Natural compounds for disease management -
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Int J Mol Sci 19, Tilvi, S. New bromotyrosine alkaloids from the marine sponge Psammaplysilla purpurea. Tetrahedron 60, — Torrent, J. For each natural product NP , the detailed descriptions on its general information were provided in NPCDR. As illustrated in Figure 4 , the descriptions included NP name, NP synonyms, species origin s , applied disease indication s , 3D and 2D molecular structures in various formats MOL and PNG, both could be directly downloaded , and other molecular information associated with the external links to: PubChem 55 , TTD 43 , HERB 27 , ETMC 31 , SymMap 28 , TCMSP 74 , and so on.
Under each therapeutic effect, the regulated molecules and pathways, in-vivo and in-vitro models, together with the results of experimental validations were demonstrated illustrated in Figure 4. Based on the information provided on the NP page of NPCDR, the users could readily retrieve a list of drugs whose therapeutic effects were improved by this particular NP.
The natural product NP page of this database. The general information upper orange panel and the combinatorial therapeutic effects of this NP lower blue panel were provided in NPCDR.
These accompanied drugs were grouped based on three types of combinatorial effects of NP: a a list of drugs whose efficacy can be enhanced by this NP, b a list of drugs whose adverse effects can be decreased by this NP and c a list of drugs whose resistance can be reversed by this NP.
Similar to the NP page, the drug page of NPCDR also provided the general information of certain drug. Such general information included drug name, drug synonyms, molecular type, the applied disease indication s , 3D and 2D drug structures in various formats MOL and PNG, both formats were directly downloadable , and other molecular information associated with the external links to ChEBI 75 , GDSC 76 , DrugBank 42 , TTD 43 and PubChem In the meantime, the combinatorial therapeutic effects of a drug on a list of NPs that were clinically or experimentally validated, were described.
These accompanied NPs were grouped by three combinatorial effects of a drug: a a list of NPs capable of enhancing the efficacy of this drug, b a list of NPs capable of decreasing the adverse reactions of this drug and c a list of NPs able to reverse the resistance of this drug.
Based on the information provided on the NPCDR drug page, the audiences could readily retrieve a list of natural products that were capable of improving the therapeutic effects enhancing drug efficacy, decreasing adverse drug reactions, or reversing drug resistance of the corresponding drug described on that particular drug page.
To make the access and analysis of NPCDR data convenient to all readers, the collected raw data were carefully cleaned up and then systematically standardized. These standardizations included: a all NPCDR diseases were standardized using the latest version of International Classification of Disease that was officially released by the World Health Organization 65 ; b all NPs, drugs, proteins, RNAs, pathways, cell lines, species and disease indications in this database were fully cross-linked to a number of well-established databases UniProt 52 , BRENDA 57 , TTD 53 , Pfam 60 , KEGG 54 , VARIDT 56 , NCBI Gene 55 , Cellosaurus 61 , TCDB 59 , INTEDE 58 , miRbase 62 , etc.
These databases could also help to discover the detailed information for each molecule in this database. Moreover, disease-specific molecular regulation data could help to clarify the elusive biological process underlying each combination, and inspire new therapeutic potential of the combinations in other disease indications.
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As coronavirus disease COVID threatens compiunds health globally, infectious disorders have become one of the most challenging problem for the medical community. Natural products NP have been Hypertension herbal remedies xompounds source of compojnds agents with widely divergent structures and Dextrose Muscle Glycogen Hydration for mental focus Natural compounds for disease management ccompounds activities. A dataset comprising articles, including Boost career prospects compounds Compouds species of natural sources with biological activities against 21 infectious pathogens from five categories, was assembled through manual selection of published articles. These data were used to identify NP-based compounds classified into ten groups, which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D, dicumarol, dihydroartemisinin and pyridomycin. The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity, whereas the chemistries inhibiting bacteria, fungi, and viruses showed more structural diversity. A total of species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources. Natural products constitute an important source of disese for Natural compounds for disease management development. Fat burning blends, despite numerous reports of Dextrose Muscle Glycogen and active extracts from biodiversity, Hypertension herbal remedies and developing countries continue to suffer mannagement endemic compounnds caused compoundx arboviral vectors, including dengue, Zika, ckmpounds and urban yellow fever. Vector control remains the most efficient disease prevention strategy. Wide and prolonged use of insecticides has resulted in vector resistance, making the search for new chemical prototypes imperative. Considering the potential of natural products chemistry for developing natural products-based products, including insecticides, this contribution discusses the general aspects and specific characteristics involved in the development of drug leads for vector control. Throughout this work, we highlight the obstacles that need to be overcome in order for natural products compounds to be considered promising prototypes.
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