Coenzyme Q and cholesterol regulation Regulatkon Cardiol. Furukawa, S. A permutation-based approach was used to control the FDR to 0. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis.

Coenzyme Q and cholesterol regulation -

Already have an account? Sign in here. The Journal of Poultry Science. Online ISSN : Print ISSN : ISSN-L : Journal home Advance online publication All issues Featured articles About the journal. Effect of Dietary Coenzyme Q10 on Cholesterol Metabolism in Growing Chickens. Kazuhisa Honda , Hiroshi Kamisoyama , Tomoki Motoori , Takaoki Saneyasu , Shin Hasegawa Author information.

Kazuhisa Honda Graduate School of Agricultural Science, Kobe University, Japan Hiroshi Kamisoyama Graduate School of Agricultural Science, Kobe University, Japan Tomoki Motoori Graduate School of Agricultural Science, Kobe University, Japan Takaoki Saneyasu Graduate School of Agricultural Science, Kobe University, Japan Shin Hasegawa Graduate School of Agricultural Science, Kobe University, Japan.

Corresponding author. Keywords: cholesterol 7alpha-hydroxylase , coenzyme Q10 , hepatic cholesterol , hydroxymethylglutaryl-coenzyme A , plasma cholesterol. JOURNAL FREE ACCESS. Coenzyme Q10 PDQ -Health Professional Version. National Cancer Institute.

IBM Micromedex. Dluda PV, et al. The impact of coenzyme Q10 on metabolic and cardiovascular disease profiles in diabetic patients: A systematic review and meta-analysis of randomized controlled trials. Endocrinology, Diabetes and Metabolism.

Goudarzi S, et al. Effect of vitamins and dietary supplements on cardiovascular health. Critical Paths in Cardiology. Natural Medicines. Arenas-Jal M, et al. Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges.

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About this Site. Contact Us. Health Information Policy. Media Requests. News Network. Price Transparency. Medical Professionals. Considering heterogeneity among studies, fixed- or random-effect models were applied to pool standardized mean differences SMD as overall effect size. A total of eight trials participants in the intervention group and in placebo group were included in the current meta-analysis.

The findings showed that taking CoQ10 by patients with CAD significantly decreased total-cholesterol SMD We found no significant effects of CoQ10 supplementation on LDL-cholesterol SMD This meta-analysis demonstrated the promising effects of CoQ10 supplementation on lowering lipid levels among patients with CAD, though it did not affect triglycerides, LDL-cholesterol and Lp a levels.

Dyslipidemia is one of the major risk factor for establishing coronary artery disease CAD [ 1 ]. Coronary artery disease and cerebral stroke account for the main causes of morbidity and mortality among elderly and middle-aged individuals [ 2 ].

Cardiovascular risk factors are including aging, hyperglycemia and insulin resistance [ 3 ]. In addition, dyslipidemia, mainly hypercholesterolemia, high LDL-cholesterol, and low HDL-cholesterol levels [ 4 ] impair mitochondrial function, leading to increased production of free radicals and reactive oxygen species, and subsequently can result in chronic inflammation and endothelial dysfunction [ 5 ].

The damage of free radicals is proposed to play an important role in endothelial dysfunction and atherogenesis [ 6 ]. Coenzyme Q10 CoQ10 is an intracellular antioxidant which prevents senescence and dysfunction caused by oxidative stress [ 6 ].

CoQ10 is commonly used to treat cardiomyopathy, and heart function has been remarkably improved following CoQ10 supplementation [ 7 ]. CoQ10 deficiency which usually occurs with aging have been shown to increase the risk of type 2 diabetes mellitus T2DM [ 8 ] and cardiovascular disease CVD [ 9 ].

On the other hand, there are trials evaluating the effects of CoQ10 on lipid profiles with inconclusive results. We have previously shown in a meta-analysis that taking CoQ10 by patients with metabolic disorders significantly reduced serum triglycerides levels, yet did not affect other lipid profiles [ 10 ].

