After the electric shock funtion Alpha-lipoic acid and cognitive function, the rat stayed in the ffunction room for f 5 s, Weight gain resources aciv was put back into the breeding cage before taking records. Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis. Purchase access. About Contact Help Cookie Policy Privacy Policy. C-YK, J-HX, YL, JW, W-CH, and S-CS conducted kinds of literature searches and data analyses and writing drafts of the manuscript.

Alpha-lipoic acid and cognitive function -

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November ALA May Impact Cognitive Function in People With Alzheimer's and Diabetes Alpha-lipoic acid ALA may have a positive impact on cognitive function, according to a study. References Fava A, Pirritano D, Plastino M, et al.

The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease. Journal of Neurodegenerative Diseases. Â www. Journal home All issues About the journal.

Improvement of Cognitive Function by α-lipoic Acid, Ginkgo biloba Extract and L-carnitine Supplementation. Takatomo TERADA , Masaya NAKASHIMA , Kouji YAMASAKI , Takako HANANO , Tetsumori YAMASHIMA Author information.

Takatomo TERADA Shiseido Co. Tetsumori YAMASHIMA Department of Restorative Neurosurgery, Graduate School of Medical Science, Kanazawa University. Corresponding author. Keywords: α-lipoic acid , Ginkgo biloba extract , L-carnitine , cognitive function , RBANS.

JOURNAL FREE ACCESS. Published: Received: - Available on J-STAGE: July 09, Accepted: February 19, Advance online publication: - Revised: -. Download PDF K Download citation RIS compatible with EndNote, Reference Manager, ProCite, RefWorks. Article overview.

D The number of crossings over the original target platform on the testing day day 5. On probe testing day, WT mice in the surgery group crossed the target quadrant fewer times 0. Treatment with ALA increased the time spent in the platform quadrant However, the crossing number 0.

Western blotting was used to assess the expression levels of cognitive function-associated proteins Cdk5 and Aβ and the phosphorylation levels of tau. A Representative images of western blotting for the analysis of p-tau, t-tau, Cdk5, Aβ and β-actin protein expression.

B Quantitative analysis of p-tau protein expression relative to β-actin. C Quantitative analysis of t-tau protein expression relative to β-actin. D Quantitative analysis of p-tau to t-tau protein expression ratio. E Quantitative analysis of Cdk5 protein expression relative to β-actin.

F Quantitative analysis of Aβ protein expression relative to β-actin. The ultrastructure of the CA3 hippocampal region was analyzed using transmission electron microscopy Fig.

The images revealed that among the WT mice, surgery Fig. Administration of ALA after surgery Fig. Ultrastructure of neurons and synapses in the hippocampus.

A previous study reported that ALA can increase the level of leptin in serum through the regulation of Cdk5. Cdk5 serves an important role in neuron differentiation and synaptic plasticity by phosphorylating cytoskeleton proteins and signaling pathway molecules Downregulation of CDK5 has been demonstrated to mitigate hippocampal degeneration and cognitive dysfunction ALA rescued the cognitive function of WT mice after surgery, as revealed by the results of the MWM learning and test.

The ultrastructure of neurons and synapses in the hippocampus was observed in mice following surgery and treatment with ALA. These results suggested that the improvement in cognitive function following administration of ALA may be associated with reduced protein expression levels of Cdk5 and Aβ, and the phosphorylation level of tau.

Furthermore, treatment with ALA enabled maintenance of the normal structure of hippocampal neurons and synapses. ALA may regulate the expression of leptin or regulate the biding to leptin receptor to alter the expression levels of Cdk5 and Aβ, and the phosphorylation level of tau to maintain the normal structure of hippocampal neurons and synapses.

Future studies should investigate the effect of ALA on the leptin signaling pathway and cognitive function in WT mice with hepatectomy. The current study was supported by grants from the National Natural Science Foundation grant no.

All data generated or analyzed during this study are available from the corresponding author on reasonable request. YZ, HGB conceived the study design. YZ and YLL performed the experiments.

YNS, JWZ and YNQ participated in the data analysis and interpretation. Krenk L and Rasmussen LS: Postoperative delirium and postoperative cognitive dysfunction in the elderly-what are the differences? Minerva Anestesiol. Hovens IB, Schoemaker RG, van der Zee EA, Absalom AR, Heineman E and van Leeuwen BL: Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning.

Brain Behav Immun. Mézière A, Paillaud E and Plaud B: Anesthesia in the elderly. Presse Med. In French. Miyoshi E, Wietzikoski EC, Bortolanza M, Boschen SL, Canteras NS, Izquierdo I and Da Cunha C: Both the dorsal hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze.

Behav Brain Res. Sawamura S: Postoperative care of the elderly. Nihon Rinsho. In Japanese. Wuri G, Wang DX, Zhou Y and Zhu SN: Effects of surgical stress on long-term memory function in mice of different ages.

Acta Anaesthesiol Scand. Xie Z and Tanzi RE: Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol. Hovens IB, Schoemaker RG, van der Zee EA, Heineman E, Nyakas C and van Leeuwen BL: Surgery-induced behavioral changes in aged rats.

Gustafson DR: Adiposity and cognitive decline: Underlying mechanisms. J Alzheimers Dis. PLoS One. Kandeil MA, Amin KA, Hassanin KA, Ali KM and Mohammed ET: Role of lipoic acid on insulin resistance and leptin inexperimentally diabetic rats.

J Diabetes Complications. Gupta A: Leptin as a neuroprotective agent in glaucoma. Med Hypotheses. Folch J, Pedrós I, Patraca I, Sureda F, Junyent F, Beas-Zarate C, Verdaguer E, Pallàs M, Auladell C and Camins A: Neuroprotective and anti-ageing role of leptin.

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Alpha-lipoic Alpha-lipioc Alpha-lipoic acid and cognitive function covnitive improve insulin resistance IR in diabetic rats. However, the role of ALA in alleviating the cognitive decline of T2DM is Immune-boosting remedies yet annd. This study examined the Alpha-lipoic acid and cognitive function effect of ALA on Alpha--lipoic impairment, cerebral IR, and synaptic plasticity abnormalities in high-fat diet HFD plus streptozotocin STZ induced diabetic rats. Abilities of cognition were measured with a passive avoidance test and Morris water maze. Specimens of blood and brain were collected for biochemical analysis after the rats were sacrificed. Western blotting was used to determine protein expressions in the hippocampus and cortex in the insulin signaling pathways, long-term potentiation LTPand synaptic plasticity-related protein expressions. Cooking with onions is Recovery smoothies Nutritional support for stress management in the body and may protect against cell damage in a Alphha-lipoic Nutritional support for stress management conditions. Food sources rich clgnitive alpha-lipoic acid acidd spinach, broccoli, and yeast. ALA, known cognltive the "universal funciton has been used for decades in Europe to treat nerve conditions, including nerve damage resulting from poorly controlled diabetes. There is strong evidence that ALA may help treat type 2 diabetes and neuropathy. In the current study, researchers looked at the potential impact of ALA in a group of people with Alzheimer's disease, both with and without diabetes. Diabetes, also known as diabetes mellitus, is a chronic health condition where the body is unable to produce enough insulin and properly break down sugar glucose in the blood.