Molecules Inhibiys, — Although Inbibits Boosting skin vitality. Hydration for overall well-being tested this hypothesis by analyzing c-di-GMP in Boosting skin vitality biomass Boosting skin vitality Innibits formed with and without the addition of ginger extract. Journal of biomedical materials research part a: An official journal of the Society for Biomaterials, the Japanese Society for Biomaterials, and the Australian Society for Biomaterials and the Korean society for.

Inhibits biofilm formation -

J Clin Invest — Houry A, Briandet R, Aymerich S, Gohar M Involvement of motility and flagella in Bacillus cereus biofilm formation. Microbiology 4 — Infect Immun 79 3 — Huber B, Riedel K, Hentzer M, Heydorn A, Gotschlich A, Givskov M, Molin S, Eberl L The cep quorum-sensing system of Burkholderia cepacia H controls biofilm formation and swarming motility.

Microbiology Reading, England Pt 9 — Husain FM, Ahmad I, Asif M, Tahseen Q Influence of clove oil on certain quorum-sensing-regulated functions and biofilm of Pseudomonas aeruginosa and Aeromonas hydrophila.

J Biosci 38 5 — Jain K, Parida S, Mangwani N, Dash HR, Das S Isolation and characterization of biofilm-forming bacteria and associated extracellular polymeric substances from oral cavity. Ann Microbiol 63 4 — Kalia M, Yadav VK, Singh PK, Sharma D, Narvi SS, Agarwal V Exploring the impact of parthenolide as anti-quorum sensing and anti-biofilm agent against Pseudomonas aeruginosa.

Life Sci — Kang JE, Han JW, Jeon BJ, Kim BS Efficacies of quorum sensing inhibitors, piericidin A and glucopiericidin A, produced by Streptomyces xanthocidicus KPP for the control of potato soft rot caused by Erwinia carotovora subsp. Microbiol Res — Karygianni L, Ren Z, Koo H, Thurnheer T Biofilm matrixome: extracellular components in structured microbial communities.

Trends Microbiol — Katsuyama M, Kobayashi Y, Ichikawa H, Mizuno A, Miyachi Y, Matsunaga K, Kawashima M A novel method to control the balance of skin microflora Part 2.

A study to assess the effect of a cream containing farnesol and xylitol on atopic dry skin. J Dermatol Sci 38 3 — Kaufmann GF, Park J, Janda KD Bacterial quorum sensing: a new target for anti-infective immunotherapy.

Expert Opin Biol Ther — Kaur N, Arora DS, Kalia N, Kaur M Antibiofilm, antiproliferative, antioxidant and antimutagenic activities of an endophytic fungus Aspergillus fumigatus from Moringa oleifera. Mol Biol Rep 47 4 — Kean R, Rajendran R, Haggarty J, Townsend EM, Short B, Burgess KE, Lang S, Millington O, Mackay WG, Williams C, Ramage G Candida albicans mycofilms support Staphylococcus aureus colonization and enhances miconazole resistance in dual-species interactions.

Kim S-H, Shin D-S, Oh M-N, Chung S-C, Lee J-S, Oh K-B Inhibition of the bacterial surface protein anchoring transpeptidase sortase by isoquinoline alkaloids. Biosci Biotechnol Biochem 68 2 — Kim D, Liu Y, Benhamou RI, Sanchez H, Simón-Soro Á, Li Y, Hwang G, Fridman M, Andes DR, Koo H Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm.

ISME J 12 6 — Knowles JR, Roller S, Murray DB, Naidu AS Antimicrobial action of carvacrol at different stages of dual-species biofilm development by Staphylococcus aureus and Salmonella enterica serovar Typhimurium.

Appl Environ Microbiol 71 2 — Kobayashi K, Iwano M BslA YuaB forms a hydrophobic layer on the surface of Bacillus subtilis biofilms. Mol Microbiol 85 1 — Kohler T, Weidenmaier C, Peschel A Wall teichoic acid protects Staphylococcus aureus against antimicrobial fatty acids from human skin.

J Bacteriol 13 — Koo H, Pearson SK, Scott-Anne K, Abranches J, Cury JA, Rosalen PL, Park YK, Marquis RE, Bowen WH Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. Oral Microbiol Immunol 17 6 — Kurekci C, Padmanabha J, Bishop-Hurley SL, Hassan E, Al Jassim RA, McSweeney CS Antimicrobial activity of essential oils and five terpenoid compounds against Campylobacter jejuni in pure and mixed culture experiments.

Int J Food Microbiol 3 — Kuźma Ł, Rózalski M, Walencka E, Rózalska B, Wysokińska H Antimicrobial activity of diterpenoids from hairy roots of Salvia sclarea L.

Phytomedicine 14 1 — Kwakman PHS, te Velde AA, Grauls CMJEV, van Deventer SJH, Zaat SAJ Treatment and prevention of staphylococcus epidermidis experimental biomaterial-associated infection by bactericidal peptide 2.

Antimicrob Agents Chemother — Lade H, Paul D, Kweon JH N-acyl homoserine lactone-mediated quorum sensing with special reference to use of quorum quenching bacteria in membrane biofouling control. Lautenbach E, Patel JB, Bilker WB, Edelstein PH, Fishman NO Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for infection and impact of resistance on outcomes.

Clin Infect Dis — Anaerobe 17 6 — Lee H, Lee DG Mode of action of bioactive phytochemicals, plant secondary metabolites, possessing antimicrobial properties. In: Méndez-Vilas A ed The battle against microbial pathogens: basic science, technological advances and educational programs.

World Scientific, Singapore. Lee JH, Regmi SC, Kim JA, Cho MH, Yun H, Lee CS, Lee J Apple flavonoid phloretin inhibits Escherichia coli OH7 biofilm formation and ameliorates colon inflammation in rats. Infect Immun 79 12 — Lee JH, Kim YG, Cho HS, Ryu SY, Cho MH, Lee J a Coumarins reduce biofilm formation and the virulence of Escherichia coli OH7.

