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Even hormonal changes can affect weight gain and loss. This is why it is important to nutritionally supplement correctly looking at pre-existing conditions and other potential health issues first.

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For dietary supplements with an inadequate number of trials for meta-analysis, a statistically and borderline clinically significant weight difference compared to placebo was found for modified cellulose, manno-oligosaccharides in males , blood orange juice extract, and three multiple-ingredient dietary supplements.

These were only reported in one trial of each. Thus, more evidence is needed before recommending them for weight loss.

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Fatima Cody Stanford, an obesity medicine specialist and the equity director of the endocrine division at Massachusetts General Hospital in Boston. For people in those studies, the optimal dose appeared to be 1 gram per day, Stanford said.

Holly Lofton, the director of the weight management program at NYU Langone Health, referring to a medication people with diabetes use to lower their blood sugar levels.

Highly effective drugs, including aspirin and morphine, come from plants. Known side effects of berberine in humans include nausea and vomiting, Stanford said. In animal studies, it appeared to enlarge the liver and the kidney and reduce the number of white blood cells, which fight off infections.

Larger studies would need to be conducted to know whether there are any serious side effects in humans. Stanford said she would recommend speaking with a doctor before taking berberine as a part of a weight loss regime. It may not be safe for pregnant women, she added. In fact, he said, if people do experience weight loss using berberine, they should stop taking it immediately and talk to a doctor.

Berkeley Lovelace Jr. is a health and medical reporter for NBC News. He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care. He previously covered the biotech and pharmaceutical industry with CNBC.

IE 11 is not supported. For an optimal experience visit our site on another browser. SKIP TO CONTENT. NBC News Logo. Kansas City shooting Politics U. My News Manage Profile Email Preferences Sign Out. Search Search. They are ideal if you are currently looking to lose or maintain your weight as part of a healthy, balanced lifestyle.

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