Shwaish Energy for sports performance, Wurantium WT, Mohammed TT. Jelenkovic L, Jovanovic Core strength development, Palic I, Anti-aying V, Radulovic M. Clavaud C, Jourdain R, Bar-Hen A et al Dandruff is associated with disequilibrium in the proportion of the major bacterial and fungal populations colonizing the scalp.

Citrus aurantium for anti-aging -

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Official CosIng Information. We have to start by writing that there are about citrus species in the world, and plenty of them are used to make different kinds of extracts used in cosmetics. This particular one, Citrus Aurantium Dulcis Fruit Extract is a very common ingredient, however, the species "Citrus Aurantium Dulcis" seem to exist only on ingredient lists and the real world calls this guy Citrus Sinensis or, you know, orange.

To complicate matters further, there are lots of varieties and lots of extraction methods, so it is a bit hard to know what you are getting with this one, but we will try our best to summarize the possibilities. A very common scenario is that Citrus Aurantium Dulcis Fruit Extract is on the ingredient list for its mild, natural exfoliant properties.

It contains mainly citric acid and some malic acid , AHA exfoliants known for their skin renewing properties. If that's the case, it is usually combined with other AHA containing fruits such as bilberry , sugar cane , lemon , and sugar maple in a super popular ingredient mix trade named ACB Fruit Mix.

But orange fruit is loaded with lots of other active compounds with a wide variety of possible effects. If you want vitamin C in your skincare, that is smart, but do not rely on orange fruit extract for it. Flavonoids hesperidin, naringin, luteolin, and ferulic acid are also nice active compounds with possible antioxidant, anti-inflammatory, and vasoprotective effects.

Some of them namely hesperidin and luteolin might even have skin brightening activity by inhibiting tyrosinase, the famous enzyme needed for melanin production. For example, the acceptable adjuvant may contain one or more agents selected from the group consisting of solvents, gelling agents, active agents, preservatives, antioxidants, screening agents, chelating agents, surfactants, dyes Coloring agent, thickening agent, filler, fragrance and odor absorber.

依據本發明，保養品可利用熟習此技藝者所詳知的技術而被製造成一適合於護膚 skincare 或化妝 makeup 的形式，這包括，但不限於：水性溶液 aqueous solution 、水-醇溶液 aqueous-alcohol solution 或油性溶液 oily solution 、呈水包油型 oil-in-watertype 、油包水型 water-in-oiltype 或複合型之乳劑、凝膠、軟膏、乳霜、面膜 mask 、貼片、貼布 pack 、擦劑、粉末、氣溶膠、噴霧、乳液、乳漿、糊劑、泡沫、分散液、滴劑、慕斯 mousse 、防曬油 sunblock 、化妝水 tonic water 、粉底 foundation 、卸妝產品 makeup remover products 、肥皂 soap 以及其他身體清潔產品 body cleansing products 等。 According to the present invention, the skin care product can be manufactured into a form suitable for skincare or makeup by using techniques well-known to those skilled in the art.

This includes, but is not limited to: aqueous solution aqueous solution , water -Alcohol solution aqueous-alcohol solution or oily solution oily solution , oil-in-water type, water-in-oil type or compound emulsion, gel, Ointment, cream, mask, patch, pack, liniment, powder, aerosol, spray, lotion, cream, paste, foam, dispersion, drops, mousse , Sunblock, tonic water, foundation, makeup remover products, soap, and other body cleansing products.

The selection and quantity of these topical agents fall within the scope of professionalism and routine techniques of those who are familiar with this technique. 依據本發明，食品產品可被當作食品添加物 food additive ，藉由習知方法於原料製備時添加，或是於食品的製作過程中添加，而與任一種可食性材料配製成供人類與非人類動物攝食的食品產品。 According to the present invention, a food product can be used as a food additive, which is added during the preparation of raw materials by a conventional method, or added during the preparation of food, and is formulated with any edible material for supply Food products consumed by humans and non-human animals.

