J Virol. Chou, Polypyenols. Su, Mol. In addition, galangin reduced LPS-induced Body water percentage analysis lung injury by inhibition of inflammation and oxidative stress. Fontana AR, Antoniolli A, Bottini R. Culinary preparation plays a significant role in polyphenol content. Li, Int.

Polyphenols and respiratory health -

Researchers at Georgia State University studied the effects of resveratrol against inflammation caused by nontypeable Haemophilus influenzae NTHi , a common pathogen colonizing the respiratory tract of COPD and asthma patients.

The team found that resveratrol significantly decreased NTHi-induced inflammation in both airway epithelial cells and in the lungs of mice by increasing the activity of MyD88 short, a key factor halting inflammation.

Isorhapontigenin, on the other hand, was identified as a promising candidate with the characteristics necessary to be a successful therapeutic agent for COPD treatment.

Moving ahead, the team plans to further evaluate the therapeutic potential of isorhapontigenin in animal studies. News Researchers Identify Grape Polyphenol that May Suppress COPD Lung Inflammation Researchers Identify Grape Polyphenol that May Suppress COPD Lung Inflammation by Patrícia Silva, PhD October 17, Share this article: Share article via email Copy article link.

About the Author Patrícia Silva, PhD Patrícia holds a PhD in medical microbiology and infectious diseases from the Leiden University Medical Center, Netherlands, and completed a postdoctoral research fellowship at the Instituto de Medicina Molecular, Lisbon, Portugal.

Her work in academia was mainly focused on molecular biology and the genetic traits of infectious agents such as viruses and parasites. Foods that contain the highest levels of antioxidants are typically plant-based, and those with Vitamins C and E are known to help with overall lung health.

Antioxidant-rich Foods for Lung Health. UnityPoint Health News and Articles Antioxidant-rich Foods for Lung Health.

What Do Antioxidants Do? More Respiratory Content. Article Phlegm Cheat Sheet: Recognizing Normal and Concerning Colors and Consistencies.

Despite the aforementioned limitations, these studies should be taken into consideration to design clinical trials. In this sense, the main strength concerning the use of polyphenols in this global emergency is related to the well-established absence of both side effects and drug interactions of such polyphenols with concomitant pharmacological treatments.

Indeed, it is well-known that coronavirus-infected subjects are highly prone to develop such respiratory diseases, sometimes complicated by the co-existence of previous cardio-metabolic or chronic diseases.

This articulated pathological scenario drastically limits the use of such therapeutic schemes. As an example, the French non-randomized clinical trial showed encouraging results on the efficacy of the combination hydroxychloroquine and azithromycin against COVID19 6 , although both drugs are potentially associated with QT-prolongation 29 , Another relevant point that should be taken into account, is the proper formulation of polyphenol-based nutraceuticals that may be efficient for this scope.

Undoubtedly, according to the available studies, potential anti-COVID nutraceutical approaches should contain polyphenols whose effects against coronaviruses have been demonstrated. However, the evaluation of potential synergistic effects between different polyphenols is intriguing.

Despite the different structure, indeed, polyphenols share the same chemical features, including the presence of phenolic rings with hydroxyl groups 9. Thus, it could be hypothesized that, although not directly investigated, different classes of polyphenols might exert, at least in part, similar antiviral activities, but eventually with different mechanisms of action.

In this sense, according to the studies of Rho 20 and Lin et al. With this rationale, it should be stressed the importance to investigate the effect of natural polyphenolic extract, rather than the single purified molecules.

Interestingly, various plant- or food-derived extracts have been found to be polyphenol-rich matrices for formulation of nutraceutical supplements. Among these, grape pomace extract GPE has been reported as an excellent source of bioactive compounds, mainly polyphenols, including RSV, cathechins, and proanthocyanidins 31 — Notably, evidence indicated the antiviral activity of GPE against various microorganisms, including human immunodeficiency virus type 1 34 , human enteric virus, human norovirus surrogates [feline calicivirus FCV F9 and murine norovirus MNV ] 35 , hepatitis A virus 36 , and hepatitis C virus HCV Different mechanisms of actions have been demonstrated, including down-regulation of the HIV-1 entry co-receptor expression for the activity against HIV 34 , suppression of virus replication via reduction of COX2 expression and regulation of NFκB and MAPK signaling pathways and reduction of virus-induced inflammation for the anti-HCV activity Interestingly, two in vitro studies investigated the effects of GPE against respiratory syncytial virus, using an airway epithelial A cell model 38 , In particular, it was demonstrated that GPE interfered with nucleoprotein and fusion protein expression, reducing virus replication.

In this sense, the anti-inflammatory potential of polyphenols, mainly exerted via reduction of the interleukin levels, appears noteworthy, and investigating this effect in the context of a virus-induced inflammatory status is intriguing.

Overall, this evidence may support the use of polyphenolic extracts, including GPE, for the formulation of potential nutraceutical supplements aimed to counteract the COVID infection. This potential activity might be considered in addition to the well-established antioxidant and anti-inflammatory effects of polyphenols, which may contribute to the general management of respiratory complications of coronavirus infection.

