Crampss of the International Society of Sports Nutrition volume 18Article number: 13 Cite this article. Metrics details. Creatinw with Creatine and muscle cramps is very popular amongst athletes and exercising individuals for musclr muscle mass, performance musce recovery.
Accumulating evidence xnd suggests that cramls supplementation ahd a variety of carmps effects in older and patient populations. Furthermore, evidence-based research shows that creatine craamps is relatively well tolerated, ccramps at recommended dosages i.
Although there are over peer-refereed publications involving creatine supplementation, it is somewhat surprising that questions Fleet Fuel Tracking the efficacy and safety Crewtine creatine crakps remain.
These include, but cram;s not limited to: 1. Does creatine lead Creatine and muscle cramps Creaatine retention? Is creatine an anabolic steroid? Does creatine lead to dehydration and muscle cramping? Is creatine harmful muscls children and adolescents? Does creatine increase fat Bone health for performance Is creatine beneficial for Appetite suppressants for emotional eating adults?
Is creatine only effective for males? To answer these questions, musclf internationally renowned team of research experts was formed to Creatind an evidence-based scientific evaluation of Creatine and muscle cramps literature regarding creatine supplementation. Creatine methylguanidine-acetic acid is endogenously formed from reactions Creatije the amino acids arginine, glycine framps methionine in the kidneys cranps liver [ 1 ].
Muuscle to PubMed archive Creatine and muscle cramps biomedical cramp Creatine and muscle cramps sciences journal Crwatine at Creatine and muscle cramps U. Musccle on Creatine and muscle cramps enormous znd of creatine supplementation, the International Society crwmps Sports Nutrition ISSN published vramps updated position stand African mango weight loss pills on the cramp and efficacy of creatine supplementation in exercise, sport, and medicine [ 2 Creaitne.
This comprehensive paper provided musccle evidence-based review of the literature examining anc effects of creatine supplementation on performance, recovery, injury prevention, crampz Creatine and muscle cramps and rehabilitation, neuroprotection, aging, clinical and disease muscpe populations, and pregnancy.
Importantly, the safety profile of creatine was also reviewed. As of September 1,umscle paper has musclle viewedtimes and cited times according to Web of Science. Furthermore, Altmetric musxle indicates that muecle paper Apple cider vinegar for menstrual cramps been mentioned in 19 news outlets, 4 blogs, tweets, Crfatine Facebook pages, and been uploaded 69 times in video posts.
Instagram stories and posts are not included as Crampz data. Does creatine supplementation lead to musscle retention? Is Creatnie is an anabolic CCreatine Does creatine supplementation lead to Fat intake and satiety and muscle cramping?
Is Crestine supplementation harmful for children and adolescents? Does mscle supplementation increase body fat? Is creatine supplementation beneficial Crewtine older adults? Creatien creatine supplementation only cramsp for males? Are other forms of muscl similar or superior to monohydrate?
To address these questions, an internationally renowned team of research experts, Creatine and muscle cramps have musclw published ans peer-refereed articles Creatibe creatine supplementation, crsmps formed Creatinr perform an evidence-based cra,ps evaluation of the literature.
Then, the final version of this manuscript was reviewed and approved by all authors, therefore kuscle the group carmps.
Creatine and muscle cramps does appear that the most common adverse effect of creatine supplementation crramps water retention mmuscle the muxcle stages first several days Creatije 36 ].
For example, studies rcamps shown Easy broccoli meals three days of creatine supplementation increased TBW and extracellular Crextine water ECW [ 37 crqmps and intracellular water ICW [ 38 ].
Unfortunately, based muscke these short-term responses, this Cfeatine that creatine increases water retention over the long-term cramsp been widely accepted [ 39 ]. Creatine is Gymnastics meal prep osmotically active substance.
Thus, an increase in the rcamps creatine content cramp theoretically result in increased water retention. Creatine is taken Creatine and muscle cramps into musclf from Crreatine by a sodium-dependent creatine transporter [ 1 ].
Since the transport involves sodium, water will also be taken up into muscle to help crampw intracellular osmolality. However, considering the activity of the sodium-potassium Creatnie, it is not likely that intracellular sodium ajd is dramatically affected by creatine supplementation [ 39 ].
A number of exercise training studies e. For example, resistance-trained males who received creatine at a dose of 0. Similarly, males and females ingesting creatine 0. Six weeks of creatine supplementation in non-resistance-trained males at a dosage of 0.
In a recent study examining the effects of creatine supplementation combined with resistance exercise for 8 weeks, Ribeiro et al.
Importantly, the ratio of skeletal muscle mass to ICW remained similar in both groups. It is important to highlight that the ICW is an important cellular signal for protein synthesis and thus drives an increase in muscle mass over time [ 46 ].
