The effect mood lycopene on Lycopene and mood enhancement status in rainbow trout Oncorhynchus mykiss reared ajd High GI foods stocking xnd. Thus, the aim of this study was to evaluate the effect of lycopene supplementation on depression, anxiety and stress scales and quality of life in infertile men. Article PubMed CAS Google Scholar Shangari, N.

Lycopene and mood enhancement -

Could reduce risk of psychiatric disorders Low levels of lycopene have been associated with an increased risk of developing psychiatric disorders.

Discover what lycopene does and 3 of the best lycopene supplements of Read more. You also asked Can lycopene help my eyesight? Can lycopene help male fertility? The advice in this article is for information only and should not replace medical care.

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Last updated : 22 September Bhupesh started his career as a Clinical Toxicologist for Public Health England, advising healthcare professionals all around the country on how to manage clinical cases of adverse exposure to supplements, pharmaceuticals, cosmetics, industrial chemicals and agricultural products.

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Find out more My Account. You can also incorporate sweet potatoes into desserts, like this delicious fudgy brownie recipe:. Half of a grapefruit contains around two milligrams of lycopene and is also considered a great source of vitamin C.

We love how versatile pink grapefruits are; they can be added to both sweet and savory dishes or used in drinks like the refreshing mocktail recipe below.

They can also be used to make frozen desserts, salads, or on their own for a morning snack. Unlike standard oranges, blood oranges have a floral or tart flavor and a darker color due to its lycopene content.

This is also an example of a food that can work well in an array of dishes, from a citrus salad or salmon marinate to smoothies and homemade popsicles. Watermelon is not only a refreshing snack during the warmer months, but it can also contain just as much or more lycopene than raw tomatoes, depending on variety and growing conditions.

A cup and a half of watermelon contains nine to 13 milligrams of lycopene. Add papaya to your morning smoothie, have as a hydrating snack, or add it to a fresh salsa. Guava is a delicious tropical fruit with a yellow or light green skin and deep red or pink fresh.

According to Iu, this powerful fruit contains over five milligrams of lycopene per grams, and contains vitamin C, vitamin A, and omega-3s. You can opt to eat guava on its own or added into a nice glaze for meats.

Red bell peppers are super versatile and can be added to almost any dish, from tofu scrambles and avocado toast to sandwiches, wraps, and grain bowls. Bottom line? There are plenty of ways to get your daily dose of lycopene, whether it be through tomato products or sweeter options, like watermelon.

The key is finding which options you like the most to add to your meals for the week. In addition to the sex steroids, environmental contaminants can influence the thyroid axis.

In fish, thyroid hormones are accepted as significant regulators in growth, differentiation, metabolism, and adaptation to salinity Orozco et al.

It was reported that ACT is a toxic constituent for fish, with LC50 0. ACT is extremely harmful to fish as it can initiate reproductive toxicity, immune toxicity, and endocrine toxicity in zebrafish Jiang et al. Moreover, ACT generates DNA injury and induces oxidative stress in bighead carp Aristichthys nobilis Mahmood et al.

It was reported that ACT is a thyroid chemical disorder-causing mediator Yang et al. It can modify the expression of the hypothalamic—pituitary—thyroid HPT axis-related genes Li et al. ACT is thought to be a carcinogen and endocrine-disrupting agent Zhang et al.

The low concentrations of ACT displayed an estrogenic effect in zebrafish Zhang et al. Lycopene Lyc is a natural carotenoid with red color pigment and existing in a variety of fruits and vegetables Kelkel et al.

Lycopene has various positive effects on human health because of its antioxidant activity; it is involved in the cure of liver damage, metabolic disorders, male infertility, and cancer Grabowska et al. In addition, Lyc can boost the transcription factors Nrf2 and NF-jB that have considerable function in the triggering of phase II detoxifying enzymes, which are associated with the antioxidant defense mechanisms Linnewiel et al.

In fish, lycopene has recently attracted interest with its possible modes of action in weakening oxidative stress prompted by aquatic environmental contaminants because of its extremely effective antioxidant scavenging role Sahin et al.

Lycopene could defend the cells from the DNA injury caused by oxidative stress owing to its capability to reduce reactive oxygen species ROS and avoid mutation, which is the chief source of chronic diseases Goralczyk and Siler, In addition, lycopene showed efficiency in the amelioration of thyroid gland organization along with DNA damage, through its antioxidant properties Abdul-Hamid and Salah, Dawood et al.

