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SIMPLE anti inflammatory breakfast - REDUCE arthritis PAIN - Dr. Alyssa Kuhn PTCitrus oil for reducing inflammation -
You can also try coconut oil pulling using a couple of drops of orange oil mixed with pure coconut oil. This citrus addition makes the flavor and scent of oil pulling more enjoyable too! D-limonene, which comprises over 90 percent of orange peel oil, is a monoterpene that has strong chemo-preventive activity, shown to reduce tumor growth in many animal studies.
Research suggests that monoterpenes block mammary, skin, liver, lung, pancreas and stomach cancers. The ability to fight carcinogenesis is likely due to the induction of Phase II carcinogen-metabolizing enzymes, resulting in carcinogen detoxification.
Monoterpenes also help induce apoptosis and growth-regulating proteins. According to a study published in the Journal of Molecular Nutrition and Food Research , orange oil can effectively help stop the proliferation of human lung and colon cancer cells.
Rats that were administered orange oil for a period of five and a half months displayed chemo-preventive effects of orange oil that were monitored using the weight of their livers.
Orange oil administration resulted in decreased liver weights, increased intercellular gap junctional complexes, and improved cell density and polarity when compared with the control group. This preserves the heat-sensitive antioxidants and active ingredients that can easily become destroyed during processing and steam distillation.
This type is made by powerfully squeezing the rind of oranges that have been grown without the use of pesticides or herbicides. Some essential oils to try combining it with include:. Wondering where to buy orange oil? How do you make orange oil? At home, you can infuse a base oil like olive oil with orange peels, but this is not at all the same as pure essential orange oil.
How to make orange oil like you find in stores or online requires specialized equipment so it really is worth purchasing a high-quality, professionally made orange oil to get the best, purest possible version. Another thing to keep in mind is that citrus oils can increase the effects of UV light exposure on the skin.
Popular Essential Oils Posts All Time This Week {position} Frankincense Essential Oil Uses and Benefits for Healing. More Essential Oils Dr. Axe on Facebook Dr.
Axe on Twitter 17 Dr. Axe on Instagram Dr. Axe on Google Plus Dr. Axe on Youtube Dr. Axe on Pintrest Share on Email Print Article 2. Axe on Twitter 46 Dr. Axe on Pintrest Share on Email Print Article Essential oils like frankincense oil have been used for thousands of years Read More.
Axe on Twitter 20 Dr. Also, the degree of benefits one receives depends on other factors too, such as diet quality, stress levels, exercise, sleep, and others, as all of these have an effect on inflammation and overall health.
Click here to read our article going over the recommended dosages for citrus bergamot. Citrus Bergamot is often compared with many other different types of herbs.
We have put together a few helpful articles going over common comparisons. Citrus bergamot is citrus fruit rich in flavonoids and other compounds that have many possible health benefits, including anti-inflammatory effects. Several studies have shown that citrus bergamot reduces inflammation and may improve a number of inflammatory-related diseases, such as fatty liver disease, IBD, and skin ailments.
About Jack Cincotta, MS. Citrus Bergamot for Inflammation Citrus bergamot is a citrus fruit that has been used as an herbal remedy for many years. Written by: Jack Cincotta, MS. Published on: February 10, Medical Review by: Daniel Powers, MS.
Learn about our editorial process. Table of Contents Citrus Bergamot Overview: Benefits of Citrus Bergamot for Inflammation: How Does Citrus Bergamot Work for Inflammation? How Long Does it Take for Citrus Bergamot to Work for Inflammation? Citrus Bergamot vs.
Other Herbs: Read More: Conclusion:. Summary: Clinical studies indicate that citrus bergamot may work to reduce inflammation. Mechanism of Action: Citrus bergamot is thought to lower inflammation by reducing oxidative stress and common inflammatory markers.
In this study, the main component of LEO and DEO was d-limonene and the proportion of d-limonene was greatly higher with DEO than that with LEO, whereas the antioxidant activity seemed to be lower with DEO than that with LEO.
In addition, LEO had a variety of other active components besides d-limonene. Therefore, we speculated that the antioxidant activity of LEO was not only from its main component d-limonene, but from the combined effect of other active components.
The specific mechanism needs to be further explored. Inflammatory response is the key cause of intestinal barrier function injury.
Zhang et al. The release of proinflammatory cytokines may lead to the interruption of tight junction and further damage the intestinal barrier Therefore, reducing the release of inflammatory factors plays an important role on alleviating intestinal mucosal injury.
By observing the effect of nutmeg EO on human fibroblasts, Matulyte et al. Limonene in citrus EO inhibited TNF-α, IL-1β, IL-8, and IL to inhibit p38 mitogen activated protein kinase signaling pathway and regulate chemokine induced chemotaxis In addition, limonene might reduce the infiltration of monocytes and eosinophils.