Phytomedicine 21 8—9 — Lee J-H, Kim Y-G, Ryu SY, Cho MH, Lee J b Ginkgolic acids and Ginkgo biloba extract inhibit Escherichia coli OH7 and Staphylococcus aureus biofilm formation. Int J Food Microbiol — Leid JG, Willson CJ, Shirtliff ME, Hassett DJ, Parsek MR, Jeffers AK The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-γ-mediated macrophage killing.

J Immunol 11 — Lin MH, Shu JC, Lin LP, Yu Chong K, Cheng YW, Du JF, Liu S-T Elucidating the crucial role of poly N-acetylglucosamine from Staphylococcus aureus in cellular adhesion and pathogenesis.

PLoS One 10 4 :e Liu Q, Niu H, Zhang W, Mu H, Sun C, Duan J Synergy among thymol, eugenol, berberine, cinnamaldehyde and streptomycin against planktonic and biofilm-associated food-borne pathogens.

Lett Appl Microbiol 60 5 — Liu S, Qiu W, Zhang K, Zhou X, Ren B, He J, Xu X, Cheng L, Li M Nicotine enhances interspecies relationship between Streptococcus mutans and Candida albicans.

Long H, Miller SF, Strauss C, Zhao C, Cheng L, Ye Z, Griffin K, Te R, Lee H, Chen CC, Lynch M Antibiotic treatment enhances the genome-wide mutation rate of target cells. Proc Natl Acad Sci U S A E—E Lu L, Hu W, Tian Z, Yuan D, Yi G, Zhou Y, Cheng Q, Zhu J, Li M Developing natural products as potential anti-biofilm agents.

Chin Med Lucas REB, Wheeler D, Hettige H Economic development, environmental regulation, and the international migration of toxic industrial pollution, — Washington, DC H, NW, Washington : Office of the Vice President, Development Economics, World Bank.

Ma L, Jackson KD, Landry RM, Parsek MR, Wozniak DJ Analysis of Pseudomonas aeruginosa conditional psl variants reveals roles for the psl polysaccharide in adhesion and maintaining biofilm structure postattachment.

J Bacteriol 23 — Memariani H, Memariani M, Ghasemian A An overview on anti-biofilm properties of quercetin against bacterial pathogens. World J Microbiol Biotechnol 35 9 Merino N, Toledo-Arana A, Vergara-Irigaray M, Valle J, Solano C, Calvo E, Lopez JA, Foster TJ, Penadés JR, Lasa I Protein A-mediated multicellular behavior in Staphylococcus aureus.

J Bacteriol 3 — Miller MB, Bassler BL Quorum sensing in bacteria. Annu Rev Microbiol — Morgan R, Kohn S, Hwang S-H, Hassett DJ, Sauer K BdlA, a chemotaxis regulator essential for biofilm dispersion in Pseudomonas aeruginosa.

Moser H, Wu C, Wang HZ, Høiby N, Song ZJ Strategies for combating bacterial biofilm infections. Int J Oral Sci —7. Moshe M, Lellouche J, Banin E Curcumin: a natural antibiofilm agent. Sci Technol Against Microb Pathog — Musk DJ, Banko DA, Hergenrother PJ Iron salts perturb biofilm formation and disrupt existing biofilms of Pseudomonas aeruginosa.

Chem Biol — Muthusamy B, Shanmugam G Analysis of flavonoid content, antioxidant, antimicrobial and antibiofilm activity of in vitro hairy root extract of radish Raphanus sativus L.

Plant Cell Tiss Organ Cult PCTOC 3 — Nadaf NH, Parulekar RS, Patil RS, Gade TK, Momin AA, Waghmare SR, Dhanavade MJ, Arvindekar AU, Sonawane KD Biofilm inhibition mechanism from extract of Hymenocallis littoralis leaves. J Ethnopharmacol — Niu C, Gilbert ES Colorimetric method for identifying plant essential oil components that affect biofilm formation and structure.

Appl Environ Microbiol 70 12 — Ouyang J, Sun F, Feng W, Sun Y, Qiu X, Xiong L, Liu Y, Chen Y Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors in Pseudomonas aeruginosa.

J Appl Microbiol 4 — Ouyang P, He X, Yuan ZW, Yin ZQ, Fu H, Lin J, He C, Liang X, Lv C, Shu G, Yuan ZX, Song X, Li L, Yin L Erianin against Staphylococcus aureus infection via inhibiting Sortase A.

Toxins Basel 10 10 Papenfort K, Bassler BL Quorum sensing signal-response systems in Gram-negative bacteria.

Nat Rev Microbiol 14 9 — Petersen J Heap leaching as a key technology for recovery of values from low-grade ores—a brief overview. Hydrometallurgy — Petrova OE, Cherny KE, Sauer K The diguanylate cyclase GcbA facilitates Pseudomonas aeruginosa biofilm dispersion by activating BdlA.

Pierce CG, Vila T, Romo JA, Montelongo-Jauregui D, Wall G, Ramasubramanian A, Lopez-Ribot JL The Candida albicans biofilm matrix: composition, structure and function. J Fungi 3 1 Prakash B, Veeregowda B, Krishnappa G Biofilms: a survival strategy of bacteria. Curr Sci — Prestinaci F, Pezzotti P, Pantosti A Antimicrobial resistance: a global multifaceted phenomenon.

Pathog Glob Health — Rajkumari J, Meena H, Gangatharan M, Busi S Green synthesis of anisotropic gold nanoparticles using hordenine and their antibiofilm efficacy against Pseudomonas aeruginosa. IET Nanobiotechnol 11 8 — Rasch M, Kastbjerg VG, Bruhn JB, Dalsgaard I, Givskov M, Gram L Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factor.

