Lycopene and cancer prevention -
Int J Cancer , Van Patten CL, de Boer JG, Tomlinson Guns ES: Diet and dietary supplement intervention trials for the prevention of prostate cancer recurrence: A review of the randomized controlled trial evidence. J Urol ; discussion , Seren S, Lieberman R, Bayraktar UD, et al: Lycopene in cancer prevention and treatment.
Am J Ther , Institute of Medicine, Food and Nutrition Board. Beta-carotene and other carotenoids. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids, pp Washington, DC; National Academy Press; Veeramachaneni S, Ausman LM, Choi SW, et al: High dose lycopene supplementation increases hepatic cytochrome PE1 protein and inflammation in alcohol-fed rats.
MCL Treatment Advances and Future Directions. Martin Dreyling, MD, spoke about the potential use of CAR T-cell therapy in earlier treatment stages for certain patient groups with mantle cell lymphoma. Stem Cell Transplant Approaches for Patients With Blood Cancers.
Scadden discusses which blood cancer patients are eligible for stem cell transplantation, as well as the latest advances in the field. Key Takeaways From ASH Emerging Trends in Hematologic Oncology.
Julie M. Current Treatment of Esophageal Cancer and Promising Clinical Trials Underway. Ku discusses considerations in the treatment of esophageal cancer, current treatments, and the emerging role of immunotherapy.
Defining a Space for NRG1 Fusion—Positive Tumors in Lung and GI Cancers. An overview of NRG1 fusion—positive tumors was given by experts in the gastrointestinal and lung cancer space in a recent Frontline Forum.
Menin Inhibitors Show Promise in Future AML Treatment. Ghayas C. Issa, MD, gave an all-encompassing review of current treatment options for acute myeloid leukemia and what to expect in the future. Clinical Topics.
Global Bulletin. All News. Approval Alert. Around the Practice. Between the Lines. Face Off. Morning Rounds. Readout Sponsored Media. Training Academy. Treatment Algorithms with the Oncology Brothers.
All Journals. Past experience has taught us that single nutrients or a few nutrients in a pill like vitamin supplements , does not give the same effect as eating WHOLE foods. There are many reasons I advise against supplementing nutrients instead of eating the foods that contain these nutrients.
Like beta-carotene, lycopene is a carotenoid. Over carotenoids have been identified in nature! That is what the beta-carotene trials were all about.
For years, scientists noted that diets high in beta-carotene FROM FOOD SOURCES, reduced risk of many types of cancer, including lung cancer in smokers. BUT, FOODS THAT CONTAIN BETA-CAROTENE DO SEEM TO REDUCE CANCER RISK. There is no guarantee the same thing wouldn't happen with lycopene.
Lycopene SEEMS to protect against cancer. This is a very weak link. Chronic infection by Helicobacter pylori is a major established risk factor for gastric cancer.
Chronic infections may increase cancer risk by increasing the oxidative load Elevated DNA oxidation occurs early during H. pylori infection Dietary antioxidants, including lycopene, may potentially reduce the impact of oxidative load from H. pylori infections in the stomach.
Another potential contributing factor to stomach cancer is the endogenous formation of N -nitrosamines. Vitamin C has been considered to be an inhibitor of the nitrosation that generates N -nitrosamines. It is interesting that an ecologic study in Japan 45 , an area with a high incidence of stomach cancer, showed no association between average plasma vitamin C level and stomach cancer, and, in fact, the area with the lowest gastric cancer incidence had the lowest vitamin C level.
A study of determinants of endogenous generation of N -nitrosamine in rats suggested that various aspects of food products may explain their inhibitory effect, including pH, and ascorbic acid, lycopene, and β-carotene contents.
Tomato and tomato-based products are the predominant sources of lycopene and one of the major sources of ascorbic acid in some populations. Reactive oxygen compounds may contribute to prostate carcinogenesis , Prostate epithelial cells in many men at the age of risk for prostate cancer are likely to be exposed to inflammatory-related reactive oxygen species because of the high prevalence of prostatitis.
However, whether an antioxidant property accounts for the apparent benefit of tomato product consumption on prostate cancer risk remains unproven.
If oxidation proves critical to carcinogenesis, the dietary contribution to antioxidation is likely to be immensely complex. Synergy among antioxidants exists in experimental systems , and synergistic effects are likely to be more complex in vivo.
