Category: Moms

Anthocyanins and immune system support

Anthocyanins and immune system support

Download citation. Kasimsetty, D. Sypport bHLH-1 proteins regulate anthocyanin biosynthesis, whereas in many plants the bHLH-2 proteins, besides being essential for anthocyanin biosynthesis Albert et al.

Video

Anthocyanins Health Benefits - World Strongest Antioxidant (2023)

Anthocyanins and immune system support -

Can miRNAs e. Are the lncRNAs newly identified in carrot conserved in other species? Can they be employed to enhance anthocyanin accumulation? Advancing our knowledge of anthocyanin biosynthesis will allow the development of new biotechnological tools for the generation of value-added plants with increased anthocyanin content, which help consumers to achieve the desired amount of anthocyanins in their daily diet.

Enrichment of foods in anthocyanins will also be particularly useful for the comparison of the nutritional properties of these bioactives from different food sources.

This may contribute to define which is the bioavailability and contribution to health-promoting properties of the single anthocyanin species present in a plant food, of their combination and eventually of the specific decorating groups in a food context.

All authors contributed equally to the manuscript, and read and approved the final manuscript. KP and CT contributed to conceptualization.

FC, AM, MT, KP, and CT contributed to writing, reviewing, and editing. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Aharoni, A. The strawberry FaMYB1 transcription factor suppresses anthocyanin and flavonol accumulation in transgenic tobacco.

Plant J. doi: CrossRef Full Text Google Scholar. Albert, N. Discrete BHLH transcription factors play functionally overlapping roles in pigmentation patterning in flowers of Antirrhinum majus. New Phytol.

PubMed Abstract CrossRef Full Text Google Scholar. Gene regulation networks generate diverse pigmentation patterns in plants. Plant Signal. Allan, A. MYB transcription factors that colour our fruit. Trends Plant Sci. An, X. MdMYB9 and MdMYB11 are involved in the regulation of the Ja-induced biosynthesis of anthocyanin and proanthocyanidin in apples.

Plant Cell Physiol. The apple WD40 protein MdTTG1 interacts with BHLH but not MYB proteins to regulate anthocyanin accumulation. Plant Physiol. An, J. EIN3-LIKE1, MYB1, and ETHYLENE RESPONSE FACTOR3 act in a regulatory loop that synergistically modulates ethylene biosynthesis and anthocyanin accumulation.

Azuma, A. Genomic and genetic analysis of Myb-related genes that regulate anthocyanin biosynthesis in grape berry skin. Ballester, A. Biochemical and molecular analysis of pink tomatoes: deregulated expression of the gene encoding transcription factor SlMYB12 leads to pink tomato fruit color.

Ban, Y. Isolation and functional analysis of a MYB transcription factor gene that is a key regulator for the development of red coloration in apple skin.

Barnett, M. A polyphenol enriched variety of apple alters circulating immune cell gene expression and faecal microbiota composition in healthy adults: a randomized controlled trial.

Nutrients Bars-Cortina, D. Phytochemical profiles of new red-fleshed apple varieties compared with traditional and new white-fleshed varieties.

Food Chem. Baudry, A. TT8 controls its own expression in a feedback regulation involving TTG1 and homologous MYB and BHLH factors, allowing a strong and cell-specific accumulation of flavonoids in Arabidopsis thaliana. TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana.

Boyer, J. Apple phytochemicals and their health benefits. Brueggemann, J. Plant Cell Rep. Butelli, E. Changes in anthocyanin production during domestication of citrus. Noemi controls production of flavonoid pigments and fruit acidity and illustrates the domestication routes of modern citrus varieties.

Retrotransposons control fruit-specific, cold-dependent accumulation of anthocyanins in blood oranges. Plant Cell 24, — Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Cai, H. Epigenetic regulation of anthocyanin biosynthesis by an antagonistic interaction between H2A.

Z and H3K4me3. Carey, C. Mutations in the pale aleurone color1 regulatory gene of the Zea mays anthocyanin pathway have distinct phenotypes relative to the functionally similar transparent testa glabra1 gene in Arabidopsis thaliana.

Plant Cell 16, — Casas, M. Flavone-rich maize: an opportunity to improve the nutritional value of an important commodity crop.

Plant Sci. Cassidy, A. Habitual intake of anthocyanins and flavanones and risk of cardiovascular disease in men. Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults.

Catola, S. The dominant allele aft induces a shift from flavonol to anthocyanin production in response to UV-B radiation in tomato fruit. Planta , — Cavallini, E. The phenylpropanoid pathway is controlled at different branches by a set of R2R3-MYB C2 repressors in grapevine.

Cerletti, C. Dietary anthocyanins and health: data from FLORA and ATHENA EU projects. Orange juice intake during a fatty meal consumption reduces the postprandial low-grade inflammatory response in healthy subjects.

Chagné, D. An ancient duplication of apple MYB transcription factors is responsible for novel red fruit-flesh phenotypes. Chang, C. LZF1, a HY5-regulated transcriptional factor, functions in Arabidopsis de-etiolation. Chaves-Silva, S. Understanding the genetic regulation of anthocyanin biosynthesis in plants — tools for breeding purple varieties of fruits and vegetables.