In another meta-analysis conducted by Sahebkar et al. However, in another meta-analysis conducted by Suksomboon et al. We are aware of no systematic review and meta-analysis of randomized controlled trials RCTs on the effect of CoQ10 supplementation on lipid profiles in patients with CAD.

This meta-analysis was conducted to summarize the existing evidence of RCTs to evaluate the impact of CoQ10 supplementation on lipid profiles in patients with CAD. PRISMA guideline the preferred reporting items for systematic reviews and meta-analyses was used to design and implement this meta-analysis.

Two independent authors RT and MA systematically searched online database including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science until 20th May To avoid missing any citation that had not been captured in the primary search, the reference lists of the relevant papers and the pervious article reviews were searched by the same two researchers RT, MA.

With no time restriction, clinical trials published in English were included in this meta-analysis. Two investigators RT, MA independently screened all studies, retrieved from the online database and hand-search, using a two-stage process in order to determine eligible studies for current meta-analysis.

Then, in the next stage, the full texts of related trials were retrieved to determine whether trials were potentially ideal for this meta-analysis, considering inclusion and exclusion criteria. Upon any disagreement, it was resolved by a discussion among themselves or with a third investigator ZA or MV.

Animal or in-vitro trials, clinical trials without control groups, no RCT design, and any trial protocols, the congress abstracts without full text, and the studies did not meet the minimum requirement for quality assessment score were excluded from this meta-analysis.

The quality assessment and data extraction from each included trial were conducted by two independent investigators RT and MA , using Cochrane Collaboration risk of bias tool and standard Excel sheet-form , respectively.

Any disagreement was discussed by a third investigator ZA or MV. All statistical analyses were conducted using STATA version The Cochran Q and I-squared statistics I 2 were applied to show the heterogeneity among included trials. Further, subgroup analyses were used based on pre-defined criteria such as type of disease HF vs.

CAD , type of intervention Q10 vs. Sensitivity analyses were conducted to specify the effect of each included trial on the pooled SMDs, using leave-one-out method.

A total of studies were identified though our initial literatures search. After screening RCTs, 8 studies were determined to be appropriate for in the present meta-analysis.

The flow diagram of step by step studies identification and selection has been illustrated in Fig. Seven clinical trials had double-blinded design and one of the trials was single-blinded.

Seven trials were conducted using parallel design and one cross-over design. Eight RCTs reported the effects of CoQ10 supplementation on total cholesterol, 6 on LDL-cholesterol, 4 on triglycerides, 5 on HDL-cholesterol, and 3 on Lp a.

Sample size varied from 21 to 73 participants with an overall number of subjects. The sample size in the placebo group was ranged from 21 to 71 with an overall number of subjects. Duration of the intervention among included trials was ranged from 4 to 48 weeks. The detailed characteristics of included trials were summarized in Table 1.

The assessment of the methodological quality of the included trials has been indicated in Fig. The findings of risk of bias assessment indicated that 6 studies were at unclear risk of bias, and 2 studies were at high risk bias based on the judgments of author.

Using random-effect model, the pooled results for lipid profiles showed that CoQ10 supplementation significantly decreased total cholesterol SMD We found no significant impact of CoQ10 supplementation on LDL-cholesterol SMD Total SS, total sample size. The detailed results of meta-analyses for the effects of CoQ10 on lipid profiles including total- and LDL-cholesterol, triglycerides, HDL-cholesterol, lipoprotein a concentrations at baseline and end of the trial in both intervention and placebo groups have been presented in Table 2.

The findings of sensitivity analyses revealed that pooled SMDs for the impact of CoQ10 on LDL-cholesterol and triglycerides were robust, and removing each trial did not affect the overall results of meta-analysis. For HDL-cholesterol also, the pre- 1. Considering type of disease, the results of subgroup analysis showed a significant reduction in total cholesterol concentrations among patients with CAD SMD LDL-cholesterol and Lp a levels did not show any significant difference applying potential moderators in subgroup analyses Table 4.

