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Thinning Hair? 4 Hormone DeficienciesRaspberry ketones and hormone balance -
Metrics details. Numerous natural products are marketed and sold claiming to decrease body weight and fat, but few undergo finished product-specific research demonstrating their safety and efficacy. Subjects were tested for changes in body composition, serum adipocytokines adiponectin, resistin, leptin, TNF-α, IL-6 and markers of health including heart rate and blood pressure.
Of the 45 subjects who completed the study, significant differences were observed in: body weight METABO placebo placebo were also observed. No changes in systemic hemodynamics, clinical blood chemistries, adverse events, or dietary intake were noted between groups.
METABO administration is a safe and effective adjunct to an eight-week diet and exercise weight loss program by augmenting improvements in body composition, waist and hip girth. Adherence to the eight-week weight loss program also led to beneficial changes in body fat in placebo.
Ongoing studies to confirm these results and clarify the mechanisms i. Obesity, particularly central adiposity, has been increasingly cited as a major health issue in recent decades. Indeed, some of the leading causes of preventable death and disability, including heart disease, stroke, type 2 diabetes, degenerative joint disease, low back pain, and specific types of cancer are obesity-related[ 1 ].
In the United States, more than one-third of adults Excess body weight is also a major risk factor for the development of Metabolic Syndrome. Metabolic Syndrome is a constellation of medical disorders including hypertension, central adiposity, hyperglycemia and dyslipidemia[ 4 , 5 ] that increase the risk of premature cardiovascular disease.
Adipocytokines including leptin, tumor necrosis factor-α, interleukin-6, resistin, visfatin, retinol binding protein-4, angiotensinogen and adiponectin are signaling cytokines produced by adipose tissue.
Adipose tissue acts as an endocrine organ producing adipocytokines to regulate insulin signaling, vascular tone, carbohydrate and lipid metabolism, and the inflammatory response. Dysregulation of certain adipocytokines can contribute to insulin resistance, amplified systemic inflammation and lead to the development of Metabolic Syndrome and hypertension[ 6 ].
For example, plasma levels of adiponectin have been reported to be significantly reduced in obese humans[ 7 ] and in patients with type-2 diabetes mellitus, hypertension and metabolic syndrome[ 8 — 11 ].
Alternative methods to aid weight loss include meal replacement preparations, and nutritional supplements such as vitamins, mineral, and botanicals.
Raspberry ketone is an ingredient found in raspberries Rubus idaeus that may have weight loss potential given preliminary findings in rodents and cell cultures, i. prevention of weight gain during a high-fat diet, and enhanced norepinephrine-lipolysis, increased adiponectin expression, and translocation of hormone-sensitive lipase in adipocytes[ 12 , 13 ].
To date, however, the effects of raspberry ketone in humans remain unexplored. In humans, oral ingestion of certain capsaicinoids, active component of chilli peppers from the genus Capsicum has been shown to increase energy expenditure, lipolysis and fat oxidation[ 15 ], activate brown adipose tissue[ 16 ] and stimulate the systemic release of norepinephrine[ 15 , 17 ].
Bioactive compounds found in the rhizomes of ginger Zingiber officinale and garlic Allium sativum extracts have been shown to influence many key features of the metabolic syndrome by modulating adipocytokine secretion from adipose tissue, reducing body fat accumulation, decreasing circulating insulin and markers of systemic inflammation in murine and cell culture models, with similar findings emerging from studies in humans[ 18 — 21 ].
Extracts of Citrus aurantium, standardized for p-synephrine and other bioactive amines have been shown to increase resting metabolic rate and enhance weight loss in human clinical trials[ 22 ]. The purpose of this study was to determine the safety and efficacy of METABO as an adjunct to an 8-week weight loss program.
Primary endpoints included determination of the effect of this product on body composition and various anthropometric measures. Secondary endpoints included determination of safety information via measurement of systemic hemodynamics and standard clinical chemistry panels of sera and plasma.