Phytochemistry , 11— Chen, L. Advance of the negative regulation of anthocyanin biosynthesis by MYB transcription factors. Chen, Q. Arogenate dehydratase isoforms differentially regulate anthocyanin biosynthesis in Arabidopsis thaliana. Plant 9, — Chialva, C. Insights into long non-coding RNA regulation of anthocyanin carrot root pigmentation.

Colanero, S. The atroviolacea gene encodes an R3-MYB protein repressing anthocyanin synthesis in tomato plants. Alternative splicing in the anthocyanin fruit gene encoding an R2R3 MYB transcription factor affects anthocyanin biosynthesis in tomato fruits. Plant Commun. Cui, L. The miRSPL9-DFR pathway coordinates the relationship between development and abiotic stress tolerance in plants.

Czemmel, S. The grapevine R2R3-MYB transcription factor VvMYBF1 regulates flavonol synthesis in developing grape berries. De Santis, S. Polyphenol enriched diet administration during pregnancy and lactation prevents dysbiosis in ulcerative colitis predisposed littermates.

Demeilliers, C. Ethanol drinking, brain mitochondrial DNA, polyunsaturated fatty acids and effects of dietary anthocyanins.

Dubos, C. MYBL2 is a new regulator of flavonoid biosynthesis in Arabidopsis thaliana. MYB transcription factors in Arabidopsis. Espley, R. Analysis of genetically modified red-fleshed apples reveals effects on growth and consumer attributes. Plant Biotechnol. Multiple repeats of a promoter segment causes transcription factor autoregulation in red apples.

Plant Cell 21, — Dietary flavonoids from modified apple reduce inflammation markers and modulate gut microbiota in mice. Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB Feller, A.

Evolutionary and comparative analysis of MYB and BHLH plant transcription factors. Feng, S. Anthocyanin biosynthesis in pears is regulated by a R2R3-MYB transcription factor PyMYB Ferreyra, M. Cloning and characterization of a UV-B-inducible maize flavonol synthase. Fu, R. Next-generation plant metabolic engineering, inspired by an ancient Chinese irrigation system.

Plant 11, 47— Fukamachi, K. Purple corn color suppresses ras protein level and inhibits 7,dimethylbenz[a]anthracene-induced mammary carcinogenesis in the rat. Cancer Sci. Glover, B. Gonzalez, A. TTG2 controls the developmental regulation of seed coat tannins in Arabidopsis by regulating vacuolar transport steps in the proanthocyanidin pathway.

Gonzali, S. Purple as a tomato: towards high anthocyanin tomatoes. Gou, J. Negative regulation of anthocyanin biosynthesis in Arabidopsis by a MiRtargeted SPL transcription factor. Plant Cell 23, — Gould, K. Andersen and K. Markham Boca Raton, Florida: CRC Press , — Google Scholar.

Grosso, G. Red orange: experimental models and epidemiological evidence of its benefits on human health. Oxidative Med. He, J. Anthocyanins: natural colorants with health-promoting properties.

Food Sci. Herath, D. An improved method for transformation of Actinidia arguta utilized to demonstrate a central role for MYB in regulating anthocyanin accumulation in kiwiberry.

Plant Cell Tissue Organ Cult. Hernandez, J. The basic helix-loop-helix domain of maize r links transcriptional regulation and histone modifications by recruitment of an EMSY-related factor.

Different mechanisms participate in the R-dependent activity of the R2R3 MYB transcription factor C1. Hichri, I. The basic helix-loop-helix transcription factor MYC1 is involved in the regulation of the flavonoid biosynthesis pathway in grapevine.

Plant 3, — Hsieh, L. Uncovering small RNA-mediated responses to phosphate deficiency in Arabidopsis by deep sequencing. Hyun, T. Apple as a source of dietary phytonutrients: an update on the potential health benefits of apple. EXCLI J. Ibraheem, F. A sorghum MYB transcription factor induces 3-deoxyanthocyanidins and enhances resistance against leaf blights in maize.

Molecules 20, — Iorizzo, M. A cluster of MYB transcription factors regulates anthocyanin biosynthesis in carrot Daucus carota L. root and petiole. Jaakola, L. New insights into the regulation of anthocyanin biosynthesis in fruits. Jeong, S. Ethylene suppression of sugar-induced anthocyanin pigmentation in Arabidopsis.

Jia, X. Small tandem target mimic-mediated blockage of microRNA induces anthocyanin accumulation in tomato. Jiang, C. Phosphate starvation root architecture and anthocyanin accumulation responses are modulated by the gibberellin-DELLA signaling pathway in Arabidopsis.

Jin, H. Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. EMBO J. Jin, W. The R2R3 MYB transcription factor PavMYB Jones, C.

Characterization and inheritance of the anthocyanin fruit Aft tomato. Jung, U. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease.

Kadowaki, T. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Kang, M. Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration.

Kang, K. Anthocyanin-rich purple corn extract inhibit diabetes-associated glomerular angiogenesis. PLoS One Kiferle, C. Tomato R2R3-MYB proteins SlANT1 and SlAN2: same protein activity, different roles.

PLoS One e Knekt, P. Flavonoid intake and risk of chronic diseases. Kobayashi, S. Retrotransposon-induced mutations in grape skin color. Science Kodama, M. Identification of transcription factor genes involved in anthocyanin biosynthesis in carrot Daucus carota L.

using RNA-Seq. BMC Genomics Koes, R. Flavonoids: a colorful model for the regulation and evolution of biochemical pathways. Kong, Q. Regulatory switch enforced by basic helix-loop-helix and ACT-domain mediated dimerizations of the maize transcription factor R.

