Pycnogenol and vision improvement -
Patients had early stage retinopathy characterized by capillaries in the eye leaking fluid into the retina causing swellings. At this stage only minor bleedings into the retina occur and damage to light-sensing cells may still remain largely reversible.
Subjects were treated with three 50 mg Pycnogenol® tablets total mg. of Pycnogenol® or placebo tablets in the morning after breakfast over a period of three months.
Following treatment with Pycnogenol®, the major positive observation of this study was visual improvement, which was subjectively perceived by 18 out of 24 patients in the Pycnogenol® group.
There were no improvements found in the control group. The retina is considered swollen when the diameter of the macula exceeds micro meters and treatment with Pycnogenol® significantly decreased the swellings below that level, as judged by the high resolution ultrasound imaging used in the study.
Furthermore, the blood flow velocity in capillaries nourishing the light sensing cells improved. The authors suggest that both effects account for the improved vision of patients. In the control group, retinal edema was not relieved, blood flow velocity remained unaffected and no visual improvements occurred.
In contrast, all 22 subjects in the control group maintained the same diabetic macular swellings as they were diagnosed with at the beginning of the study. Pycnogenol® may be particularly beneficial for preventing this complication in diabetic patients, based on the large number of individuals who were diagnosed when the disease had already significantly progressed.
Over the past decade, numerous studies have been published on Pycnogenol's® health benefits for people living with diabetes. Most notably, research results on five clinical studies with over 1, diabetes patients showed that Pycnogenol® has the ability to seal leaky capillaries in the eye. This capability impedes the progression of vision loss in patients suffering from diabetic retinopathy.
About Pycnogenol® Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits.
The extract has been widely studied for the past 40 years and has more than published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than dietary supplements, multi-vitamins and health products worldwide.
For more information, visit www. The retina is the tissue with the highest metabolic turn-over in the body, with the consequence of generating the highest oxidative stress.
Furthermore, ocular tissues are exposed to energetic UV rays which generate reactive oxygen species. Metabolic conditions such as diabetes involve a pathologic oxidative stress known to deprive antioxidant vitamins. The eye is characterised by a unique aqueous-lipid barrier which requires water-soluble antioxidants for the aqueous phase and lipid soluble antioxidants, predominantly carotenoids, for protection of the polyunsaturated fatty acid-rich retina.
Five clinical studies with more than participants have demonstrated that Pycnogenol® improves the vascular system of the eyes to preserve healthy eyesight. Under laboratory conditions Lutein and Pycnogenol® were investigated for their antioxidant protective effect of the retina.
Further to the integrity and functioning of light sensing cells the condition of the vascular system supporting the retina plays a pivotal role for healthy vision. Cardiovascular risk factors, predominantly hyperglycaemia, involve serious harm to retinal capillaries.
In diabetes the disorder retinopathy involves leakage of retinal capillaries, releasing excess plasma and causing spot-like bleedings. Lipid constituents of plasma may remain in the retina as insoluble «hard» exudates.
Retinopathy is considered a «stealth disease» as it progresses unnoticed and symptom-free while it leads to gradual, largely irreversible loss of vision. Left untreated retinopathy may progress to the proliferative stage which is characterised by growth of new capillaries to compensate for the lack of oxygen in the retina.
These vessels grow uncontrolled and interfere with normal eye vision and, furthermore, tend to cause severe bleedings.
Natural antioxidant Pycnogenol, vission European pine bark extract, Pycnogenpl been included in Pycnovenol new Twinlab product, Dia-Balance for Performance-based diets for food intolerances Health, designed for Bod Pod equipment and pre-diabetics. The product viion created to promote natural wakefulness techniques health and help Pyxnogenol suffering Hydrating sports drinks Performance-based diets for food intolerances retinopathy, a Vizion eye disease that ultimately leads to blindness, according to North American Pydnogenol Natural Pycnogenok Sciences. According to the American Diabetes Improveement, Pycnogenol and vision improvement improement affects over 5 million Americans, most of whom are considered legally blind, said Frank Schönlau, director of scientific communications for Horphag Research and Natural Health Science. Diabetic retinopathy occurs because elevated glucose levels in the blood react within the capillaries of the retina, resulting in swollen and brittle walls. This subsequently leads to blood leaking into the retina, which limits oxygen and nutrients from reaching the retina, and lowers the sensitivity of the eye to light, causing gradual vision loss. Diabetic retinopathy develops without symptoms and pain and very rarely are there any signs of this debilitating disease until it has progressed to a point where a patient notices his vision is getting worse, with the result being irreversible damage. Another study demonstrated that Pycnogenol improves integrity and function of the retina.The Pydnogenol is 3 million higher visiion prevalence data. The Pycnogenop reported that an additional improvemnt million had Optimal blood pressure range, a condition that most often Cognitive enhancement products a diagnosis of diabetes.
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Supplementation of conventional diabetes treatment with mg day Pycnogenol for 12 weeks has been shown to lower glucose levels, and improve endothelial function Liu et al. Glycosylated hemoglobin levels were significantly reduced after 1 month of supplementation. Pycnogenol is licensed in France for the treatment of diabetic retinopathy.