Former studies have revealed that Harness ® active ingredient: acetochlor has an extensive range of effects, such as hemato-biochemical parameters, genotoxicity, and histopathological changes Sayed A.

et al. Consequently, it is crucial to comprehend the potential impacts of Harness ® on the health and productivity of important economic fish species such as tilapia and also to evaluate the potential detoxifying effect of lycopene.

Consequently, the existent study aimed to define the impact of Harness ® on oxidative stress, thyroid toxicity, and reproductive dysfunction.

Antioxidant enzymes, thyroid and sex steroid hormone production with the detection of thyroid follicles, and testicular and ovarian tissue histological alterations are used as bioindicators. Another purpose is to investigate the effect of dietary lycopene supplementation to relieve the oxidative stress and the stabilization of the alterations induced by acetochlor exposure.

The lycopene red pigment natural carotenoid was purchased from Sigma-Aldrich Cairo, Egypt. Healthy Nile tilapia, O. niloticus , with an average total weight of 2.

They were healthy and free from parasites according to AFS-FHS The water was completely replaced, and feces and leftover food were removed daily, and the photoperiod light—darkness regime was followed for 2 weeks.

The first group identified as a control group was fed a commercial diet without any added lycopene or Harness ® exposure. Harness ® dosages were selected according to the work of Xu et al.

After 15 days of experimental exposure, six fish per replicate from every group were arbitrarily chosen and benumbed with ice Hamed et al. Blood was withdrawn from the caudal vein and then allowed to clot at 4°C. The blood samples, then, were centrifuged at 4, g for 10 min to obtain serum.

Superoxide dismutase SOD was measured based on its capability to prevent the phenazine methosulphate-mediated reduction of nitroblue tetrazolium dye to form a red product consistent with the work of Nishikimi et al.

Catalase CAT was determined based on the fact that 3,5-dichlorohydroxybenzene sulfonic acid could rapidly dismiss the degradation reaction of hydrogen peroxide catalyzed by CAT and react with the residual hydrogen peroxide to generate a yellow product Aebi, Total antioxidant capacity TAC was measured as stated by Koracevic et al.

Testosterone T was also evaluated using a test kit CAN-TE as described by Check et al. For thyroid hormones, T3 was assessed using the T3 ELISA kit EIAab, no. Then, fixed gonad and EDTA-treated head samples were dehydrated through arising grades of ethanol and then were cleared and embedded in paraffin wax.

For thyroid follicle sections, serial frontal sections were cut at 7 μm from the ventral side of the head. The sections were examined under an Olympus microscope model BX50F4, Olympus Optical Co. Data are stated as mean ± SE. Significant changes amongst the treatments and control groups were verified using one-way analysis of variance ANOVA and, subsequently, the Tukey-HSD test for multiple comparisons.

The analysis was achieved using the SPSS ® version FIGURE 1. Antioxidant enzyme activity in Nile tilapia after 15 days of exposure: A TAC enzyme, B SOD enzyme and C CAT enzyme. Ctr, H1, H1Lyc, H2 and H2Lyc. Results are presented as mean ± SE. Lycopene co-treatment suppressed the Harness ® -induced increase, resulting in a significantly less SOD activity than for the Harness ® alone, and restored SOD levels to the control levels Figure 1B.

The Harness®-exposed groups treated with lycopene displayed a marked normalization of serum CAT activity with no statistically significant effect compared to the control group level Figure 1C.

Thyroid hormones T3 and T4 were detected in serum of both males and females and displayed comparable values without significant differences between male and female samples.

FIGURE 2. Thyroid hormonal activity T3 and T4 in Nile tilapia after 15 days of exposure, Ctr, H1, H1Lyc, H2, and H2Lyc.

Data are accessible as mean ± SE. This reduction was herbicide concentration dependent Figures 3A, B. FIGURE 3. Testosterone T and estradiol E2 activities in Nile tilapia after 15 days of exposure: A male serum T, B female serum T, C male serum E2, and D female serum E2. Ctr, H1, H1Lyc, H2, and H2Lyc.

The highest increase in serum E2 levels was found in fish subjected to H2 dose. The lycopene supplementation neutralized the E2 levels to the control levels Figure 3C.