Kozłowska, A. Targeting inflammation by anthocyanins as the novel therapeutic potential for chronic diseases: an update. Molecules Kumar, D. Ethylene mediates repression of anthocyanin accumulation in black rice pericarps in the absence of light.

Lachman, J. Genetics and chemistry of pigments in wheat grain — a review. Cereal Sci. LaFountain, A. Repressors of anthocyanin biosynthesis. Lee, S. Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-ΚB independent of NRF2-mediated mechanism.

Lee, B. Adiponectin and energy homeostasis. Li, S. Transcriptional control of flavonoid biosynthesis. Li, Y. MicroRNAmediated regulation of anthocyanin biosynthesis in kiwifruit Actinidia arguta based on small RNA sequencing. Li, W. Kiwifruit R2R3-MYB transcription factors and contribution of the novel AcMYB75 to red kiwifruit anthocyanin biosynthesis.

Li, L. Functional characterization of SmMYB86, a negative regulator of anthocyanin biosynthesis in eggplant Solanum melongena L. Li, J. Genome-wide analysis of MYB gene family in potato provides insights into tissue-specific regulation of anthocyanin biosynthesis.

Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy.

MdCOP1 ubiquitin E3 ligases interact with MdMYB1 to regulate light-induced anthocyanin biosynthesis and red fruit coloration in apple. MYB75 phosphorylation by MPK4 is required for light-induced anthocyanin accumulation in Arabidopsis.

Plant Cell 28, — Li, D. Health benefits of anthocyanins and molecular mechanisms: update from recent decade. TCP3 interacts with R2R3-MYB proteins, promotes flavonoid biosynthesis and negatively regulates the auxin response in Arabidopsis thaliana.

Lin-Wang, K. An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae. BMC Plant Biol.

Engineering the anthocyanin regulatory complex of strawberry Fragaria vesca. Liso, M. A bronze-tomato enriched diet affects the intestinal microbiome under homeostatic and inflammatory conditions.

Liu, Y. StMYB44 negatively regulates anthocyanin biosynthesis at high temperatures in tuber flesh of potato. Functional diversification of the potato R2R3 MYB anthocyanin activators AN1, MYBA1, and MYB and their interaction with basic helix-loop-helix cofactors.

Liu, J. TarDB: an online database for plant miRNA targets and miRNA-triggered phased siRNAs. Liu, T. Improved peach peel color development by fruit bagging. Enhanced expression of anthocyanin biosynthetic and regulatory genes using white non-woven polypropylene as replacement for yellow paper.

Anthocyanin biosynthesis and degradation mechanisms in solanaceous vegetables: a review. Lloyd, A. Advances in the MYB-BHLH-WD repeat MBW pigment regulatory model: addition of a WRKY factor and co-option of an anthocyanin MYB for betalain regulation.

Long, N. Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways. Lorenc-Kukuła, K. Ectopic expression of anthocyanin 5-o-glucosyltransferase in potato tuber causes increased resistance to bacteria.

Lotkowska, M. The Arabidopsis transcription factor MYB promotes anthocyanin formation during salinity and under high light stress.

Luo, Q. An autoregulatory feedback loop involving PAP1 and TAS4 in response to sugars in Arabidopsis. Plant Mol. Maeda, H. Genetic dissection of black grain rice by the development of a near isogenic line.

Magni, G. Purple corn extract as anti-allodynic treatment for trigeminal pain: role of microglia. Mahmood, K. The Arabidopsis transcription factor ANAC represses anthocyanin biosynthesis in response to high sucrose and oxidative and abiotic stresses. Maier, A. Martin, C. How can research on plants contribute to promoting human health?

Mathews, H. Activation tagging in tomato identifies a transcriptional regulator of anthocyanin biosynthesis, modification, and transport. Plant Cell 15, — Matsui, K. AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis.

Mattioli, R. Anthocyanins: a comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases. Matus, J. A group of grapevine MYBA transcription factors located in chromosome 14 control anthocyanin synthesis in vegetative organs with different specificities compared with the berry color locus.

Isolation of WDR and BHLH genes related to flavonoid synthesis in grapevine Vitis vinifera L. McIntosh, R. Catalogue of gene symbols for wheat. Meng, X. An R2R3-MYB gene, LeAN2, positively regulated the thermo-tolerance in transgenic tomato. Mes, P.

Characterization of tomatoes expressing anthocyanin in the fruit. Morishita, T. Arabidopsis NAC transcription factor, ANAC, regulates flavonoid biosynthesis under high-light. Nag, A. MiRa targeting of TCP4 is critical for petal growth and development in Arabidopsis. Napoleone, E.

Both red and blond orange juice intake decreases the procoagulant activity of whole blood in healthy volunteers. Nardozza, S. Carbon starvation reduces carbohydrate and anthocyanin accumulation in red-fleshed fruit via trehalose 6-phosphate and MYB Plant Cell Environ.

