Chitosan for respiratory health -
It is low toxicity and it can be bound with therapeutic drugs and made into nanoparticles. Islam said that while many scientists were investigating the delivery of chemotherapy drugs via the lungs, none has exclusively looked at chitosan as a safe carrier for lung drug delivery. Chitosan also has mucoadhesive properties, which means it sticks to the lining of the lung cells.
It has been found to improve the absorption of therapeutic agents by opening the junctions between cells of the lung lining to allow the drug to target cancer cells. Islam said much research suggested chitosan-based nanoparticle drug delivery could be the way of the future to deliver drugs for many different conditions besides lung cancer.
BCCI secretary Jay Shah stresses that all centrally contracted players must participate in domestic red ball tournaments upon request from selectors, coach, and captain.
However, the national cricket academy's guidance will be taken into consideration for players with physical limitations. News Lifestyle Health Inhalable chemotherapy may help treat lung cancer Inhalable chemotherapy may help treat lung cancer The research is concerned with dry powder inhalation using chitosan nanoparticles loaded with drugs that can reach the lower respiratory tract and from there diffuse into the bloodstream.
By: PTI Melbourne April 15, IST. Follow Us. Chitosan-based nanoparticle drug delivery could be the way of the future to deliver drugs for many different conditions besides lung cancer.
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Scientific news - Chitosan Company news. Chitin Chitosan Derivatives Chitosan Standard Custom manufacturing Contract research. Home News Scientific news - Chitosan SARS-COVID-2 and Chitosan News Scientific news - Chitin and Chitosan Chitosan for pulmonary applications. A review on chitosan and its development as pulmonary particulate anti-infective and anti-cancer drug carriers Ruhisy Mohd Rasul, M.
The following inhalation devices are currently in use in pulmonary medicine: Pressure Dosing Inhalers Powder Inhalers Nebulizers Lots of research about chitosan-based drug delivery systems is conducted for the treatment of tuberculosis.
Formulation and preparation Testing Source Chitosan nanoparticles loaded with "Prothionamide" active ingredient for tuberculosis , ionic cross-linking and freeze-drying, powder formulation In vivo : Prolongation of the availability of active ingredients through the nanoparticles Debnath et al.
tuberculosis infected mice with nebulized nanoparticles for 28 days, after treatment no detectable mycobacterial colony forming unit in lung and spleen homogenates Garg et al. Congress and fairs Meet us in person EASO Winterschool , Wittenberg, Germany, Contact Heppe Medical Chitosan GmbH Heinrich-Damerow-Strasse 1 Halle Saale Germany Tel.
You need JavaScript enabled to view it. News Reviews and publications with chitosan in Chitosan and Cheese? Chitosan-based matrix as a carrier for bacteriophages Improved chitosan nerve conduits through crosslinking.
Ok More information. Chitosan nanoparticles loaded with "Prothionamide" active ingredient for tuberculosis , ionic cross-linking and freeze-drying, powder formulation. In vivo : Prolongation of the availability of active ingredients through the nanoparticles.
In vitro : Treatment of M. LPS injection is commonly used to induce ALI Lei et al. First, we confirmed that treatment of LPS mice with blank NPs did not alter the level of lung injury vs. LPS mice, as shown by absence of change in BALF protein concentration Supplementary Figure S1C.
Figures 4A,B demonstrates that IL-1β and IL-6 levels in peripheral blood promptly ascended at 24 h after intraperitoneal injection of LPS. FIGURE 4. Lung tissues were collected at 24 h post-LPS challenge. PBS vehicle and vs. Scale bar, 1 mm upper row or μm lower row.
Moreover, pro-inflammation cytokines such as TNF-α and IL play crucial roles in lung inflammation, so we also determined the levels of such cytokines in BALF.
Treatment with blank NPs, however, had no discernable effects on inflammatory cytokine levels or NO production in LPS-treated mice, which implied that HPD acts as the anti-inflammatory agent, while the chitosan NPs act as passive drug carriers.
We determined alterations in vascular permeability by assessing pulmonary transvascular flux of Evans blue dye-conjugated albumin EBA Huang et al. Figure 5A demonstrates the experimental scheme of the EBA assay. Figure 5B shows representative images of lungs extracted from EBA-injected-mice.
FIGURE 5. A EBA assay schematic. B Representative images of murine lung tissues after EBA-injection. PBS group. To investigate whether cell pyroptosis Bergsbaken et al. The septic lung tissues in the PBS-treated group showed significantly increased expressions of IL-1β and caspase 1 compared with mice in the basal group.
