visual abstract icon Diurrtic Diuretic effect on weight management. It is likely that higher BMI increases the risk of gout by increasing the serum uric acid level. As soon as the water returns to the body, the weight is typically regained.

Diuretic effect on weight management -

These findings agree with those from the Johns Hopkins Precursor Study. Similarly, weight gain since the study baseline mean age, 54 years was associated with the risk of gout. In contrast, we found that weight loss greater than 10 lb since the study baseline was associated with a substantially reduced risk of gout.

To our knowledge, our study is the first to document this important potential benefit of weight loss. By demonstrating an association between weight loss and the prevention of gout together with an association between weight gain and the development of gout, the present study makes a much stronger case for a causal relation than the previous studies.

Furthermore, although these findings are based on incident gout, these findings support the current recommendation for weight reduction to prevent recurrent gout attacks. It is likely that higher BMI increases the risk of gout by increasing the serum uric acid level. Hyperuricemia has been associated with obesity via both increased production and decreased renal excretion of urate.

The population-attributable risk for incident gout due to increased BMI was substantial. The presence of hypertension was strongly associated with the incidence of gout independent of diuretic use and chronic renal failure.

Since more than half of the gout cases in our cohort occurred among those with hypertension, the potential impact of the prevention of hypertension on the incidence of gout is substantial.

Several strengths and potential limitations of our study deserve comment. As in other epidemiologic studies, 1 , 3 - 5 , 28 our definition of gout did not require observation of urate crystal in joint fluid examination. Potentially biased recall of diet was avoided in the present study because the intake data were collected before the diagnosis of gout.

Our findings are most directly generalizable to men 40 years and older the most gout-prevalent population 3 with no history of gout. Whether these findings apply to women or men with existing gout remains to be studied.

In conclusion, our large prospective study indicates that increased adiposity and weight gain are strong risk factors for gout in men. In contrast, weight loss reduces the risk. Correspondence: Hyon K. Choi, MD, DrPH, Rheumatology Unit, Bulfinch , Massachusetts General Hospital, 55 Fruit St, Boston, MA hchoi partners.

Acknowledgment: The authors thank Walter Willett, MD, DrPH, for his critical review of the manuscript. full text icon Full Text. Download PDF Top of Article Abstract Methods Results Comment Article Information References.

Table 1. View Large Download. Baseline Characteristics According to Body Mass Index BMI , Weight Gain, and Waist-to-Hip Ratio. Relative Risk RR of Gout According to Body Mass Index and Waist-to-Hip Ratio.

Relative Risk RR of Gout According to Weight Change. Relative Risk RR of Gout According to Presence of Hypertension and Diuretic Use.

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J Rheumatol ; PubMed Google Scholar. Ann Rheum Dis ; PubMed Google Scholar Crossref. Spironolactone is a unique type of water pill in a class of medications called potassium-sparing diuretics. Many water pills work in the kidneys to eliminate extra water from the body along with sodium and potassium.

Spironolactone works differently. It blocks a hormone called aldosterone , which causes the body to remove water along with sodium but reduces how much potassium is removed.

In addition to its diuretic effects, spironolactone also blocks androgen receptors. This means that it can decrease the effects of testosterone in the body. Because of this unique effect, spironolactone is often used off-label for conditions that involve excess testosterone.

Some of these include:. No scientific research has evaluated spironolactone specifically for weight loss. But it makes sense that spironolactone might reduce weight in some people, especially those with fluid retention.

Spironolactone works as a diuretic, which means that it causes the body to remove extra fluid. Reducing fluid in the body can result in body weight loss.

These require good nutrition and exercise. Weight loss due to fluid reduction might not be long-lasting. Decreasing body fluid too much can result in dehydration. Once body fluid levels return to normal, the weight will return. Spironolactone has been studied in women who have bloating and swelling due to premenstrual syndrome PMS.

Spironolactone can cause significant improvement in these symptoms by reducing fluid retention. As a result, some doctors prescribe spironolactone for women who develop bloating and weight gain from water retention due to PMS. Spironolactone comes in milligram mg , 50 mg, and mg tablets.

Your doctor will tell you what dosage is right for you. In some cases, people who take spironolactone can become dehydrated.

Be sure to drink adequate water while taking spironolactone. Watch for signs of dehydration, including:. Spironolactone is a prescription medication. Spironolactone also blocks androgen receptors. Because of its unique effects, spironolactone has a wide variety of FDA-approved and off-label uses.

Kermott CA, et al. Premenstrual syndrome PMS. In: Mayo Clinic Book of Home Remedies. New York, N. Products and Services The Mayo Clinic Diet Online A Book: The Mayo Clinic Diet Bundle. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press.

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Weiyht been independently researching Diurstic testing products for over years. If you buy Potassium and stress management our links, we may weighf a Diuretic effect on weight management. Learn more about our weivht process. Feeling puffy after enjoying a delicious-yet-salty meal, during times of hormonal fluctuations such as menstruation or menopause is no fun Diuretic effect on weight management anyone. Being bloated is a common complaint that happens to just about all of us at some point, but that doesn't make it any easier to deal with. Bloating occurs when the body holds on to excess water, whether that's due to having a bit too much sodium, or from a medical condition that causes fluid retention, such as hypertension. There are a bunch of tactics you can employ to banish bloating like ruling out food intolerances or giving yourself a belly massagebut one healthy quick fix is to eat foods that are natural diuretics. But the Magnesium for athletes is, water Diuretic effect on weight management were never designed to help people effecr weight. So, maanagement are they for? Here are your top questions about water pills, including how to take them safely and whether they may be right for you. The medical term for water pills is diuretics. Essentially, diuretics help your kidneys flush excess water and salt from the body.