依據本發明，食品產品的種類包括但不限於：飲料 beverages 、發酵食品 fermented foods 、烘培產品 bakery products 、健康食品 health foods 以及膳食補充品 dietary supplements 。 According to the present invention, the types of food products include, but are not limited to: beverages, fermented foods, bakery products, health foods, and dietary supplements.

本發明提供一種代代花萃取物用於製備減緩皮膚老化及減少細胞中脂肪含量之組合物的用途，本發明之代代花萃取物係以一溶劑萃取一代代花乾料所獲得，該溶劑為水、醇、或醇水混合物，其可用於減緩皮膚老化、以及減少細胞中脂肪的含量。 The present invention provides a use of a flower extract for preparing a composition for slowing skin aging and reducing the fat content in cells.

The flower extract of the present invention is obtained by extracting a dry material of the flower from the solvent. It is water, alcohol, or alcohol-water mixture, which can be used to slow down skin aging and reduce the fat content in cells.

同時，本發明用於製備減緩皮膚老化及減少細胞中脂肪含量之組合物，亦可包含一有效量之代代花萃取物及一醫藥上可接受之載體，該組合物係一醫藥品、一食品或一保養品。 At the same time, the present invention is used to prepare a composition for slowing down skin aging and reducing the fat content in cells.

It can also include an effective amount of a flower extract and a pharmaceutically acceptable carrier. The composition is a medicine, a Food or a skin care product.

以下將詳細說明本發明代代花萃取物之詳細萃取方法，與該代代花萃取物於抗糖化活性之測試、於抑制脂肪累積能力之測試、以及促進脂肪分解能力之測試，以證實該代代花萃取物對於減緩皮膚老化並達到皮膚美化的效果，以及減少細胞中脂肪的含量並達到減脂的效果。 The following will describe the detailed extraction method of the flower extract of the present invention, and the test of the anti-glycation activity of the flower extract, the test of the ability to inhibit fat accumulation, and the test of the ability to promote lipolysis to confirm the generation.

The flower extract has the effect of slowing down skin aging and beautifying the skin, as well as reducing the fat content in the cells and achieving the effect of reducing fat. After extraction, it was cooled to room temperature, and the crude extract was filtered through a mesh filter to obtain a filtrate.

Finally, the filtrate is concentrated under reduced pressure at °C to obtain the flower extract of the present invention. 本實施例係為了測試本發明之代代花萃取物的抗糖化活性，因此以抑制D-果糖 D-fructose 使膠原蛋白 Collagen 產生糖化的效率，進行糖化活性之定量。首先，分別取0. First, take 0. Finally, the following formula is used to calculate the efficiency of the ability to eliminate advanced glycation end-products AGEs to represent its anti-glycation activity.

The less the amount of glycation end-products, the higher the anti-glycation activity. It inhibits non-enzymatic browning and avoids the denaturation of functional proteins in the body.

This result shows that the daidaihua extract of the present invention can effectively improve its ability to remove the final glycation products , And help delay the progression of chronic diseases and aging, and studies have shown that glycation can cause deterioration of skin collagen, damage collagen fibers and elastic fibers, and cause wrinkles, sagging and even sallow dullness in the skin.

The invention of Daidaihua extract can also effectively slow down skin aging and achieve skin beautification effects. The mouse bone marrow stromal cell line was purchased from the American Type Culture Collection ATCC ® , numbered CRL TM.

為證實本發明之代代花萃取物具有抑制脂肪堆積的功效，首先將小鼠骨髓基質細胞分化成脂肪細胞，將8x10 4 個小鼠骨髓基質細胞培養於含有0. After 7 days, observe the formation of lipid droplets under a microscope to ensure that the cells are fully differentiated. Divide into 1 the experimental group with 0.

Value to quantify oil red O. This result shows that the daidaihua extract of the present invention can effectively inhibit fat accumulation and reduce the fat content in cells. 本實施例以上述小鼠骨髓基質細胞進行本發明之代代花萃取物於促進脂肪分解功效的測試。首先以實施例3之實驗步驟將小鼠骨髓基質細胞分化成脂肪細胞，同樣於開始培養7天後以顯微鏡觀察脂滴的形成，確保細胞已完全分化，接著將細胞分成 1 加入0.