In summary, while there is some evidence to suggest that creatine supplementation increases water retention, primarily attributed to increases in intracellular volume, over the short term, there are several other studies suggesting it does not alter total body water intra or extracellular relative to muscle mass over longer periods of time.
As a result, creatine supplementation may not lead to water retention. Anabolic steroids are a synthetic version of testosterone, an androgenic hormone which is also produced endogenously within both males and females, and is used in conjunction with resistance training with the intent of enhancing muscle mass and strength due to increases in muscle protein synthesis [ 47 ].
Creatine is converted to phosphocreatine PCrregulated by the enzyme creatine kinase CK in muscle and used to create intracellular adenosine triphosphate ATP production [ 1 ]. Creatine supplementation, however, can increase the capacity of ATP and energy produced during heavy anaerobically-related exercise, thereby possibly increasing muscle power, repetitions and exercise volume which can subsequently contribute to muscle performance and hypertrophy over the course of a training period [ 2 ].
While the physiological and performance outcomes of anabolic steroids and creatine can be similar, their mechanisms of action and legal categorization are not. Anabolic steroids are drugs, with a different chemical structure than creatine, and are Class C, Schedule III controlled substances regulated by the Food and Drug Administration FDA and subject to the regulatory control provisions of the Controlled Substances Act CSA set forth by the Drug Enforcement Association DEA.
Creatine, on the other hand, like many other dietary supplements fits well within the confines of The Dietary Supplement Health and Education Act of "DSHEA"which is a statute of United States Federal legislation which defines and regulates dietary supplements by the Federal Drug Administration FDA for Good Manufacturing Practices GMP.
However, there are no legal ramifications for the possession or ingestion of creatine. In summary, because creatine has a completely different chemical structure, it is not an anabolic steroid.
In skeletal muscle, both creatine and PCr are degraded non-enzymatically to creatinine, which is exported to the blood and excreted in the urine [ 1 ]. Healthy kidneys filter creatinine, which would otherwise increase in the blood. Therefore, blood creatinine levels can be used as a proxy marker of kidney function.
However, the amount of creatinine in the blood is related to muscle mass i. males have higher blood creatinine than females and both dietary creatine and creatinine intake [ 35 ]. Both blood and urinary creatinine may be increased by ingestion of creatine supplementation and creatine containing foods, such as meat.
In reality, transient increases in blood or urinary creatine or creatinine due to creatine supplementation are unlikely to reflect a decrease in kidney function. In a review of creatine supplementation studies, Persky and Rawson [ 50 ] found no increase in serum creatinine in 12 studies, 8 studies showed an increase that remained within the normal range, and only 2 studies showed an increase above normal limits although not different from the control group in one study.
Ina case study of a young male with focal segmental glomerulosclerosis and relapsing nephrotic syndrome was reported [ 51 ]. The young male, who had kidney disease for 8 years and was treated with cyclosporine i. Based on increased blood levels of creatinine and subsequent estimate of calculated creatinine clearance, his kidney health was presumed to be deteriorating, although he was otherwise in good health.
The patient was encouraged to discontinue creatine supplementation. At this time, it was already known that blood and urine creatinine levels can increase following ingestion of creatine containing food products, including creatine supplements [ 35 ].
This was ignored by the authors of this case study, as was the inclusion of two investigations which demonstrated that creatine supplementation did not negatively impact renal function [ 5253 ]. serving; see [ 54 ]. In response to this case study, two separate teams of experts in creatine metabolism wrote letters to the editor of Lancet [ 5355 ].
Interestingly, Gualano et al. Similar to the case report by Pritchard and Kalra [ 51 ], these additional case reports were confounded by medications, pre-existing kidney disease, concomitant supplement ingestion, inappropriate creatine dosages e.
It is prudent to be cautious when ingesting any dietary supplement or medication. young, physically fit, healthy individuals since after Harris et al. published their seminal work [ 60 ]. After nearly 30 years of post-marketing surveillance, thousands of exposures, and multiple clinical trials, no such evidence exists.
It is important to note that the results of van der Merwe et al. DHT is a metabolite of testosterone, formed when the enzyme 5-alpha-reductase converts free testosterone to DHT [ 63 ]. In males, DHT can bind to androgen receptors in susceptible hair follicles and cause them to shrink, ultimately leading to hair loss [ 64 ].
However, in the van der Merwe et al. Free testosterone was not measured. Moreover, the increase in DHT and the DHT: testosterone ratio remained well within normal clinical limits. To date, 12 other studies have investigated the effects of creatine supplementation i.
