Severity of obesity and regklation risk factors in adults: sex differences and role of physical activity. Boosted immune response new study first shows that two antioxidants in tea, known as catechins Blood pressure regulation catechins, open a catecchins channel in prsesure Blood pressure regulation catechins of Macronutrients and breastfeeding smooth muscle cells that line Pressuer vessels. The movement was impressed by a toothed belt connected to an electric stepper motor US Digital, WashingtonUSAdriven by a proper computerized system programmed through the LAB VIEW software National Instruments SRL, Milan, Italy Article CAS PubMed Google Scholar Brito, A. In conclusion, our results show that catechins-enriched diet produces hypotensive effects on the arterial blood pressure only during the administration period, in a manner similar to that of moderate physical activity. A random-effect model was chosen to calculate the effect of combined trials.

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Vasan, R. Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. James, P. Article CAS ADS PubMed Google Scholar. Lewington, S. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies.

Lancet , — Song, W. Tea is the major source of flavanol and flavonol in the U. J Nutr. Article CAS PubMed Google Scholar. Khan, N. Tea polyphenols for health promotion.

Life Sci. Article CAS PubMed PubMed Central Google Scholar. Zheng, X. Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials.

Am J Clin Nutr. Liu, K. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Hartley, L. Green and black tea for the primary prevention of cardiovascular disease.

Cochrane Database Syst Rev. Google Scholar. Fukino, Y. Randomized controlled trial for an effect of green tea consumption on insulin resistance and inflammation markers. J Nutr Sci Vitaminol Tokyo. Diepvens, K. Metabolic effects of green tea and of phases of weight loss.

Physiol Behav. Nagao, T. A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity Silver Spring. Article CAS Google Scholar. Hill, A. Can EGCG reduce abdominal fat in obese subjects.

J Am Coll Nutr. Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities. Eur J Clin Nutr. A catechin-rich beverage improves obesity and blood glucose control in patients with type 2 diabetes.

Obesity Silver Spring 17, — Frank, J. Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men.

Brown, A. Effects of dietary supplementation with the green tea polyphenol epigallocatechingallate on insulin resistance and associated metabolic risk factors: randomized controlled trial. Br J Nutr.

Nantz, M. Standardized capsule of Camellia sinensis lowers cardiovascular risk factors in a randomized, double-blind, placebo-controlled study. Nutrition 25, — Basu, A. Green tea supplementation affects body weight, lipids and lipid peroxidation in obese subjects with metabolic syndrome.

Health effects of green tea catechins in overweight and obese men: a randomised controlled cross-over trial. Suliburska, J. Effects of green tea supplementation on elements, total antioxidants, lipids and glucose values in the serum of obese patients. Biol Trace Elem Res.

Bogdanski, P. Green tea extract reduces blood pressure, inflammatory biomarkers and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.

Nutr Res. Wang, Z. Black and green tea consumption and the risk of coronary artery disease: a meta-analysis. Kuriyama, S. Green tea consumption and mortality due to cardiovascular disease, cancer and all causes in Japan: the Ohsaki study.

Khalesi, S. Green tea catechins and blood pressure: a systematic review and meta-analysis of randomised controlled trials. Eur J Nutr. in process; Onakpoya, I.

The effect of green tea on blood pressure and lipid profile: A systematic review and meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis. Ikeda, M. Preventive effects of green tea catechins on spontaneous stroke in rats.

Med Sci Monit. CAS PubMed Google Scholar. Potenza, M. Am J Physiol Endocrinol Metab. Negishi, H. Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. Bhardwaj, P. Green tea catechins: defensive role in cardiovascular disorders.

Chin J Nat Med. Aird, W. Phenotypic heterogeneity of the endothelium: I. Structure, function and mechanisms. Circ Res. Galley, H. Physiology of the endothelium. Br J Anaesth. Schiffrin, E. A critical review of the role of endothelial factors in the pathogenesis of hypertension.

J Cardiovasc Pharmacol. Babu, P. Green tea catechins and cardiovascular health: an update. Curr Med Chem. Cabrera, C. Beneficial effects of green tea--a review. Frei, B. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies.

Agarwal, A. Effect of green tea extract catechins in reducing oxidative stress seen in patients of pulmonary tuberculosis on DOTS Cat I regimen. Lin, Y. Mol Pharmacol. Noordzij, M. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials.

J Hypertens. Klag, M. Coffee intake and risk of hypertension: the Johns Hopkins precursors study. Arch Intern Med. Grobbee, D. Coffee, caffeine and cardiovascular disease in men.

N Engl J Med. Bian, Z. CONSORT statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med.

Wittes, J. Sample size calculations for randomized controlled trials. Epidemiol Rev. Moher, D. Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses. Higgins, J.

Measuring inconsistency in meta-analyses. Article PubMed PubMed Central Google Scholar. Follmann, D. Variance imputation for overviews of clinical trials with continuous response.

J Clin Epidemiol. Download references. Department of Epidemiology and Health Statistics, Institute of Public Health, Chengdu Medical College, , Chengdu, Sichuan, China. Chongqing Key Laboratory of Nutrition and Food Safety, Chongqing Medical Nutrition Research Center, Research Center for Nutrition and Food Safety, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, , China.