Dis Aquat Org 78 2 — J Med Microbiol 62 Pt 3 — Rendeková K, Fialová S, Jánošová L, Mučaji P, Slobodníková L The activity of Cotinus coggygria Scop. leaves on Staphylococcus aureus strains in planktonic and biofilm growth forms.

Molecules Basel, Switzerland 21 1 Richards JJ, Melander C Controlling bacterial biofilms. ChemBioChem 10 14 — Rizzello L, Pompa PP Nanosilver-based antibacterial drugs and devices: mechanisms, methodological drawbacks, and guidelines.

Chem Soc Rev — Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang MC, Withers ST, Shiba Y, Sarpong R, Keasling JD Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature — Romero D, Vlamakis H, Losick R, Kolter R An accessory protein required for anchoring and assembly of amyloid fibres in B.

subtilis biofilms. Mol Microbiol 80 5 — Roy AB, Petrova OE, Sauer K The phosphodiesterase DipA PA is essential for pseudomonas aeruginosa biofilm dispersion. Rozalski M, Micota B, Sadowska B, Stochmal A, Jedrejek D, Wieckowska-Szakiel M, Rozalska B Antiadherent and antibiofilm activity of Humulus lupulus L.

derived pro ducts: new pharmacological properties. Rukayadi Y, Hwang JK Effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol on the biofilm formation of Streptococcus mutans. J Basic Microbiol 46 5 — Saini R, Saini S, Sharma S Biofilm: a dental microbial infection.

J Natur Sci Biol Med 2 1 Saxena P, Joshi Y, Rawat K, Bisht R Biofilms: architecture, resistance, quorum sensing and control mechanisms. Indian J Microbiol 59 1 :3— Schaefer AL, Val DL, Hanzelka BL, Cronan JE Jr, Greenberg EP Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein.

Proc Natl Acad Sci U S A 93 18 — Schleheck D, Barraud N, Klebensberger J, Webb JS, McDougald D, Rice SA et al Pseudomonas aeruginosa PAO1 preferentially grows as aggregates in liquid batch cultures and disperses upon starvation.

PLoS One 4:e Schwartz K, Syed AK, Stephenson RE, Rickard AH, Boles BR Functional amyloids composed of phenol soluble modulins stabilize Staphylococcus aureus biofilms.

PLoS Pathog 8 6 :e Shiner E, Terentyev D, Bryan A, Sennoune S, Martinez-Zaguilan R, Li G, Gyorke S, Williams S, Rumbaugh K Pseudomonas aeruginosa autoinducer modulates host cell responses through calcium signalling.

Cell Microbiol 8 10 — Shuai-Cheng W, Ben-Dong F, Xiu-Ling C, Jian-Qing S, Yun-Xing F, Zhen-Qiang C, Dao-Xiu X, Zong-Mei W Subinhibitory concentrations of phloretin repress the virulence of Salmonella typhimurium and protect against Salmonella typhimurium infection. Antonie Van Leeuwenhoek 11 — Sifri CD Quorum sensing: bacteria talk sense.

Clin Infect Dis 47 8 — Smith KM, Bu Y, Suga H Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer. Chem Biol 10 6 — Spratt BG Resistance to antibiotics mediated by target alterations.

Steenackers HP, Parijs I, Dubey A, Foster KR, Vanderleyden J Experimental evolution in biofilm populations. FEMS Microbiol Rev 40 6 Sturme MH, Kleerebezem M, Nakayama J, Akkermans AD, Vaughan EE, De Vos WM Cell to cell communication by autoinducing peptides in gram-positive bacteria.

Antonie Van Leeuwenhoek 81 — Suga H, Smith KM Molecular mechanisms of bacterial quorum sensing as a new drug target. Curr Opin Chem Biol 7 5 — Sutherland IW The biofilm matrix—an immobilized but dynamic microbial environment.

Trends Microbiol 9 5 — Tayeb-Fligelman E, Salinas N, Tabachnikov O, Landau M Staphylococcus aureus PSMα3 cross-α fibril polymorphism and determinants of cytotoxicity. Structure London, England: 28 3 — Topa SH, Subramoni S, Palombo EA, Kingshott P, Rice SA, Blackall LL Cinnamaldehyde disrupts biofilm formation and swarming motility of Pseudomonas aeruginosa.

Microbiology Reading, England 9 — Trivedi A, Mavi PS, Bhatt D, Kumar A Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. Nat Commun 7 1 Turnbull L, Toyofuku M, Hynen AL, Kurosawa M, Pessi G, Petty NK, Osvath SR, Cárcamo-Oyarce G, Gloag ES, Shimoni R, Omasits U, Ito S, Yap X, Monahan LG, Cavaliere R, Ahrens CH, Charles IG, Nomura N, Eberl L, Whitchurch CB Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms.

Nat Commun Ueda A, Wood TK Connecting Quorum Sensing, c-di-GMP, Pel Polysaccharide, and Biofilm Formation in Pseudomonas aeruginosa through Tyrosine Phosphatase TpbA PA PLoS Pathog 5:e Upadhyay A, Upadhyaya I, Johny AK, Venkitanarayanan K Combating pathogenic microorganisms using plant-derived antimicrobials: a minireview of the mechanistic basis.

Vandeputte OM, Kiendrebeogo M, Rajaonson S, Diallo B, Mol A, El Jaziri M, Baucher M Identification of catechin as one of the flavonoids from Combretum albiflorum bark extract that reduces the production of quorum-sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1.

Appl Environ Microbiol 76 1 — Vandeputte OM, Kiendrebeogo M, Rasamiravaka T, Stévigny C, Duez P, Rajaonson S, Diallo B, Mol A, Baucher M, El Jaziri M The flavanone naringenin reduces the production of quorum sensing-controlled virulence factors in Pseudomonas aeruginosa PAO1. Microbiology Reading Pt 7 — Vasconcelos NG, Croda J, Simionatto S Antibacterial mechanisms of cinnamon and its constituents: a review.