Two studies reported small, physiologically insignificant increases in total testosterone after six and seven days of supplementation [ 6566 ], while the remaining ten studies reported no change in testosterone concentrations. In five of these studies [ 6768697071 ], free testosterone, which the body uses to produce DHT, was also measured and no increases were found.
Speculation exists that creatine supplementation causes dehydration and muscle cramping [ 7273 ]. The physiological rationale suggesting that creatine supplementation may cause dehydration and muscle cramping is based on the premise that creatine is an osmotically active substance found primarily in skeletal muscle and may alter whole-body fluid distribution by preferentially increasing intracellular water uptake and retention, particularly over the short-term [ 3875 ].
The initial loading phase of creatine supplementation i. Some anecdotal evidence indicates that creatine users perceive supplementation to result in some adverse effects [ 77 ].
Importantly, these studies failed to control for the use of other supplements and the dosage of creatine ingested. Greenwood et al. However, these self-report surveys are in contradiction to experimental and clinical evidence. Injuries treated by the athletic training staff were monitored.
Non-contact joint injuries, contact injuries, illnesses, missed practices due to injuries, and players lost for the season were not different between groups. These beneficial effects from creatine may be explained by fluid distribution and electrolyte imbalances, as previously discussed.
: Creatine and muscle cramps| Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration | Creatine may enter Orange Salad Recipes cells and increase Creatine and muscle cramps Creayine. Creatine and muscle cramps risks of tattoos and tips Micronutrient-rich grains safer inking Orly Avitzur, MD. Canete Cgamps, San Juan AF, Perez M, Gomez-Gallego F, Lopez-Mojares LM, Earnest CP, Fleck SJ, Lucia A. Making informed and responsible decisions when it comes to creatine supplementation can help you get the most out of any performance-enhancing regimen. The authors declare that the content of this paper has not been published or submitted for publication elsewhere. |
| Your wishlist | Creatine is safe to use if taken with enough water. More recently, Chilibeck et al. Creatine, on the other hand, like many other dietary supplements fits well within the confines of The Dietary Supplement Health and Education Act of "DSHEA" , which is a statute of United States Federal legislation which defines and regulates dietary supplements by the Federal Drug Administration FDA for Good Manufacturing Practices GMP. Close mobile search navigation Article Navigation. Davey RA, Grossmann M. Article CAS PubMed Google Scholar Bermon S, Venembre P, Sachet C, Valour S, Dolisi C. This is because these minerals are essential for proper muscle functioning and contraction. |
| Creatine and Muscle Cramps | Creatine supplementation post-exercise does not enhance training-induced adaptations in middle to older aged males. Hoffman J, Ratamess N, Kang J, Mangine G, Faigenbaum A, Stout J. Volek JS, Ratamess NA, Rubin MR, Gomez AL, French DN, McGuigan MM, Scheett TP, Sharman MJ, Hakkinen K, Kraemer WJ. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. Rahimi R, Faraji H, Vatani DS, Qaderi M. Creatine supplementation alters the hormonal response to resistance exercise. Dalbo VJ, Roberts MD, Stout JR, Kerksick CM. Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration. Adverse effects of creatine supplementation: fact or fiction? Terjung RL, Clarkson P, Eichner ER, Greenhaff PL, Hespel PJ, Israel RG, Kraemer WJ, Meyer RA, Spriet LL, Tarnopolsky MA, Wagenmakers AJ, Williams MH. American College of Sports Medicine roundtable. The physiological and health effects of oral creatine supplementation. Sci Sports Exerc. Kraemer WJ, Volek JS. Its role in human performance. CAS Google Scholar. Deminice R, Rosa FT, Pfrimer K, Ferrioli E, Jordao AA, Freitas E. Creatine Supplementation Increases Total Body Water in Soccer Players: a Deuterium Oxide Dilution Study. Greenwood M, Farris J, Kreider R, Greenwood L, Byars A. Creatine supplementation patterns and perceived effects in select division I collegiate athletes. Greenwood M, Kreider RB, Melton C, Rasmussen C, Lancaster S, Cantler E, Milnor P, Almada A. Creatine supplementation during college football training does not increase the incidence of cramping or injury. Chang CT, Wu CH, Yang CW, Huang JY, Wu MS. Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis. Unnithan VB, Veehof SH, Vella CA, Kern M. Is there a physiologic basis for creatine use in children and adolescents? Strength Cond Res. Hayashi AP, Solis MY, Sapienza MT, Otaduy MC, de Sa Pinto AL, Silva CA, Sallum AM, Pereira RM, Gualano B. Efficacy and safety of creatine supplementation in childhood-onset systemic lupus erythematosus: a randomized, double-blind, placebo-controlled, crossover trial. Tarnopolsky MA, Mahoney DJ, Vajsar J, Rodriguez C, Doherty TJ, Roy BD, Biggar D. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Sakellaris G, Kotsiou M, Tamiolaki M, Kalostos G, Tsapaki E, Spanaki M, Spilioti M, Charissis G, Evangeliou A. Prevention of complications related to traumatic brain injury in children and adolescents with creatine administration: an open label randomized pilot study. Kayton S, Cullen RW, Memken JA, Rutter R. Supplementation and ergogenic aid use by competitive male and female high school athletes. Diehl K, Thiel A, Zipfel S, Mayer J, Schnell A, Schneider S. Elite adolescent athletes' use of dietary supplements: characteristics, opinions, and sources of supply and information. Gotshalk LA, Kraemer WJ, Mendonca MA, Vingren JL, Kenny AM, Spiering BA, Hatfield DL, Fragala MS, Volek JS. Creatine supplementation improves muscular performance in older women. Gotshalk LA, Volek JS, Staron RS, Denegar CR, Hagerman FC, Kraemer WJ. Creatine supplementation improves muscular performance in older men. Sports Exerc. Silva AJ, Machado Reis V, Guidetti L, Bessone Alves F, Mota P, Freitas J, Baldari C. Effect of creatine on swimming velocity, body composition and hydrodynamic variables. Forbes SC, Sletten N, Durrer C, Myette-Cote E, Candow D, Little JP. Creatine Monohydrate Supplementation Does Not Augment Fitness, Performance, or Body Composition Adaptations in Response to Four Weeks of High-Intensity Interval Training in Young Females. Antonio J, Ciccone V. The effects of pre versus post workout supplementation of creatine monohydrate on body composition and strength. Becque MD, Lochmann JD, Melrose DR. Effects of oral creatine supplementation on muscular strength and body composition. Chilibeck PD, Magnus C, Anderson M. Effect of in-season creatine supplementation on body composition and performance in rugby union football players. Volek JS, Duncan ND, Mazzetti SA, Staron RS, Putukian M, Gomez AL, Pearson DR, Fink WJ, Kraemer WJ. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Chrusch MJ, Chilibeck PD, Chad KE, Davison KS, Burke DG. Creatine supplementation combined with resistance training in older men. Gualano B, Macedo AR, Alves CR, Roschel H, Benatti FB, Takayama L, de Sa Pinto AL, Lima FR, Pereira RM. Creatine supplementation and resistance training in vulnerable older women: a randomized double-blind placebo-controlled clinical trial. Candow DG, Vogt E, Johannsmeyer S, Forbes SC, Farthing JP. Strategic creatine supplementation and resistance training in healthy older adults. Bourgeois JM, Nagel K, Pearce E, Wright M, Barr RD, Tarnopolsky MA. Creatine monohydrate attenuates body fat accumulation in children with acute lymphoblastic leukemia during maintenance chemotherapy. Blood Cancer. Lobo DM, Tritto AC, da Silva LR, de Oliveira PB, Benatti FB, Roschel H, Niess B, Gualano B, Pereira RM. Effects of long-term low-dose dietary creatine supplementation in older women. Sales LP, Pinto AJ, Rodrigues SF, Alvarenga JC, Goncalves N, Sampaio-Barros MM, Benatti FB, Gualano B, Rodrigues Pereira RM. A Biol. Forbes S, Candow D, Krentz J, Roberts M, Young K. Journal of Functional Morphology and Kinesiology. Article PubMed Central Google Scholar. Hunter A. Monographs on biochemistry: creatine and creatinine. London: Longmans, Green and Co; Myers V. The creatine content of muscle under normal conditions. Its relation to the urinary creatinine. J Biol Chem. Casey A, Constantin-Teodosiu D, Howell S, Hultman E, Greenhaff PL. Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans. Greenhaff PL, Bodin K, Soderlund K, Hultman E. Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis. Ostojic SM, Ahmetovic Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent? Gualano B, Artioli GG, Poortmans JR, Lancha Junior AH. Exploring the therapeutic role of creatine supplementation. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M. Writing Group for the European Working Group on Sarcopenia in Older People 2 EWGSOP2 , and the Extended Group for EWGSOP2 Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. Mcleod JC, Stokes T, Phillips SM. Resistance Exercise Training as a Primary Countermeasure to Age-Related Chronic Disease. Stout JR, Sue Graves B, Cramer JT, Goldstein ER, Costa PB, Smith AE, Walter AA. Effects of creatine supplementation on the onset of neuromuscular fatigue threshold and muscle strength in elderly men and women 64 - 86 years. Health Aging. Canete S, San Juan AF, Perez M, Gomez-Gallego F, Lopez-Mojares LM, Earnest CP, Fleck SJ, Lucia A. Does creatine supplementation improve functional capacity in elderly women? PubMed Google Scholar. Baker TP, Candow DG, Farthing JP. Effect of Preexercise Creatine Ingestion on Muscle Performance in Healthy Aging Males. Chami J, Candow DG. Effect of Creatine Supplementation Dosing Strategies on Aging Muscle Performance. Bermon S, Venembre P, Sachet C, Valour S, Dolisi C. Effects of creatine monohydrate ingestion in sedentary and weight-trained older adults. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Rawson ES, Clarkson PM. Acute creatine supplementation in older men. Wiroth JB, Bermon S, Andrei S, Dalloz E, Hebuterne X, Dolisi C. Effects of oral creatine supplementation on maximal pedalling performance in older adults. Branch JD. Effect of creatine supplementation on body composition and performance: a meta-analysis. Devries MC, Phillips SM. Creatine supplementation during resistance training in older adults-a meta-analysis. Candow DG, Chilibeck PD, Forbes SC. Creatine supplementation and aging musculoskeletal health. Chilibeck PD, Chrusch MJ, Chad KE, Shawn Davison K, Burke DG. Creatine monohydrate and resistance training increase bone mineral content and density in older men. Candow DG, Little JP, Chilibeck PD, Abeysekara S, Zello GA, Kazachkov M, Cornish SM, Yu PH. Low-dose creatine combined with protein during resistance training in older men. Chilibeck PD, Candow DG, Landeryou T, Kaviani M, Paus-Jenssen L. Effects of Creatine and Resistance Training on Bone Health in Postmenopausal Women. Green AL, Hultman E, Macdonald IA, Sewell DA, Greenhaff PL. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Steenge GR, Simpson EJ, Greenhaff PL. Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans. Kerksick CM, Wilborn CD, Roberts MD, Smith-Ryan A, Kleiner SM, Jager R, Collins R, Cooke M, Davis JN, Galvan E, Greenwood M, Lowery LM, Wildman R, Antonio J, Kreider RB. Cooke MB, Rybalka E, Williams AD, Cribb PJ, Hayes A. Creatine supplementation enhances muscle force recovery after eccentrically-induced muscle damage in healthy individuals. Santos RV, Bassit RA, Caperuto EC, Costa Rosa LF. The effect of creatine supplementation upon inflammatory and muscle soreness markers after a 30km race. Life Sci. Greenwood M, Kreider R, Earnest CP, Rasmussen C, Almada AL. Differences in creatine retention among three nutritional formulations of oral creatine supplements. Hespel P, Op't Eijnde B, Van Leemputte M, Urso B, Greenhaff PL, Labarque V, Dymarkowski S, Van Hecke P, Richter EA. Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. Op 't Eijnde, B. Effect of oral creatine supplementation on human muscle GLUT4 protein content after immobilization. Diabetes , 50, Kreider RB. Effects of creatine supplementation on performance and training adaptations. Kreider RB, Melton C, Rasmussen CJ, Greenwood M, Lancaster S, Cantler EC, Milnor P, Almada AL. Long-term creatine supplementation does not significantly affect clinical markers of health in athletes. Rosene JM, Whitman SA, Fogarty TD. A Comparison of Thermoregulation With Creatine Supplementation Between the Sexes in a Thermoneutral Environment. Volek JS, Mazzetti SA, Farquhar WB, Barnes BR, Gomez AL, Kraemer WJ. Physiological responses to short-term exercise in the heat after creatine loading. Watson G, Casa DJ, Fiala KA, Hile A, Roti MW, Healey JC, Armstrong LE, Maresh CM. Creatine use and exercise heat tolerance in dehydrated men. Weiss BA, Powers ME. Creatine supplementation does not impair the thermoregulatory response during a bout of exercise in the heat. Wright GA, Grandjean PW, Pascoe DD. The effects of creatine loading on thermoregulation and intermittent sprint exercise performance in a hot humid environment. Beis LY, Polyviou T, Malkova D, Pitsiladis YP. The effects of creatine and glycerol hyperhydration on running economy in well trained endurance runners. Easton C, Turner S, Pitsiladis YP. Creatine and glycerol hyperhydration in trained subjects before exercise in the heat. Easton C, Calder A, Prior F, Dobinson S, I'Anson R, MacGregor R, Mohammad Y, Kingsmore D, Pitsiladis YP. The effects of a novel "fluid loading" strategy on cardiovascular and haematological responses to orthostatic stress. Kilduff LP, Georgiades E, James N, Minnion RH, Mitchell M, Kingsmore D, Hadjicharlambous M, Pitsiladis YP. The effects of creatine supplementation on cardiovascular, metabolic, and thermoregulatory responses during exercise in the heat in endurance-trained humans. Polyviou TP, Easton C, Beis L, Malkova D, Takas P, Hambly C, Speakman JR, Koehler K, Pitsiladis YP. Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters. Polyviou TP, Pitsiladis YP, Lee WC, Pantazis T, Hambly C, Speakman JR, Malkova D. Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists. Polyviou TP, Pitsiladis YP, Celis-Morales C, Brown B, Speakman JR, Malkova D. The Effects of Hyperhydrating Supplements Containing Creatine and Glucose on Plasma Lipids and Insulin Sensitivity in Endurance-Trained Athletes. Lopez RM, Casa DJ, McDermott BP, Ganio MS, Armstrong LE, Maresh CM. Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses. Buford TW, Kreider RB, Stout JR, Greenwood M, Campbell B, Spano M, Ziegenfuss T, Lopez H, Landis J, Antonio J. International Society of Sports Nutrition position stand: creatine supplementation and exercise. Kley RA, Tarnopolsky MA, Vorgerd M. Creatine for treating muscle disorders. Cochrane Database Syst. Tarnopolsky MA. Potential benefits of creatine monohydrate supplementation in the elderly. Clinical use of creatine in neuromuscular and neurometabolic disorders. Hausmann ON, Fouad K, Wallimann T, Schwab ME. Protective effects of oral creatine supplementation on spinal cord injury in rats. Spinal Cord. Rabchevsky AG, Sullivan PG, Fugaccia I, Scheff SW. Creatine diet supplement for spinal cord injury: influences on functional recovery and tissue sparing in rats. Prass K, Royl G, Lindauer U, Freyer D, Megow D, Dirnagl U, Stockler-Ipsiroglu G, Wallimann T, Priller J. Improved reperfusion and neuroprotection by creatine in a mouse model of stroke. Blood Flow Metab. Adcock KH, Nedelcu J, Loenneker T, Martin E, Wallimann T, Wagner BP. Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia. Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. Allah Yar R, Akbar A, Iqbal F. Brain Res. Sullivan PG, Geiger JD, Mattson MP, Scheff SW. Dietary supplement creatine protects against traumatic brain injury. Brosnan JT, Brosnan ME. Creatine: endogenous metabolite, dietary, and therapeutic supplement. Delanghe J, De Slypere JP, De Buyzere M, Robbrecht J, Wieme R, Vermeulen A. Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians. Kalhan SC, Gruca L, Marczewski S, Bennett C, Kummitha C. Whole body creatine and protein kinetics in healthy men and women: effects of creatine and amino acid supplementation. Parise, G. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Bundey S, Crawley JM, Edwards JH, Westhead RA. Serum creatine kinase levels in pubertal, mature, pregnant, and postmenopausal women. King B, Spikesman A, Emery AE. The effect of pregnancy on serum levels of creatine kinase. Ellery SJ, Dickinson H, McKenzie M, Walker DW. Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy--Creatine prophylaxis and the need for multi-organ protection. Dickinson H, Davies-Tuck M, Ellery SJ, Grieger JA, Wallace EM, Snow RJ, Walker DW, Clifton VL. Maternal creatine in pregnancy: a retrospective cohort study. Ellery SJ, LaRosa DA, Kett MM, Della Gatta PA, Snow RJ, Walker DW, Dickinson H. Maternal creatine homeostasis is altered during gestation in the spiny mouse: is this a metabolic adaptation to pregnancy? BMC Pregnancy Childbirth. Dickinson H, Ellery S, Ireland Z, LaRosa D, Snow R, Walker DW. Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy. Ireland Z, Castillo-Melendez M, Dickinson H, Snow R, Walker DW. A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia. De Guingand DL, Ellery SJ, Davies-Tuck ML, Dickinson H. Creatine and pregnancy outcomes, a prospective cohort study in low-risk pregnant women: study protocol. BMJ Open. Riehemann S, Volz HP, Wenda B, Hubner G, Rossger G, Rzanny R, Sauer H. Frontal lobe in vivo 31 P-MRS reveals gender differences in healthy controls, not in schizophrenics. NMR Biomed. Kondo DG, Forrest LN, Shi X, Sung YH, Hellem TL, Huber RS, Renshaw PF. Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression. Hellem TL, Sung YH, Shi XF, Pett MA, Latendresse G, Morgan J, Huber RS, Kuykendall D, Lundberg KJ, Renshaw PF. Creatine as a Novel Treatment for Depression in Females Using Methamphetamine: A Pilot Study. Dual Diagn. Bebbington PE, Dunn G, Jenkins R, Lewis G, Brugha T, Farrell M, Meltzer H. The influence of age and sex on the prevalence of depressive conditions: report from the National Survey of Psychiatric Morbidity. Kuehner C. Gender differences in unipolar depression: an update of epidemiological findings and possible explanations. Acta Psychiatr. Lyoo IK, Kong SW, Sung SM, Hirashima F, Parow A, Hennen J, Cohen BM, Renshaw PF. Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate. Psychiatry Res. Vandenberghe K, Goris M, Van Hecke P, Van Leemputte M, Vangerven L, Hespel P. Long-term creatine intake is beneficial to muscle performance during resistance training. Cox G, Mujika I, Tumilty D, Burke L. Acute creatine supplementation and performance during a field test simulating match play in elite female soccer players. Hamilton KL, Meyers MC, Skelly WA, Marley RJ. Oral creatine supplementation and upper extremity anaerobic response in females. Kambis KW, Pizzedaz SK. Short-term creatine supplementation improves maximum quadriceps contraction in women. Smith-Ryan AE, Ryan ED, Fukuda DH, Costa PB, Cramer JT, Stout JR. The effect of creatine loading on neuromuscular fatigue in women. Aguiar, A. Long-term creatine supplementation improves muscular performance during resistance training in older women. Greenhaff, P. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Lond , 84, Wyss M, Braissant O, Pischel I, Salomons GS, Schulze A, Stockler S, Wallimann T. Creatine and creatine kinase in health and disease--a bright future ahead? Wallimann T, Riek U, Moddel M. Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients. Deldicque L, Decombaz J, Zbinden Foncea H, Vuichoud J, Poortmans JR, Francaux M. Kinetics of creatine ingested as a food ingredient. Persky AM, Brazeau GA, Hochhaus G. Pharmacokinetics of the dietary supplement creatine. Jager R, Purpura M, Shao A, Inoue T, Kreider RB. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Negrisoli G, Del Corona L. Hydrosoluble organic salts of creatine; Italy; Pischel, I. New creatine pyruvate derivatives from crystallization in polar solvents; Germany, ; , pp 1. Creatine ascorbates and a method of producing them; United States, ; , pp 1. Abraham, S. Process for preparing a creatine heterocyclic acid salt and method of use; United States, ; , pp 1. Child, R. In In Creatine ethyl ester rapidly degrades to creatinine in stomach acid; International Society of Sports Nutrition 4th Annual Meeting; Las Vegas, NV, ;. Giese MW, Lecher CS. Non-enzymatic cyclization of creatine ethyl ester to creatinine. Dalton RL, Sowinski RJ, Grubic TJ, Collins PB, Coletta AM, Reyes AG, Sanchez B, Koozehchian M, Jung YP, Rasmussen C, Greenwood M, Murano PS, Earnest CP, Kreider RB. Hematological and Hemodynamic Responses to Acute and Short-Term Creatine Nitrate Supplementation. Galvan, E. Acute and chronic safety and efficacy of dose dependent creatine nitrate supplementation and exercise performance. eCollection Kreider R, Willoughby D, Greenwood M, Parise G, Payne E, Tarnopolsky M. Effects of serum creatine supplementation on muscle creatine content. Pischel I, Gastner T. Creatine--its chemical synthesis, chemistry, and legal status. Howard AN, Harris RC. Compositions containing creatine; USP Office Editor: United States; Edgar G, Shiver HE. The equilibrium between creatine and creatinine, in aqueous solution: the effect of hydrogen ion. J Am Chem Soc. Cannon JG, Orencole SF, Fielding RA, Meydani M, Meydani SN, Fiatarone MA, Blumberg JB, Evans WJ. Acute phase response in exercise: interaction of age and vitamin E on neutrophils and muscle enzyme release. Download references. Department of Health and Human Performance, Nova Southeastern University, Davie, Florida, USA. Faculty of Kinesiology and Health Studies, University of Regina, Regina, Canada. Department of Physical Education, Faculty of Education, Brandon University, Brandon, MB, Canada. Sports Medicine Department, Mayo Clinic Health System, La Crosse, WI, USA. Department of Health, Nutrition, and Exercise Science, Messiah University, Mechanicsburg, PA, USA. Department of Exercise and Sport Science, University of North Carolina, Chapel Hill, NC, USA. Department of Exercise Science and Sport Management, Kennesaw State University, Kennesaw, GA, USA. School of Exercise and Sport Science, University of Mary Hardin-Baylor, Belton, TX, USA. The Center for Applied Health Sciences, Canfield, Ohio, USA. You can also search for this author in PubMed Google Scholar. Conceptualization: DGC; Writing-original draft preparation: All authors. The authors declare that the content of this paper has not been published or submitted for publication elsewhere. The author s read and approved the final manuscript. Correspondence to Jose Antonio. DGC has received research grants and performed industry sponsored research involving creatine supplementation, received creatine donation for scientific studies and travel support for presentations involving creatine supplementation at scientific conferences. In addition, DGC serves on the Scientific Advisory Board for Alzchem a company which manufactures creatine and the editorial review board for the Journal of the International Society of Sports Nutrition and is a sports science advisor to the ISSN. Furthermore, DGC has previously served as the Chief Scientific Officer for a company that sells creatine products. BG has received research grants, creatine donation for scientific studies, travel support for participation in scientific conferences includes the ISSN and honorarium for speaking at lectures from AlzChem a company which manufactures creatine. In addition, BG serves on the Scientific Advisory Board for Alzchem a company that manufactures creatine. ARJ has consulted with and received external funding from companies that sell certain dietary ingredients and also writes for online and other media outlets on topics related to exercise and nutrition. RBK is co-founder and member of the board of directors for the ISSN. In addition, RBK has conducted