Nguyen, N. MYBD employed by HY5 increases anthocyanin accumulation via repression of MYBL2 in Arabidopsis. Ohno, S. Differences in the CaMYBA genome between anthocyanin-pigmented cultivars and non-pigmented cultivars in pepper Capsicum annuum. Oikawa, T. The birth of a black rice gene and its local spread by introgression.

Plant Cell 27, — Paolocci, F. The strawberry transcription factor FaMYB1 inhibits the biosynthesis of proanthocyanidins in lotus corniculatus leaves. Passeri, V. New challenges for the design of high value plant products: stabilization of anthocyanins in plant vacuoles.

Patra, B. Ubiquitin protein ligase 3 mediates the proteasomal degradation of GLABROUS 3 and ENHANCER of GLABROUS 3, regulators of trichome development and flavonoid biosynthesis in Arabidopsis. Transcriptional regulation of secondary metabolite biosynthesis in plants.

Acta , — Payyavula, R. Transcription factors, sucrose, and sucrose metabolic genes interact to regulate potato phenylpropanoid metabolism.

Pedreschi, R. Phenolic profiles of andean purple corn Zea mays L. Peng, Z. Brassinosteroid enhances jasmonate-induced anthocyanin accumulation in Arabidopsis seedlings. Plant Biol. Peng, Y. The proanthocyanin-related transcription factors MYBC1 and WRKY44 regulate branch points in the kiwifruit anthocyanin pathway.

Pérez-Díaz, J. New member of the R2R3-MYB transcription factors family in grapevine suppresses the anthocyanin accumulation in the flowers of transgenic tobacco. Persico, G. Comparative analysis of histone H3k4me3 distribution in mouse liver in different diets reveals the epigenetic efficacy of cyanidino-glucoside dietary intake.

Petroni, K. Anthocyanins in corn: a wealth of genes for human health. Recent advances on the regulation of anthocyanin synthesis in reproductive organs. Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice. Pojer, E. The case for anthocyanin consumption to promote human health: a review.

Food Saf. Povero, G. Transcriptional analysis in high-anthocyanin tomatoes reveals synergistic effect of Aft and Atv genes. Prior, R. Qi, T. Ramsay, N. MYB-BHLH-WD40 protein complex and the evolution of cellular diversity. Rowan, D. Environmental regulation of leaf colour in red 35S:PAP1 Arabidopsis thaliana.

Saclier, M. Nutritional intervention with cyanidin hinders the progression of muscular dystrophy. Cell Death Dis. Sainz, M. Evidence for direct activation of an anthocyanin promoter by the maize C1 protein and comparison of DNA binding by related Myb domain proteins.

Plant Cell 9, — Sakamoto, W. The Purple leaf Pl locus of rice: the Pl w allele has a complex organization and includes two genes encoding basic helix-loop-helix proteins involved in anthocyanin biosynthesis.

Salamone, F. Moro orange juice prevents fatty liver in mice. World J. Salehi, B. The therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action. Sapir, M. Molecular aspects of anthocyanin fruit tomato in relation to high pigment Sarma, A. Anthocyanin-DNA copigmentation complex: mutual protection against oxidative damage.

Phytochemistry 52, — Scarano, A. Combined dietary anthocyanins, flavonols, and stilbenoids alleviate inflammatory bowel disease symptoms in mice. Schaart, J. Identification and characterization of MYB-BHLH-WD40 regulatory complexes controlling proanthocyanidin biosynthesis in strawberry fragaria × ananassa fruits.

Schreiber, G. Sharma, D. MicroRNA is a potential regulator of phenylpropanoid pathway and plant development. Shi, S. R2R3-MYB transcription factor SmMYB75 promotes anthocyanin biosynthesis in eggplant Solanum melongena L.

Shin, D. FEBS Lett. Speciale, A. CyanidinO-glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathway. Food Res. Spelt, C. Plant Cell 14, — Stommel, J. Coordinated regulation of biosynthetic and regulatory genes coincides with anthocyanin accumulation in developing eggplant fruit.

Stracke, R. Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling.

Strazzer, P. Hyperacidification of citrus fruits by a vacuolar proton-pumping P-ATPase complex. Su, Z. Foods Sun, C.

A transcriptional network promotes anthocyanin biosynthesis in tomato flesh. Plant 13, 42— Sun, X. The C-S-A gene system regulates hull pigmentation and reveals evolution of anthocyanin biosynthesis pathway in rice.

Sweeney, M. Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice. Plant Cell 18, — Takos, A. Light-induced expression of a MYB gene regulates anthocyanin biosynthesis in red apples. Tamagnone, L. The AmMYB and AmMYB transcription factors from antirrhinum regulate phenylpropanoid and lignin biosynthesis in transgenic tobacco.

Plant Cell 10, — Tang, B. Anthocyanin accumulation and transcriptional regulation of anthocyanin biosynthesis in purple pepper. Tirumalai, V. MiR and MiR regulate VvMYB to promote anthocyanin and flavonol accumulation in grapes.

Titta, L. Blood orange juice inhibits fat accumulation in mice. Tohge, T. Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor.

Tomay, F. Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice. Toufektsian, M. Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury.

Dietary flavonoids increase plasma very long-chain n-3 fatty acids in rats. Tsuda, T. Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies. Dietary cyanidin 3-O-β-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.

Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Tuerck, J. Elements of the maize A1 promoter required for transactivation by the anthocyanin BICI or phlobaphene P regulatory genes.