FIGURE 6. A Representative images and B quantification of lung tissue cross-sections immune-stained for caspase 1. C Representative images and D quantification of lung tissue cross-sections immune-stained for IL-1β.
ALI following sepsis or infection with SARS-CoV, MERS-CoV, or SARS-CoV-2, represent major healthcare and financial problems worldwide Su et al. Additionally, human studies have shown that patients with severe COVID also demonstrate CSS He et al.
Wu et al. Although this anti-inflammatory and anti-viral agent Lin et al. However, the impact of different types of NP on nasal mucosal absorption per se should be assessed in future studies. These studies suggest that the anti-inflammatory impact of HPD is enhanced by delivery in chitosan NPs.
This delivery system also alleviated the need for DMSO as a solubility agent in vivo , which could damage nasal mucosa when administrated nasally. Furthermore, excessive amounts of NO can promote cytokine and matrix metalloproteinase production, mitochondrial dysfunction, and cell apoptosis, which aggravates inflammation and tissue injury Wu et al.
It is worth mentioning that the HPD dose that had protective effects on CSS-induced lung injury in our study is 5-fold lower than HPD dose in free form used to reduce smoke-induced lung inflammation in a previous study Yu et al.
Previous experimental studies have shown that treatment efficacy can be improved through delivery strategies that target inflammatory tissues Zhang et al. In this work, the anti-inflammatory effects of HPD on macrophages and lungs of LPS-challenged mice was improved by using the nasal NP-based drug delivery system.
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. HJ, ZZ, and XL proposed and supervised the project. HJ, QL, ZM, HZ, YW, XD, WZ, and JP performed the experiments. HJ wrote the paper. CE revised and polished the manuscript. XL provided the funding in this study.
All authors have given approval to the final version of the manuscript. This work was supported by National Natural Science Foundation of China No.
CE received an American Heart Association Career Development Award 19CDA The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Bergsbaken, T. Pyroptosis: host cell death and inflammation. PubMed Abstract CrossRef Full Text Google Scholar. Bruinsmann, F. Chitosan-coated nanoparticles: effect of chitosan molecular weight on nasal transmucosal delivery. Pharmaceutics 11 2 , CrossRef Full Text Google Scholar.
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Ciftci, O. Du, Z. Saikosaponin a ameliorates LPS-induced acute lung injury in mice. Inflammation , 41 1 , — Gao, W. Size-dependent anti-inflammatory activity of a peptide-gold nanoparticle hybrid in vitro and in a mouse model of acute lung injury.
Acta Biomater. Garg, U. Current advances in chitosan nanoparticles based drug delivery and targeting. Gholizadeh, H. Application of a thermosensitive in situ gel of ChitosanBased nasal spray loaded with tranexamic acid for localised treatment of nasal wounds.
AAPS PharmSciTech , 20 7 , Gupta, K. Constitutive inflammatory cytokine storm: a major threat to human Health. Interferon Cytokine Res. He, J. Molecular mechanism of evolution and human infection with SARS-CoV Viruses 12 4 , Hemanth Kumar, B.
Hesperidin, a citrus flavonoid, protects against l-methionine-induced hyperhomocysteinemia by abrogation of oxidative stress, endothelial dysfunction and neurotoxicity in Wistar rats. Huang, X.
Open fot peer-reviewed chapter. Submitted: 01 April Reviewed: 08 June Chitosan for respiratory health healfh June Edited by Rajeev K. Tyagi, Neeraj Garg, Rahul Shukla and Prakash Singh Bisen. com customercare cbspd. Pulmonary administration is an effective method for treating lung and other diseases.Video
If You Want Healthy Lungs, Do THIS Every Day for 30 Days ❗ Scientists are resliratory a targeted chemotherapy for lung cancer Chitosan for respiratory health, that can be inhaled instead respiratorg being injected or taken orally. According to fr scientist Nazrul Chitosan for respiratory health, from Queensland University of Nutritional strategies for blood sugar balance QUT in Australia, lung cancer is one of the deadliest and most common cancers. Chitosan is a natural polymer that is biodegradable and biocompatible. It is low toxicity and it can be bound with therapeutic drugs and made into nanoparticles. Islam said that while many scientists were investigating the delivery of chemotherapy drugs via the lungs, none has exclusively looked at chitosan as a safe carrier for lung drug delivery.
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