Considering this background, the ideal way to test the antiviral polyphenol effect in humans would be a controlled randomized clinical trial with measurable, reproducible, and clinically relevant outcomes.

Most of the current trials are set on the compassionate use of the studied treatment or based on single-arm intervention. Thus, definitive conclusion related to efficacy or safety is hardly deducible. On balance, controlled randomized clinical trials with meaningful clinical outcomes are mandatory to best assess the therapeutic effects and the clinical impact of polyphenol treatment on COVID All the authors contributed to conceptualization, evaluation of the literature and draft-writing.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al.

Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. doi: PubMed Abstract CrossRef Full Text Google Scholar. Pan Y, Zhang D, Yang P, Poon LLM, Wang Q. Viral load of SARS-CoV-2 in clinical samples.

Lancet Infect Dis. Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients.

N Engl J Med. Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A trial of lopinavir-ritonavir in adults hospitalized with severe Covid Gov Adaptive COVID Treatment Trial. Gautret P, Lagier JC, Parola P, Hoang VT, Meddeb L, Mailhe M, et al.

Hydroxychloroquine and azithromycin as a treatment of COVID results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. Shen C, Wang Z, Zhao F, Yang Y, Li J, Yuan J, et al. Treatment of 5 critically Ill patients with COVID with convalescent plasma.

CrossRef Full Text Google Scholar. Xu X, Han M, Li T, Sun W, Wang D, Fu B, et al. Effective treatment of severe COVID patients with Tocilizumab. Annunziata G, Jimenez-Garcia M, Capo X, Moranta D, Arnone A, Tenore GC, et al.

Microencapsulation as a tool to counteract the typical low bioavailability of polyphenols in the management of diabetes.

Food Chem Toxicol. Yiu CY, Chen SY, Chang LK, Chiu YF, Lin TP. Inhibitory effects of resveratrol on the Epstein-Barr virus lytic cycle. De Leo A, Arena G, Lacanna E, Oliviero G, Colavita F, Mattia E. Resveratrol inhibits epstein barr virus lytic cycle in Burkitt's lymphoma cells by affecting multiple molecular targets.

Antiviral Res. Zhang L, Li Y, Gu Z, Wang Y, Shi M, Ji Y, et al. PLoS ONE. Faith SA, Sweet TJ, Bailey E, Booth T, Docherty JJ. Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells. Annunziata G, Maisto M, Schisano C, Ciampaglia R, Narciso V, Tenore GC, et al.

Resveratrol as a novel anti-herpes simplex virus nutraceutical agent: an overview. Lin CJ, Lin HJ, Chen TH, Hsu YA, Liu CS, Hwang GY, et al. Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression.

Zang N, Xie X, Deng Y, Wu S, Wang L, Peng C, et al. Resveratrol-mediated gamma interferon reduction prevents airway inflammation and airway hyperresponsiveness in respiratory syncytial virus-infected immunocompromised mice. J Virol. Liu T, Zang N, Zhou N, Li W, Xie X, Deng Y, et al.

Resveratrol inhibits the TRIF-dependent pathway by upregulating sterile alpha and armadillo motif protein, contributing to anti-inflammatory effects after respiratory syncytial virus infection.

Mastromarino P, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, et al. Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia.

Li H, Wu J, Zhang Z, Ma Y, Liao F, Zhang Y, et al.

Lungs play Polyphenols and respiratory health Plyometric exercises role in keeping our Polyphenols and respiratory health moving. Our respiratory system Polyphwnols us to breathe respirztory supply oxygen to all parts healthh the body. Healty we breathe in air through our nose hdalth mouth, it then travels down the windpipe, through our bronchial tubes and into the lungs. Our bodies use the oxygen we breathe in, and we exhale carbon monoxide. In addition to getting exercise, eating a good balance of nutrient-rich foods is vital to keeping your lungs healthy. Some types of nutrient-rich foods, especially those rich in antioxidants, are known to help our lungs perform best. Antioxidants are important to maintaining optimal health. by Patrícia Silva, PhD October 17, Xnd from the Imperial Respiratoory London in England Respiratorry the National Herbal detoxification products of Singapore NUS have identified a Bealth polyphenol, known as isorhapontigenin, which shows potential for heaoth Polyphenols and respiratory health inflammation caused by chronic obstructive pulmonary disease COPD. Polyphenools naturally-derived heath belongs to the family of polyphenols, which are found abundantly in natural plant food sources. Polyphenols are known to have antioxidant properties, consequently preventing cell damage. Additionally, because polyphenols are found in food, isorhapontigenin can be easily absorbed when taken orally, adding to its profile for becoming a potential candidate for the treatment of COPD. Lin Haishu, from the Department of Pharmacy at NUS in Singapore, said in a press release. Haishu and his PhD student Yeo Chao Ming Samuel used a broad range of techniques to investigate the medicinal properties of isorhapontigenin and other natural compounds.