Subjects were excluded if they had used weight-loss supplements within the 30 days prior to the start of the study, had gained or lost more than 4. Subjects were also excluded if they had metabolic disorders, heart disease, hypertension, a known allergy to any ingredients in the supplement or placebo or had smoked cigarettes in the last six months.
Prior to being enrolled in the study, all subjects underwent a physical examination by a licensed physician, lead electrocardiogram, health history screen and provided written informed consent.
This study utilized a randomized, placebo-controlled, parallel-group, double-blind design. Subjects were matched according to sex and BMI prior to being randomized into placebo or METABO groups.
Capsules were produced in accordance with current Good Manufacturing Practices cGMP in a United States Food and Drug Administration FDA registered facility. Prior to production, all raw materials were tested for purity and potency.
The study intervention included an 8-week diet and exercise program consisting of recreationally active men and women, randomly assigned to receive either a placebo or the manufacturer recommended dosage of their respective supplement two capsules with breakfast and two capsules with lunch.
Jeor equation[ 23 ] x an activity factor of 1. Each subject was given seven days of menus based off their daily allowance for calories. Each study participant was contacted on a weekly basis to assess compliance to diet and supplement protocol.
Every training session was supervised by a certified fitness professional and conducted at a single local facility to verify participation, and all subjects trained as one group.
The fitness professional used a participant attendance log to monitor training compliance. All subjects had measurements of their weight, BMI, waist and hip girths, body fat and lean mass taken at week 0 baseline , week 4 midpoint of the study and week 8 end of the study.
A member of the research staff contacted all subjects on a weekly basis to ensure compliance to the supplementation protocol, and pill counts were performed during mid and post testing. Blood samples were drawn at week 0 and week 8 for standard assessment of clinical laboratory parameters i.
comprehensive metabolic panel, lipid panel and at weeks 0, 4 and 8 for serum concentrations of adipocytokines adiponectin, resistin, leptin, tumor necrosis factor-α TNF-α and interleukin-6 IL Vital signs, including blood pressure and heart rate, were also recorded at weeks 0, 4 and 8.
All measurements were completed by the same researcher to minimize between-trial variation. Energy levels and food craving data were analyzed using a whole unit Likert-type scale[ 24 ]. All energy levels and food craving data were collected at weeks 0, 4 and 8.
All blood samples were taken in the morning at approximately the same time of day i. One aliquot was immediately analyzed for a item clinical chemistry profile Hitachi D, Roche Diagnostics, Germany by a certified clinical laboratory.
This profile consisted of a comprehensive metabolic panel glucose, BUN, creatinine, sodium, potassium, chloride, carbon dioxide, calcium, total protein, albumin, globulin, total bilirubin, alkaline phosphatase, AST [SGOT], and ALT [SGPT] as well as a lipid profile total cholesterol, HDL-C, LDL-C, VLDL-C, triacylglycerols [TAG].
The second aliquot was stored at °C until later batch analysis for serum adipokines adiponectin, resistin, leptin, TNF-α, IL-6 via enzyme-linked immunosorbent assay. Adipokines were analyzed using a MAGPIX® Luminex Corporation, Austin, TX and customized commercially available magnetic bead panels Millipore Corporation, Billerica, MA.
Prior to each assay, the MAGPIX was calibrated using the MAGPIX Calibration Kit Millipore catalog and performance verified using the MAGPIX Performance Verification Kit Millipore catalog Each assay was run in one batch, therefore no inter-assay CV was determined.
Lean mass, percent body fat and trunk limb fat ratios were assessed using dual energy x-ray absorptiometry DEXA, GE Lunar, DPX Pro. All DEXA scans were performed by the same technician and analyzed via current manufacturer software enCORE version Female subjects were measured during the early follicular phase of their menstrual cycle, based on reported last menstrual period, to minimize effects of menstrual hormonal changes on dependent variables.