The histological inspections displayed that the thyroid tissue, which was unencapsulated, consisted of scattered follicles of variable size diffusely distributed beneath the pharyngeal region, positioned at the dorsal and lateral aspects of the ventral aorta.

The follicles were detected to be bound by connective tissue. Serial sections in the control group showed that the thyroid follicles had colloid-filled lumens and were enclosed by simple cuboidal cells thyrocytes with a rounded nucleus Figures 4A, B.

FIGURE 4. Histological sections of Nile tilapia taken through the glossopharyngeal region showing thyroid follicles after 15 days of exposure. A Control group displaying thyroid follicle F , thyrocyte T , and colloid C.

B Magnification of thyroid follicles in the control group displaying cuboidal epithelium thyrocytes T and a homogeneously eosin-stained colloid C. E In the H1Lyc group, the thyroid follicles displayed similar results as the control group with some hypertrophy in the thyrocytes red arrows.

F, G H2 fish group, with an increasing number of the melanomacrophage center m , hypertrophy in the thyrocytes red arrows , and increasing degeneration in follicle colloid D. Colloid depletion of some follicles was observed, and some melanomacrophage centers MMCs were recognized with hypertrophy in thyrocytes Figures 4C, D.

For the fish group co-treated with lycopene H1lyc , the thyroid follicles displayed normal histological structure as the control group with some hypertrophy in the thyrocytes in few follicles Figure 4E.

When the same Harness ® dose was co-treated with lycopene H2lyc , the thyroid follicles exhibited a normal histological structure as in the control group, with some hypertrophy in the thyrocytes, and few thyroid follicles displayed vacuolated colloid while others were lacking colloid Figure 4H.

Semi-quantitative scoring for histological changes in the thyroid follicles displayed in Table 1. TABLE 1. Semi quantitative scoring of the histopathology in the thyroid follicles, female gonads, and male gonads of Oreochromis niloticus exposed to Harness ®.

The histology microphotographs of the ovaries displayed the control group with different oocyte growth stages including the primary growth phase with early and late perinucleolar oocytes, in addition to the secondary growth phase including primary yolk oocytes, secondary yolk oocytes, and tertiary yolk oocytes Figure 5A.

In fish group H1Lyc, the ovarian histology microphotographs were similar to those of the control Figure 5C. The number of secondary growth phases and late stage decreased with an increasing number of perinucleolar oocytes compared to that of the control group; in addition, an increase in the number of atretic follicles was observed Figures 5D, E.

For lycopene-supplemented group H2Lyc, the ovaries showed less number of atretic oocytes compared to the H2 group, with a substantial number of perinucleolar oocytes compared to the control group Figure 5F. The ovarian alterations of different treatment groups were assessed using Semi-quantitative scoring as described in Table 1.

FIGURE 5. Histological cross section in Nile tilapia ovaries after 15 days of exposure. A Control group displaying different oocyte growth stages; early perinucleolar oocytes EPOs , late perinucleolar oocytes LPOs , primary yolk oocytes PYOs , secondary yolk oocytes SYOs , and tertiary yolk oocytes TYOs.

The histology microphotographs of the testicular tissue displayed the control group with the cystic arrangement having different spermatogenic cell primary spermatocytes, secondary spermatocytes, spermatids, and spermatozoa Figure 6A. While feeding a lycopene-supplemented diet H1Lyc group , the sections were similar to those in control but displayed a slight insufficiency of spermatozoa in the lumen of the testicular lobules Figure 6C.

FIGURE 6. Histological cross section of Nile tilapia testes after 15 days of exposure. A Control group displaying the cystic organization with different spermatogenic cells, primary spermatocytes Psc , secondary spermatocytes Ssc , spermatids St , and spermatozoa SZ in the lumen of the cysts.

B H1 fish group showing few spermatozoa in the lumen of the testicular lobules asterisks and melanomacrophage center m.

C In the H1Lyc fish group, the sections displayed a slight deficiency of spermatozoa asterisks. D, E H2 fish group, with different alterations, proliferation of interstitial tissue T , and increasing melanomacrophage centers m and necrosis red arrow , also exists.

In the present study, the oxidative stress, thyroid toxicity, and reproductive toxicity of Harness ® to tilapia were studied. Oxidative stress is recognized as excess creation or deficient elimination of highly reactive molecules as ROS and reactive nitrogen species Yonar, Oxidative injury is correlated to the failure of the antioxidant defense system for the exclusion of ROS inducing destruction of biomolecules like lipids, proteins, or DNA Yonar et al.

