Zhang YK, Wu KC, Klaassen CD Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. PLoS One 8:e Download references. This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, Grant No.

Department of Molecular Biology, Institute for Biological Research Siniša Stanković, University of Belgrade, Belgrade, Serbia. You can also search for this author in PubMed Google Scholar.

Correspondence to Aleksandra Uskoković. Reprints and permissions. Uskoković, A. Liver Diseases: Epigenetic Mechanisms, Oxidative Stress and Use of Alpha-Lipoic Acid. In: Patel, V. eds Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham.

Received : 11 September Accepted : 11 September Published : 14 October Publisher Name : Springer, Cham. Print ISBN : Online ISBN : eBook Packages : Springer Reference Medicine Reference Module Medicine.

Policies and ethics. Skip to main content. Abstract The liver is the central organ for lipid and glucose metabolism. Keywords Nonalcoholic fatty liver disease Steatosis Fibrosis Alpha-lipoic acid Drug toxicity Reactive oxygen species Oxidative stress Antioxidant enzymes DNA methylation Sirtuins.

Abbreviations α-SMA: α-smooth muscle actin ALT: Alanine aminotransferase AMPK: AMP-activated protein kinase ARE: Antioxidant response element AST: Aspartate aminotransferase CAT: Catalase CBP: CREB binding protein DHLA: Dihydrolipoic acid FoxO: Forkhead box O Foxo3a: Forkhead transcription factor 3a GCL: γ-Glutamylcysteine ligase GCLC: Catalytic subunit of GCL GCLM: Modulatory subunit of GCL GPx: Glutathione peroxidase GSH: Glutathione GSSG: Oxidized glutathione HAT: Histone acetyl transferases HDAC: Histone deacetylases 4HNE: 4-hydroxynonenal HSC: Hepatic stellate cells LA: Alpha-lipoic acid miRNA: microRNA MDA: Malondialdehyde MMP Matrix metalloproteinase-2 NAFLD: Nonalcoholic fatty liver disease Nrf2: Nuclear factor erythroid 2-related factor 2 ROS: Reactive oxygen species SAM: S-adenosyl methionine SIRT1: Sirtuin 1 SOD: Superoxide dismutase SREBP Sterol regulatory element-binding protein 1 TGF-β1: Transforming growth factor-β1.

References Ali SO, Darwish HA, Ismail NA Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. Chem Biol Interact —33 Article CAS PubMed Google Scholar Bandiera S, Pfeffer S, Baumert TF et al miR — a key factor and therapeutic target in liver disease.

J Hepatol — Article CAS PubMed Google Scholar Bbosa GS, Kitya D, Odda J et al Aflatoxins metabolism, effects on epigenetic mechanisms and their role in carcinogenesis. Health —34 Article Google Scholar Bedogni G, Miglioli L, Masutti F et al Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study.

Hepatology —52 Article PubMed Google Scholar Bernal W, Wendon J Acute liver failure. N Engl J Med — Article CAS PubMed Google Scholar Bosch-Presegué L, Vaquero A Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity.

FEBS J — Article PubMed Google Scholar Bustamante J, Lodge JK, Marcocci L et al Alpha-lipoic acid in liver metabolism and disease. Free Radic Biol Med — Article CAS PubMed Google Scholar Chalasani N, Gorski JC, Asghar MS et al Hepatic cytochrome P 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis.

Hepatology — Article CAS PubMed Google Scholar Chen WL, Kang CH, Wang SG et al α-lipoic acid regulates lipid metabolism through induction of sirtuin 1 SIRT1 and activation of AMP-activated protein kinase. Diabetologia — Article CAS PubMed Google Scholar Cyr AR, Domann FE The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Antioxid Redox Signal — Article CAS PubMed PubMed Central Google Scholar Dinić S, Arambašić J, Mihailović M et al Decreased O -GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver.

Br J Nutr — Article PubMed Google Scholar Duvnjak M, Lerotic I, Barsic N et al Pathogenesis and management issues for non-alcoholicfatty liver disease.

World J Gastroenterol — Article CAS PubMed PubMed Central Google Scholar Förstermann U Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med — Article PubMed Google Scholar Frye RA Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.

Biochem Biophys Res Commun — Article CAS PubMed Google Scholar Gao Z, Zhang J, Kheterpal I et al Sirtuin 1 SIRT1 protein degradation in response to persistent c-Jun N-terminal kinase 1 JNK1 activation contributes to hepatic steatosis in obesity.