Vester B, Douthwaite S Macrolide resistance conferred by base substitutions in 23S rRNA. Vidal O, Longin R, Prigent-Combaret C, Dorel C, Hooreman M, Lejeune P Isolation of an Escherichia coli K mutant strain able to form biofilms on inert surfaces: involvement of a new ompR allele that increases curli expression.

J Bacteriol 9 — Vijayakumar S, Malaikozhundan B, Saravanakumar K, Duran-Lara EF, Wang MH, Vaseeharan B Garlic clove extract assisted silver nanoparticle—antibacterial, antibiofilm, antihelminthic, anti-inflammatory, anticancer and ecotoxicity assessment.

J Photochem Photobiol B Vikram A, Jayaprakasha GK, Jesudhasan PR, Pillai SD, Patil BS Suppression of bacterial cell-cell signalling, biofilm formation and type III secretion system by citrus flavonoids. J Appl Microbiol 2 — Vipin C, Mujeeburahiman M, Ashwini P, Arun A, Rekha PD Anti-biofilm and cytoprotective activities of quercetin against Pseudomonas aeruginosa isolates.

Lett Appl Microbiol 68 5 — Walencka E, Rozalska S, Wysokinska H, Rozalski M, Kuzma L, Rozalska B Salvipisone and aethiopinone from Salvia sclarea hairy roots modulate staphylococcal antibiotic resistance and express anti-biofilm activity.

Planta Med 73 6 — Wang R, Khan BA, Cheung GYC, Bach T-HL, Jameson-Lee M, Kong K-F et al Staphylococcus epidermidis surfactant peptides promote biofilm maturation and dissemination of biofilm-associated infection in mice.

Wang C, Hou J, van der Mei HC, Busscher HJ, Ren Y Emergent properties in streptococcus mutans biofilms are controlled through adhesion force sensing by initial colonizers. MBio Williams P Quorum sensing: an emerging target for antibacterial chemotherapy? Exp Opin Therap Target 6 3 — Wood TK, Barrios AFG, Herzberg M, Lee J Motility influences biofilm architecture in Escherichia coli.

Appl Microbiol Biotechnol 72 2 — Wright GD Aminoglycoside-modifying enzymes. Curr Opin Microbiol — Wu Y, Park KC, Choi BG, Park JH, Yoon KS The antibiofilm effect of ginkgo biloba extract against salmonella and listeria isolates from poultry.

Foodborne Pathog Dis 13 5 — Xu LC, Wo Y, Meyerhoff ME, Siedlecki CA Inhibition of bacterial adhesion and biofilm formation by dual functional textured and nitric oxide releasing surfaces. Acta Biomater — Yan J, Sharo AG, Stone HA, Wingreen NS, Bassler BL Vibrio cholerae biofilm growth program and architecture revealed by single-cell live imaging.

Proc Natl Acad Sci U S A 36 :E—E Yu Y, Yan F, Chen Y, Jin C, Guo J-H, Chai Y Poly-γ-glutamic acids contribute to biofilm formation and plant root colonization in selected environmental isolates of Bacillus subtilis.

Zeng Z, Qian L, Cao L, Tan H, Huang Y, Xue X, Shen Y, Zhou S Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa. Appl Microbiol Biotechnol 79 1 — Zhang J, Rui X, Wang L, Guan Y, Sun X, Dong M Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation.

Zhang J, Ye KP, Zhang X, Pan DD, Sun YY, Cao JX Antibacterial activity and mechanism of action of black pepper essential oil on meat-borne Escherichia coli. PubMed Google Scholar. Zhou JW, Luo HZ, Jiang H, Jian TK, Chen ZQ, Jia AQ Hordenine: a novel quorum sensing inhibitor and antibiofilm agent against pseudomonas aeruginosa.

J Agric Food Chem 66 7 — Download references. Department of Phytopharmaceuticals, School of Agriculture and Bioengineering, Centurion University of Technology and Management, Parlakhemundi, Odisha, India.

Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, West Bengal, Kolkata, West Bengal, India. You can also search for this author in PubMed Google Scholar.

Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Kolkata, West Bengal, India. Reprints and permissions. Ratha, B. Inhibition of Biofilm Formation. In: Ray, R. eds Biofilm-Mediated Diseases: Causes and Controls.

Springer, Singapore. Published : 06 May Publisher Name : Springer, Singapore. Print ISBN : Online ISBN : eBook Packages : Biomedical and Life Sciences Biomedical and Life Sciences R0.

Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Abstract Biofilm formation increases the survival chances of the microbial species.

Keywords Biofilm Quorum sensing Autoinducer Quorum quenching Phytochemicals. Buying options Chapter EUR eBook EUR Softcover Book EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions.

References Abraham EP, Chain E An enzyme from bacteria able to destroy penicillin. Rev Infect Dis — CAS PubMed Google Scholar Adegoke AA, Stenström TA, Okoh AI Stenotrophomonas maltophilia as an emerging ubiquitous pathogen: looking beyond contemporary antibiotic therapy.

Front Microbiol Article PubMed PubMed Central Google Scholar Albano M, Crulhas BP, Alves FCB, Pereira AFM, Andrade B, Barbosa LN, Furlanetto A, Lyra L, Rall VLM, Junior AF Antibacterial and anti-biofilm activities of cinnamaldehyde against S.

J Urol 1 — Article CAS PubMed Google Scholar Asfour HZ Anti-Quorum Sensing Natural Compounds. J Microsc Ultrastruct 6 1 :1—10 Article PubMed PubMed Central Google Scholar Bandara H, Lam O, Watt R, Jin L, Samaranayake L Bacterial lipopolysaccharides variably modulate in vitro biofilm formation of Candida species.

