These effects have been associated with polyphenols in the fruit. We investigated the excretion of anthocyanins in human urine after ingestion of cranberry juice. Eleven healthy volunteers consumed ml of cranberry juice containing Urine samples were collected within 24 h before and after consumption.

Six of 12 anthocyanins identified in cranberry were quantified in human urine by HPLC coupled with electrospray ionization and tandem mass spectrometry HPLC-ESI-MS-MS. Among these, peonidin 3-O-galactoside, the second most plentiful anthocyanin in the juice, was found most abundantly in urine within 24 h, corresponding to In herbal medicine, anthocyanins are thought to be useful for several health conditions, including:.

It should be noted that this is not an exhaustive list. Anthocyanins continue to be researched for many other health conditions. While it is clear that anthocyanin-rich foods play a role in human nutrition, it remains unclear if they can prevent or treat any health condition independently.

Evidence is lacking, and even where there is evidence that anthocyanins are beneficial, it is unknown how much is needed for anthocyanins to be considered preventive.

Below is a look into some of the research on anthocyanins. Some research suggests that anthocyanins may reduce the risk of heart disease. A review on the effect of anthocyanin-rich berries on heart disease showed promising results. The review included 44 studies and evaluated anthocyanin-rich berries such as cranberries, blueberries , bilberries, and blackcurrant.

According to the review, regular intake of anthocyanins may improve blood lipids while reducing inflammation that can lead to the development of heart disease. Anthocyanins are also believed to have potential blood pressure—lowering effects. However, study results have been mixed, which means anthocyanins may only help lower blood pressure in some cases.

Although some researchers believe that anthocyanins may possess protective properties against certain types of cancer, no human studies have found any significant benefit. Lab studies have shown that anthocyanins extracted from various sources were able to shrink, kill, or inhibit cancer cells.

This was demonstrated in colon, bladder, breast, and thyroid cancer cells, among others. Animal studies have had similar results, yet human trials on anthocyanins and cancer remain limited.

One small human study looked at the effect of anthocyanins on colon cancer. Despite positive findings from preliminary research, anthocyanins were found to have no significant impact on colon cancer in the human trial.

More research is certainly needed in this area. There is research that suggests anthocyanins may be beneficial for diabetes management. In a small human study cited in , 58 people with type 2 diabetes were given either placebo an intentionally given ineffective substance or milligrams mg of anthocyanins twice daily for 24 weeks.

By the end of the study, those taking anthocyanins had decreased fasting blood sugar. The anthocyanins were also thought to improve insulin resistance when cells stop responding to insulin, causing glucose to build up in the blood in the study participants.

In another study performed on women with diabetes , intake of anthocyanins was associated with lower levels of inflammation.

This study also found an association between a high intake of anthocyanin-rich foods and improved insulin resistance. It should be noted that no large-scale studies looking at the effects of anthocyanins on diabetes have been performed to date.

Larger and better-designed studies on the subject certainly are needed. Although anthocyanin-rich foods are considered "heart-healthy," there is little evidence that they can actively treat or prevent any health condition. This is especially true with respect to anthocyanins and the prevention of cancer.

As a natural substance in many foods, anthocyanins are not thought to have side effects when eaten in normal amounts. For this reason, it is recommended to take a food-first approach to the intake of anthocyanins. Supplements containing high doses of anthocyanins may be more likely to cause mild or severe side effects.

You may experience side effects when taking supplements that contain anthocyanins. However, anthocyanins in supplement form are thought to be generally safe. In the human trials that we do have on anthocyanins as supplements, little to no adverse events have been reported.

In the few cases where side effects have occurred, they have mostly been mild. Reported side effects include eczema and gastrointestinal stomach upset. Evidence suggests that side effects occur only when anthocyanins are taken in doses that are too large. Despite this belief, there are still no reports of severe side effects caused by anthocyanins.

To avoid all side effects, choose to obtain anthocyanins through food. If you do take supplements containing anthocyanins, use them only as directed, and never take more than you should.

Some people may need to take extra precautions when using anthocyanins in supplement form. Anthocyanins are thought to be safe when consumed through food. However, the safety of anthocyanin supplements in certain populations has not been established at this time.

Children, people who are pregnant or breastfeeding , and those with medical conditions should seek advice from their healthcare provider before using anthocyanin supplements. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.

When it comes to anthocyanin supplements, there are no guidelines for recommended dosage. More research is needed to establish safe dosage information for all people. There is also no Dietary Reference Intake DRI for anthocyanins from food.

However, a joint committee comprising the Food and Agriculture Organization of the United Nations FAO and the World Health Organization WHO has established 2. However, this recommendation applies to anthocyanins from grape skin extracts, not anthocyanins in general. The committee found this to be a safe, nontoxic dose.

If necessary, your healthcare provider can help determine the right anthocyanin dose for you. You may be more likely to experience side effects if you take a dose of anthocyanins that is too high. However, anthocyanins are generally considered safe, especially when consumed through food.

Reports of anthocyanin toxicity or overdose have not been made. Anthocyanins have also been labeled as having low to no toxicity. Regardless, it's still important to be safe and only use anthocyanin supplements as directed.

You should also only consume anthocyanins through food in normal amounts. Anthocyanins may interact with certain nutrients and medications. Some research suggests that anthocyanins interfere with various enzymes and protein transporters responsible for helping the body absorb some nutrients, like thiamine and folic acid.

Anthocyanins may also affect enzymes or transporters needed to metabolize certain medications. Unfortunately, anthocyanin interactions are not well-documented or understood. It is also important that you carefully read the ingredients list and nutrition facts panel of a supplement.

This will ensure you know which ingredients are in the product and how much of each ingredient is included in the supplement. For best practice, please speak with your healthcare provider regarding the potential for interactions between anthocyanins and any other supplements or medications you take.

Anthocyanin supplements should be stored in a cool, dry place. Keep them out of direct sunlight. Foods containing anthocyanins should be stored normally. BUY BLUE BUTTERFLY PEA TEA NOW. Butterfly Pea Tea - so refreshing - adds a bit of fun with its colour changing properties.

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Also keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established.

You can get tips on using supplements, but if you're considering the use of anthocyanins, talk with your primary care provider first. Self-treating a condition and avoiding or delaying standard care may have serious consequences. healthbenefits Vegan tea anthocyanins antioxidant brewbluetea.