J Biol Chem — Article CAS PubMed PubMed Central Google Scholar García-Monzón C, Martín-Pérez E, Iacono OL et al Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated obesity.

J Hepatol — Article PubMed Google Scholar Hijona E, Hijona L, Arenas JI et al Inflammatory mediators of hepatic steatosis.

PLoS One 7:e Article CAS PubMed PubMed Central Google Scholar Li S, Tan HY, Wang N et al The role of oxidative stress and antioxidants in liver diseases. BBA-Mol Cell Res — CAS Google Scholar Ma Q, Li Y, Fan Y et al Molecular mechanisms of lipoic acid protection against aflatoxin B1-induced liver oxidative damage and inflammatory responses in broilers.

Toxins — Article CAS PubMed PubMed Central Google Scholar Malhi H, Gores GJ Cellular and molecular mechanisms of liver injury. Gastroenterology — Article CAS PubMed PubMed Central Google Scholar Mansour DF, El-Denshary ES, Bahgat AK et al Hepatoprotective effect of alpha lipoic acid against Bromobenzene-induced liver damage in rats.

Med J Cairo Univ —30 Google Scholar Mohamed J, Nafizah AHN, Zariyantey AH et al Mechanisms of diabetes-induced liver damage: the role of oxidative stress and inflammation. Sultan Qaboos Univ Med J — Article Google Scholar Monastra G, De Grazia S, Micili SC et al Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage.

J Appl Toxicol —26 Article CAS PubMed Google Scholar Parker GJ, Lund KC, Taylor RP et al Insulin resistance of glycogen synthase mediated by O -linked N -acetylglucosamine. J Biol Chem — Article CAS PubMed Google Scholar Paschos P, Paletas K Non alcoholic fatty liver disease and metabolic syndrome.

Hippokratia —19 CAS PubMed PubMed Central Google Scholar Purushotham A, Schug TT, Xu Q et al Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

Cell Metab — Article CAS PubMed PubMed Central Google Scholar Ryu SH, Park EY, Kwak S et al Protective effect of α-lipoic acid against radiation-induced fibrosis in mice.

Oncotarget — Article PubMed PubMed Central Google Scholar Sadi G, Yılmaz Ö, Güray T Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of cu—Zn SOD and catalase.

Mol Cell Biochem — Article CAS PubMed Google Scholar Shay KP, Moreau RF, Smith EJ et al Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta — Article CAS PubMed PubMed Central Google Scholar Shukla SD, Lim RW Epigenetic effects of ethanol on the liver and gastrointestinal system.

Alcohol Res —55 PubMed PubMed Central Google Scholar Singh U, Jialal I Alpha-lipoic acid supplementation and diabetes. Nutr Rev — Article PubMed PubMed Central Google Scholar Slepneva IA, Sergeeva SV, Khramtsov VV Reversible inhibition of NADPH-cytochrome P reductase by alpha-lipoic acid.

Biochem Biophys Res Commun — Article CAS PubMed Google Scholar Suh JH, Shenvi SV, Dixon BM et al Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.

Proc Natl Acad Sci USA — Article CAS PubMed PubMed Central Google Scholar Tang W, Jiang YF, Ponnusamy M et al Role of Nrf2 in chronic liver disease.

World J Gastroenterol — Article CAS PubMed PubMed Central Google Scholar Valdecantos MP, Pérez-Matute P, González-Muniesa P et al Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.

Obesity Silver Spring — Article CAS Google Scholar Viollet B, Guigas B, Leclerc J et al AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.

Acta Physiol Oxf —98 Article CAS Google Scholar Webster BR, Lu Z, Sack MN et al The role of sirtuins in modulating redox stressors. Free Radic Biol Med — Article CAS PubMed Google Scholar Wolff SP Diabetes mellitus and free radicals. Therapies can be given at different times and different dosages depending on medical history.

We also use other treatments such as IV NAD in addiction and detox from drugs and alcohol. We also use Nutrition and Diet plans, Natural Therapies, and Supplements. We recommend each of these therapies, including the IV ones, based on specific history and goals.

These treatments are a safe and effective method for detoxing the liver. Glutathione aids in the detoxification process. This detoxifier neutralizes metabolic wastes, prescription drugs, and other toxins and carcinogens.

Additionally, it also plays a vital role in DNA repair and the immune response. Glutathione depletion is also associated with various diseases and signs of aging. These supplements though may have little or no effect on the glutathione levels within the body due to poor absorption.

With IV Glutathione therapy, a high dose of glutathione quickly enters your bloodstream. This immediately floods your liver with essential detoxifying antioxidants. Specific nutrients improve wide-spread glutathione status.