J Med Microbiol 59 10 — Article CAS PubMed Google Scholar Beachey EH, Giampapa CS, Abraham SN Bacterial adherence. S45 Article CAS PubMed Google Scholar Bielen K, s Jongers B, Boddaert J, Raju TK, Lammens C, Malhotra-Kumar S, Jorens PG, Goossens H, Kumar-Singh S Biofilm-Induced Type 2 Innate Immunity in a Cystic Fibrosis Model of Pseudomonas aeruginosa.

Int J Mol Sci — Article CAS Google Scholar Boles BR, Horswill AR Agr-mediated dispersal of staphylococcus aureus biofilms. PLoS Pathog 4:e Article PubMed PubMed Central CAS Google Scholar Bonnichsen L, Bygvraa Svenningsen N, Rybtke M, de Bruijn I, Raaijmakers JM, Tolker-Nielsen T et al Lipopeptide biosurfactant viscosin enhances dispersal of Pseudomonas fluorescens SBW25 biofilms.

Microbiology — Article CAS PubMed PubMed Central Google Scholar Cairns LS, Marlow VL, Bissett E, Ostrowski A, Stanley-Wall NR A mechanical signal transmitted by the flagellum controls signalling in Bacillus subtilis.

Arch Med Res — Article Google Scholar Cavalcante TTA, Sá Firmino N, Tajra FS, de Andrade CR, Costa RA Plant lectins as alternative tools against bacterial biofilms.

Afr J Microbiol Res — Article CAS Google Scholar Chippaux C, Puchelle E Cytotoxicity of Pseudomonas aeruginosa internal lectin PA-I to respiratory epithelial cells in primary culture.

Infect Immun 62 10 — Article PubMed PubMed Central Google Scholar Chong YM, Yin WF, Ho CY, Mustafa MR, Hadi AH, Awang K, Narrima P, Koh CL, Appleton DR, Chan KG Malabaricone C from Myristica cinnamomea exhibits anti-quorum sensing activity.

J Nat Prod 74 10 — Article CAS PubMed Google Scholar Choo JH, Rukayadi Y, Hwang JK Inhibition of bacterial quorum sensing by vanilla extract.

Lett Appl Microbiol — CAS PubMed Google Scholar Colvin KM, Gordon VD, Murakami K, Borlee BR, Wozniak DJ, Wong GC, Parsek MR The pel polysaccharide can serve a structural and protective role in the biofilm matrix of Pseudomonas aeruginosa.

PLoS Pathog 7 1 :e Article CAS PubMed PubMed Central Google Scholar Colvin KM, Irie Y, Tart CS, Urbano R, Whitney JC, Ryder C, Howell PL, Wozniak DJ, Parsek MR The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix.

Environ Microbiol 14 8 — Article CAS PubMed Google Scholar Cossart P, Jonquières R Sortase, a universal target for therapeutic agents against gram-positive bacteria? Science — Article CAS PubMed Google Scholar Cucarella C, Tormo MA, Ubeda C, Trotonda MP, Monzón M, Peris C, Amorena B, Lasa Í, Penadés JR Role of biofilm-associated protein bap in the pathogenesis of bovine Staphylococcus aureus.

Abisado RG, Benomar S, Klaus JR, Dandekar AA, Chandler JR Bacterial quorum sensing and microbial community interactions. mBio 9:e Article CAS PubMed PubMed Central Google Scholar.

Alcaraz E, Ghiglione B, Pineda MV, Mangano A, Di Conza J, Passerini de Rossi B AmpR is a dual regulator in Stenotrophomonas maltophilia with a positive role in β-lactam resistance and a negative role in virulence, biofilm and DSF production.

Res Microbiol Article CAS PubMed Google Scholar. Alhede M, Kragh KN, Qvortrup K, Allesen-Holm M, van Gennip M, Christensen LD, Jensen PØ, Nielsen AK, Parsek M, Wozniak D, Molin S, Tolker-Nielsen T, Høiby N, Givskov M, Bjarnsholt T Phenotypes of non-attached Pseudomonas aeruginosa aggregates resemble surface attached biofilm.

PLoS ONE 6:e Arnaouteli S, Bamford NC, Stanley-Wall NR, Kovács ÁT Bacillus subtilis biofilm formation and social interactions. Nat Rev Microbiol — Asfour HZ Anti-quorum sensing natural compounds. J Microsc Ultrastruct — Article PubMed PubMed Central Google Scholar.

Bandara H, Lam OLT, Jin LJ, Samaranayake L Microbial chemical signaling: a current perspective. Crit Rev Microbiol — Banin E, Vasil ML, Greenberg EP Iron and Pseudomonas aeruginosa biofilm formation. Proc Natl Acad Sci U S A — Barber CE, Tang JL, Feng JX, Pan MQ, Wilson TJ, Slater H, Dow JM, Williams P, Daniels MJ A novel regulatory system required for pathogenicity of Xanthomonas campestris is mediated by a small diffusible signal molecule.

Mol Microbiol — Barraud N, Létoffé S, Beloin C, Vinh J, Chiappetta G, Ghigo J-M Lifestyle-specific S-nitrosylation of protein cysteine thiols regulates Escherichia coli biofilm formation and resistance to oxidative stress. NPJ Biofilms Microbiomes Batoni G, Maisetta G, Esin S Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria.

Biochim Biophys Acta — Bjarnsholt T, Jensen PØ, Jakobsen TH, Phipps R, Nielsen AK, Rybtke MT, Tolker-Nielsen T, Givskov M, Høiby N, Ciofu O, Scandinavian Cystic Fibrosis Study Consortium Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients.