CoQ10 supplementation significantly increased HDL-cholesterol concentrations in patients with CVD SMD 2. The detailed results of subgroup analyses have been summarized in Table 4.

The findings of current systematic review and meta-analysis showed that CoQ10 supplementation significantly improved lipid profiles by decreasing total cholesterol and increasing HDL-cholesterol levels, though did not affect triglycerides, LDL-cholesterol and Lp a levels in patients with CAD.

CoQ10 deficiency usually occurs with aging and may increase the risk of CVD [ 9 , 16 , 17 ]. We have previously demonstrated in another meta-analysis that taking CoQ10 by patients with metabolic disorders significantly reduced serum triglycerides levels, yet did not affect other lipid profiles [ 10 ].

Meta-analysis conducted by Pirro et al. In a meta-analysis conducted by Suksomboon et al. The anti-hyperlipidemic effect of fenofibrate has already been proven; though its synergistic impact with CoQ10 is promising. Significant reduction in serum triglyceride levels was reported following supplementation with CoQ10 plus fenofibrate [ 12 ].

However, Sahebkar et al. In addition, CoQ10 administration to diabetic patients had no beneficial effects on lipid profiles and blood pressure [ 12 ].

The type and different dosages of CoQ10 used are some of the possible reasons that might explain the discrepant results among previous published studies. Although the main reason CoQ10 affects lipid profiles is unknown; several mechanisms have been proposed by which CoQ10 supplements could improve lipid profiles.

As an intracellular antioxidant, CoQ10 protects the cell membrane phospholipids and mitochondrial membrane protein against free radical-induced damage [ 6 ].

Aldehyde derivatives from lipid peroxidation, such as malondialdehyde, inhibit lecithin-cholesterol acyl transferase LCAT , which esterifies free cholesterol on HDL-cholesterol.

So, CoQ10 can promote HDL-cholesterol production, suppress oxidative stress and subsequently reduce malondialdehyde levels [ 20 ]. In addition, CoQ10 ingestion may induce gene expression of peroxisome proliferator-activated receptor-γ PPAR-γ through activating calcium-mediated AMPK pathway and inhibiting differentiation-induced adipogenesis [ 21 ].

PPAR-γ is a nuclear receptor protein which acts as a ligand-activated transcription factor in regulating gene expression affecting insulin and lipid metabolism, differentiation, proliferation, survival and inflammation [ 22 ]. CoQ10 supplementation significantly improved some of the parameters of lipid profile including total cholesterol and HDL-cholesterol levels in patients with CAD, though it might not affect the other parameters of lipid profiles.

Additional prospective studies regarding the effect of CoQ10 intake on lipid profiles in patients with CAD are necessary. Liu HH, Li JJ. Aging and dyslipidemia: a review of potential mechanisms. Ageing Res Rev. Article CAS Google Scholar. Pisciotta L, Bertolini S, Pende A. Lipoproteins, stroke and statins.

Curr Vasc Pharmacol. Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, et al.

Mayo Clinic ahd appointments in Arizona, Florida and Regultion and at Cuolesterol Clinic Health System Multi-channel resupply solutions. Coenzyme Q10 Anr is an antioxidant that your body produces naturally. Your cells use CoQ10 for growth and maintenance. Levels of CoQ10 in your body decrease as you age. CoQ10 levels have also been found to be lower in people with certain conditions, such as heart disease, and in those who take cholesterol-lowering drugs called statins. Thank you rrgulation visiting Coenzyme Q and cholesterol regulation. You are Coenzyme Q and cholesterol regulation a browser choledterol with rgeulation support for CSS. To obtain the best experience, we recommend you B vitamins for weight loss a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Our recent studies revealed that supplementation with the reduced form of coenzyme Q10 CoQ 10 H 2 inhibits oxidative stress and slows the process of aging in senescence-accelerated mice.