Plant Cell 6, — Scott Smith, Kansas State University professor of food chemistry. Anthocyanins are more prevalent in fruits than vegetables, Smith said, noting the deep red and purple hues of apple skin and grapes. Because anthocyanins are pH sensitive, they can appear more red or blue depending on the type of food.

Anthocyanins are especially common in berries, including blueberries, cranberries, raspberries and blackberries. Even the extracts from foods that contain anthocyanins are healthy, Smith said.

A recent trend in the food industry is to use natural, instead of synthetic, food dyes. Anthocyanins can be extracted from fruits or vegetables and then used as a natural purple or blue-hued food dye.

Because red wine comes from grapes, it also contains anthocyanins. In addition, red wine contains resveratrol, which is an antioxidant and may be heart-healthy. Some lesser-known purple foods also contain anthocyanins. South Americans have grown purple corn for centuries, Smith said, and a purple cauliflower and a purple carrot also exist.

Source: J. Scott Smith,jsschem sydtem. Nutritional supplement for metabolism support Note to editor: This is the Anthocyanins and immune system support in Anthocyznins series of news releases about the color purple Cranberry wine varieties honor of Kansas State University's immine on Feb. News release prepared by: Jennifer Torline,jtorline k-state. MANHATTAN -- When it comes to healthy eating, consider adding some powerful purple foods to your diet. That's because many purple foods contain anthocyanins, which are red, blue and purple natural pigments. Anthocyanins are healthy because they're powerful antioxidants and may help boost the immune system, maintain health and prevent disease, said J.

Anthocyanins and immune system support -

The R2R3 MYB transcription factor PavMYB Jones, C. Characterization and inheritance of the anthocyanin fruit Aft tomato. Jung, U. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease.

Kadowaki, T. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. Kang, M. Purple corn anthocyanins inhibit diabetes-associated glomerular monocyte activation and macrophage infiltration.

Kang, K. Anthocyanin-rich purple corn extract inhibit diabetes-associated glomerular angiogenesis. PLoS One Kiferle, C. Tomato R2R3-MYB proteins SlANT1 and SlAN2: same protein activity, different roles.

PLoS One e Knekt, P. Flavonoid intake and risk of chronic diseases. Kobayashi, S. Retrotransposon-induced mutations in grape skin color. Science Kodama, M. Identification of transcription factor genes involved in anthocyanin biosynthesis in carrot Daucus carota L. using RNA-Seq. BMC Genomics Koes, R.

Flavonoids: a colorful model for the regulation and evolution of biochemical pathways. Kong, Q. Regulatory switch enforced by basic helix-loop-helix and ACT-domain mediated dimerizations of the maize transcription factor R.

Kozłowska, A. Targeting inflammation by anthocyanins as the novel therapeutic potential for chronic diseases: an update. Molecules Kumar, D. Ethylene mediates repression of anthocyanin accumulation in black rice pericarps in the absence of light.

Lachman, J. Genetics and chemistry of pigments in wheat grain — a review. Cereal Sci. LaFountain, A. Repressors of anthocyanin biosynthesis. Lee, S.

Berry anthocyanins suppress the expression and secretion of proinflammatory mediators in macrophages by inhibiting nuclear translocation of NF-ΚB independent of NRF2-mediated mechanism. Lee, B.

Adiponectin and energy homeostasis. Li, S. Transcriptional control of flavonoid biosynthesis. Li, Y. MicroRNAmediated regulation of anthocyanin biosynthesis in kiwifruit Actinidia arguta based on small RNA sequencing. Li, W. Kiwifruit R2R3-MYB transcription factors and contribution of the novel AcMYB75 to red kiwifruit anthocyanin biosynthesis.

Li, L. Functional characterization of SmMYB86, a negative regulator of anthocyanin biosynthesis in eggplant Solanum melongena L. Li, J.

Genome-wide analysis of MYB gene family in potato provides insights into tissue-specific regulation of anthocyanin biosynthesis. Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy.

MdCOP1 ubiquitin E3 ligases interact with MdMYB1 to regulate light-induced anthocyanin biosynthesis and red fruit coloration in apple. MYB75 phosphorylation by MPK4 is required for light-induced anthocyanin accumulation in Arabidopsis.

Plant Cell 28, — Li, D. Health benefits of anthocyanins and molecular mechanisms: update from recent decade. TCP3 interacts with R2R3-MYB proteins, promotes flavonoid biosynthesis and negatively regulates the auxin response in Arabidopsis thaliana.

Lin-Wang, K. An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae. BMC Plant Biol. Engineering the anthocyanin regulatory complex of strawberry Fragaria vesca. Liso, M. A bronze-tomato enriched diet affects the intestinal microbiome under homeostatic and inflammatory conditions.

Liu, Y. StMYB44 negatively regulates anthocyanin biosynthesis at high temperatures in tuber flesh of potato. Functional diversification of the potato R2R3 MYB anthocyanin activators AN1, MYBA1, and MYB and their interaction with basic helix-loop-helix cofactors.

Liu, J. TarDB: an online database for plant miRNA targets and miRNA-triggered phased siRNAs. Liu, T. Improved peach peel color development by fruit bagging. Enhanced expression of anthocyanin biosynthetic and regulatory genes using white non-woven polypropylene as replacement for yellow paper.

