. Theoretically, if our guts have more of those kinds of bacteria, it should be harder to lose weight.
But is there evidence that it really is true? Several studies in animals, and some in humans, say that it is. For example, scientists transferred bacteria from the guts of two strains of mice — one that naturally becomes obese and one that naturally stays lean — into a third lean strain raised from birth to have no gut bacteria.
Gut bacteria transferred from the naturally obese mice made the germ-free mice become fat, but gut bacteria transferred from the naturally lean mice kept them lean. Then scientists took bacteria from the guts of human identical twins, one of whom was obese and one of whom was lean, and transferred those bacteria into the guts of lean, germ-free mice.
Bacteria from the obese twin made the mice become fat, but bacteria from the lean twin did not. We are just beginning to understand the role of gut bacteria in obesity, and the science hasn't led yet to treatments that will make it easier to lose weight.
However, I believe that day is coming. Based on a solid foundation of current nutrition science, Harvard's Special Health Report Healthy Eating: A guide to the new nutrition describes how to eat for optimum health.
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.
Thanks for visiting. Don't miss your FREE gift. The Best Diets for Cognitive Fitness , is yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School. Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive health , plus the latest advances in preventative medicine, diet and exercise , pain relief, blood pressure and cholesterol management, and more.
Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight loss from exercises to build a stronger core to advice on treating cataracts. The researchers found that the extent of weight loss was not correlated with baseline dietary patterns or blood metabolite levels.
The levels of only one obesity-associated protein in the blood, the KIT ligand, were positively associated with resistance to weight loss. In contrast, a number of baseline features were associated with the initial BMI of the participants.
Although the researchers found no association between microbiome composition and weight loss, the levels of 31 microbiome genes were associated with weight loss. In other words, the microbiome gene profile was a better predictor of weight loss than baseline dietary patterns or blood metabolite and protein levels.
Overall, lead author Christian Diener, Ph. The class of microbiome genes most abundant in the weight loss group was that associated with the synthesis of bacterial cell walls. Increased synthesis of cell walls occurs during bacterial replication. The researchers found that the bacterial replication rates were indeed higher in the weight loss group than in the no-weight-loss group.
Furthermore, bacteria belonging to the genus Prevotella were responsible to a large extent for the increased replication rate in the weight loss group. Notably, previous research has shown that individuals with higher levels of Prevotella in the gut are more likely to lose weight on a high fiber diet.
Higher Prevotella levels in the gut are associated with increased levels of degradation of complex carbohydrates by fermentation, resulting in the production of short-chain fatty acids. These short-chain fatty acids are less energy-dense than the consumed carbohydrates and can reduce inflammation.
This is especially noteworthy since experts believe that obesity is likely associated with chronic low grade inflammation. In contrast, microbiome genes associated with the breakdown of complex carbohydrates and proteins and those involved in the stress response and cellular respiration were enriched in individuals resistant to weight loss.
To be precise, genes enriched in the no-weight-loss group included those coding for enzymes that degrade complex carbohydrates into simple sugars. At the same time, the lower levels of bacteria with the ability to transform these simple sugars into fermentation products in individuals resistant to weight loss may result in greater absorption of simple sugars by the host, i.
Thus, the authors hypothesize that the lower replication rates of bacteria involved in fermentation and high levels of carbohydrate-degrading enzymes may be responsible for the lack of response to weight loss interventions.
He continued:. Thus, the microbiome appears to modulate the efficiency by which the host extracts calories from the diet. Describing the strengths of the study, Dr. These factors are highly correlated because people with higher BMIs tend to lose more weight in response to an intervention.
Therefore, we corrected for baseline BMI when looking for associations with weight loss. The results reported here are features associated with weight loss that are fully independent of baseline BMI.
The authors acknowledged that the study had certain limitations. To address the small sample size in the present study, the authors intend to replicate the research with larger groups of participants. Discussing future research directions, Dr. How much influence do your gut bacteria have on your state of mind?
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Medical News Today. Health Conditions Health Products Discover Tools Connect. By Deep Shukla on September 21, — Fact checked by Hannah Flynn. Share on Pinterest According to a new study, the microbiome can influence how the body responds to weight loss interventions.
A genetic approach. Baseline BMI and weight loss. Changes in blood metabolic markers. Association between weight loss and baseline features.
Microbiome functional genes. Strengths and limitations.