industry sponsored research on creatine, received financial support for presenting on creatine at industry sponsored scientific conferences includes the ISSN , and served as an expert witness on cases related to creatine. Additionally, he serves as Chair of the Scientific Advisory Board for Alzchem that manufactures creatine monohydrate. ESR serves on the Scientific Advisory Board for Alzchem a company which manufactures creatine. AESR has received research funding from industry sponsors related to sports nutrition products and ingredients. In addition, AESR serves on the Scientific Advisory Board for Alzchem a company that manufactures creatine. TAV has received funding to study creatine and is an advisor for supplement companies who sell creatine. In addition, TAV is the current president of the ISSN. DSW serves as a scientific advisor to the ISSN and on the editorial review board for the Journal of the International Society of Sports Nutrition. In addition, DSW is Past President of the ISSN and has received financial compensation from the ISSN to speak about creatine supplementation. TNZ has conducted industry sponsored research involving creatine supplementation and has received research funding from industry sponsors related to sports nutrition products and ingredients. In addition, TNZ serves on the editorial review board for the Journal of the International Society of Sports Nutrition and is Past President of the ISSN. Why primary care is like air traffic control. August 18, Kevin 9. The July Effect and causes of the spike in medication errors. August 18, Kevin 2. More by Orly Avitzur, MD What are the health risks of eyelash extensions? Orly Avitzur, MD. Health risks of tattoos and tips for safer inking Orly Avitzur, MD. How to avoid Zumba injuries: 10 physician tips Orly Avitzur, MD. More in Meds Can we finally say goodbye to opioids? There may be new pain relief on the horizon. Joseph Parker, MD. Now is a good time to reassess your medications with your clinician Paula Rochon, MD, Jerry Gurwitz, MD, and Lisa McCarthy, PharmD. Creatine might benefit athletes who need short bursts of speed or increased muscle strength, such as sprinters, weight lifters and team sport athletes. While taking creatine might not help all athletes, evidence suggests that it generally won't hurt if taken as directed. Although an older case study suggested that creatine might worsen kidney dysfunction in people with kidney disorders, creatine doesn't appear to affect kidney function in healthy people. When used orally at appropriate doses, creatine is likely safe to take for up to five years. As with any dietary supplement, it's important to choose a product that follows recommended manufacturing practices and subscribes to third-party testing to ensure the product's quality. Creatine might be unsafe for people with preexisting kidney problems. However, further research is needed. There is a problem with information submitted for this request. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Click here for an email preview. Error Email field is required. Error Include a valid email address. 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This content does not have an Arabic version. Appointments at Mayo Clinic Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Request Appointment. Products and services. Creatine By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry. Show references Kreider RB, et al. International Society of Sports Nutrition position stand: Safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition. IBM Micromedex. Accessed Nov. |
| Creatine - Mayo Clinic | Heart disease Preliminary studies suggest that creatine supplements may help lower levels of triglycerides fats in the blood in men and women with high concentrations of triglycerides. Medicine and science in sports and exercise. Basically, the effect of creatine on muscle creatine is sometimes abrupt, causing various changes and minor issues that can be easily resolved in no time. Why primary care is like air traffic control. This article explains…. |
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Straight Facts: The Biggest Mistake To Avoid When Using Creatine Creatine Creatine and muscle cramps Creatime top sports mkscle supplement available. Some claim it causes musc,e gain, cramping, and Ceeatine with digestion, the liver, Creatine and muscle cramps the kidneys. Antimicrobial foot care products hundreds of studies support its safety and effectiveness. Despite this negative press, the International Society of Sports Nutrition regards creatine as extremely safe, concluding that it is one of the most beneficial sports supplements available 2. One study examined 69 health markers after participants took creatine supplements for 21 months.
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