Some conditions though call for more intense doses, and this is achieved by administering it intravenously.

Intravenous Glutathione bypasses the digestive tract for effective delivery to the target tissues. Glutathione has been called the mother of all anti-oxidants.

Known for having excellent detoxifying effects and health benefits. Alpha Lipoic Acid does all sorts of great things for the body and has been known to be a miraculous potent antioxidant supplement. It is found in the body and within every cell. It can neutralize toxins and protect against any DNA damage.

ALA helps with the treatment of liver damage, diabetes, cancer, and other diseases. Alpha Lipoic Acid can be used as an oral supplement or taken intravenously. It is believed that Alpha Lipoic Acid administered intravenously will assist in the detox of the liver and its regeneration.

ALA is useful in the treatment of a variety of liver diseases. Where it has shown to decrease the amount of hepatic fibrosis associated with liver injury. It has demonstrated to trap harmful free radicals, chelate toxic heavy metals, and help in mutations in gene expression. Alpha-Lipoic acid also enhances the effects of other essential antioxidants, including glutathione.

IV NAD or Nicotinamide Adenine Dinucleotide has significant detoxifying effects. It has been used to detoxify patients who suffer from addiction. IV NAD is useful to detoxify the body from many substances such as. NAD is thought to play an essential role in the therapeutic process of the brain.

It has also been helpful in the treatment of depression, anxiety, and PTSD. Patients who have been detoxed with NAD state that they have much fewer cravings and withdrawal symptoms. Vitamin C has long been known for its antioxidant properties and its role in trapping free radicals and detoxifying the body.

IV Vitamin C can be given in higher dosages to cleanse the body and the liver and at the same time provide an immune boost to the body. IV Myers cocktail has been around for many years. It encompasses many of the significant vitamins such as vitamin C, B complex, magnesium, calcium, phosphate, and more.

Many patients add glutathione to their Myers cocktail, and it is often used in vitamin infusions that to clean the body.

IV Chelation therapy is useful in removing heavy metals from the body. It has been around for many years. Chelation therapy using EDTA extracts and detoxify the body.

Removing heavy metals such as lead, mercury too much consumption of sushi and fish , copper, iron, aluminum, arsenic, and more. Our doctors will review your medical history in great detail and depth. While making recommendations based on your specific conditions, lifestyle, and medications.

Certain vitamins, minerals, and essential trace elements play a vital role in liver detoxification. Our physicians and nutritionists will create custom menus for you.

Helping ensure that you are receiving the proper supplements and dietary needs. All these play a vital role in the metabolism of carbohydrates, fats, and functioning of the nervous and GI systems. We provide intramuscular injection and intravenous therapy of all these B complex vitamins.

Other treatments offered for liver detox cleanse include high dose intravenous vitamin c. As well as intramuscular injection of Coenzyme Q Did you know the liver manages thousands of enzymes and produces thousands of necessary chemicals and hormones?

Important hormones such as estrogen for women, testosterone for men, and cholesterol. Plus, it aids in regulating blood sugar levels to help the body avoid dangerously high and low blood sugar.

It also contributes to the production of blood proteins and red blood cells, as well as storing essential vitamins and minerals. When the livers overloaded with too many medications, processed foods, alcohol, and other toxins, it finds another to rid this waste.

When this happens, balls of fat start collecting on the liver. Resulting in grease spilling right into your bloodstream, causing triglycerides. Not only can an overloaded liver form fat on the liver and fat spill into the bloodstream, but the liver may move toxins to other areas of the body.

A poorly functioning liver has been linked to high blood pressure and chronic fatigue. Our office provides a variety of liver detox cleanse, body detox, and liver detox treatment options.

Your liver is a vital organ in maintaining a healthy body. You can keep your liver healthy by having a liver detox performed. As mentioned above, foods such as spinach, broccoli, and potatoes not fried, of course are good sources of Alpha-Lipoic Acid.

We also recommend beets, Brussels sprouts, carrots, tomatoes, yams, and yeast. Supplements can provide additional support during occasional liver detoxes. It was designed to work synergistically with other natural ingredients to be easily absorbed and processed by the body.

By Product Thrine Kasvi Isle Encarna. Your cart is empty. Alpha-Lipoic Acid and liver detoxification Non-alcoholic fatty liver disease NAFLD is considered the most common cause of chronic liver disease in the United States today.