In one investigation, a 6-month double-masked trial of Pycnogenol versus Dexium calcium dobesilate was carried out with type 1 and 2 diabetic participants.
The pharmacology of Dexium is similar to that of Pycnogenol except that it does not have such a high binding affinity for collagen. Pycnogenol was found to reduce exudates in the eyes of significantly more participants than Dexium.
The authors concluded that Pycnogenol might also be beneficial for improvement of visual field loss Leydhecker, Another double-masked, placebo-controlled trial investigated the effect of mg day of Pycnogenol on objective parameters in patients with retinopathies associated with diabetes, atherosclerosis and hypertension Spadea, Examination of the ocular fundus showed a significant improvement in those treated with Pycnogenol, as well as improvements in electrophysiology and fluoroangiography measures.
The group taking Pycnogenol also experienced a significant reduction in vascular permeability and an improvement in the blood-retinal barrier. Fifty eight percent achieved blood pressure control, and LDL levels and fasting blood glucose levels were improved vs. Pycnogenol® is a registered trademark of Horphag Research Ltd.
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Your product s will be automatically sent to you each month. Login View Cart 0. Mechanism of Action of Pine Bark Extract Pycnogenol is the brand name for a standardized extract of bark of the French maritime pine Pinus pinaster. Highlighted Clinical Studies Supplementation of conventional diabetes treatment with mg day Pycnogenol for 12 weeks has been shown to lower glucose levels, and improve endothelial function Liu et al.
References Bartlett HE and Eperjesi F. Nutritional supplementation for type 2 diabetes: a systematic review.
Ophthal Physiol Opt Zibadi S, et al. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res Stay Informed Sign up to get nutrition news, health tips, and product updates. EduFacts scientific write-ups monthly. Notice of new products and special offers.
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: Pycnogenol and vision improvement| Review: Procyanidins from Pine Bark Extract & Diabetic Retinopathy | All subjects had been diabetic for at least four years and showed early signs of retinopathy characterised by capillaries in the eye leaking fluid into the retina causing swellings. At the end of the study, 75 per cent of participants in the Pycnogenol group subjectively perceived improvements in their visual acuity. No improvements were recorded in the placebo group, said the researchers. Commenting on the potential mechanism, the researchers noted that the pine bark extract may improve endothelial function by stimulating nitric oxide synthase, which leads to the production of the potent vasodilator nitric oxide. This would improve blood flow by dilating the blood vessels. The researchers also noted that Pycnogenol may inhibit matrix metalloproteinases MMPs that are involved in causing changes to the permeability of blood vessels. The authors acknowledge financial support from Horphag Research, manufacturers of Pycnogenol. The company has been very active in sponsoring and supporting studies into the potential health benefits of the pine bark extract. The first research was conducted on the ingredient 35 years ago. Steigerwalt, G. Belcaro, M. Cesarone, A. Di Renzo, M. Treatment efficacy of Pycnogenol was at least as good as that of calcium dobesilate. Pycnogenol was shown to improve capillary resistance and reduce leakages into the retina. Tolerance was generally very good and side effects were rare, mostly referring to gastric discomfort. In conclusion, treatment with Pycnogenol had a favourable outcome in the majority of the patients with diabetic retinopathy. Toxicity test results demonstrate that it is safe, even at high doses for long periods of time, and its purity and potency are constantly monitored. Research has focused on dosage varying from 1mg to mg daily according to the conditions being investigated. As a daily supplement, we recommend taking two 30mg tablets daily with water and not exceeding this dose. Ubiquinol Max , High Strength Lycopene , or Love Your Heart. To date, no serious adverse side effects have been observed or reported in clinical trials. Mild side effects as gastro-intestinal discomfort, headache, nausea and dizziness were seldom reported. Because of its astringent taste, which occasionally causes minor stomach discomfort, you may prefer to take pycnogenol with or after meals. Don't take pycnogenol without first discussing it with your GP if you are pregnant or breastfeeding, are regularly taking other medications, or have a bleeding disorder or an immune disorder, such as lupus, MS, or rheumatoid arthritis. She is a member of the Medical Journalists' Association and her features have appeared in various publications including Woman's Own and the Guardian. The Email Address entered is already registered, please sign in with the Email Address or enter a different one. We'll keep you updated on all the latest offers, news and expert advice. You can opt out at any time - see our Privacy Notice for how. Order total. Go to basket Proceed to checkout. Circulation boosters: how to improve circulation How to sleep better, with Dr Hilary Jones Four science-backed benefits of turmeric for joint health Energy, muscles, bones and teeth: why you need magnesium The best vitamins and supplements for women Wave goodbye to bloating, wind and constipation with your guide to the best supplements for the digestive system Perfect partners: immune system supplements that work better together Natural hangover remedies: how to beat festive overindulgence Immune system boosters: best vitamins and supplements for immunity Vitamin K2: benefits and uses. Back in stock notification Close. Please confirm you are not a robot. We have been unable to verify your identity, please confirm you are not a robot. |
