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Metformin and prediabetes -

It's approved in the US to treat type 2 diabetes when used with diet and exercise by people ages 10 and older. But in recent years, interest has grown regarding its potential to prevent or treat a variety of other conditions, including aging.

Yes, aging. If that's true, "wonder drug" might be an understatement. The history of metformin goes back hundreds of years. In Europe, the medicinal herb Galega officinalis was popular for digestive health and to treat urinary problems and other ailments.

Then in , a scientist discovered that one of its ingredients, guanidine, could lower blood sugar. Medicines containing guanidine, such as metformin and phenformin, were developed to treat diabetes. But they fell out of favor due to serious side effects caused by phenformin, and by the discovery of insulin.

Metformin was rediscovered decades later and approved as a treatment for diabetes in Europe in the s. It wasn't until that the FDA approved it for use in the US.

It has since become the most widely prescribed medication for people with diabetes who cannot control their blood sugar through diet and exercise alone. For decades we've known that metformin does more than just help lower blood sugar in people with diabetes.

It also offers them cardiovascular benefits , including lower rates of death due to cardiovascular disease. And it sometimes helps people with diabetes lose excess weight.

Metformin may also have health benefits for people who don't have diabetes. Obesity, an underlying cause of insulin resistance, is a major risk factor. A study published in found that participants who had obesity were about six times more likely to develop type 2 diabetes than those at a healthy weight, regardless of genetic predisposition; people who were overweight had 2.

Other common risk factors for prediabetes include being older than 45, exercising fewer than three times a week, having a parent or sibling with or a family history of type 2 diabetes, and giving birth to a baby that weighed more than 9 pounds.

Women who have polycystic ovary syndrome PCOS , a hormonal disorder, are also at higher risk for the condition. However, risk can be complicated for some people. Anam explains. Anyone who is not sure about their risk can take a simple online prediabetes test provided by the Centers for Disease Control and Prevention CDC.

Problems with insulin often start around puberty, says Yale Medicine endocrinologist Ania Jastreboff, MD, PhD , who treats both children and adults. But there are other factors, too. Pregnancy can also lead to struggles with weight for many women. Gestational diabetes , which usually resolves after the baby is born, is another prediabetes trigger.

Around menopause, changes in estrogen levels are associated with an increase in fat around the waist, which is considered a risk factor for diabetes.

In general, those who maintain good physical health as they age can avoid prediabetes. Heart disease can impact physical activity, as can the use of multiple medications, including glucocorticoids—steroids that, among other things, increase insulin resistance and glucose production by the liver, resulting in increased blood glucose levels.

They can also make people who take them feel hungrier, which leads to increased food intake and further contributes to hyperglycemia. Anam says. All children experience metabolic and hormonal changes during puberty, along with a decrease in insulin sensitivity; problems tend to develop when an adolescent has obesity, explains Dr.

Lifestyle changes are critical to prevention in kids because there are no effective medications for reversing prediabetes in that age group, says Michelle Van Name, MD , a Yale Medicine pediatric endocrinologist.

The DPP consists of an intensive week healthy lifestyle intervention followed by a maintenance phase, administered via smartphone or computer. There are also CDC-recognized lifestyle change programs that provide structured support from a trained lifestyle coach and support groups in person or online.

Programs are year-long and focus on making long-term changes. Van Name also recommends starting with simple interventions at home and expanding on them over time, especially when working with children.

The interventions might include pursuing more physical activity as a family or trying different-colored foods on the dinner plate, she adds. Van Name says. If adults and children have difficulty changing lifestyle habits themselves, there are options, including a variety of types of weight-loss surgery which in itself has been shown to reverse type 2 diabetes and medications.

Anam says, adding that studies have shown the drug can decrease the risk of progression to type 2 diabetes, although to a lesser degree than lifestyle changes.

Meanwhile, Dr. Jastreboff is studying medications to treat obesity. Another medication is tirzepatide Mounjaro® , which is FDA-approved as a treatment for type 2 diabetes and also results in a substantial and sustained reduction in body weight, says Dr.

In , a U. Preventive Services Task Force recommended lowering the initial screening age for prediabetes and type 2 diabetes to age 35 for asymptomatic adults who have overweight or obesity. Parents may need to talk to a pediatrician when their children are in adolescence—or even before that—and adults should assess their lifestyles while they are still in their 20s or 30s, she adds.

Anyone who is concerned should understand their glucose numbers and check them routinely.

Ideal prevention strategies Metformmin both type prediwbetes and Metformin and prediabetes preddiabetes diabetes Metformin and prediabetes range from efforts focused on individuals identified as being at Turmeric hair masks for developing diabetes to Megformin group- and population-based strategies. Prevention or delay in the onset of diabetes should not only alleviate the burden of the disease on the individual, but could also decrease the associated morbidity and mortality. Ideal prevention strategies would differ depending on the type of diabetes. Given its increasing incidence and prevalence, the development of safe and cost-effective interventions to reduce the risk of developing diabetes are urgently needed to decrease the burden on individuals and the health-care system. Type 1 diabetes is a chronic autoimmune condition characterized by destruction of pancreatic beta cells. Mayer B. Davidson; Metformin Should Metformin and prediabetes Be Used to Metformin and prediabetes Metformon. Diabetes Care prediabetfs September Metformn 43 prediabees : — Based on the results of the Predibaetes Prevention Metformin and prediabetes Outcomes Study DPPOS Non-chemical gardening tips, in which metformin significantly decreased the development of diabetes in individuals with baseline fasting plasma glucose FPG concentrations of — vs. Since the association between prediabetes and cardiovascular disease is due to the associated nonglycemic risk factors in people with prediabetes, not to the slightly increased glycemia, the only reason to treat with metformin is to delay or prevent the development of diabetes. There are three reasons not to do so.

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Role of Metformin in Prediabetes with Comorbidities