DEXA segments for the arms, legs, and trunk were subsequently obtained using standard anatomical landmarks. Percent fat was calculated by dividing fat mass by the total scanned mass.
Quality control calibration procedures were performed prior to all scans using a calibration block provided by the manufacturer. Prior to this study, we determined test-retest reliability for repeated measurements of lean mass, bone mineral content, and fat mass with this DEXA via intra-class correlation coefficients[ 25 ].
Waist girth defined as the narrowest part of the trunk between the bottom of the rib cage and the top of the pelvis and hip girth defined as the largest laterally projecting prominence of the pelvis or pelvic region from the waist to the thigh were measured in duplicate using standardized anthropometric procedures[ 26 ].
Seated, resting heart rate and blood pressure were measured in duplicate using an automated sphygmomanometer Omron HEM A baseline 3-d food record was completed for each subject after screening and enrollment, prior to randomization and intervention.
To verify dietary compliance, subjects completed 3-d food records which included two weekdays and one weekend day during baseline testing, week 4, and week 8. All food records were analyzed by a state-licensed, registered dietitian using commercially available software NutriBase IV Clinical Edition, AZ.
To enhance accuracy of the food records, all subjects received instruction during baseline testing on how to accurately estimate portion sizes. This counseling was reinforced during each visit to the laboratory.
No other dietary supplements were allowed with the exception of standard strength multivitamins. Safety and tolerability of the supplements were assessed through adverse event reports that were coded using the Medical Dictionary for Regulatory Activities MedDRA.
Differences between groups from baseline to week 4 and baseline to week 8 were analyzed using analysis of covariance ANCOVA with the baseline scores employed as the covariate.
All analyses were verified to meet the homogeneity of regression assumption parallelism of ANCOVA. Non-normally distributed variables were log-transformed before analysis. For descriptive purposes, raw values as well as the change scores week 4 minus baseline, week 8 minus baseline of all dependent variables are displayed.
Statistical significance was accepted when the probability of a type 1 error was less than or equal to 0. Data were analyzed using statistical software written using LabVIEW National Instruments, Austin TX programming software.
However, a goal of 70 total subjects were be enrolled due to higher expected attrition from a study involving multiple independent variables including a prescribed diet, regular exercise, and supplement intervention. Of the 70 subjects initially recruited, 25 were lost due to attrition i.
Statistically significant decreases were observed from week 0 to week 8 for subjects who received METABO versus those who received placebo in body weight From week 0 to week 4 the mean differences in decreased waist girths for the subjects who received METABO versus those who received placebo were Similarly, the mean differences in decreased hip girths for the subjects who received METABO versus those who received placebo were The mean target daily dietary intake calculated using the Mifflin-St.
Jeor equation x 1. No differences were observed in energy consumption, or in absolute or relative amounts of dietary carbohydrate, protein or fat between METABO and placebo. Subjects who received METABO also exhibited a statistically significant decrease in relative fats cravings compared to the placebo group No statistically significant differences between the two groups were observed for sweet, fast food fats, carbohydrates or healthy food cravings.
No serious adverse events occurred during this study and analyses of standard clinical chemistry panels of serum and plasma revealed no statistically significant abnormalities of clinical importance. There were no significant between group effects for any cardiovascular variable during the 8-week trial, and the changes within groups were modest and non-significant.
For resting systolic blood pressure, the placebo group went from Similarly, for resting diastolic blood pressure the placebo group dropped from For resting heart rate, the placebo group went from The incidence of non-serious adverse events e.
were transient and similar, with no significant differences between placebo and METABO. The results from this study demonstrate that as an adjunct to an 8-week diet and weight loss program, administration of METABO significantly decreases body weight, body fat mass, waist and hip girth, while increasing lean mass compared to the placebo.
Although a restricted diet can lead to weight loss, it is often accompanied by a loss of lean tissue[ 28 — 30 ], which can have deleterious metabolic consequences.