Anthocyanin biosynthesis and degradation mechanisms in solanaceous vegetables: a review. Lloyd, A. Advances in the MYB-BHLH-WD repeat MBW pigment regulatory model: addition of a WRKY factor and co-option of an anthocyanin MYB for betalain regulation. Long, N. Purple corn color inhibition of prostate carcinogenesis by targeting cell growth pathways.

Lorenc-Kukuła, K. Ectopic expression of anthocyanin 5-o-glucosyltransferase in potato tuber causes increased resistance to bacteria. Lotkowska, M. The Arabidopsis transcription factor MYB promotes anthocyanin formation during salinity and under high light stress.

Luo, Q. An autoregulatory feedback loop involving PAP1 and TAS4 in response to sugars in Arabidopsis. Plant Mol. Maeda, H. Genetic dissection of black grain rice by the development of a near isogenic line. Magni, G. Purple corn extract as anti-allodynic treatment for trigeminal pain: role of microglia.

Mahmood, K. The Arabidopsis transcription factor ANAC represses anthocyanin biosynthesis in response to high sucrose and oxidative and abiotic stresses. Maier, A. Martin, C. How can research on plants contribute to promoting human health? Mathews, H. Activation tagging in tomato identifies a transcriptional regulator of anthocyanin biosynthesis, modification, and transport.

Plant Cell 15, — Matsui, K. AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis. Mattioli, R. Anthocyanins: a comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases.

Matus, J. A group of grapevine MYBA transcription factors located in chromosome 14 control anthocyanin synthesis in vegetative organs with different specificities compared with the berry color locus.

Isolation of WDR and BHLH genes related to flavonoid synthesis in grapevine Vitis vinifera L. McIntosh, R. Catalogue of gene symbols for wheat. Meng, X. An R2R3-MYB gene, LeAN2, positively regulated the thermo-tolerance in transgenic tomato. Mes, P. Characterization of tomatoes expressing anthocyanin in the fruit.

Morishita, T. Arabidopsis NAC transcription factor, ANAC, regulates flavonoid biosynthesis under high-light. Nag, A. MiRa targeting of TCP4 is critical for petal growth and development in Arabidopsis.

Napoleone, E. Both red and blond orange juice intake decreases the procoagulant activity of whole blood in healthy volunteers. Nardozza, S. Carbon starvation reduces carbohydrate and anthocyanin accumulation in red-fleshed fruit via trehalose 6-phosphate and MYB Plant Cell Environ.

Nguyen, N. MYBD employed by HY5 increases anthocyanin accumulation via repression of MYBL2 in Arabidopsis. Ohno, S. Differences in the CaMYBA genome between anthocyanin-pigmented cultivars and non-pigmented cultivars in pepper Capsicum annuum.

Oikawa, T. The birth of a black rice gene and its local spread by introgression. Plant Cell 27, — Paolocci, F. The strawberry transcription factor FaMYB1 inhibits the biosynthesis of proanthocyanidins in lotus corniculatus leaves.

Passeri, V. New challenges for the design of high value plant products: stabilization of anthocyanins in plant vacuoles. Patra, B. Ubiquitin protein ligase 3 mediates the proteasomal degradation of GLABROUS 3 and ENHANCER of GLABROUS 3, regulators of trichome development and flavonoid biosynthesis in Arabidopsis.

Transcriptional regulation of secondary metabolite biosynthesis in plants. Acta , — Payyavula, R. Transcription factors, sucrose, and sucrose metabolic genes interact to regulate potato phenylpropanoid metabolism. Pedreschi, R. Phenolic profiles of andean purple corn Zea mays L.

Peng, Z. Brassinosteroid enhances jasmonate-induced anthocyanin accumulation in Arabidopsis seedlings. Plant Biol. Peng, Y. The proanthocyanin-related transcription factors MYBC1 and WRKY44 regulate branch points in the kiwifruit anthocyanin pathway.

Pérez-Díaz, J. New member of the R2R3-MYB transcription factors family in grapevine suppresses the anthocyanin accumulation in the flowers of transgenic tobacco. Persico, G. Comparative analysis of histone H3k4me3 distribution in mouse liver in different diets reveals the epigenetic efficacy of cyanidino-glucoside dietary intake.

Petroni, K. Anthocyanins in corn: a wealth of genes for human health. Recent advances on the regulation of anthocyanin synthesis in reproductive organs. Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice.

Pojer, E. The case for anthocyanin consumption to promote human health: a review. Food Saf. Povero, G. Transcriptional analysis in high-anthocyanin tomatoes reveals synergistic effect of Aft and Atv genes.

Prior, R. Qi, T. Ramsay, N. MYB-BHLH-WD40 protein complex and the evolution of cellular diversity. Rowan, D. Environmental regulation of leaf colour in red 35S:PAP1 Arabidopsis thaliana.

Saclier, M. Nutritional intervention with cyanidin hinders the progression of muscular dystrophy. Cell Death Dis. Sainz, M. Evidence for direct activation of an anthocyanin promoter by the maize C1 protein and comparison of DNA binding by related Myb domain proteins.

Plant Cell 9, — Sakamoto, W. The Purple leaf Pl locus of rice: the Pl w allele has a complex organization and includes two genes encoding basic helix-loop-helix proteins involved in anthocyanin biosynthesis. Salamone, F. Moro orange juice prevents fatty liver in mice.

