As vitamin C Sports nutrition tips a precursor to collagen, it is metabolisn for maintaining the integrity and healing oorange the skin. com on November 14, Does Vaping Make You Lose Weight? Common Names: bitter orange, Seville orange, sour orange, zhi shi. Nutrition Evidence Based What Is Bitter Orange, and Does It Aid Weight Loss?

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Bitter Orange as Traditional Chinese Medicine. Herbal Spotlight with Dr. Jenelle Kim

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Keep in Mind. Take charge of your health—talk with your health care providers about any complementary health approaches you use. Together, you can make shared, well-informed decisions. For More Information. Using Dietary Supplements Wisely Know the Science: How Medications and Supplements Can Interact Know the Science: How To Make Sense of a Scientific Journal Article.

NCCIH Clearinghouse The NCCIH Clearinghouse provides information on NCCIH and complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature.

Toll-free in the U. gov Email: info nccih. PubMed® A service of the National Library of Medicine, PubMed® contains publication information and in most cases brief summaries of articles from scientific and medical journals.

Office of Dietary Supplements ODS , National Institutes of Health NIH ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public.

gov Email: ods nih. Key References. Bitter orange. Natural Medicines website. Accessed at naturalmedicines. com on November 14, Bouchard NC, Howland MA, Greller HA, et al.

Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine. Mayo Clinic Proceedings. Firenzuoli F, Gori L, Galapai C. Adverse reaction to an adrenergic herbal extract Citrus aurantium.

Gange CA, Madias C, Felix-Getzik EM, et al. Variant angina associated with bitter orange in a dietary supplement. Mannucci C, Calapai F, Cardia L, et al.

Clinical pharmacology of Citrus aurantium and Citrus sinensis for the treatment of anxiety. Evidence-Based Complementary and Alternative Medicine. Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Annals of Pharmacotherapy.

Office of Dietary Supplements website. Dietary Supplements for Weight Loss. Orange peel, bitter. In: Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; Rasmussen CB, Glisson JK, Minor DS.

The plant compounds in bitter orange, which are called protoalkaloids, have been used for over 20 years in supplements for weight loss, athletic performance, skin care, appetite control, and brain health, as well as perfumery 1 , 2 , 3 , 5 , 6 , 7 , 8.

P-synephrine, the main extract from bitter orange, has a similar structure to ephedrine, the main component of the herbal weight loss supplement ephedra 8. This supplement was banned by the U.

Food and Drug Administration FDA because it raised blood pressure, increased heart rate, and caused heart attacks and stroke among some consumers 1 , 3 , 7. In addition, p-synephrine is structurally similar to your flight-or-fight hormones, epinephrine and norepinephrine, which also increase your heart rate 1 , 4.

P-synephrine is also found in other citrus fruits and their juices, such as mandarins and clementines 4 , 7. Like other citrus fruits, bitter orange provides limonene — a compound shown to have anti-inflammatory and antiviral properties 10 , 11 , Population studies suggest that limonene may prevent certain cancers, namely colon cancer.

However, more rigorous human research is needed An ongoing study is also exploring the use of limonene as a treatment for COVID However, the results are not yet known.

Bear in mind that limonene cannot prevent or cure COVID Another protoalkaloid found in bitter orange is p-octopamine. However, little to no p-octopamine exists in bitter orange extracts. The leaves of the bitter orange plant are rich in vitamin C , which acts as an antioxidant.

Antioxidants are substances that may protect your body from disease by preventing cell damage. They work by deactivating free radicals, which are unstable compounds that damage your cells, increasing inflammation and your disease risk 15 , Protoalkaloids are plant compounds found in bitter orange that have anti-inflammatory and antiviral properties.

They have been shown to be safe for consumption. Many weight loss supplements use bitter orange extracts in combination with other ingredients. However, scientific studies have not thoroughly examined the composition of these supplements to determine which ingredient, if any, supports weight loss.

Notably, p-synephrine has been shown to increase fat breakdown, raise energy expenditure, and mildly suppress appetite , all of which may contribute to reduced weight.

Yet, these effects occur at high doses that are discouraged due to the lack of safety information 4 , 8 , Bitter orange and its extracts are used in Traditional Chinese Medicine TCM to treat indigestion, diarrhea, dysentery, and constipation. In other regions, the fruit is used to treat anxiety and epilepsy 3.

Another study noted that the bitter orange compound p-synephrine may improve athletic performance though by increasing total reps and volume load, or your ability to train harder A stimulant is a substance that increases your heart rate and blood pressure 1.

Several sports organizations, such as the National Collegiate Athletic Association NCAA , list synephrine as a stimulant. Furthermore, one study determined that bitter orange juice contains furanocoumarin, a compound that may cause the same medication interactions as grapefruit juice Therefore, people taking decongestants or those who have high blood pressure, an irregular heartbeat, or glaucoma should avoid the juice and fruit of bitter oranges.

Despite numerous studies showing that bitter orange extracts are not stimulants, widespread controversy exists, and the NCAA has listed it as a banned substance. That's because bitter orange may cause potentially serious health problems. So if you're trying to lose weight, stick to healthier methods and skip the bitter orange.

Bitter orange extract is often used in weight-loss supplements. Bitter orange contains synephrine, which is similar to the main chemical in the herb ephedra ma-huang. Ephedra was banned by the U.

Food and Drug Administration because it raises blood pressure and has been linked to heart attacks and strokes.

Bitter orange Metabolims aurantium metabklism, Sports nutrition tips known as suppplements orange and Seville orange, supplemments a citrus fruit with Biter multitude of uses. This article covers Sports nutrition tips you need to know Bitter orange supplements for metabolism bitter orange, including its role Nootropic for Brain Aging weight loss and skin health, as well as its overall safety as a supplement. The bitter orange plant thrives in subtropical regions but can withstand adverse environmental conditions like frost for short periods 2. Oval or oblong in shape, the fruit is red-orange when ripe and has a distinctively thick, dimpled skin. There are 23 cultivars of the fruit, the most prominent of which is Bergamot. You can expect some varieties to be more bitter than others. Bitter orange contains several potent plant compounds that are sometimes extracted from the dried peel to make dietary supplements.