We also use Nutrition and Diet plans, Natural Therapies, and Supplements. We recommend each of these therapies, including the IV ones, based on specific history and goals.

These treatments are a safe and effective method for detoxing the liver. Glutathione aids in the detoxification process. This detoxifier neutralizes metabolic wastes, prescription drugs, and other toxins and carcinogens.

Additionally, it also plays a vital role in DNA repair and the immune response. Glutathione depletion is also associated with various diseases and signs of aging.

These supplements though may have little or no effect on the glutathione levels within the body due to poor absorption. With IV Glutathione therapy, a high dose of glutathione quickly enters your bloodstream. This immediately floods your liver with essential detoxifying antioxidants.

Specific nutrients improve wide-spread glutathione status. Some conditions though call for more intense doses, and this is achieved by administering it intravenously.

Intravenous Glutathione bypasses the digestive tract for effective delivery to the target tissues. Glutathione has been called the mother of all anti-oxidants.

Known for having excellent detoxifying effects and health benefits. Alpha Lipoic Acid does all sorts of great things for the body and has been known to be a miraculous potent antioxidant supplement.

It is found in the body and within every cell. It can neutralize toxins and protect against any DNA damage. ALA helps with the treatment of liver damage, diabetes, cancer, and other diseases. Alpha Lipoic Acid can be used as an oral supplement or taken intravenously.

It is believed that Alpha Lipoic Acid administered intravenously will assist in the detox of the liver and its regeneration. ALA is useful in the treatment of a variety of liver diseases. Where it has shown to decrease the amount of hepatic fibrosis associated with liver injury.

It has demonstrated to trap harmful free radicals, chelate toxic heavy metals, and help in mutations in gene expression. Alpha-Lipoic acid also enhances the effects of other essential antioxidants, including glutathione.

IV NAD or Nicotinamide Adenine Dinucleotide has significant detoxifying effects. It has been used to detoxify patients who suffer from addiction. IV NAD is useful to detoxify the body from many substances such as.

NAD is thought to play an essential role in the therapeutic process of the brain. It has also been helpful in the treatment of depression, anxiety, and PTSD.

Patients who have been detoxed with NAD state that they have much fewer cravings and withdrawal symptoms. Vitamin C has long been known for its antioxidant properties and its role in trapping free radicals and detoxifying the body.

IV Vitamin C can be given in higher dosages to cleanse the body and the liver and at the same time provide an immune boost to the body. IV Myers cocktail has been around for many years. It encompasses many of the significant vitamins such as vitamin C, B complex, magnesium, calcium, phosphate, and more.

Many patients add glutathione to their Myers cocktail, and it is often used in vitamin infusions that to clean the body. IV Chelation therapy is useful in removing heavy metals from the body.

It has been around for many years. Chelation therapy using EDTA extracts and detoxify the body. Removing heavy metals such as lead, mercury too much consumption of sushi and fish , copper, iron, aluminum, arsenic, and more.

Our doctors will review your medical history in great detail and depth. While making recommendations based on your specific conditions, lifestyle, and medications. Certain vitamins, minerals, and essential trace elements play a vital role in liver detoxification.

Our physicians and nutritionists will create custom menus for you. Helping ensure that you are receiving the proper supplements and dietary needs.

All these play a vital role in the metabolism of carbohydrates, fats, and functioning of the nervous and GI systems. We provide intramuscular injection and intravenous therapy of all these B complex vitamins. Other treatments offered for liver detox cleanse include high dose intravenous vitamin c.

As well as intramuscular injection of Coenzyme Q Did you know the liver manages thousands of enzymes and produces thousands of necessary chemicals and hormones?

Important hormones such as estrogen for women, testosterone for men, and cholesterol. Plus, it aids in regulating blood sugar levels to help the body avoid dangerously high and low blood sugar. It also contributes to the production of blood proteins and red blood cells, as well as storing essential vitamins and minerals.

When the livers overloaded with too many medications, processed foods, alcohol, and other toxins, it finds another to rid this waste.

When this happens, balls of fat start collecting on the liver. Resulting in grease spilling right into your bloodstream, causing triglycerides.

Not only can an overloaded liver form fat on the liver and fat spill into the bloodstream, but the liver may move toxins to other areas of the body. A poorly functioning liver has been linked to high blood pressure and chronic fatigue. Our office provides a variety of liver detox cleanse, body detox, and liver detox treatment options.

Your liver is a vital organ in maintaining a healthy body. You can keep your liver healthy by having a liver detox performed. It is a simple process and well worth it in the end.