For example, synergy between α-tocopherol and ascorbic acid is well established , resulting from the ability of ascorbic acid to reduce α-tocopheroxyl radicals, thereby recycling α-tocopherol.
Complex synergistic effects may occur as a result of such direct interactions e. Possibly, the benefits of tomatoes may result from the complex interaction of various carotenoids, ascorbic acid, and other antioxidant polyphenolic compounds.
Although the notion that lycopene may exert its role in humans through limiting cellular macromolecule damage from reactive oxygen species is appealing, other mechanisms may be operative. In addition, preliminary in vitro evidence indicates that lycopene reduces cellular proliferation of various cancer cell lines induced by insulin-like growth factor-I IGF-I This finding, which requires confirmation, is intriguing, given recent evidence that the circulating level of IGF-I is positively associated with higher risk of various cancers, including prostate cancer Various other potential mechanisms have been postulated ,,, Most of the mechanistic data have been based on in vitro studies, but a recent study found that supplementation with tomato products, as well as carrot and spinach products, resulted in a marked decrease in endogenous levels of strand breaks in lymphocyte DNA.
More human studies are clearly needed. Intake of tomatoes and tomato-based products and plasma levels of lycopene, a carotenoid found predominantly in tomatoes, have been relatively consistently associated with a lower risk of a variety of cancers. Evidence is strongest for cancers of the lung, stomach, and prostate gland and is suggestive for cancers of the cervix, breast, oral cavity, pancreas, colorectum, and esophagus.
A large body of evidence also indicates that other fruits and vegetables may have additional or complementary benefits 3 - 5. The likelihood that the associations between increased consumption of tomato and tomato-based products and lower risk for several cancer sites are causal is supported by the consistency of evidence by study design ecologic, case-control, and prospective and by exposure assessment dietary-based and plasma-based and by the unlikelihood that biases or uncontrolled confounding could plausibly account for all these associations in diverse populations.
These findings add further support to current dietary recommendations to increase consumption of fruits and vegetables to reduce cancer risk. The benefits of tomatoes and tomato products are often attributed to the carotenoid lycopene.
However, a direct benefit of lycopene has not been proven, and other compounds in tomatoes alone or interacting with lycopene may be important. It is critical to recognize that the current evidence regarding dietary intake and lycopene blood concentrations reflects consumption of tomatoes and tomato products rather than purified lycopene supplements.
The pharmacokinetic properties of lycopene remain poorly understood, and it is premature to recommend use of pharmacologic doses of lycopene for any health benefit. Further research on the bioavailability, pharmacology, and biology of this potentially important carotenoid is clearly warranted.
Until more definitive data regarding specific benefits of purified forms of lycopene are available, current recommendations should emphasize the health benefits of diets rich in a variety of fruits and vegetables, including tomatoes and tomato-based products.
Summary of epidemiologic studies examining tomato intake or lycopene intake or level and cancers of the lung and pleura. Summary of epidemiologic studies examining tomato intake or lycopene intake or level and cancer of the stomach.
Summary of epidemiologic studies examining tomato intake or lycopene intake or level and cancer of the genitourinary tract. Summary of epidemiologic studies examining tomato intake or lycopene intake or level and cancers of female reproductive organs.
The relative risk is only for all 50 cases; the 50 cases comprise 18 invasive carcinomas and 32 carcinomas in situ; results are not presented for the 18 and 32 cases individually. Summary of the relative risks for high versus low intakes levels of tomatoes lycopene across the study characteristics.
From 61 studies that provided data ,,31,,,,,59,60,,74,75,,86, ; there are 74 relative risks because some studies present results stratified by sex, racial or ethnic group, colon and rectum cancers separately, and results both for blood lycopene level and for dietary tomato or lycopene intakes.
Summary relative risks RR for high versus low consumption of tomatoes or level of lycopene from epidemiologic studies.
Supported by Public Health Service grants CA, CA, CA, and CA National Cancer Institute and HL National Heart, Lung, and Blood Institute , National Institutes of Health, Department of Health and Human Services. National Research Council, Committee on Diet and Health. Diet and health: implications for reducing chronic disease risk.