World J. Salehi, B. The therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action. Sapir, M. Molecular aspects of anthocyanin fruit tomato in relation to high pigment Sarma, A.

Anthocyanin-DNA copigmentation complex: mutual protection against oxidative damage. Phytochemistry 52, — Scarano, A. Combined dietary anthocyanins, flavonols, and stilbenoids alleviate inflammatory bowel disease symptoms in mice.

Schaart, J. Identification and characterization of MYB-BHLH-WD40 regulatory complexes controlling proanthocyanidin biosynthesis in strawberry fragaria × ananassa fruits. Schreiber, G.

Sharma, D. MicroRNA is a potential regulator of phenylpropanoid pathway and plant development. Shi, S. R2R3-MYB transcription factor SmMYB75 promotes anthocyanin biosynthesis in eggplant Solanum melongena L. Shin, D. FEBS Lett. Speciale, A. CyanidinO-glucoside counters the response to TNF-alpha of endothelial cells by activating Nrf2 pathway.

Food Res. Spelt, C. Plant Cell 14, — Stommel, J. Coordinated regulation of biosynthetic and regulatory genes coincides with anthocyanin accumulation in developing eggplant fruit.

Stracke, R. Differential regulation of closely related R2R3-MYB transcription factors controls flavonol accumulation in different parts of the Arabidopsis thaliana seedling.

Strazzer, P. Hyperacidification of citrus fruits by a vacuolar proton-pumping P-ATPase complex. Su, Z. Foods Sun, C. A transcriptional network promotes anthocyanin biosynthesis in tomato flesh. Plant 13, 42— Sun, X. The C-S-A gene system regulates hull pigmentation and reveals evolution of anthocyanin biosynthesis pathway in rice.

Sweeney, M. Caught red-handed: Rc encodes a basic helix-loop-helix protein conditioning red pericarp in rice. Plant Cell 18, — Takos, A. Light-induced expression of a MYB gene regulates anthocyanin biosynthesis in red apples. Tamagnone, L. The AmMYB and AmMYB transcription factors from antirrhinum regulate phenylpropanoid and lignin biosynthesis in transgenic tobacco.

Plant Cell 10, — Tang, B. Anthocyanin accumulation and transcriptional regulation of anthocyanin biosynthesis in purple pepper. Tirumalai, V. MiR and MiR regulate VvMYB to promote anthocyanin and flavonol accumulation in grapes.

Titta, L. Blood orange juice inhibits fat accumulation in mice. Tohge, T. Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor.

Tomay, F. Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice. Toufektsian, M. Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury.

Dietary flavonoids increase plasma very long-chain n-3 fatty acids in rats. Tsuda, T. Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies. Dietary cyanidin 3-O-β-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.

Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Tuerck, J. Elements of the maize A1 promoter required for transactivation by the anthocyanin BICI or phlobaphene P regulatory genes.

Plant Cell 6, — Ullah, R. Natural antioxidant anthocyanins—a hidden therapeutic candidate in metabolic disorders with major focus in neurodegeneration.

Vimolmangkang, S. An apple MYB transcription factor, MdMYB3, is involved in regulation of anthocyanin biosynthesis and flower development. Wada, T. Epidermal cell differentiation in Arabidopsis determined by a Myb homolog, CPC.

Science , — Walker, A. White grapes arose through the mutation of two similar and adjacent regulatory genes. Wallace, T. Wallace and M. Giusti Boca Raton: CRC Press , — Wang, L.

Wang, Y. Repression of MYBL2 by both microRNAa and HY5 leads to the activation of anthocyanin biosynthetic pathway in Arabidopsis. Transcriptional regulation of strigolactone signalling in Arabidopsis.

Nature , — Xie, X. The BHLH transcription factor MdbHLH3 promotes anthocyanin accumulation and fruit colouration in response to low temperature in apples. Xie, Y. Xu, W. Transcriptional control of flavonoid biosynthesis by MYB-BHLH-WDR complexes.

Xu, Z. A MYB transcription factor, DcMYB6, is involved in regulating anthocyanin biosynthesis in purple carrot taproots. Xu, H. The molecular mechanism underlying anthocyanin metabolism in apple using the MdMYB16 and MdbHLH33 genes.

Changing carrot color: insertions in DcMYB7 alter the regulation of anthocyanin biosynthesis and modification.

DcMYB, a root-specific R2R3-MYB, conditions anthocyanin biosynthesis and modification in carrot. Yan, S. Anthocyanin fruit encodes an R2R3-MYB transcription factor, SlAN2-like, activating the transcription of SlMYBATV to fine-tune anthocyanin content in tomato fruit.

Yang, F. Overexpression of microRNA reduces anthocyanin accumulation in Arabidopsis. Yao, G. Map-based cloning of the pear gene MYB identifies an interaction with other transcription factors to coordinately regulate fruit anthocyanin biosynthesis.

Ye, H. MYBL2 is a substrate of GSK3-like kinase BIN2 and acts as a corepressor of BES1 in brassinosteroid signaling pathway in Arabidopsis. Yuste, S. Metabolic fate and cardiometabolic effects of phenolic compounds from red-fleshed apple in hypercholesterolemic rats: a comparative study with common white-fleshed apple.

