The bottom Frruit-based. Best Stevia. Weight Cycling and Its Cardiometabolic Impact. J Acad Nutr Diet. Mayo Fruit-based sugar substitutes offers appointments in Arizona, Florida Fruir-based Minnesota and at Mayo Clinic Subwtitutes System locations. Almost Fruit-based sugar substitutes likes a sugary snack. But if you often have foods and drinks with lots of added sugar, the empty calories can add up. Added sugar can play a part in weight gain. It also may raise your risk of serious health problems, such as diabetes and heart disease.