Zamir, E. and Simeonova, V. Wiedau-Pazos, M. Nutrition 31, —

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How Oxidative STRESS Affects Metabolic Health, and How Can Antioxidants Help REDUCE Imbalances

Oxidative stress and health -

Aminjan, H. Life Sci. Andreyev, A. Mitochondrial metabolism of reactive oxygen species. Biochemistry 70, — Google Scholar.

Antonioni, A. Redox homeostasis in sport: do athletes really need antioxidant support? Sports Med. Antunes dos Santos, A. Oxidative stress in methylmercury-induced cell toxicity. Toxics Aroor, A. Mitochondria and oxidative stress in the cardiorenal metabolic syndrome. Cardiorenal Med.

Ayala, A. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxynonenal. Banafsheh, A. Studies on oxidants and antioxidants with a brief glance at their relevance to the immune system. Barbieri, R.

Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity. Barrera, G. Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncol. Bartosz, G.

Reactive oxygen species: destroyers or messengers? Battelli, M. Pathophysiology of circulating xanthine oxidoreductase: new emerging roles for a multi-tasking enzyme.

Acta , — Xanthine oxidoreductase in atherosclerosis pathogenesis: not only oxidative stress. Atherosclerosis , — Battin, E. Antioxidant activity of sulfur and selenium: a review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms.

Cell Biochem. Bedard, K. The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Rev 87, — Benfeitas, R. New challenges to study heterogeneity in cancer redox metabolism. Cell Dev. Beyer, C. Antioxidant properties of melatonin—an emerging mystery.

CrossRef Full Text Google Scholar. Bhattacharyya, A. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Birben, E.

Oxidative stress and antioxidant defense. World Allergy Organ. Blokhuis, A. Protein aggregation in amyotrophic lateral sclerosis. Acta Neuropathol. Borek, C. Antioxidant health effects of aged garlic extract. Buga, A.

Molecular and cellular stratagem of brain metastases associated with melanoma. Buj, R. Deoxyribonucleotide triphosphate metabolism in cancer and metabolic disease. Cadet, J. Formation and repair of oxidatively generated damage in cellular DNA. Free Radic.

Oxidatively generated complex DNA damage: tandem and clustered lesions. Cancer Lett. DNA base damage by reactive oxygen species, oxidizing agents, and UV radiation. Cold Spring Harb. Cardoso, B. Glutathione peroxidase 4: A new player in neurodegeneration?

Psychiatry 22, — Chen, J. Nitric oxide bioavailability dysfunction involves in atherosclerosis. Chen, X. Effect of puerarin in promoting fatty acid oxidation by increasing mitochondrial oxidative capacity and biogenesis in skeletal muscle in diabetic rats.

Diabetes 8, 1— Oxidative stress in neurodegenerative diseases. Chondrogianni, N. Proteasome activation delays aging in vitro and in vivo. Cillard, J. Clark, I. Free radical-induced pathology. Cobley, J. Redox Biol. Conti, V. Antioxidant supplementation in the treatment of aging-associated diseases.

Cortat, B. The relative roles of DNA damage induced by UVA irradiation in human cells. Curi, R. Regulatory principles in metabolism-then and now.

Da Pozzo, E. Antioxidant and antisenescence effects of bergamot juice. Danielson, S. Davalli, P. ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases. De Bont, R. Endogenous DNA damage in humans: a review of quantitative data.

Mutagenesis 19, — Delcambre, S. Buhlman Cham: Springer. Di Meo, S. Role of ROS and RNS sources in physiological and pathological conditions. Docea, A. Food Chem. Immunohistochemical expression of TGF beta TGF-β , TGF beta receptor 1 TGFBR1 , and Ki67 in intestinal variant of gastric adenocarcinomas.

Duarte, T. Review: when is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C. Egea, J. European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM EU-ROS.

Elahi, M. Oxidative stress as a mediator of cardiovascular disease. Ertani, A. Biological activity of vegetal extracts containing phenols on plant metabolism. Molecules Esper, R. Endothelial dysfunction: a comprehensive appraisal. Fan, J. Quantitative flux analysis reveals folate-dependent NADPH production.

Nature , — Fenga, C. Fernández-García, E. Carotenoids bioavailability from foods: from plant pigments to efficient biological activities. Food Res. Finkel, T. Oxidant signals and oxidative stress.

Cell Biol. Signal transduction by reactive oxygen species. Oxidants, oxidative stress and the biology of ageing. Firuzi, O. Antioxidant therapy: current status and future prospects.