All health content on bbcgoodfood. com is provided for general information only, and should not be treated as a substitute for the medical advice of your own doctor or any other healthcare professional.

If you have any concerns about your general health, you should contact your local healthcare provider. See our website terms and conditions for more information.

Have you heard of anthocyanins? Which purple foods do you enjoy the most? Let us know in the comments below…. Search, save and sort your favourite recipes and view them offline. Join the BBC Good Food Wine Club. Join our Subscriber Club Download our app Good Food Shows Wine Club Recipe boxes Videos.

Recipes Back to Main menu Dinner ideas Back to Recipes Healthy dinners Dinner for two Low-carb dinners Gluten-free dinners. Back to Recipes Quick breakfast recipes Breakfast smoothie recipes Vegan breakfast recipes Low-carb breakfast recipes.

Back to Recipes Family lunch recipes Quick lunch recipes Healthy packed lunch recipes Budget Sunday lunch recipes. Back to Recipes Healthy salmon recipes Seafood recipes Paella recipes seafood White fish recipes. Back to Recipes Vegetable soup recipes Creamy soup recipes Chicken soup recipes Low-carb soup recipes.

Back to Recipes Quick pasta recipes Carbonara recipes Lasagne recipes Bolognese recipes. Back to Recipes Low-calorie chicken recipes Low-calorie vegetarian recipes calorie meal recipes Low-carb family meals.

Back to Recipes High-protein vegan High-protein lunch recipes High-protein snacks High protein bowl recipes. Back to Recipes Vegan dinner recipes Easy vegan recipes Vegan slow cooker recipes Vegan soup recipes. Back to Recipes Easy vegetarian recipes Healthy vegetarian recipes Vegetarian dinner recipes Vegetarian slow cooker recipes.

Back to Recipes Winter warmers Winter salads Healthy winter meals Quick winter recipes. Back to Health Oily fish benefits Is peanut butter healthy? Is sourdough good for you?

Healthiest winter foods. Back to Health Celeb diets reviewed Intermittent fasting 's best diets Weight-loss myths busted. Back to Health Is vegan 'meat' healthy? Do aphrodisiacs work? Back to Health Daily steps to lose weight Protein for muscle building Your healthiest exercises Protein — all you need to know.

Back to Main menu Cooking tips Back to How to Roast timer Seasonal calendar Conversion guides Glossary. Back to How to School packed lunch ideas Hot lunch ideas Healthy lunch ideas for work Easy lunch ideas.

Back to How to Vegetarian family classics Twists on chilli con carne Best vegan curry recipes Vegetarian fakeaway recipes. Back to How to How to cook sprouts How to cook cabbage How to cook sweet potatoes How to cook long stem broccoli.

Ashley L. Steed, George P. Christophi et al The microbial metabolite desaminotyrosine protects from influenza through type I interferon, Science 04 Aug Vol. Ali, S. Casscells, and M. View at: Publisher Site Google Scholar Neurath, N. Strick, Y. Li, and A.

Kotwal and D. Lahiri, Eds. View at: Google Scholar J. HIV , potentially pandemic e. H5N1 strain of influenza and carcinogenic e. Aviram, N. Volkova, R. Coleman et al.

View at: Google Scholar G. Kasimsetty, D. Bialonska, M. Reddy, C. Thornton, K. Willett, and D. Anti-influenza virus effects of elderberry juice and its fractions.

Biosci Biotechnol Biochem.

Fruits, vegetables, nuts, seeds, and legumes Sugar alternatives for candy not lmmune rich Spuport vitamins and minerals but also contain a range of imune compounds that benefit your health. Nutritional supplement for metabolism support is one Anthocynins example. This Anthkcyanins explains what anthocyanin suppkrt, plus its health benefits and the foods and drinks that contain it. Anthocyanins are a group of antioxidants found in red, purple, and blue fruits and vegetables 1. They belong to the flavonoid family — the same family as the antioxidants found in wine, tea, and dark chocolate 2. Flavonoids are part of a larger group of antioxidants known as polyphenols, which are believed to help prevent or treat health conditions connected to inflammation and oxidative stress. anc Koru Nutrition Ysstem 24, Koru Nutrition Blog. Anthocyanins are a Muscle building arm exercises of flavonoid, a class of Anthochanins with antioxidant Anthocyanins and immune system support. Anthocyanins are the pigments Muscle building arm exercises are Anthocyankns for giving fruits and vegetables their sysstem, purple, and blue colours, which Homeopathy commonly ijmune in berries such as pomegranates, Nutritional supplement for metabolism support, bilberryelderberryblack currants, blueberries, raspberries, blackberries, and cranberries. Anthocyanins may offer anti-inflammatoryanti-cancer and even anti-viral, benefits. In fact studies show that there is a positive relationship between antiviral activity and polyphenol content of the berries, indicating the possibility that polyphenol is one of the key factors in the antiviral effects of berries 1,2. Studies have shown that anthocyanins can prevent influenza viruses from penetrating human cells and may inhibit viral release once the cell is infected 5. Based on certain studies, the Vitamin C content in a bilberry is five times higher than that in an orange.

Author: Kagajas

0 thoughts on “Anthocyanins and immune system support

Leave a comment

Yours email will be published. Important fields a marked *

Design by ThemesDNA.com