Flavonoids and cognitive function -
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Can watching sports be bad for your health? Beyond the usual suspects for healthy resolutions. April 14, These plant chemicals, found in most fruits and vegetables, may play an important role in cognitive fitness and dementia prevention.
Class in itself Flavonoids are phytochemicals commonly found in plant foods. Flavonoids and food There are six subclasses of flavonoids, which are abundant in most plant foods. Flavonoid subclass Common food sources Anthocyanidins berries red, blue, and purple , grapes, red wine Flavanols tea black, white, green, oolong , cocoa-based products, grapes, berries, apples, red wine Flavanones citrus fruit oranges, lemons, grapefruit Flavones parsley, thyme, celery, hot peppers Flavonols onions, peppers, broccoli, spinach, apples, berries, tea Polymers berries cranberries, blueberries, strawberries , wine, grapes, black tea Many factors in play Large human studies of flavonoids are still in their early phases, but initial findings show promise.
Color coordination So, to protect your brain from dementia, should you load up your plate with as many flavonoid-rich foods as possible? Share This Page Share this page to Facebook Share this page to Twitter Share this page via Email.
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Download references. This manuscript is dedicated to Dr. Narelle Berry who had been driving this research work prior to her untimely death on July 24, CS was funded by a Wellcome Clinical Research Fellowship WTMA.
Norwich Medical School, University of East Anglia, Norwich, UK. You can also search for this author in PubMed Google Scholar. CS and AC study concept. CS, AMacG and TS established and coordinated the collection of all the data.
CS processed the cognitive and imaging data to produce the variables of interest. AJ, CS and AC designed the study. AJ performed the statistical analysis. AJ and AC wrote the paper. The authors read and approved the final manuscript.
AC has the primary responsibility for the final content. Correspondence to Aedín Cassidy. AC has received funding from the US Highbush Blueberry Council USHBC with oversight from the USDA and the Biotechnology and Biological Sciences Research Council BBSRC to conduct clinical trials on anthocyanins, and AC acts as an advisor to the USHBC grant committee.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Baseline characteristics by tertile of flavonoid subclass intake in females. Table S2. Baseline characteristics by tertile of year change in flavonoid subclass intake in females.
Table S3. Figure S1. Participant flow chart. Open Access This article is licensed under a Creative Commons Attribution 4. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material.
If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Reprints and permissions. Jennings, A.
et al. Increased habitual flavonoid intake predicts attenuation of cognitive ageing in twins. BMC Med 19 , Download citation. Received : 19 April Accepted : 08 July Published : 23 August Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Research article Open access Published: 23 August Increased habitual flavonoid intake predicts attenuation of cognitive ageing in twins Amy Jennings 1 , Claire J.
Abstract Background Although the pathophysiology of cognitive decline is multifactorial, and modifiable by lifestyle, the evidence for the role of diet on cognitive function is still accumulating, particularly the potentially preventive role of constituents of plant-based foods.
Methods We aimed to determine whether higher habitual intake of dietary flavonoids, key components of plant-based diets, were associated with improved cognition and medial temporal lobe volumes using three complementary approaches longitudinal, cross-sectional and co-twin analyses.
Conclusion Small increases in habitual intake of flavonoid-rich foods containing anthocyanins, flavanones and proanthocyanidins; equivalent to approximately two servings of oranges and blueberries per day over long time periods have the potential to attenuate cognitive ageing.
Background There is increasing evidence that dietary flavonoids, part of a diverse range of polyphenolic compounds present in plant-based foods, may be beneficial for cognitive health.
Methods Study population Participants who were included in these analyses were female twins who were enrolled in the TwinsUK registry, which is a nationwide registry of UK adult twins who were recruited from the general population [ 21 ].
Assessment of cognition and brain volumes Cognition was measured using CANTAB Cambridge Neuropsychological Test Automated Battery tests which were combined using principal component analysis to assess age-related change in global cognition; the full details of the tests and the generation of the composite cognition score have been described previously [ 25 ].
Assessment of flavonoid intakes Participants completed a item FFQ [ 27 ]. Assessment of covariates Information on education, occupation, smoking, supplement use and menopausal status was obtained by a standardised nurse-administered questionnaire.
Statistical analysis First, in longitudinal analysis, we calculated a year change in age-related change ARC score and examined associations with tertiles of a year change in intake of flavonoid subclasses.
Full size image. Table 2 Measures of cognition by tertile of flavonoid subclass intake in females aged 18—89 years Full size table. Table 3 Regional brain volumes stratified by high and low flavonoid subclass intake in 32 female twins aged 42—69 years Full size table.
Discussion To our knowledge, this is the first study to integrate longitudinal, cross-sectional, co-twin and mechanistic data to examine the associations between habitual intake of flavonoid sub-classes and cognition. Conclusions In conclusion, our longitudinal data in female twins suggest that several flavonoids, specifically the flavanone and anthocyanin sub-classes attenuate cognitive ageing and further co-twin analyses demonstrated associations independently of shared genetic and common environmental factors.
Availability of data and materials The datasets used and analysed during the current study are available from the corresponding author on reasonable request. References Devore EE, Kang JH, Breteler MM, Grodstein F.
Article CAS PubMed PubMed Central Google Scholar Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P. Article CAS PubMed Google Scholar Kent K, Roodenrys S, Charlton K, Richards R, Morgan O, Gilbert H. Article CAS PubMed Google Scholar Shishtar E, Rogers GT, Blumberg JB, Au R, Jacques PF.
BMC Medicine volume 19Article number: Cite this article. Metrics details. Although the vognitive of cognitive decline is multifactorial, cognitivf modifiable by lifestyle, Flavonooids evidence for the role cotnitive Hydration strategies for strength athletes Selenium grid cognitive function is still accumulating, particularly Focus and concentration training potentially preventive role of constituents of plant-based foods. We aimed to determine whether higher habitual intake of dietary flavonoids, key components of plant-based diets, were associated with improved cognition and medial temporal lobe volumes using three complementary approaches longitudinal, cross-sectional and co-twin analyses. Cognition was assessed using the Cambridge Neuropsychological Test Automated Battery test. Hippocampal volumes were measured in a subset using magnetic resonance imaging 16 monozygotic-twin pairs. Statistical models were adjusted for a range of diet and lifestyle factors. In the PAQUID Personnes Agées Quid study, the cognigive prospectively examined flavonoid intake in Proactive weight reduction to functio function Flavonoidss decline among subjects aged Diet for blood sugar control years or older. A total of Energy Boost Tips, subjects free Energy Boost Tips dementia at baseline in and with reliable dietary assessment were reexamined four times over a year period. Information on flavonoid intake was collected at baseline. A linear mixed model was used to analyze the evolution of cognitive performance according to quartiles of flavonoid intake. Subjects included in the two highest quartiles of flavonoid intake had better cognitive evolution than did subjects in the lowest quartile.
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