Because of this, it is important to achieve weight loss with a high ratio of fat to lean mass loss that is essential for both short-term efficacy and long-term metabolic health and body weight maintenance[ 31 , 32 ]. In this study, overweight subjects who received METABO achieved significantly greater improvements in their lean mass-to-fat mass ratio.
Future studies should follow subjects during a washout period to determine if this effect helps maintain long-term weight control i. minimize weight re-gain. Additionally, a future investigation should include a METABO only group with dietary control and no structured exercise program to explore the role of diet with METABO alone on body composition and metabolic outcomes.
Future studies may attempt to explore this observation further with studies designed to look for differences in these important metabolic and biochemical markers as primary outcome measures.
Another important finding in our study relates to the observed differences in adipokine concentrations in the METABO group, although most of these did not achieve statistical significance.
For example, we observed a trend for decreased serum resistin concentrations in subjects who received METABO compared to placebo at week 4, but not week 8. High serum resistin concentrations have been found in obese individuals and have been linked to insulin resistance, hence the trend for decreased resistin levels in METABO is an intriguing finding that requires further investigation in a future study[ 33 ].
The current study may have been underpowered to detect significant differences in serum adiponectin, given that fat loss occurred in both groups as a result of caloric restriction and a consistent exercise program.
In addition, trends for maintaining elevated serum leptin from week 0 to week 4 were observed in subjects who received METABO compared to placebo. Leptin acts on receptors in the hypothalamus to regulate appetite, energy expenditure, sympathetic tone and neuroendocrine function, and circulating levels have been shown to decline in response to caloric restriction or negative energy balance[ 34 ].
Leptin deficiency has been shown to promote hunger and food seeking behaviour, in addition to reduced metabolic rate in humans[ 35 ]. Collectively, the trend for resistin and significant change in leptin may help to partly explain the effects of METABO on body composition.
The combination of ingredients with potentially complementary and interactive mechanisms of action may account for the favorable changes observed in many of the clinical endpoints in the METABO group. Razberi-K® contains Raspberry ketone 4- 4-hydroxyphenyl butanone , which is a naturally occurring phenolic compound in red raspberry Rubus ideas that has been shown to enhance norepinephrine-induced lipolysis in adipocytes, prevent high-fat diet-induced body weight gain in mice, and increase adiponectin gene expression and secretion in adipocytes in culture[ 12 , 13 ].
Moreover, Wang et al. demonstrated anti-inflammatory benefits, improved antioxidant capacity, and enhanced leptin and insulin sensitivity in Sprague-Dawly rats using a high-fat diet induced nonalcoholic steatohepatitis NASH model[ 36 ]. From the limited preclinical literature, it appears that raspberry ketones require norepinephrine for maximizing their hormone-sensitive lipolytic action.
Capsimax® is a concentrated capsicum extract found in an encapsulated beadlet form to decrease gastric irritation. Advantra Z® is an ingredient extracted from the Citrus aurantium traditional Chinese herb known as zhi-shi and standardized for the bioactive alkaloid p-synephrine.
Raspberry Ketone Author: Dr. Last Updated: February 3rd, Share This Page. All Peptides. Peptide Therapy Weight Loss Peptides Growth Hormone Peptides Wound Healing Peptides.
All Guides. Hormone Therapy Guide Peptide Therapy Guide Weight Loss Guide Sexual Health Guide Hair Loss Guide. Book a Free Consultation. How Raspberry Ketone Works Raspberry ketone is high in fiber, which helps promote weight loss. Proven Health Benefits of Raspberry Ketone Lowers Risk of Diabetes and Improves Blood Sugar Levels Studies suggest that raspberry ketone can help reduce diabetes risk through its blood sugar-lowering effects: A study showed that the nutrient profile of red raspberries and their polyphenolic components can help reduce the risk of diabetes.
Improves Sexual Health There are also increasing evidence supporting the beneficial effects of raspberry ketone on sexual health: In sterile male Queensland fruit fly, raspberry ketone supplementation improved mating performance.
