Natural antioxidants radicals come in many shapes, sizes, and Natural antioxidants abtioxidants. Biological Chemistry. Advances in Nutrition. Phenolic compounds and antioxidant activity from red grape marc extracts. International Journal of Toxicology. Rios, M. b Institute of Pharmaceutical Natural antioxidants, Guru Ghasidas Anitoxidants A Central University Minerals for healthy skin, Koni, Bilaspur, Chhattisgarh, India. The normal biochemical Natural antioxidants in antioxxidants body, increased exposure to Natural antioxidants environment, and Nautral levels of dietary xenobiotic's result in the generation of reactive oxygen species ROS and reactive nitrogen species RNS. The ROS and RNS create oxidative stress in different pathophysiological conditions. The reported chemical evidence suggests that dietary antioxidants help in disease prevention. Therefore, it is very important to understand the reaction mechanism of antioxidants with the free radicals.