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TURMERIC Is Good for Virtually EVERYTHING!Curcumin for Digestive Health -
These results suggest curcumin administration was associated with improvements in overall GI symptoms and reductions in anxiety. Curcumin was well-tolerated with no significant differences in adverse effects between the curcumin and placebo groups.
Compared to the placebo, there were no significant changes in microbial diversity from the phylum to genus level or in examined selected microbiota comprising Bacteroidetes Phyla , Firmicutes Phyla , Clostridia class , Enterobacteriaceae family , Bacteroides genus , Clostridiales genus , Faecalibacterium genus , and Bifidobacterium genus.
These intestinal bacteria were chosen for examination as differences in these bacteria have been regularly observed in adults with IBS [ 28 , 29 , 30 ]. An examination of the effects of curcumin on SIBO also revealed curcumin did not influence SIBO rates.
These results suggest that although curcumin was associated with improvements in GI symptoms and anxiety levels in adults with self-reported digestive complaints, changes in intestinal bacteria were not responsible for its therapeutic mechanisms of action. Importantly, despite increasing interest in the relationship between microbial diversity and GI conditions, in this study, increases in microbial diversity from the phylum to genus level were not associated with GI symptomatic improvements.
This finding provides further confirmation that in this examined population of adults with self-reported digestive complaints, therapeutic actions of curcumin were not via its impact on intestinal bacteria.
However, it is important to note that 16S rRNA analysis was utilised in this study which lacks the resolution to identify microbial changes at lower taxonomic classifications e.
In a review by Ghosh et al. In particular, curcumin may modulate intestinal barrier function at several layers including the lumen via its effect on intestinal alkaline phosphatase , the mucus layer, the epithelium through its influence on the expression of tight junction proteins , and antibacterial peptides via its expression of anti-microbial peptides.
In an acute study, curcumin supplementation reduced gastrointestinal damage and associated pro-inflammatory cytokine activity in adults exposed to exercise and heat stress [ 33 ].
Moreover, curcumin has anti-inflammatory effects and this presents as another mechanism associated with its therapeutic effects. Increased concentrations of systemic LPS are identified in several intestinal and extra-intestinal diseases [ 34 , 35 , 36 , 37 ].
Curcumin has been identified in animal studies to attenuate LPS-induced immune response and tissue damage [ 38 , 39 , 40 ]. Disturbances in the activity of the hypothalamus-pituitary-adrenal HPA axis have also been identified in people with IBS and FGID [ 41 , 42 , 43 ]. Curcumin has been shown in animal studies to influence HPA activity, and in human trials, is associated with lower concentrations of cortisol [ 44 , 45 ].
Disturbances in serotonergic activity have also been implicated in GI diseases and altered serotonergic signalling may lead to both intestinal and extraintestinal symptoms in IBS [ 46 ]. This presents as another mechanism of action associated with curcumin as it has been shown to influence serotonergic activity [ 47 , 48 ].
Even though there were improvements in GI symptoms in adults with self-reported GI complaints, these results should be cautiously generalised to adults presenting with diagnosed GI disorders until confirmation in future clinical trials. How the severity of digestive complaints in the population recruited in this study compares to healthy individuals without GI complaints, or people with diagnosed GI disorders, could not be evaluated as there are no published norms for the GSRS.
However, in a study on adults with gastroesophageal reflux disease, an average GSRS total score of 2. This suggests that the population of recruited participants had a mild-to-moderate severity of GI symptoms, as their baseline GSRS score was 2. Further examination of changes in GI symptoms utilising other outcome measures will be helpful in future trials to provide further analysis of symptomatic changes.
Examples include the Bristol Stool Scale [ 49 ], clinician-administered questionnaires, measures of colonic transit time and stool frequency, and provocation tests for the evaluation of visceral sensitivity [ 50 , 51 ]. Research confirms that there are significant differences in the bioavailability and composition of curcumin extracts.
In an unpublished study, it was associated with a fold increase in free curcumin compared to standard curcumin. Given the differences in the profile and bioavailability of curcumin extracts, the GI effects of curcumin should be cautiously extended to other curcumin extracts until further confirmatory research is conducted.