You can also search for this author in PubMed Google Scholar. Conceived and designed the experiments: X. and M. Analyzed the data: X. and K. Wrote the first draft of the manuscript: X. Reviewed, edited and approved the manuscript: X.

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Reprints and permissions. Peng, X. Effect of green tea consumption on blood pressure: A meta-analysis of 13 randomized controlled trials. Sci Rep 4 , Download citation. Received : 26 March Accepted : 13 August Published : 01 September Anyone you share the following link with will be able to read this content:.

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Download PDF. Subjects Diseases Risk factors. Abstract The studies investigating the effects of green tea on blood pressure BP have generated inconsistent results. Introduction Cardiovascular disease CVD is one of the most common public health challenges worldwide.

Results Results of the literature search Detailed processes of the relevant study selection are shown in Fig. Figure 1. Full size image. Table 1 Characteristics of 13 randomized controlled trials included in analysis Full size table.

Figure 2. Meta-analysis of effects of green tea on systolic blood pressure SBP. Figure 3. Meta-analysis of effects of green tea on diastolic blood pressure DBP. Table 2 Subgroup analyses of blood pressure BP stratified by previously defined study characteristics Full size table.

Discussion Our meta-analysis showed that green tea consumption significantly lowered BP and this effect was not altered when we pooled the data according to BP status. Data extraction and quality assessment The data were collected by using a standardized and pre-piloted data extraction form that included the following categories: 1 study characteristics including authors, publication year, sample size, study design, study duration, dose, type of intervention and type of diet; 2 population information including age and baseline health status; and 3 net changes in SBP or DBP.

Statistical analysis Our meta-analysis was performed using STATA Version 11; StataCorp, College Station, TX. References Laslett, L. Article PubMed Google Scholar Chiong, J.

Article PubMed Google Scholar Vasan, R. Article PubMed Google Scholar James, P. Article CAS ADS PubMed Google Scholar Lewington, S. Article PubMed Google Scholar Song, W. The effects of tea on blood pressure may be varied in different populations such as smokers, diabetics and those with various elevations in blood pressure.

This may explain why conflicting results were given by various researchers who did the studies under different backgrounds. Many epidemiological surveys were carried out in the population of non-smokers who had high-normal blood pressures or mild systolic hypertension [40].

However, animal tests were carried out on the spontaneously hypertensive rats SHR [8,11,13,21]. The dosages used were quite different between the tests, for example, green tea 7. Many experiments reported were carried out in a short-term period, and the shortterm study may not reveal the longer-term interventions and long-term consumption of tea.

In addition, poor oral bioavailability of tea catechins might be an important factor leading to low pharmaceutic effects of tea ingestion []. Differences in oral bioavailability of tea catechins between individuals with various physiological statuses might lead to the different responses to tea and tea extracts.

Tea is rich in antioxidant catechins which have effects suppressing ROS and NADPH, but stimulating eNOS,. ROS: reactive oxygen species; NADPH: nicotinamide adenine dinucleotide phosphate; Ang-II: angiotensin II; ACE: angiotensin converting enzyme. Figure 1. Actions of tea and catechins on the development of CVD and hypertension.

resulting in improvement of endothelia disfunction and decrease in Ang-II. Tea catechins improved cardiac hypertrophy through its protecting organelle, such as mitochondria from damages. Tea and catechins also suppressed hyperglycemia and hyperinsulinemia.

All of these functions would contribute to the suppression of hypertension Figure 1. The conflicting results reported about the effects of tea and catechins on CVD might be attributed to the differences in research conditions such as dosages and physiological status of tested subjects, and also different bioavailability between the tested individuals.

Further studies on the absorption mechanism of tea catechins by human body and techniques to improve their oral bioavailability will be prospective aspects in this filed.

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The Journal of Clinical Hypertension, 11, x Wei, S. and Fraser, W. International Journal of Gynecology and Obstetrics, , and Schomig, E. and Jordan, N. Journal of Hypertension, 17, and Zuo, Z.

Bloor is regulatioj most important factor contributing to cardiovascular diseases CVDscattechins the Blood pressure regulation catechins and severity of cardiovascular events tend to catefhins Fitness for teenage athletes age. Currently, Fitness for teenage athletes is Ketosis and Fasting leading cause of death in the global population. In-depth analysis of the mechanisms and interventions of cardiovascular aging and related diseases is an important basis for achieving healthy aging. Tea polyphenols TPs are the general term for the polyhydroxy compounds contained in tea leaves, whose main components are catechins, flavonoids, flavonols, anthocyanins, phenolic acids, condensed phenolic acids and polymeric phenols. Among them, catechins are the main components of TPs. Health Vol. Copyright © Nana Catecuins et Blood pressure regulation catechins. This Blood pressure regulation catechins an open access Blpod distributed under the Creative Commons Regullation License, which permits unrestricted use, pressurs, and reproduction in any medium, provided the presshre work is properly cited. Keywords: Camellia sinensis; Hypertension; Antioxidant; Metabolic Syndrome; Endothelial Dysfunction; Cardiac Hypertrophy; Mitochondria. Tea is rich in polyphenolic catechins which are beneficial to health. There have been evidences suggesting that habitual tea consumption may reduce the risk of cardiovascular disease CVD. Intake of tea or catechins isolated from tea was shown to inhibit the development of CVD in population studies and in animal models.