Protects Against Liver Injury Raspberry ketone has been found to protect the liver against various forms of injury: A study showed that raspberry ketone prevented programmed cell death of liver cells.
Lowers Risk of Cardiovascular Diseases Studies found that raspberry ketone may help ward off cardiovascular diseases by improving various health parameters: In male and female mice, administration with raspberry ketone improved blood circulation. Promotes Weight Loss A number of high-quality studies recommend raspberry ketone as a weight loss supplement: In overweight men and women, raspberry ketone consumption for 8 weeks reduced hip and waist girth, and increased energy levels.
Prevents Bone Abnormalities There are also studies supporting the benefits of raspberry ketone on bone health: In a rat model of arthritis, raspberry ketone extract administration lowered the incidence of bone breakdown. References: Burton-Freeman BM, Sandhu AK, Edirisinghe I.
Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links. Adv Nutr. Published Jan Zhao, L. et al. Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase AMPK α1.
Schell J, Betts NM, Lyons TJ, Basu A. Raspberries Improve Postprandial Glucose and Acute and Chronic Inflammation in Adults with Type 2 Diabetes. Ann Nutr Metab. doi: Epub Feb PMID: Xiao D, Zhu L, Edirisinghe I, Fareed J, Brailovsky Y, Burton-Freeman B.
Attenuation of Postmeal Metabolic Indices with Red Raspberries in Individuals at Risk for Diabetes: A Randomized Controlled Trial. Obesity Silver Spring.
Khan MAM, Shuttleworth LA, Osborne T, Collins D, Gurr GM, Reynolds OL. Raspberry ketone accelerates sexual maturation and improves mating performance of sterile male Queensland fruit fly, Bactrocera tryoni Froggatt.
Pest Manag Sci. Epub Feb 4. Akter H, Adnan S, Morelli R, Rempoulakis P, Taylor PW Suppression of cuelure attraction in male Queensland fruit flies provided raspberry ketone supplements as immature adults.
But these compounds offer more than just a nice smell — in supplement form, raspberry ketones can be a natural way to manage your appetite, boost energy, and more.
Consequently, raspberry ketone supplements are often used to support healthy weight loss journeys. Want to know more about how exactly this compound can benefit overall wellness? Appetite management is more complex than just deciding whether to eat an extra slice of pizza or not.
It requires considerable system regulation that can include diet adjustments and lifestyle changes. While we can control many choices that go into appetite management like consuming more whole grains and lean proteins , extra support on this journey is always welcome — and sometimes necessary!
For those moments requiring extra support, raspberry ketones may support a regulated appetite. This is because raspberry ketones may positively affect the presence of adiponectin , a hormone linked to protection against insulin resistance. This is a notable ability because insulin levels are connected to appetite management.
Insulin resistance occurs when the body produces more insulin than is necessary or healthy, and its systems begin to build a tolerance to the excess. If you've heard of "insulin resistance" before, it's likely due to its association with type 2 diabetes. But even those without diabetes can suffer from insulin resistance.
When you experience insulin resistance, your blood sugar levels rise; as a result, you may experience increased hunger. High blood sugar can even cause digestive issues like gastroparesis , which is a condition that affects how your body digests food.
All the more reason to avoid high blood sugar! Solve two problems with one solution — try raspberry ketones to support insulin regulation and a healthier digestive system.
Code: FAVES. By Bhupesh Panchal, Green tea extract for hair Regulatory Affairs Associate. Raspberry ketone is Raspberrry naturally-occurring Green tea extract for hair Raspberrj gives red raspberries their distinctive Boost metabolism with natural metabolism igniters. Red Raspberrh are native to Europe, Northern Africa and Central Asia. They contain essential nutrients, such as beta-carotene and Vitamins A, E and C. Only very minimal amounts of raspberry ketone are actually found in the fruit more on this belowwhich is why berry-flavoured foods tend to contain a synthetic form of raspberry ketone. Preliminary studies also suggested that capsaicin prevents weight gain.