In future trials, the efficacy of curcumin should be examined using different doses, frequency of dosing, and treatment duration. This will help to identify optimal treatment regimens for people with GI disorders. Even though no significant changes in intestinal microbiota were identified in this study, different dosages and treatment periods may lead to microbial changes.
Moreover, microbial changes may occur in adults with clearly defined and diagnosed GI disorders including IBS, other FGIDs, and inflammatory bowel disease. In this study, adults with self-reported GI complaints with no previous diagnosis of a GI disorder were recruited.
In addition, more detailed analysis of microbial changes at different taxonomic levels e. However, for this greater resolution to occur accurately, whole-genome testing is preferred [ 52 ]. Other factors that may have affected the lack of change in intestinal microbiota over time included the recruitment of people taking the contraceptive pill, the inclusion of volunteers with a BMI in the overweight and obese range, and limitations associated with our ability to monitor or control for dietary changes over time.
The recruitment of larger samples sizes may also be required to elucidate microbial changes associated with curcumin use. Despite recruiting 79 volunteers, pre- and post-treatment changes in intestinal microbiota were only undertaken on 50 participants but data on GSRS changes were available for 77 participants.
This has the potential to confound the results. It will be important in future trials to examine other potential mechanisms of action of curcumin including examining its effects on intestinal barrier function, inflammation, HPA-axis activity, and serotonergic activity.
Compared to the placebo, there were also greater reductions in anxiety. Curcumin was well-tolerated with no reported significant adverse effects. An examination of the potential mechanisms associated with curcumin supplementation suggests its therapeutic effects may not be due to its influence on intestinal microbiota.
However, before definitive conclusions about the effects of curcumin on intestinal bacteria can be made, further research using larger sample sizes and testing methods that allow more detailed analysis of microbial changes at lower taxonomic levels e.
Further studies on adults with clearly-defined GI disorders, using objective and subjective outcome measures, varying dosages and treatment durations, and differing curcumin extracts are required to elucidate the effects of curcumin on GI symptoms. Further trials are also required to examine the potential therapeutic actions of curcumin.
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Like its cousin ginger, turmeric has antioxidant and anti-inflammatory properties and those benefits are conferred from the active ingredient in turmeric known as curcumin. Turmeric is no newcomer to its health and wellness benefits, having been used medicinally for around 4, years.
Turmeric is often promoted as a super food, but for many of the touted benefits, the research is inconclusive or in the early stages. More on that later. Most, if not all, of the potential benefits to follow are tied in to the antioxidant and anti-inflammatory properties of turmeric through curcumin.
A healthy immune system is vital for good health. Strong bodily immunity protects your body from germs, infections and disease. But even developing the common cold will make you run to your medicine cabinet or kitchen pantry for a way to build back your immunity.
While your body needs some inflammation to help with its healing process, when inflammatory molecules run amok without interference that can lead to chronic inflammation.
Chronic inflammation can lead to all kinds of health problems, from sinus infections to heart disease and so much in between. Simply put, curcumin helps mediate the chronic inflammation drivers that play an important role in inflammation. Without the proper amount of bodily inflammation, chronic inflammation can damage cells, tissues and organs.
Read more here and here. The anti-inflammatory properties of curcumin are what make turmeric a potential ally in reducing joint pain, stiffness and swelling from your weekly tennis game, or even from osteoarthritis, the most common form of arthritis. According to this article , one study compared the results in reducing osteoarthritis pain between taking a turmeric extract three times daily to a 1, milligram dose of ibuprofen, finding the beneficial effects were comparable.
This pilot clinical study found potential benefit for patients with rheumatoid arthritis in the areas of disease activity and reduction of joint swelling and tenderness. In both areas, results in the curcumin group showed the highest percentage of improvement.
The study authors further advised that the curcumin treatment was safe. Inflammation is a hallmark of heart disease.
As an inflammation fighter, can turmeric help with heart health? Some studies suggest the answer is yes. For example, this article advises that early research suggests turmeric may help prevent plaque build-up, one of the blocked-artery culprits that often ends in heart attacks or strokes.
Curcumin was found to induce remission within 4 weeks in patients who had not previously responded to standard drug therapies. A meta-analysis reviewed the literature and trials on curcumin for CD and found a significant increase in clinical and endoscopic remission in patients who added curcumin to their treatment.