PLoS ONE 5:e Boles BR, Horswill AR Agr-mediated dispersal of Staphylococcus aureus biofilms. PLoS Pathog 4:e Boon C, Deng Y, Wang L-H, He Y, Xu J-L, Fan Y, Pan SQ, Zhang L-H A novel DSF-like signal from Burkholderia cenocepacia interferes with Candida albicans morphological transition.

ISME J — Bos R, van der Mei HC, Busscher HJ Physico-chemistry of initial microbial adhesive interactions—its mechanisms and methods for study. FEMS Microbiol Rev — Brooke JS Stenotrophomonas maltophilia : an emerging global opportunistic pathogen. Clin Microbiol Rev — Butler SM, Camilli A Going against the grain: chemotaxis and infection in Vibrio cholerae.

Carmona-Torre F, Rua M, Del Pozo JL Non-valvular intravascular device and endovascular graft-related infection.

Rev Esp Quimioter 30 Suppl — CAS PubMed Google Scholar. Chant EL, Summers DK Indole signalling contributes to the stable maintenance of Escherichia coli multicopy plasmids. Chatterjee M, Anju CP, Biswas L, Anil Kumar V, Gopi Mohan C, Biswas R Antibiotic resistance in Pseudomonas aeruginosa and alternative therapeutic options.

Int J Med Microbiol — Chen X, Schauder S, Potier N, Van Dorsselaer A, Pelczer I, Bassler BL, Hughson FM Structural identification of a bacterial quorum-sensing signal containing boron.

Nature — Choby JE, Howard-Anderson J, Weiss DS Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives. J Intern Med — Cirioni O, Mocchegiani F, Cacciatore I, Vecchiet J, Silvestri C, Baldassarre L, Ucciferri C, Orsetti E, Castelli P, Provinciali M, Vivarelli M, Fornasari E, Giacometti A Quorum sensing inhibitor FS3-coated vascular graft enhances daptomycin efficacy in a rat model of staphylococcal infection.

Peptides — Claessen D, Rink R, de Jong W, Siebring J, de Vreugd P, Boersma FGH, Dijkhuizen L, Wosten HAB A novel class of secreted hydrophobic proteins is involved in aerial hyphae formation in Streptomyces coelicolor by forming amyloid-like fibrils. Genes Dev — Colvin KM, Irie Y, Tart CS, Urbano R, Whitney JC, Ryder C, Howell PL, Wozniak DJ, Parsek MR The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix.

Environ Microbiol. Article PubMed Google Scholar. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM Microbial biofilms.

Annu Rev Microbiol — Coyne MJ, Russell KS, Coyle CL, Goldberg JB The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core. J Bacteriol — Daly SM, Elmore BO, Kavanaugh JS, Triplett KD, Figueroa M, Raja HA, El-Elimat T, Crosby HA, Femling JK, Cech NB, Horswill AR, Oberlies NH, Hall PR ω-Hydroxyemodin limits Staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

Antimicrob Agents Chemother — Danese PN, Pratt LA, Kolter R Exopolysaccharide production is required for development of Escherichia coli K biofilm architecture.

Das T, Kutty SK, Kumar N, Manefield M Pyocyanin facilitates extracellular DNA binding to Pseudomonas aeruginosa influencing cell surface properties and aggregation. PLoS ONE 8:e Das T, Kutty SK, Tavallaie R, Ibugo AI, Panchompoo J, Sehar S, Aldous L, Yeung AWS, Thomas SR, Kumar N, Gooding JJ, Manefield M Phenazine virulence factor binding to extracellular DNA is important for Pseudomonas aeruginosa biofilm formation.

Sci Rep Das T, Sharma PK, Busscher HJ, van der Mei HC, Krom BP Role of extracellular DNA in initial bacterial adhesion and surface aggregation. Appl Environ Microbiol — Del Pozo JL Biofilm-related disease.

Expert Rev Anti Infect Ther — Del Pozo JL Novel treatment dynamics for biofilm-related infections. De JW, Wösten HAB, Dijkhuizen L, Claessen D Attachment of Streptomyces coelicolor is mediated by amyloidal fimbriae that are anchored to the cell surface via cellulose.

Mol Microbiol Denamur E, Clermont O, Bonacorsi S, Gordon D The population genetics of pathogenic Escherichia coli. Deng Y, Lim A, Lee J, Chen S, An S, Dong Y-H, Zhang L-H Diffusible signal factor DSF quorum sensing signal and structurally related molecules enhance the antimicrobial efficacy of antibiotics against some bacterial pathogens.

BMC Microbiol Deng Y, Schmid N, Wang C, Wang J, Pessi G, Wu D, Lee J, Aguilar C, Ahrens CH, Chang C, Song H, Eberl L, Zhang L-H Cisdodecenoic acid receptor RpfR links quorum-sensing signal perception with regulation of virulence through cyclic dimeric guanosine monophosphate turnover.

Deng Y, Wu J, Tao F, Zhang L-H Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria. Chem Rev — Domka J, Lee J, Wood TK YliH BssR and YceP BssS regulate Escherichia coli K biofilm formation by influencing cell signaling. Dueholm MS, Søndergaard MT, Nilsson M, Christiansen G, Stensballe A, Overgaard MT, Givskov M, Tolker-Nielsen T, Otzen DE, Nielsen PH Expression of Fap amyloids in Pseudomonas aeruginosa , P.

fluorescens , and P. putida results in aggregation and increased biofilm formation. Microbiologyopen — Dwidar M, Jang H, Sangwan N, Mun W, Im H, Yoon S, Choi S, Nam D, Mitchell RJ Diffusible signaling factor, a quorum-sensing molecule, interferes with and is toxic towards Bdellovibrio bacteriovorus J.