DEAR MAYO CLINIC: Gut health and weight loss friend insists that taking a Antimicrobial coatings supplement has helped her lose 50 pounds by keeping Gut health and weight loss gut bacteria in check. Will taking poss probiotic in conjunction with a balanced diet losw exercise heealth me lose weighht ANSWER: It is true that the gut bacterial population in people who are obese differs from the population in people who are lean. Whether this difference contributes to obesity or is a consequence of obesity is unknown. So far, research hasn't yielded clear answers. Although taking a probiotic is unlikely to cause harm, it may not help fight obesity. First and foremost, it is important to understand that weight gain is essentially a function of energy imbalance.
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How could they affect our weigth When we eat food, looss gut breaks Guf down into healrh pieces. Only the heapth pieces get ewight into our blood. The ahd is eliminated as healtn material.
In other words, not all of the calories in wejght food we eat annd into our body and increase our Gut health and weight loss. The gut bacteria help break down food.
Some bacteria Gut health and weight loss better able to chop food heath those smallest pieces that get digested, add calories to losss body and thereby tend to increase our weight.
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Wegiht studies adn Gut health and weight loss, and some in humans, say that it is. For example, scientists transferred bacteria from the guts of two strains of mice — one that naturally becomes obese and one that naturally stays lean — into a third lean strain raised from birth to have no gut bacteria.
Gut bacteria transferred from the naturally obese mice made the germ-free mice become fat, but gut bacteria transferred from the naturally lean mice kept them lean.
Then scientists took bacteria from the guts of human identical twins, one of whom was obese and one of whom was lean, and transferred those bacteria into the guts of lean, germ-free mice. Bacteria from the obese twin made the mice become fat, but bacteria from the lean twin did not.
We are just beginning to understand the role of gut bacteria in obesity, and the science hasn't led yet to treatments that will make it easier to lose weight. However, I believe that day is coming. Based on a solid foundation of current nutrition science, Harvard's Special Health Report Healthy Eating: A guide to the new nutrition describes how to eat for optimum health.
As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles.
No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Thanks for visiting. Don't miss your FREE gift. The Best Diets for Cognitive Fitnessis yours absolutely FREE when you sign up to receive Health Alerts from Harvard Medical School.
Sign up to get tips for living a healthy lifestyle, with ways to fight inflammation and improve cognitive healthplus the latest advances in preventative medicine, diet and exercisepain relief, blood pressure and cholesterol management, and more.
Get helpful tips and guidance for everything from fighting inflammation to finding the best diets for weight loss from exercises to build a stronger core to advice on treating cataracts. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts.
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: Gut health and weight loss| Latest news | Your digestive tract, also called the Consistency through proper hydration practices, contains trillions of bacteria. The probiotics Gut health and weight loss in losd fermented poss listed nealth are crucial for Guh healthy gut. High-fiber foods like whole grains, fruits, vegetables, nuts and seeds can all promote healthy gut bacteria. Our latest research has found strong links between specific gut microbes and body composition. Just science. Making your gut healthier is crucial if you want to lose weight successfully. |
| Most viewed | Eating for your unique metabolism and gut microbiome can improve your gut health, with weight loss as a favorable outcome, without restrictive dieting. Find out more My Account. In a healthy gut, endotoxins are part of the lifecycle of microbes that play a key role in overall human health. What is known is that you can take steps to maintain a healthier gut microbiome, and these steps also should help with your weight-loss journey. Read more. Based on the biological functions that these genes perform, the researchers were able to infer the functional profile of the entire gut microbiome. |
| Helpful Links | Gut bacteria influence body weight, but can probiotics help with weight loss? Share this article. More about food diet. The reason for this is that the initial BMI could distort or mask the potential association between weight loss and other baseline factors. PLUS, the latest news on medical advances and breakthroughs from Harvard Medical School experts. These foods contain a form of fibre that passes through your digestive system and provides a feast for waiting microbes. |
| Can improving your gut health help with weight loss? | In this edition of Medical Myths, we Gut health and weight loss five persistent Vitality about obesity. The weibht collected blood and fat heatlh from the participants, which healtth included people weightt obesity who underwent bariatric surgery. However, another review of 15 studies found that probiotic supplements were more successful than placebos for weight loss and reducing body fat. Get the latest nutrition tips from world-leading scientists for free. Hidden DNA found in blue whales reveals they've been mating with other species — and their hybrid offspring. |
| Gut Health and Weight Loss: Do Gut Bacteria Play a Role? | Probiotics are beneficial in many ways. Not all probiotics aid weight loss, and some may even cause weight gain. By that, we mean eating when you feel hungry and stopping when you feel full— a mindful approach to eating that doesn't include restricting foods think: the keto diet or the times you eat during the day think: intermittent fasting. Can you take probiotics to lose weight? Journal of Diabetes Nursing, JDN |
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