Researchers recommend curcumin as an add-on therapy because it targets intestinal inflammation through a wide range of anti-inflammatory mechanisms, whereas pharmaceutical treatment is generally limited to a sole mechanism.
Curcumin inhibits the dysregulated activity of NF-kB signaling pathways , and suppresses the activity of IL-1β , a pro-inflammatory cytokine. It also inhibits excess levels of TNFα and reduces oxidative stress , two leading causes of chronic inflammation.
Last but certainly not least, curcumin positively affects the gut microbiota , restoring homeostasis to the gut. When purchasing curcumin for intestinal inflammation, look for a gut-directed formula. Most curcumin on the market contains boosted bioavailability, which is helpful for other conditions but not for gut inflammation.
Gut-directed curcumin ensures the release of curcumin in the intestines so it can directly target gut inflammation. The general daily dose of gut-directed curcumin for gut inflammation is mg — 1. Gut-directed curcumin takes roughly weeks to take effect under consistent dosing, although many report relief sooner.
If you have any concerns at all about taking curcumin, consult your doctor or reach out to our clinic at clinic evinature. com , and one of our medical experts will be in touch.
Curcumin can potentially cause adverse effects, especially in large doses. Side effects include:. Curcumin may increase levels of urinary oxalate. It may also negatively interact with some medications such as antibiotics, blood thinners, antihistamines, cardiac medications, chemotherapy treatments, and antidepressants.
Since curcumin is a blood thinner, it should be avoided if you have a bleeding disorder. Curcumin should also be avoided by women who are expecting or breastfeeding. According to the latest research, turmeric extract curcumin may not only be able to ease anxiety and depression, but also reverse the damage of stress and depression on the body.
These changes were reversed after curcumin treatment. Curcumin treatment resulted in antidepressant-like actions, reduced the inflammatory response, and the neuronal changes caused by stress. Another trial tested curcumin in an animal study on PTSD, with a focus on anxiety.
Curcumin alleviates anxiety by inhibiting monoamine oxidase and increasing serotonin and norepinephrine. And although research is still underway, it appears that curcumin can also improve mental health through its anti-inflammatory actions. Studies show that patients with depression or generalized anxiety disorder GAD show higher markers of inflammation than healthy controls.
Pro-inflammatory cytokines affect our behavior through molecular pathways that impact our neurotransmitter systems, which in turn influence the neurocircuits that regulate behavior. This generally manifests as low motivation, avoidance or alarm. In other words, depressive and anxious symptoms.
The pro-inflammatory cytokines IL-1β and tumor necrosis factor TNF are especially damaging as they reduce the availability of serotonin, dopamine, and noradrenaline — all involved in anxiety modulation.
Turmeric Digetsive an Heaalth remedy used in Ayurveda and Curcumin for Digestive Health Chinese Medicine for a Body image confidence range of ailments, especially conditions involving digestion, chronic pain, stomach Sports nutrition coachingDDigestive inflammation. Sports nutrition for vegetarians and vegans active compound in turmeric, curcuminhas come under thorough clinical observation due to its potent biological properties. Curcumin is a potent anti-inflammatory and antioxidant that can ease digestion, promote the healing of the gut barrier, and even recompose the gut microbiome. For these reasons, researchers are investigating curcumin as a treatment for IBD, IBS, and a range of other inflammatory conditions. A number of studies found curcumin alongside 5ASA medication can significantly improve response, remission rates, and remission maintenance in UC patients.
Curcumin diferuloylmethane is Diestive active compound phytochemical Protein intake for reducing cravings the common, bright yellow curry Haelth, turmeric. Indian, Chinese, and Western Eating disorder causes medicines traditionally Curcumkn turmeric, of the Digeative family, for conditions such as poor digestion, abdominal pain, and distension. Inthe World Health Organization recommended it for treatment of acid refluxflatulenceand functional dyspepsiaas used in Ayurvedic medicine. Salh and his Vancouver team contributed to a building body of evidence that this flavourful spice can help prevent cancerous cells from developing in the colon. A basic research study 2 from India looked at mice with induced colitis and found that curcumin exerts beneficial effects in experimental colitis by mediating the inflammatory processes.
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