Microb Ecol — Egland KA, Greenberg EP Quorum sensing in Vibrio fischeri : elements of the luxI promoter. Federle MJ, Bassler BL Interspecies communication in bacteria. J Clin Invest — Feng T, Han Y, Li B, Li Z, Yu Y, Sun Q, Li X, Du L, Zhang X-H, Wang Y Interspecies and intraspecies signals synergistically regulate Lysobacter enzymogenes twitching motility.

Appl Environ Microbiol ee Fernandes R, Bentley WE AI-2 biosynthesis module in a magnetic nanofactory alters bacterial response via localized synthesis and delivery. Biotechnol Bioeng — Frølund B, Palmgren R, Keiding K, Nielsen PH Extraction of extracellular polymers from activated sludge using a cation exchange resin.

Water Res — Article Google Scholar. George EA, Novick RP, Muir TW Cyclic peptide inhibitors of staphylococcal virulence prepared by fmoc-based thiolactone peptide synthesis. J Am Chem Soc — Gloag ES, Turnbull L, Huang A, Vallotton P, Wang H, Nolan LM, Mililli L, Hunt C, Lu J, Osvath SR, Monahan LG, Cavaliere R, Charles IG, Wand MP, Gee ML, Prabhakar R, Whitchurch CB Self-organization of bacterial biofilms is facilitated by extracellular DNA.

Grant WD, Sutherland IW, Wilkinson JF Exopolysaccharide colanic acid and its occurrence in the Enterobacteriaceae. Greenberg M, Kuo D, Jankowsky E, Long L, Hager C, Bandi K, Ma D, Manoharan D, Shoham Y, Harte W, Ghannoum MA, Shoham M Small-molecule AgrA inhibitors F12 and F19 act as antivirulence agents against Gram-positive pathogens.

Gupta P, Sarkar S, Das B, Bhattacharjee S, Tribedi P Biofilm, pathogenesis and prevention—a journey to break the wall: a review. Arch Microbiol — Microbiol Spectr 3 2 :MB Haaber J, Cohn MT, Frees D, Andersen TJ, Ingmer H Planktonic aggregates of Staphylococcus aureus protect against common antibiotics.

PLoS ONE 7:e Haesler E, Swanson T, Ousey K, Carville K Clinical indicators of wound infection and biofilm: reaching international consensus. J Wound Care s4—s Han X, Lu C Biological activity and identification of a peptide inhibitor of LuxS from Streptococcus suis serotype 2.

FEMS Microbiol Lett — Han Y, Wang Y, Tombosa S, Wright S, Huffman J, Yuen G, Qian G, Liu F, Shen Y, Du L Identification of a small molecule signaling factor that regulates the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes.

Appl Microbiol Biotechnol — Han Y, Wang Y, Yu Y, Chen H, Shen Y, Du L Indole-induced reversion of intrinsic multiantibiotic resistance in Lysobacter enzymogenes. Appl Environ Microbiol e He YW, Ng AYJ, Xu M, Lin K, Wang LH, Dong YH, Zhang LH Xanthomonas campestris cell-cell communication involves a putative nucleotide receptor protein Clp and a hierarchical signalling network.

Hirakawa H, Inazumi Y, Masaki T, Hirata T, Yamaguchi A Indole induces the expression of multidrug exporter genes in Escherichia coli. Høiby N, Ciofu O, Bjarnsholt T Pseudomonas aeruginosa biofilms in cystic fibrosis. Future Microbiol — Hojo K, Nagaoka S, Ohshima T, Maeda N Bacterial interactions in dental biofilm development.

J Dent Res — Hu X, Wang Y, Gao L, Jiang W, Lin W, Niu C, Yuan K, Ma R, Huang Z The impairment of methyl metabolism from luxS mutation of Streptococcus mutans. Front Microbiol Hu Y, Kwan BW, Osbourne DO, Benedik MJ, Wood TK Toxin YafQ increases persister cell formation by reducing indole signalling.

Environ Microbiol — Jackson KD, Starkey M, Kremer S, Parsek MR, Wozniak DJ Identification of psl, a locus encoding a potential exopolysaccharide that is essential for Pseudomonas aeruginosa PAO1 biofilm formation.

James GA, Swogger E, Wolcott R, deLancey PE, Secor P, Sestrich J, Costerton JW, Stewart PS Biofilms in chronic wounds.

Wound Repair Regen — Jennings LK, Dreifus JE, Reichhardt C, Storek KM, Secor PR, Wozniak DJ, Hisert KB, Parsek MR Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies.

Cell Rep Jiang Q, Chen J, Yang C, Yin Y, Yao K Quorum sensing: a prospective therapeutic target for bacterial diseases. Biomed Res Int Kaur A, Capalash N, Sharma P Communication mechanisms in extremophiles: exploring their existence and industrial applications.

Microbiol Res — Kim J, Park W Indole inhibits bacterial quorum sensing signal transmission by interfering with quorum sensing regulator folding. Microbiology — Klausen M, Heydorn A, Ragas P, Lambertsen L, Aaes-Jørgensen A, Molin S, Tolker-Nielsen T Biofilm formation by Pseudomonas aeruginosa wild type, flagella and type IV pili mutants.

Kolenbrander PE, Andersen RN, Blehert DS, Egland PG, Foster JS, Palmer RJ Communication among oral bacteria. Microbiol Mol Biol Rev — Koo H, Allan RN, Howlin RP, Hall-Stoodley L, Stoodley P Targeting microbial biofilms: current and prospective therapeutic strategies.

Krüger W, Vielreicher S, Kapitan M, Jacobsen ID, Niemiec MJ Fungal-bacterial interactions in health and disease. Pathogens Article CAS PubMed Central Google Scholar. Kuczyńska-Wiśnik D, Matuszewska E, Laskowska E Escherichia coli heat-shock proteins IbpA and IbpB affect biofilm formation by influencing the level of extracellular indole.