First, the mouse bone marrow stromal cells were differentiated into adipocytes according to the experimental procedure of Example 3.

The formation of lipid droplets was observed under a microscope 7 days after the start of culture to ensure that the cells were fully differentiated, and then the cells were divided into 1 and 0.

After the triglycerides stored in the cells are broken down, free glycerol and fatty acids are produced, so by measuring the extracellular Glycerin content can be used to infer the value of fat breakdown in cells.

This kit uses the measurement of the product content of the coupled enzyme reaction system that produces a bright purple product to quantify the value of extracellular glycerol, and establishes a standard curve with standard products to calculate the value of extracellular glycerol in the sample.

Collect the cell culture supernatant of each well, and transfer 25μL of the cell culture supernatant to a new well culture plate, and then add μL of reconstituted free glycerol assay reagent Free Glycerol Assay Reagent to each well React at room temperature for 15 minutes, and then read the value at OD nm.

This result shows that the daidaihua extract of the present invention can effectively promote lipolysis and reduce the fat content in cells. 綜上所述，本發明以水、醇類、或醇水混合物為溶劑所萃取得之代代花萃取物，能有效提升其清除糖化終產物之能力、有效抑制脂肪堆積、及有效促進脂肪分解，以減緩皮膚老化並達到皮膚美化的效果，以及減少細胞中脂肪的含量並達到減脂的效果。因此本發明之代代花萃取物可用於製備減緩皮 膚老化及減少細胞中脂肪含量之組合物的用途，該組合物該組合物是一醫藥品、一食品或一保養品，可藉由口服、皮膚塗抹等方式給予一個體。 To sum up, the present invention uses water, alcohol, or alcohol-water mixture as the solvent to extract the daidaihua extract, which can effectively improve its ability to remove the final glycation products, effectively inhibit fat accumulation, and effectively promote lipolysis , In order to slow down skin aging and achieve the effect of skin beautification, as well as reduce the fat content in the cell and achieve the effect of fat reduction.

Therefore, the flower extract of the present invention can be used to prepare skin The use of a composition for skin aging and reducing fat content in cells.

The composition is a medicine, a food or a skin care product, which can be administered to a body by oral administration, skin application, etc.

The present invention provides a use of Citrus aurantium extract for reducing skin aging and fat content. The Citrus aurantium extract can improve the ability of removing advanced glycation end products AGEs , inhibit fat accumulation, and promote fat decomposition, so as to slow skin aging to improve the appearance of the skin, as well as to reduce the amount of fat in the cells to reduce the body fat.

The Citrus aurantium extract is prepared by extracting Citrus aurantium using water, alcohols, or mixtures of water and alcohols as solvents. 代代花萃取物用於減緩皮膚老化及減少細胞中脂肪含量的用途 The use of Daidaihua extract to slow down skin aging and reduce fat content in cells 本發明係關於一代代花萃取物之用途，尤其是一種代代花萃取物用於減緩皮膚老化及減少細胞中脂肪含量的用途。 The present invention relates to the use of Daidaihua extract, especially a use of Daidaihua extract to slow down skin aging and reduce the fat content in cells.

實施例2 本發明之代代花萃取物具有良好的抗糖化活性 Example 2 The Daidaihua extract of the present invention has good anti-glycation activity 本實施例係為了測試本發明之代代花萃取物的抗糖化活性，因此以抑制D-果糖 D-fructose 使膠原蛋白 Collagen 產生糖化的效率，進行糖化活性之定量。首先，分別取0.

FATTY ACID. Palmitic Acid C Stearic Acid Anti-aing Oleic Acid C n Linoleic Acid C n Alpha-Linolenic Acid C n Hélène LESUR aurantiym Citrus aurantium for anti-aging Zero pesticide usage order Energy for sports performance anti-agijg the contributor. Documentation EN French FR. Sign in. Search Loading Author Author multi-criteria Author multi-criteria Author: Full name Author: Last name Author: First name Author: middle name Author: funding institution Author: IdHal string Author: function Author: personID integer Author: funding institution identifier Author: Structure identifier Thesis director Publisher Scientific editor Series editor Add.