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Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood , — Liu, C. Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR Jackson, V.
Robinson, B. FEBS Lett. Lowther, D. PD-1 marks dysfunctional regulatory T cells in malignant gliomas. JCI Insight 1 , e Overacre-Delgoffe, A. Interferon-γ drives T reg fragility to promote anti-tumor immunity.
Macintyre, A. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Li, L. TLR8-mediated metabolic control of human Treg function: a mechanistic target for cancer immunotherapy. Procaccini, C. The proteomic landscape of human ex vivo regulatory and conventional T cells reveals specific metabolic requirements.
Immunity 44 , — Priyadharshini, B. Cutting edge: TGF-β and phosphatidylinositol 3-kinase signals modulate distinct metabolism of regulatory T cell subsets.
Consoli, A. Contribution of liver and skeletal muscle to alanine and lactate metabolism in humans. CAS PubMed Google Scholar. Proia, P. Lactate as a metabolite and a regulator in the central nervous system. Arpaia, N. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation.
Smith, P. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Article CAS ADS PubMed Google Scholar. Colegio, O.
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Jung, Y. CD association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma.
Head Neck 37 , — Article PubMed Google Scholar. Jha, M. Monocarboxylate transporter 1 in Schwann cells is critical for maintenance of sensory nerve myelination during aging.
Glia 68 , — Lennon, G. T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 31 , — Ostanin, D. T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Liver Physiol. Martin, M.
Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. Download references. We thank A. Burton and C.
Workman for the generation and gift of Foxp3 FlpO-Ametrine mice, and G. Camirand for the gift of OT-II Foxp3 RFP Thy1. Old STAR Award; and the Sy Holzer Endowed Immunotherapy Fund all to G. is supported by grants R01DK, R01CA and P01AI all NIH.
Trainees on this manuscript were supported by grants T32CA NIH to M. and K. P and S. Mass spectrometry was supported by grant S10OD NIH to S.
and B. and R01 NS NIH to B. Synthesis of GlucoseCy5 was supported by grant R21AI NIH to G. RNA-seq analysis was supported in part by the University of Pittsburgh Center for Research Computing through the resources provided.
This work used the UPMC Hillman Cancer Center Flow Cytometry and Animal Facilities, supported in part by grant P30CA NIH. Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
McLane J. Watson, Paolo D. Vignali, Abigail E. Overacre-Delgoffe, Ronal M. Peralta, Stephanie Grebinoski, Kristin DePeaux, Ryan D. Whetstone, Dario A. Tumor Microenvironment Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Vignali, Ronal M.
Peralta, Ashley V. Menk, Kristin DePeaux, Ryan D. Graduate Program of Microbiology and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Health Sciences Metabolomics and Lipidomics Core, University of Pittsburgh, Pittsburgh, PA, USA. Abigail E. Overacre-Delgoffe, Natalie L.
Rittenhouse, Timothy W. Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. Dario A. Vignali, Timothy W. Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Departments of Pharmacology and Chemical Biology and Clinical Translational Science, University of Pittsburgh, Pittsburgh, PA, USA.
You can also search for this author in PubMed Google Scholar. performed most of the experiments, analysed data, and wrote the manuscript.
helped to perform isotopic flux analysis and suppression assays, and contributed to writing. performed and analysed isotopic flux experiments.
carried out the transfer colitis experiments. performed in vitro differentiation and suppression assays. helped to purify and analyse cells from NOD mice. performed extracellular flux analysis and tumour histology analysis. analysed RNA-seq data.
performed various in vitro experiments. sorted cells for isotopic flux analysis and RNA sequencing. provided Foxp3 FlpO-Ametrine and NOD. Foxp3GFP mice and scientific insight. and J. provided insight and facilities for transfer colitis experiments. helped to perform and analyse RNA-seq experiments.
oversaw analysis of isotopic flux data. conceived of the study, carried out initial experiments, obtained funding, and wrote the manuscript. Correspondence to Greg M. Peer review information Nature thanks the anonymous reviewer s for their contribution to the peer review of this work.
a , Gating strategy for sorting and analysis of T reg and T conv cells. ΔECAR, maximum reading after treatment with glucose minus basal ECAR.
Max ECAR, maximum reading after treatment with oligomycin minus basal ECAR. f , Lymphocytes from Foxp3-Ametrine reporter mice were simultaneously pulsed with 2NBDG and GlucoseCy5. i , Ex vivo GlucoseCy5 uptake by T conv cells isolated from various tissues.
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Home » Genetics and Metabolism » Metabolic Service. Metabolic Service Metabolism is the process by which our bodies make energy from the foods we eat proteins, carbohydrates and fats.
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