These findings could spur research around novel and effective treatment for gouty arthritis, a form of arthritis caused by hyperuricemia that causes significant pain. Oxidative stress and inflammation have been reported to be related to the development of gouty arthritis, so anti-inflammatory drugs and uric acid-lowering medicines are widely used in its management.

However, these drugs may cause adverse side effects such as renal, gastrointestinal, and cardiovascular complications. Astaxanthin is known for its anti-inflammatory and antioxidant properties, so this research conducted in China involved studying astaxanthin intake on relevant biomarkers, doing so through animal studies with rats and zebrafish, as well as a human clinical trial.

For the human clinical study, 60 participants diagnosed with acute gout arthritis were recruited. They were randomly divided into the intervention and drug control group. The trial lasted seven days. Follow-up visits were scheduled on days one, three and seven, with examinations on biomarkers performed on days one and seven.

The biomarkers analysed include immunity indexes such as C-reactive protein, erythrocyte sedimentation rate, as well as uric acid levels. The results showed astaxanthin combined with celecoxib worked better than celecoxib alone in reducing uric acid levels and erythrocyte sedimentation rate.

These results suggest astaxanthin has potential as a dietary supplement to assist in the treatment of gouty arthritis. The results of the animal experiments showed that in terms of animal serological indicators, astaxanthin has the same effect as colchicine in treating gouty arthritis.

Astaxanthin also demonstrated a significant inhibitory effect on cyclooxygenase-2 COX-2 activity. in zebrafish, thus suggesting that astaxanthin might play a role in the treatment of gouty arthritis through exhibiting anti-inflammatory, antioxidant properties and suppressing COX When the body is stimulated by inflammation, it produces a large amount of COX-2, which can lead to tissue damage.

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Grant Number is F. Pharmacology Division, University Institute of Pharmaceutical Sciences UIPS , Panjab University, Chandigarh, , India. Pharmacology Research Laboratory, UGC Centre of Advanced Studies, University Institute of Pharmaceutical Sciences UIPS , Panjab University, Chandigarh, , India.

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Reprints and permissions. Kumar, A. et al. Astaxanthin attenuates oxidative stress and inflammatory responses in complete Freund-adjuvant-induced arthritis in rats. Rep 72 , — Download citation. Received : 13 May Revised : 15 September Accepted : 11 October Published : 19 December Issue Date : February Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Background Astaxanthin ATX , a natural xanthophyll carotenoid, has shown to exert significant protective effects against various diseases via its antioxidant and anti-inflammatory properties.

Conclusions Our findings suggest that ATX possesses potential anti-arthritic activity, which could be attributed to its anti-inflammatory and antioxidant properties. Access this article Log in via an institution. References Lan Z, Wei M, Chen L, Xie G, Liu X, Zhang X.

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