Amorim et al. Maurya et al. Those authors speculated that the anti-inflammatory activity of citrus peel EO may be the result of limonene component Furthermore, Wattenberg and Coccia 27 reported that d-limonene and citrus EOs could inhibit NNK-induced carcinogenesis when they were administered 1 h prior to carcinogen challenge, suggesting that the inhibitory effects of these two EOs might be accounted for the presence of d-limonene.
Our results indicated that lower dose of LEO could inhibit inflammatory factors, but higher dose was needed for DEO, which suggest that the anti-inflammatory activity of LEO was not solely due to its main active component D-limonene. According to the GC-MS results, we found that the components of LEO include β-pinene, γ-terpinene, β-laurene, and α-pinene Therefore, we speculated that the better role of LEO in inhibiting inflammatory factors was due to the interaction of its complex active components.
Intestinal mechanical barrier, also known as physical barrier, is an intestinal epithelial structure composed of intestinal mucosal epithelial cells and their tight connections It is an important barrier to prevent harmful substances such as virulence factors of intestinal pathogens from entering the blood circulation and even tissues and organs.
The function of intestinal barrier can usually be evaluated by many indicators, such as serum endotoxin level, intestinal morphology and intestinal tight junction protein Acheampong et al.
Wang et al. In this study, mice infected with E. coli showed that typical pathological changes, including increased inflammatory cells, disordered arrangement and sparse villi, indicating that the duodenal structure was damaged.
Our results showed that LEO and DEO had beneficial effects on reducing the infiltration of inflammatory cells, maintain the integrity of intestinal tract and protect animal body from damage. In addition, occludin, claudin and ZO-1 are the main proteins that play an important role in the tight junction of intestinal epithelial cells and the intestinal barrier The tight junctions, represented by claudins, occludin, connective adhesion molecules and scaffold proteins, is mainly responsible for regulating paracellular transport and is also the main structural component forming the structural barrier function of epithelial cells 33 , They act as barriers and fences under normal and pathological conditions, preventing countless ions and small solutes from freely passing through the space between two interacting cells EOs with the active ingredient of Zou et al.
Hui et al. Liu et al. and E. coli in the intestines. In this study, both LEO and DEO could improve the expression of three tight junction proteins compared with E. Pretreatment with LEO and DEO increased relative expression of ZO-1, occludin and claudin, which demonstrated their potential role of improving tight junction and maintaining the integrity of intestinal barrier.
In conclusion, the citrus EOs exhibited anti-inflammatory, antioxidant activities and alleviated intestinal barrier damage. Both of LEO and DEO had positive effects on intestinal barriers function of mice. The pretreatment with LEO or DEO could protect the inflammation of E.
coli infected mice by reducing the production of proinflammatory factors, increasing the concentration of antioxidant indexes and maintaining the integrity of duodenum. The anti-inflammatory effect of LEO appeared to be better than that of DEO whose main component was d-limonene when the same dose was applied.
It speculated that besides of d-limonene, other active components in LEO may play significant role. Our work will shed light on developing new additive with anti-inflammatory activity from LEO. Escherichia coli ATCC was purchased from China General Microbiological Culture Collection Center Beijing, China.
TNF-α, IL-6, and IL-1β enzyme-linked immunosorbent assay ELISA kit were provided by Beijing SINO-UK Institute of Biological Technology Beijing, China. All other reagents were of analytical grade. The EO samples were diluted with n-hexane before analysis and their active components were determined using a GC-MS QP ultra Shimadzu, Kyoto, Japan.
The active compounds were separated on a Rxi-5Sil MS 30 m × 0. The injection volume was 1 μL, with a split ratio of The injector, transfer line and ion-source temperatures were , , and °C, respectively.
Beijing, China. All experimental procedures were approved by the Laboratory Animal Ethics Committee of Beijing University of Agriculture, and conformed to the legal mandates and national guidelines for the care and maintenance of laboratory animals [SYXK 京 , One hundred mice 50 male and 50 female were randomly assigned into one of 10 groups 10 mice in each group with equal number of male and female.
Five groups of mice were given LEO at dose of 1,, 2,, 2, The survival rate of mice for 2 weeks was recorded. LD50 of EOs was calculated by modified Karber's method coli group E. All mice were given EOs by oral gavage for 1 week, except those in the NS group and E.
coli group that were given normal saline by oral gavage. After 1 h of the last administration gavage, all mice were injected intraperitoneally with E. coli , except those in the NS group that were injected intraperitoneally with normal saline.
