One popular hypothesis oxidde this loss centers around sustained damage from free radicals [35]. Stefanovic BSchwindt WHoehn MSilva AC. Prog Neurobiol.

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Studies show nitric oxide can stimulate blood flow Fernando Zelaya, Peter Nitric oxide and brain function. Goadsby and Ajay Oxidde. Shah shared Joint senior authors. Nitruc nitric oxide synthase nNOS is highly expressed within the Nitric oxide and brain function and nervous brai. Studies BCAAs for endurance genetically modified mice suggest roles in braiin blood flow regulation while dysfunctional nNOS signalling is implicated in cerebrovascular ischaemia and migraine. Previous human studies have investigated the effects of non-selective NOS inhibition but there has been no direct investigation of the role of nNOS in human cerebrovascular regulation. We hypothesized that inhibition of the tonic effects of nNOS would result in global or localized changes in cerebral blood flow CBFas well as changes in functional brain connectivity.