The best therapies are effective methods to help improve your liver function. For more information, please give us a call at Our team will set up an appointment to meet with one of our doctors in our Beverly Hills office for a consultation.

As Featured on Extra TV. Nazarian practices Integrative Medicine with focus on preventative medicine, anti-aging, hormone replacement therapy and IV Vitamin optimizations. David Nazarian, received his bachelor of sciences from the University of Los Angeles, California in Psychology and Biology.

He obtained his Medical Doctorate degree from Sackler School of Medicine. He completed his medical residency at Huntington Memorial Hospital, a University of Southern California affiliate hospital.

Once completed, he established a practice in the heart of Beverly Hills. Nazarian is a Diplomat of the American Board of Internal Medicine. He has received numerous awards and recognition as a top doctor in his field. Skip to content. Monday — Friday 9 AM — PM info myconciergemd. CALL US NOW Liver Detox Cleanse.

Book Appointment. We use a variety of IV, or Intravenous cleanse protocols using IV Glutathione therapy IV Vitamin C IV Myers Cocktail IV NAD IV Alpha Lipoic Acid ALA IV hydration IV Vitamin Therapy Chelation Natural supplements and more.

Therapies used in Liver Detox Cleanse There are many different therapies available to use in detoxing the liver. IV Alpha Lipoic Acid ALA Alpha Lipoic Acid does all sorts of great things for the body and has been known to be a miraculous potent antioxidant supplement. IV NAD IV NAD or Nicotinamide Adenine Dinucleotide has significant detoxifying effects.

IV NAD is useful to detoxify the body from many substances such as Opioids Alcohol Benzodiazepines such as Xanax or valium Stimulants such as Adderall or Ritalin And other addictive substances NAD is thought to play an essential role in the therapeutic process of the brain. IV Vitamin C Vitamin C has long been known for its antioxidant properties and its role in trapping free radicals and detoxifying the body.

IV Vitamin C can be given in higher dosages to cleanse the body and the liver and at the same time provide an immune boost to the body IV Myers cocktail IV Myers cocktail has been around for many years.

Chelation therapy IV Chelation therapy is useful in removing heavy metals from the body. Natural Therapies Our doctors will review your medical history in great detail and depth.

As Seen On. Supplements for Liver Detox B complex vitamins include: Vitamin B1 or thiamine B2 or Riboflavin B3 or Niacin B5 or Panthothenic Acid B6, or Pyridoxine B12 or Cyanocobalamin All these play a vital role in the metabolism of carbohydrates, fats, and functioning of the nervous and GI systems.

Did you know liver manages Did you know the liver manages thousands of enzymes and produces thousands of necessary chemicals and hormones? Author: David Nazarian, M. Name Required First Last. Phone Required. Email Required. Street Address Address Line 2 City State Alabama Alaska American Samoa Arizona Arkansas California Colorado Connecticut Delaware District of Columbia Florida Georgia Guam Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Northern Mariana Islands Ohio Oklahoma Oregon Pennsylvania Puerto Rico Rhode Island South Carolina South Dakota Tennessee Texas Utah U.

Pharmacy Transfer RX SyncRX Refill Prescription Program Prescribers Compounding PGx Testing Podiatry Compounds Low-Dose Naltrexone Dispill® Multi-Dose Pill Packaging E. Discount Program. Liver -G. Detox vegcaps. Detox vegcaps quantity. Share Share on Facebook Share on Twitter Share on LinkedIn Share via email.

Supplement Facts. Serving Size: 2 Capsule. Amount Per Serving. Alpha lipoic acid thioctic acid mg. N-acetyl-l-cysteine free-form mg. Broccoli Brassica oleracea italica sprout concentrate whole plant standardized to contain a minimum of mcg sulforaphane mg.

Artichoke Cynara scolymus l. extract leaf mg. Taurine free-from mg. Glycine free-form mg. L-glutamine free-form mg. L-methionine free-form mg. Chlorella Chollera spp.