The major antioxidant SOD and CAT defense enzymes are inducible enzymes. They can be prompted by an oxidative stress and represent the first line of resistance contrary to excessive free radicals in the body Lin et al.

The antioxidant enzymes CAT and SOD inhibit oxidative stress, and the actions of these enzymes are commonly used to observe the risk of pesticides and herbicides Jin et al.

The results of the current study show that the SOD and CAT activities were altered throughout the experiment period. The present study declared that the TAC activity declined in fish groups exposed to the Harness ® H1 and H2 , while feeding a lycopene-supplemented diet restored the control levels.

Similarly, a lycopene-supplemented diet can significantly upsurge the activity of TAC in Goldfish Carassius auratus Meng et al. In the current study, during Harness ® exposure, simultaneous feeding with lycopene-supplemented diets neutralized the TAC, SOD, and CAT enzyme activities and restored their control levels.

Lycopene is regarded as a chemoprotectant agent due to its significant antioxidant scavenging action. In addition, it is also considered the most effective carotenoid used against biological ROS Sahin et al. Abd El-Gawad et al. They described a significant drop of the hepatic SOD and CAT activities.

Several studies have suggested the use of lycopene as a strong antioxidant to attenuate the oxidative stress reactions in fish species subjected to insecticides Dawood et al.

Lycopene displayed an ameliorative effect against trichlorfon oxidative stress in common carp Cyprinus carpi Yonar et al. Previous studies also verified that acetochlor is a thyroid-disrupting chemical Helbing et al.

Similarly, Yang et al. Acetochlor induced whole body T3 but not the whole body T4 in zebrafish larvae Guo et al. The exposure of adult rare minnow to acetochlor for 21 days resulted in the suppression of blood T3 and T4 levels in male and female fish Li et al.

Acetochlor could disturb not only the secretion of thyroid hormones but also the expression of genes correlated to thyroid hormones Li et al. In addition, acetochlor was found to elicit different responses in the secretion of THs, TH-linked crucial gene expression, and binding affinity to TRs that resulted in thyroid disruption, thus affecting the growth of zebrafish larvae Xu et al.

The present results displayed histological alterations induced by Harness ® exposure. The enlarged thyrocyte cells of the Harness-exposed fish corroborated the increased level of serum T4 and T3 over the control levels. The size and height of the thyrocyte follicular epithelium are well thought as a marker of the thyroid secretory activity Schnitzler et al.

These changes in both T3 and T4 levels and thyroid follicle histology have typically been used as direct endpoints to evaluate thyroid disruption in former studies on pesticides Ortiz-Delgado et al. Our findings suggest that exposure to Harness ® could alter the HPT axis through oxidative stress initiation.

Lycopene supplementation reduced the thyroid cellular changes. Moreover, lycopene reduced the serum T3 and T4 levels induced by Harness ®. These results suggest the effectiveness of lycopene in improvement of thyroid disorders through its antioxidant attributes.

In this context, Abdul-Hamid and Salah reported that lycopene supplementation displayed an efficacy in amelioration of thyroid gland configurations against the insecticide deltamethrin, which may result from its antioxidant properties for albino rats.

In addition, lycopene showed verified effectiveness in reinstating the thyroid structure and function after Aroclor exposure due to its antioxidant property Ibrahim et al. In addition, it is strongly proposed that oral lycopene supplementation plays a significant role in diminishing the oxidative stress, where it is well thought as one of the best functional plant source antioxidants and widely used for defense counter to oxidative stress arbitrating cell and tissue injuries Ibrahim et al.

In the current study, the reproductive impairments induced by Harness ® exposure for both male and female tilapia were studied.

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Lycopene and mood enhancement -

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Download references. We appreciate the efforts of the following undergraduate students; Salami K. Sukurat, Ezenandu O. Emmanuel, Emmanuel E. Ayobami, Abegunde Moyosore, Graham Richmond, Adegoke Sodiq, Omoyeni V.

Omotolani, Adebiyi Ayomide, and Shiaka Dickson during the project administration. Department of Biochemistry, College of Biosciences, Federal University of Agriculture, P.

B , Abeokuta, Ogun State, Nigeria. Department of Chemical Sciences Biochemistry Program , Augustine University Ilara-Epe, Epe, Lagos State, Nigeria. Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Federal University of Agriculture, P.

Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Queensgate, HD1 3DH, UK. You can also search for this author in PubMed Google Scholar. and A. conceptualized the study; E. did data curation; F. Prepared the manuscript, A. supervised the project, A. and E. administered the project.

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Lycopene suppresses palmitic acid-induced brain oxidative stress, hyperactivity of some neuro-signalling enzymes, and inflammation in female Wistar rat. Sci Rep 11 , Download citation.

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Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects Biochemistry Neuroscience. Abstract Neuroinflammation can be triggered by certain high caloric nutrients such as palmitic acid PA.

Introduction Neuro-inflammation due to meta-inflammation describes an immuno-metabolic disorder of the nervous system, arising from derangements of the metabolic and inflammatory pathways in response to various cues including infection, autoimmunity, or certain high caloric nutrients 1.

Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Discussion In this study, PA overload caused the elevation of acetylcholine esterase AchE , adenosine deaminase ADA , monoamine oxidase- A MAO-A , and nucleotide triphosphatase NTPDase activities.

Conclusion Conclusively, excessive PA intake caused the alteration of neuro-behavioural enzymes activities and induced OS by inhibiting the antioxidant system.

Figure 7. Graphical abstract. Materials and methods Chemicals and reagents Lycopene All- Trans and TRIzol were purchased from Solarbio Life Science and Co.

Methods Experimental animals Thirty 30 female Wistar rats 8 weeks of age were purchased and kept in the Animal Housing Unit of the Department of Biochemistry, Federal University of Agriculture, Abeokuta FUNAAB , Ogun State, Nigeria. Induction of neuroinflammation and experimental design Neuroinflammation was induced via administration of 5 mM PA intraperitoneally i.

Table 1 Experimental design. Full size table. Table 2 Gene target primer sequences. References Tomassoni, D. Article PubMed Central CAS Google Scholar Chen, D.

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Article PubMed CAS Google Scholar Galijasevic, S. Article ADS PubMed PubMed Central CAS Google Scholar Carta, G. Background: Infertility is a major worldwide problem which is caused by several factors such as environmental, physiological, and genetic conditions.

Lycopene is considered to be one of the most important antioxidants that can contribute to reducing or preventing the psychological damage that leads to infertility.

Thus, the aim of this study was to evaluate the effect of lycopene supplementation on depression, anxiety and stress scales and quality of life in infertile men.

Materials and methods: In this randomized clinical trial, 44 infertile men with oligozoospermia were randomly divided into the following two groups: the experimental group was supplemented with 25 mg lycopene, once per day for 12 weeks, and the control group received a placebo, for 12 weeks.

Anthropometric and dietary data, physical activity, mood status, including depression, anxiety, stress, and quality of life scores were recorded pre- and post-intervention.

Ubiquitous, High GI foods, persistent, and substantial uses of Harness Enhancment in Lycopene and mood enhancement processes have resulted in the pollution of nearby Lyxopene sources, posing a threat to various Nutritional liver support biotas, including Lycopene and mood enhancement. The effects of Harness ® toxicity on fish health enhancemenh little Lycopene and mood enhancement. So, this study Lycopene and mood enhancement to Lycopene and mood enhancement mmood impact of herbicide Enhamcement ® on ehhancement oxidative stress and reproductive and thyroid performance of male and female tilapia Oreochromis niloticus and also investigate the prospective role of the natural antioxidant lycopene supplementation in dismissing the adverse properties of Harness ®. Antioxidant enzyme catalase, superoxide dismutase, and total antioxidant capacity and hormone measurements T, E2, T3, and T4 were carried out, and gonadal and thyroid follicle histological sections were examined as a method to investigate the effects of Harness ® toxicity on fish. Our results demonstrated that the antioxidant enzyme activity was altered by Harness exposure and serum T for both males and females dropped; also, female E2 levels decreased, but male E2 increased. Thank you for visiting nature. You are using a browser version with anx support for CSS. To obtain the best mlod, we recommend Pomegranate Infused Olive Oil use mooc more up Lycopene and mood enhancement moox Lycopene and mood enhancement or turn Lycoopene compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Neuroinflammation can be triggered by certain high caloric nutrients such as palmitic acid PA. The effect of lycopene against PA-induced neuroinflammation in female rats has not been as explored. After seven weeks of PA challenge 5 mM including two weeks of lycopene treatment, the brain was excised for analyses.