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He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care. He previously covered the biotech and pharmaceutical industry with CNBC.

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Featured NBC News Now Nightly Films Stay Tuned Special Features Newsletters Podcasts Listen Now. Contraindications: This medication is not recommended for people with a history of seizures, end-stage renal disease, pregnancy, and current use of monoamine oxidase inhibitors, opioids, or certain other prescription medications.

Setmelanotide, sold as Imcivree, is in a class of medications known as melanocortin 4 MC4 receptor agonists. How it works: People with specific genetic mutations may experience insufficient activation of the MC4 receptor in the brain, which could contribute to obesity.

Setmelanotide works by increasing the activation of this receptor, leading to reduced hunger, decreased calorie intake, and increased metabolism , all of which could promote weight loss. Participants also experienced a significant reduction in hunger with no serious treatment-related adverse events reported.

Another small study in children, adolescents, and adults found that setmelanotide significantly improved quality of life as early as 5 weeks after starting treatment, which could be related to reduced hunger and body weight.

Side effects: Some of the most common side effects of setmelanotide include injection site reactions, hyperpigmentation , nausea, headache, diarrhea, and stomach or back pain. Fatigue, vomiting, and depression have also been reported. Contraindications: This medication is not recommended for people with renal impairment, and those who are pregnant or breastfeeding.

There are several anorectics, or appetite suppressants , available. However, phentermine Adipex-P or Lomaira is the most commonly prescribed. Phentermine is taken orally and requires a prescription from a doctor or other healthcare professional.

How it works: These medications reduce appetite by altering levels of certain neurotransmitters in the brain, which can lead to weight loss.

Effectiveness: One study in 3, people compared the effectiveness of several medications for obesity and found that people taking phentermine lost the highest percentage of body weight over 12 weeks. Those taking phentermine lost an average of 8. However, keep in mind that these medications are only recommended for short-term use, as you can build up a tolerance after several weeks, resulting in decreased effectiveness.

Side effects: Potential side effects may include nausea, vomiting, diarrhea, and stomach cramps. Other severe side effects have been reported and require immediate medical attention, including shortness of breath, chest pain, and swelling of the lower extremities.

Contraindications: This medication is not recommended for people with a history of heart disease, hypertension, hyperthyroidism, glaucoma, diabetes, pregnancy, and certain prescription medications. Most weight loss medications are approved for adults with obesity or overweight and at least one weight-related condition, such as:.

Similarly, setmelanotide Imcivree , is intended to treat obesity caused by certain genetic disorders. Keep in mind that weight loss medications are not suitable for everyone, including people who are pregnant, those with certain health conditions, or individuals taking specific medications.

A healthcare professional can provide guidance on whether you might be a candidate for a prescription, depending on your personal goals, medical history, and health status. Contact a trusted healthcare professional, like your OB-GYN, before taking any weight loss medications or supplements.

Some digital weight loss platforms, including Ro and Calibrate, include GLP-1 medications in their treatment plans for people who meet certain eligibility criteria. You can read our comprehensive reviews of Calibrate and Ro Health to learn more.

Studies also suggest that people with higher body weights are disproportionately more likely to experience disordered eating and eating disorder symptoms. These behaviors may indicate a disordered relationship with food or an ED.

Disordered eating and EDs can affect anyone, regardless of gender identity, race, age, body size, socioeconomic status, or other identities. They can be caused by any combination of biological, social, cultural, and environmental factors — not just by exposure to diet culture.

GLP-1 agonists are currently the most effective anti-obesity medications and are considered safe for long-term use. Currently, only liraglutide Saxenda , semaglutide Wegovy , and tirzepatide Zepbound are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label.

Still, keep in mind that individual results can vary based on many factors, including your diet, health status, and activity level. In addition to maximizing your potential results, it can increase the likelihood of maintaining weight loss in the long term.

If considered medically necessary, insurance companies may cover certain prescription weight loss medications. Some manufacturers also offer savings cards, which can help lower your copay. Ozempic and Wegovy are two different brands of the same drug, semaglutide.

However, there are differences in the recommended dosage and how each is administered. Additionally, Wegovy is FDA approved for weight management. Saxenda liraglutide , Wegovy semaglutide , and tirzepatide Zepbound are three GLP-1 medications recently approved for weight loss. Other GLP-1 medications, such as Ozempic semaglutide , are also sometimes prescribed off-label for weight management.

Prescription medications have strong evidence to support their effectiveness for meaningful weight loss. Additionally, though they can promote weight loss and may even offer other health benefits, note that these medications are not suitable for everyone and can lead to weight regain once you stop taking them.

A doctor or other trusted healthcare professional can help you determine which is right for you and how to incorporate it into a healthy weight management plan.

Obesity is a chronic condition, and medications are just one part of a treatment plan to help achieve and maintain weight loss. Instead, they should be used only as directed and paired with a balanced diet, healthy lifestyle, and regular physical activity for best results. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

VIEW ALL HISTORY. This article tells you all you need to know about GLP-1 agonists like Wegovy, including whether they are safe and effective for weight loss.

Alli diet pills are the over-the-counter version of a weight loss drug called orlistat. This article looks at whether they are actually worth taking….

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We include products wdight think Lentil recipes useful Organic weight loss pills our readers. If Lice treatment spray buy through links on this page, we may earn a Orgaic Organic weight loss pills. Healthline Organic weight loss pills weigth you brands and wsight that we stand lpss. Prescription weight loss pllls, including GLP-1 agonists, orlistat, and setmelanotide, may be effective for some people. But other lifestyle changes are still necessary for long-term success. When paired with other lifestyle changes and taken under the supervision of a healthcare professional, these drugs may offer an effective way to lower your weight. We reviewed all of the weight loss medications that are currently available, including how they work, who they might be appropriate for, research on their effectiveness, and potential safety concerns.