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Prveention, a red-colored carotenoid, present in many Lycolene Quality herbal supplements vegetables, including cancre and their processed Herbal womens health, watermelon, guava, Lyvopene, Lycopene and cancer prevention nad, and sweet potatoes, is cancee associated with the risk of many cancers. Lycopeen beta-carotene, lycopene lacks a beta-ionone ring and therefore Acupuncture no provitamin A activity. However, the 11 conjugated and two nonconjugated double bonds in lycopene make it highly reactive toward oxygen and free radicals. Lycopene has been proposed to protect against cancer through various properties including decreased lipid oxidation, inhibition of cancer cell proliferation, and most notably potent antioxidant properties, apoptosis, increased gap-junctional communication, interferences in insulin-like growth factor 1 receptor signaling pathways, and cell cycle progression. Preclinical studies and clinical trials show that lycopene has potent in vitro and in vivo antitumor effects, suggesting potential preventive and therapeutic roles for lycopene.Lycopene and cancer prevention -
How well do you score on brain health? Shining light on night blindness. Can watching sports be bad for your health? Beyond the usual suspects for healthy resolutions. April 3, By Harvard Prostate Knowledge Men who have been adding lycopene, a nutrient found in tomatoes, and other carotenoids to their diet in the hopes of staving off prostate cancer might want to reconsider.
Originally published April ; last reviewed February 24, About the Author. Harvard Prostate Knowledge See Full Bio. Share This Page Share this page to Facebook Share this page to Twitter Share this page via Email.
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I want to get healthier. Institute of Medicine, Food and Nutrition Board. Beta-carotene and other carotenoids. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids, pp Washington, DC; National Academy Press; Veeramachaneni S, Ausman LM, Choi SW, et al: High dose lycopene supplementation increases hepatic cytochrome PE1 protein and inflammation in alcohol-fed rats.
MCL Treatment Advances and Future Directions. Martin Dreyling, MD, spoke about the potential use of CAR T-cell therapy in earlier treatment stages for certain patient groups with mantle cell lymphoma. Stem Cell Transplant Approaches for Patients With Blood Cancers.
Scadden discusses which blood cancer patients are eligible for stem cell transplantation, as well as the latest advances in the field. Key Takeaways From ASH Emerging Trends in Hematologic Oncology.
Julie M. Current Treatment of Esophageal Cancer and Promising Clinical Trials Underway. Ku discusses considerations in the treatment of esophageal cancer, current treatments, and the emerging role of immunotherapy.
Defining a Space for NRG1 Fusion—Positive Tumors in Lung and GI Cancers. An overview of NRG1 fusion—positive tumors was given by experts in the gastrointestinal and lung cancer space in a recent Frontline Forum.
Menin Inhibitors Show Promise in Future AML Treatment. Ghayas C. Issa, MD, gave an all-encompassing review of current treatment options for acute myeloid leukemia and what to expect in the future. Clinical Topics. Global Bulletin. All News. Approval Alert. Around the Practice.
Between the Lines. Face Off. Morning Rounds. Readout Sponsored Media. Training Academy. Treatment Algorithms with the Oncology Brothers. All Journals. Editorial Board. For Authors. Frontline Forum. Satellite Sessions. Contemporary Concepts. It is important to note that the report did not conclude that tomato products are not beneficial, but rather, that the data are too mixed at this time to reach a conclusive decision.
In fact, some data are very promising. Tomato products or lycopene have strong anti-cancer effects in a number of animal models of prostate cancer. A recent human study showed that high intake of dietary lycopene, largely from tomatoes, was strongly correlated with less blood vessel formation in prostate cancers.
New blood vessel formation is critical to feed prostate cancers, and in fact, in this study, cancers with more new blood vessel formation were much more likely to progress to metastasis than those with few new vessels. We are finding that just pooling all prostate cancers as one entity is an inadequate way to study it.
Newer studies are now considering specific factors in the prostate cancer, such has specific types of genetic damage or blood formation. I expect that firmer conclusions on dietary factors and prostate cancer can be reached over the next several years. For the latest news from us, please follow twitter.
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Lycopene is a carotenoid found Quality herbal supplements tomatoes, grapefruit, watermelons, and Quality herbal supplements. It is also synthesized by pfevention and microorganisms, but prdvention be synthesized by the Ac monitoring frequency body and can only be obtained via diet. Lycopene as a dietary supplement is a potent antioxidant used to help prevent cancer, heart disease, and macular degeneration. It is classified as a nonprovitamin A carotenoid because it cannot be converted to vitamin A. Lycopene is a carotenoid found in grapefruit, watermelons, and papaya in addition to tomatoes.
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