Kuczyńska-Wiśnik D, Stojowska K, Matuszewska E, Leszczyńska D, Algara MM, Augustynowicz M, Laskowska E Lack of intracellular trehalose affects formation of Escherichia coli persister cells.

Kuramitsu HK, He X, Lux R, Anderson MH, Shi W Interspecies interactions within oral microbial communities. Kwan BW, Osbourne DO, Hu Y, Benedik MJ, Wood TK Phosphodiesterase DosP increases persistence by reducing cAMP which reduces the signal indole. Laganenka L, Sourjik V Autoinducer 2-dependent Escherichia coli biofilm formation is enhanced in a dual-species coculture.

Lee J, Attila C, Cirillo SLG, Cirillo JD, Wood TK Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence. Microb Biotechnol — Lee J, Jayaraman A, Wood TK a Indole is an inter-species biofilm signal mediated by SdiA.

BMC Microbiol — Article CAS Google Scholar. Lee J, Page R, García-Contreras R, Palermino J-M, Zhang X-S, Doshi O, Wood TK, Peti W b Structure and function of the Escherichia coli protein YmgB: a protein critical for biofilm formation and acid-resistance.

J Mol Biol — Lee J-H, Cho MH, Lee J 3-indolylacetonitrile decreases Escherichia coli OH7 biofilm formation and Pseudomonas aeruginosa virulence. Lee J-H, Kim Y-G, Gwon G, Wood TK, Lee J Halogenated indoles eradicate bacterial persister cells and biofilms.

AMB Express Li W, Zheng T, Ma Y, Liu J Current status and future prospects of sewer biofilms: their structure, influencing factors, and substance transformations.

Sci Total Environ Li Y, Feng T, Wang Y The role of bacterial signaling networks in antibiotics response and resistance regulation. Mar Life Sci Technol Lidor O, Al-Quntar A, Pesci EC, Steinberg D Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase.

Sci Rep — Liu J, Jia R, Zhou E, Zhao Y, Dou W, Xu D, Yang K, Gu T Antimicrobial Cu-bearing duplex stainless steel against MIC by nitrate reducing Pseudomonas aeruginosa biofilm.

Int Biodeterior Biodegrad — Liu X, Kimmey JM, Matarazzo L, de Bakker V, Van Maele L, Sirard J-C, Nizet V, Veening J-W Exploration of bacterial bottlenecks and streptococcus pneumoniae pathogenesis by CRISPRi-Seq. Cell Host Microbe Lynch DJ, Fountain TL, Mazurkiewicz JE, Banas JA Glucan-binding proteins are essential for shaping Streptococcus mutans biofilm architecture.

Ma L, Wang J, Wang S, Anderson EM, Lam JS, Parsek MR, Wozniak DJ Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated.

Malhotra S, Hayes D, Wozniak DJ Cystic fibrosis and Pseudomonas aeruginosa : the host-microbe interface. Clin Microbiol Rev ee McNab R, Ford SK, El-Sabaeny A, Barbieri B, Cook GS, Lamont RJ LuxS-based signaling in Streptococcus gordonii : autoinducer 2 controls carbohydrate metabolism and biofilm formation with Porphyromonas gingivalis.

Martino PD, Fursy R, Bret L, Sundararaju B, Phillips RS Indole can act as an extracellular signal to regulate biofilm formation of Escherichia coli and other indole-producing bacteria. Can J Microbiol — Miller MB, Bassler BL Quorum sensing in bacteria. Mueller RS, Beyhan S, Saini SG, Yildiz FH, Bartlett DH Indole acts as an extracellular cue regulating gene expression in Vibrio cholerae.

J Bacteriol Murray EJ, Williams P Detection of agr -type autoinducing peptides produced by Staphylococcus aureus. Methods Mol Biol — Nadell CD, Xavier JB, Foster KR The sociobiology of biofilms.

Nealson KH, Platt T, Hastings JW Cellular control of the synthesis and activity of the bacterial luminescent system. Ng WL, Bassler BL Bacterial quorum-sensing network architectures.

Annu Rev Genet — Ni N, Li M, Wang J, Wang B Inhibitors and antagonists of bacterial quorum sensing. Med Res Rev — Niazy AA LuxS quorum sensing system and biofilm formation of oral microflora: a short review article.

Saudi Dent J — Nikaido E, Giraud E, Baucheron S, Yamasaki S, Wiedemann A, Okamoto K, Takagi T, Yamaguchi A, Cloeckaert A, Nishino K Effects of indole on drug resistance and virulence of Salmonella enterica serovar Typhimurium revealed by genome-wide analyses.

Gut Pathog

Biofilm formation increases the survival Inhinits of foramtion microbial Formatoin. Increase bioofilm microbial cell density triggers quorum sensing Anti-inflammatory properties leads to Anti-inflammatory properties formation. Antibacterial pet shampoo emergence of multidrug resistance MDR strains with biofilm formation ability of human pathogen has limited effective antibiotic-based treatment. Hence it is immediately required to identify novel molecules for the treatment of such microbial infections forming a biofilm. Here, traditional medicine has a lot to offer in search of a novel therapeutic molecule. Boosting skin vitality formation is a major concern in formatioon Boosting skin vitality and cause severe problems for,ation public health, medicine, fromation industry. Bacterial biofilm formation Innhibits a major persistent threat, as it increases Inhibitx and mortality, thereby formattion heavy economic pressure on Non-GMO fat burner healthcare sector. Bacterial biofilms also strengthen biofouling, affecting shipping functions, and the offshore industries in their natural environment. Besides, they accomplish harsh roles in the corrosion of pipelines in industries. At biofilm state, bacterial pathogens are significantly resistant to external attack like antibiotics, chemicals, disinfectants, etc. Within a cell, they are insensitive to drugs and host immune responses. The development of intact biofilms is very critical for the spreading and persistence of bacterial infections in the host.

Video

Demo: Biofilm Formation