Glutathione also supports a healthy defense against hepatotoxic environmental pollutants, gamma-radiation,. Alpha-Lipoic Acid Sometimes referred to as thioctic acid, alpha-lipoic acid is both water- and fat-soluble. supports glutathione, helps regenerate antioxidant vitamins C and E, helps maintain the ratio of reduced to.

oxidized CoQ10 in the mitochondria, and helps support healthy levels of nitric oxide in the liver and kidney. Milk Thistle Seed Extract Silymarin, the active component in milk thistle, has a history of use in promoting.

liver health. Like alpha-lipoic acid, silymarin supports production of cellular glutathione. Its actions in the liver. include maintaining normal levels of fat peroxidation and fibrous tissue formation; supporting a healthy immune.

response and the natural response to inflammation; and promoting protein synthesis and normal regeneration. of liver tissue. Selenium as selenomethionine An important coenzyme for the glutathione peroxidase detoxification system,.

selenium also appears to support the endogenous antioxidant defenses of hepatocytes by upregulating their. manganese superoxide dismutase MnSOD expression. At the same time, selenium appears to support healthy. The combined actions of curcumin and silymarin include enhancing phase II detoxification enzymes, supporting glutathione….

orders palmharborpharmacy. Follow us on linkedin Follow us on facebook Follow us on instagram. Pharmacy Transfer RX SyncRX Refill Prescription Program Prescribers Compounding PGx Testing Podiatry Compounds Low-Dose Naltrexone Dispill® Multi-Dose Pill Packaging E.

Discount Program. Liver -G. Detox vegcaps. Detox vegcaps quantity. Share Share on Facebook Share on Twitter Share on LinkedIn Share via email.

Supplement Facts. Serving Size: 2 Capsule. Amount Per Serving. Pari L, Murugavel P Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.

J Appl Toxicol — Parker GJ, Lund KC, Taylor RP et al Insulin resistance of glycogen synthase mediated by O -linked N -acetylglucosamine. Paschos P, Paletas K Non alcoholic fatty liver disease and metabolic syndrome. Hippokratia — CAS PubMed PubMed Central Google Scholar.

Purushotham A, Schug TT, Xu Q et al Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

Cell Metab — Ryu SH, Park EY, Kwak S et al Protective effect of α-lipoic acid against radiation-induced fibrosis in mice. Oncotarget — Article PubMed PubMed Central Google Scholar.

Sadi G, Yılmaz Ö, Güray T Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of cu—Zn SOD and catalase.

Mol Cell Biochem — Shay KP, Moreau RF, Smith EJ et al Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta — Shukla SD, Lim RW Epigenetic effects of ethanol on the liver and gastrointestinal system.

Alcohol Res — PubMed PubMed Central Google Scholar. Singh U, Jialal I Alpha-lipoic acid supplementation and diabetes. Nutr Rev — Slepneva IA, Sergeeva SV, Khramtsov VV Reversible inhibition of NADPH-cytochrome P reductase by alpha-lipoic acid.

Suh JH, Shenvi SV, Dixon BM et al Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA — Tang W, Jiang YF, Ponnusamy M et al Role of Nrf2 in chronic liver disease.

Valdecantos MP, Pérez-Matute P, González-Muniesa P et al Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Obesity Silver Spring — Article CAS Google Scholar.

Viollet B, Guigas B, Leclerc J et al AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol Oxf — Webster BR, Lu Z, Sack MN et al The role of sirtuins in modulating redox stressors. Wolff SP Diabetes mellitus and free radicals.

Free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br Med Bull — Xu DP, Wells WW Alpha-lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria.

J Bioenerg Biomembr — Xu Z, Chen L, Leung L et al Liver-specific in activation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia.

Xu R, Zhang Z, Wang FS Liver fibrosis: mechanisms of immune-mediated liver injury. Cell Mol Immunol — Yang X, Su K, Roos MD et al O-linkage of Nacetylglucosamine to Sp1 activation domain inhibits its transcriptional capability.

J Nutr Biochem — Zeybel M, Mann DA, Mann J Epigenetic modifications as new targets for liver disease therapies. Zeybel M, Hardy T, Robinson SM et al Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease.

Clin Epigenetics Zhang YK, Wu KC, Klaassen CD Genetic activation of Nrf2 protects against fasting-induced oxidative stress in livers of mice. PLoS One 8:e Download references.

This work was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, Grant No. Department of Molecular Biology, Institute for Biological Research Siniša Stanković, University of Belgrade, Belgrade, Serbia.

You can also search for this author in PubMed Google Scholar. Correspondence to Aleksandra Uskoković. Reprints and permissions. Uskoković, A. Liver Diseases: Epigenetic Mechanisms, Oxidative Stress and Use of Alpha-Lipoic Acid. In: Patel, V.

eds Handbook of Nutrition, Diet, and Epigenetics. Springer, Cham. Received : 11 September Accepted : 11 September Published : 14 October Publisher Name : Springer, Cham. Print ISBN : Online ISBN : eBook Packages : Springer Reference Medicine Reference Module Medicine.