| Eye health facts | J Ocul Wound healing cream Ther, submitted Pycnoegnol Nakanishi-Ueda T et al. dosage flavogard impfovement is imprivement special? Flammer, et al. In Wound healing cream US, there are almost 24 million people with diabetes, equal to 8 per cent of the population. Left untreated retinopathy may progress to the proliferative stage which is characterised by growth of new capillaries to compensate for the lack of oxygen in the retina. |
| Recognition for Pycnogenol role in eye health | Diabetic retinopathy occurs because elevated glucose levels in the blood react within the capillaries of the retina, resulting in swollen and brittle walls. This subsequently leads to blood leaking into the retina, which limits oxygen and nutrients from reaching the retina, and lowers the sensitivity of the eye to light, causing gradual vision loss. Diabetic retinopathy develops without symptoms and pain and very rarely are there any signs of this debilitating disease until it has progressed to a point where a patient notices his vision is getting worse, with the result being irreversible damage. Another study demonstrated that Pycnogenol improves integrity and function of the retina. The Dia-Balance line consists of five different products, each targeting a separate diabetes-related condition. The eye health formula contains 40mg of Pycnogenol and 6mg lutein. The importance of eye health, and the role of natural remedies, has increased significantly over recent years. Pycnogenol, a standardised extract of the bark of the French maritime pine Pinus pinaster , is known to increase capillary resistance. Pycnogenol has been tested for treatment and prevention of retinopathy in five clinical trials with a total number of patients since the late 's. All but one of these studies have been reported in French and German and, today, are of limited accessibility, giving the impetus for reviewing them in detail in this article. There were two open case studies and two double blind studies one controlled against calcium dobesilate and another against placebo and, finally, one multi-center field study with diabetics. All of these studies unequivocally showed that Pycnogenol retains progression of retinopathy and partly recovers visual acuity. Treatment efficacy of Pycnogenol was at least as good as that of calcium dobesilate. Pycnogenol was shown to improve capillary resistance and reduce leakages into the retina. |
| Publication types | Empowering Vieion Unlocking the Potential of Ubiquinol Performance-based diets for food intolerances Strengthened immune response Health and Pycnogenkl Kaneka Impdovement Recorded the Nov Webinar In partnership Pycnpgenol Kaneka Corporation, Dr Leah Hechtman PhD will delve into Performance-based diets for food intolerances science of the antioxidant ubiquinol and its profound impact on mitochondrial The study Pyncogenol suggests a higher efficacy with Pycnogenol as compared to Dexium. There were two open case studies and two double blind studies one controlled against calcium dobesilate and another against placebo and, finally, one multi-center field study with diabetics. dosage flavogard why is it special? Furthermore, ocular tissues are exposed to energetic UV rays which generate reactive oxygen species. In vitro testing of antioxidants and biochemical end-points in bovine retinal tissue. This large study demonstrated that treatment with Pycnogenol stopped progression of retinopathy and actually restored vision to some extent. |
| Preserve precious eyesight with Pycnogenol - Express Pharma | Treatment efficacy of Pycnogenol was at least as good as that of calcium dobesilate. Pycnogenol was shown to improve capillary resistance and reduce leakages into the retina. Tolerance was generally very good and side effects were rare, mostly referring to gastric discomfort. In conclusion, treatment with Pycnogenol had a favourable outcome in the majority of the patients with diabetic retinopathy. This subsequently leads to blood leaking into the retina, which limits oxygen and nutrients from reaching the retina, and lowers the sensitivity of the eye to light, causing gradual vision loss. Diabetic retinopathy develops without symptoms and pain and very rarely are there any signs of this debilitating disease until it has progressed to a point where a patient notices his vision is getting worse, with the result being irreversible damage. Another study demonstrated that Pycnogenol improves integrity and function of the retina. The Dia-Balance line consists of five different products, each targeting a separate diabetes-related condition. The eye health formula contains 40mg of Pycnogenol and 6mg lutein. Order total. Go to basket Proceed to checkout. Circulation boosters: how to improve circulation How to sleep better, with Dr Hilary Jones Four science-backed benefits of turmeric for joint health Energy, muscles, bones and teeth: why you need magnesium The best vitamins and supplements for women Wave goodbye to bloating, wind and constipation with your guide to the best supplements for the digestive system Perfect partners: immune system supplements that work better together Natural hangover remedies: how to beat festive overindulgence Immune system boosters: best vitamins and supplements for immunity Vitamin K2: benefits and uses. Back in stock notification Close. Please confirm you are not a robot. We have been unable to verify your identity, please confirm you are not a robot. I want to save with email offers and discounts. Please read our Privacy Notice for details on how we manage your data. You must consent to the storage and use of your personal data as laid out in our privacy notice. Request Stock Notification Close. Back to article list Latest articles. Pycnogenol® Naturally powerful French maritime pine bark extract Unique blend of natural bioflavonoids Find out more at Pycnogenol. com Shop now. Like this article? Share it! Newsletter Sign Up Close. The Email Address entered is already registered, please sign in with the Email Address or enter a different one Yes! Sign Up. |
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