Mice were killed by cervical dislocation, and blood and duodenal samples were collected at 6 h after E. coli administration. The plasma collected from mouse eyeballs in anticoagulant tubes was used for determination of antioxidant indexes and inflammatory factors. The plasma antioxidant indexes and inflammatory factors were determined with enzyme-linked immunosorbent assay Blood antioxidant indexes were characterized by analyzing antioxidant enzyme activities including SOD, MDA and MPO in plasma as described by using ELISA Kit Beijing Sino-UK Institute of Biological Technology, Beijing, China.
Inflammatory factors including TNF-α, IL-1β, and IL-6 were determined to assess the anti-inflammatory activities in plasma as described by using ELISA Kit Beijing Sino-UK Institute of Biological Technology, Beijing, China.
The images were viewed and acquired using a microscope ECLIPSE Ni-E, Nikon, Tokyo, Japan. The RNA of duodenum was extracted by RNA prep pure animal tissue total RNA Extraction Kit DP, TIANGEN. Primer sequences were designed with software Primer 3.
Table 4. Finally refer to TransStart® Top Green qPCR SuperMix was detected by real-time fluorescence quantitative PCR RT-PCR. RT-PCR was performed with the reaction conditions as follows: pre-denaturalization at 95°C for 10 min. The primers of ZO-1, occludin, claudin and β-actin are shown in Table 4.
Data on the effect of E. coli stimulated mice, were analyzed using the general linear model GLM procedure of SAS 9. coli group with the NS group. Statistical significance was assessed in pairwise comparisons using one-way ANOVA.
To investigate the dose effect of LEO and DEO on E. coli injected mice, the data were analyzed using the MIXED procedure of SAS 9.
Contrasts were generated to compare the verage of the four EOs doses. The effect of increasing EOs dose was examined through linear and quadratic orthogonal contrasts using the CONTRAST statement of SAS. The graphs of antioxidant indexes, inflammatory factors and tight junction proteins were drawn by GraphPad prism 7.
The pretreatment of LEO and DEO had a protective effect on intestinal barriers function of E. Both LEO and DEO had beneficial effects on preventing intestinal injury and inflammatory response by reducing the production of proinflammatory factors, increasing the concentration of antioxidant indexes and maintaining the integrity of duodenum.
Whereas the LEO appeared to have higher anti-inflammatory activity than that of DEO. Our results suggest that as the main active componebt of LEO, the d-limonene not only played the major role in anti-inflammatory activities, but an increase the activity is expected in combination with other active components of LEO.
The animal study was reviewed and approved by the Laboratory Animal Ethics Committee of Beijing University of Agriculture. YLL cover the project. CZ designed and performed the experiments and analyzed the raw data. ZZ and DCN assisted with the experiments.
All authors have read and agreed to the published version of the manuscript. All authors contributed to the article and approved the submitted version. This work was supported by Capital Science and Technology Innovation Voucher of Beijing, China BNCXQ The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
DEO, d-limonene essential oil; Eos, Essential oils; E. coli , Escherichia coli ; IL-6, Interleukin-6; IL-1β, Interleukin-1β; LEO, Lemon essential oil; MDA, Malondialdehyde; MPO, Myeloperoxidase; RT-PCR, Real-time polymerase chain reaction; SOD, Superoxide dismutase; TNF-α, Tumor necrosis factor alpha; ZO, Zonula occludens.
Talbot J, Hahn P, Kroehling L, Nguyen H, Li D, Littman DR. Feeding-dependent VIP neuron-ILC3 circuit regulates the intestinal barrier. doi: PubMed Abstract CrossRef Full Text Google Scholar. Wang Y, An Y, Ma W, Yu H, Lu Y, Zhang X, et al.
J Neuroinflammation. Reverter M, Sarter S, Caruso D, Avarre JC, Combe M, Pepey E, et al.
The peel of Citrus sinensis Redhcing. The redicing Chromium browser for Linux of fof study was Citrus oil for reducing inflammation test Recharge your body potential analgesic and anti-inflammatory properties of limonene-rich essential oils derived from the peel of C. sinensis L. orange in vivoas well as their antioxidant activity in vitro. Carrageenan-induced paw edema in Wistar rats and the formalin test in Swiss albino mice were used to examine anti-inflammatory activity. Citrus oil for reducing inflammation the healing powers inflammtaion essential Citrue in BCAA and muscle damage prevention inflammation. Explore the top 5 reducihg, their unique properties, applications, safety tips, and complementary therapies for a holistic recucing to Chromium browser for Linux relief. In a world where our bodies redufing constantly bombarded by external and internal stressors, inflammation has emerged as a common ailment, sometimes teetering on the edge of chronic disruption. Amidst the mass of over-the-counter pills and treatments, the ancient wisdom of essential oils offers a gentle whisper of relief. Exploring this aromatic realm promises insights into nature's own pharmacy, brimming with remedies that have stood the test of time. Often regarded as the 'soul' of a plant, essential oils are highly concentrated plant extracts.
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