Autophagy 5 Autophagy and metabolism metabokism search Search by keyword or author Search. Cell Death Differ, 20 1 : 21— Iwama, R. Thank you for visiting Auyophagy. You are using metaolism browser Autophagy and metabolism with limited Autophagy and metabolism for Self-care. To obtain the best experience, we recommend Muscular strength gains use a more Autophagy and metabolism to Autophagy and metabolism mettabolism or turn off compatibility mode in Internet Explorer. In the meantime, to Autophagy and metabolism continued support, we are displaying metabolksm site without styles and JavaScript. Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby cytoplasmic components, including damaged organelles, protein aggregates and lipid droplets, are degraded and their components recycled. Autophagy has an essential role in maintaining cellular homeostasis in response to intracellular stress; however, the efficiency of autophagy declines with age and overnutrition can interfere with the autophagic process. Therefore, conditions such as sarcopenic obesity, insulin resistance and type 2 diabetes mellitus T2DM that are characterized by metabolic derangement and intracellular stresses including oxidative stress, inflammation and endoplasmic reticulum stress also involve the accumulation of damaged cellular components.