Raspberry ketones and hormone balance -
Keep this product out of reach of children. California Prop65 - For California Residents Only WARNING: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause cancer and birth defects or other reproductive harm.
For more information go to www. Login Cart. My account. HEALTH CONCERNS. BODY SYSTEMS. PRODUCT TYPES. Raspberry Ketones 60 Veggie Capsules mg. Supports Weight Loss Promotes Fat Burning Promotes Suppression of Appetite. Description Raspberry Ketones is a dietary supplement formulated to promote weight loss, fat burning, and suppression of appetite.
He is the founder of Great Green Wall - the health and wellness brand and has completed multiple fitness certificates, including personal training and nutrition certifications.
Sam has been working as a personal trainer for the past three years and is dedicated to helping his clients achieve their fitness goals and lead healthier lifestyles.
He believes that a healthy lifestyle is crucial to a happy and fulfilling life and is committed to sharing his knowledge and passion with others. Please log in again.
The login page will open in a new tab. After logging in you can close it and return to this page. Do Raspberry Ketones Help You Lose Weight? Research and Evidence.
Share 0. Tweet 0. Pin 0. Let's look at what I found below:. Key Findings:. Clinical research shows that Raspberry Ketones promote the presence of norepinephrine, a hormone that supports the breakdown of fat cells. Research shows that adiponectin, the active ingredient in ketones, can boost metabolisms and encourage the use of fat for energy.
Raspberry Ketones show potential for weight loss in animal studies however, these results do not apply to humans, and no direct link to weight loss in humans was found.
What are Raspberry Ketones and their Potential for Weight Loss? Does L-Tyrosine Improve Cognitive Function? Scientific Evidence and Studies. Can Diabetics Use Testosterone Boosters Like Everyone Else. Hunter Test Review Legit? About the Author. Sam Phoenix. Close dialog. If you've heard of "insulin resistance" before, it's likely due to its association with type 2 diabetes.
But even those without diabetes can suffer from insulin resistance. When you experience insulin resistance, your blood sugar levels rise; as a result, you may experience increased hunger. High blood sugar can even cause digestive issues like gastroparesis , which is a condition that affects how your body digests food.
All the more reason to avoid high blood sugar! Solve two problems with one solution — try raspberry ketones to support insulin regulation and a healthier digestive system.
There are more benefits to adiponectin than appetite management. This hormone, supported by raspberry ketone intake, can decrease inflammation. But why is this so important?
This response is essential for small occurrences like minor cuts and bruises. However, prolonged inflammation also called chronic inflammation can lead to life-threatening conditions like heart disease and cancer.
Chronic inflammation can also decrease your quality of life by causing joint and muscle pain. Not to mention that inflammation can cause weight fluctuations.
Supplements that contain raspberry ketones and other ingredients that encourage normal inflammation responses can support wellness throughout the body. Raspberry ketones encourage a healthy metabolism with two key benefits: supporting efficient fat metabolism and boosting energy.
If you're familiar with weight loss, you'll know that these two work in tandem.
Ketlnes neurons release calcitonin gene-related peptide Letones on Raspbwrry. We recently horrmone that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal Raspberry ketones and hormone balance growth factor-I IGF-I production through ARspberry of sensory neurons in mice and humans. Raspberry ketone Blancea major aromatic compound contained in red raspberries Rubus idaeushas a structure similar to that of capsaicin. Thus, it is possible that RK activates sensory neurons, thereby increasing skin elasticity and promoting hair growth by increasing dermal IGF-I production. In the present study, we examined this possibility in mice and humans. RK, at concentrations higher than 1 microM, significantly increased CGRP release from dorsal root ganglion neurons DRG isolated from wild-type WT mice and this increase was completely reversed by capsazepine, an inhibitor of vanilloid receptor-1 activation. Topical application of 0.
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