Forcados, G. Oxidative stress and carcinogenesis: potential of phytochemicals in breast cancer therapy. Cancer 69, — Forman, H. Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Care Med. Forni, C. Beneficial role of phytochemicals on oxidative stress and age-related diseases.

BioMed Res. Fountoucidou, P. A mixture of routinely encountered xenobiotics induces both redox adaptations and perturbations in blood and tissues of rats after a long-term low-dose exposure regimen: The time and dose issue. Galati, G. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.

Gandhi, S. Mechanism of oxidative stress in neurodegeneration. Gaziano, J. Jama , 52— Gebicka, L. Catalytic scavenging of peroxynitrite by catalase. Glasauer, A. Targeting antioxidants for cancer therapy.

Goodman, M. Clinical trials of antioxidants as cancer prevention agents: past, present, and future. Grigoras, A. Catalase immobilization—A review. Gutteridge, J. Free radicals and antioxidants in the year A historical look to the future.

Hamanaka, R. Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Hare, J. Hasanuzzaman, M. Glutathione in plants: biosynthesis and physiological role in environmental stress tolerance. Plants 23, — He, F.

Redox roles of reactive oxygen species in cardiovascular diseases. Hernández-Almanza, A. Lycopene: progress in microbial production. Trends Food Sci. Herrera, B. Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes.

Homem de Bittencourt, P. Hsu, T. Activator protein 1 AP-1 - and nuclear factor kappaB NF-kappaB -dependent transcriptional events in carcinogenesis.

Hu, N. Reactive oxygen species regulate myocardial mitochondria through post-translational modification. Species 2, — Huai, J. Structural properties and interaction partners of familial ALS-associated SOD1 mutants. Hussain, T. Oxidative stress and inflammation: what polyphenols can do for us?

Imam, M. Antioxidants mediate both iron homeostasis and oxidative stress. Nutrients Jan, A. Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants. Jaramillo, M. The emerging role of the Nrf2-Keap1 signaling pathway in cancer.

Genes Dev. Jerome-Morais, A. Dietary supplements and human health: for better or for worse? Jomova, K. Advances in metal-induced oxidative stress and human disease.

Toxicology , 65— Kabe, Y. Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Kaminski, K. Kang, Y. Chen Y, and epstein PN. Suppression of doxorubicin cardiotoxicity by overexpression of catalase in the heart of transgenic mice.

Karam, B. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Kimura, S. Black garlic: a critical review of its production, bioactivity, and application.

Food Drug Anal. Klein, E. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial SELECT. Jama , — Kocot, J. Does vitamin C influence neurodegenerative diseases and psychiatric disorders? Kostoff, R. Adverse health effects of 5G mobile networking technology under real-life conditions.

Kucukgoncu, S. Alpha-lipoic acid ALA as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Kumar, S. Chemistry and biological activities of flavonoids: an overview.

World J. Kurutas, E. Lamy, M. Vincent Berlin: Springer , 83— Lazzarino, G. Water- and fat-soluble antioxidants in human seminal plasma and serum of fertile males. Antioxidants Lee, I. Jama , 56— Lee, S. Cellular factories for coenzyme Q10 production.

Cell Fact. Li, H. Vascular oxidative stress, nitric oxide and atherosclerosis. Li, J. Oxidative stress and neurodegenerative disorders. Li, W. Liang, X. Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of drp1-mediated maladaptive mitochondrial fission.

Liguori, I. Sarcopenia: assessment of disease burden and strategies to improve outcomes. Aging Lin, J. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial.

Cancer Inst. Liou, G. Mutant KRas-induced mitochondrial oxidative stress in acinar cells upregulates EGFR signaling to drive formation of pancreatic precancerous lesions. Cell Rep. Liu, Z. Bridging free radical chemistry with drug discovery: a promising way for finding novel drugs efficiently.

Lü, J. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. Mach, F. CD40 signaling in vascular cells: a key role in atherosclerosis? Atherosclerosis Suppl. Mahajan, L. Alteration in thiols homeostasis, protein and lipid peroxidation in renal tissue following subacute oral exposure of imidacloprid and arsenic in Wistar rats.

Marchitti, S. Ultraviolet radiation: cellular antioxidant response and the role of ocular aldehyde dehydrogenase enzymes. Eye Contact Lens Marti, R.

Tomato as a source of carotenoids and polyphenols targeted to cancer prevention. Cancers Meybodi, N. Phytochemicals in Cancer prevention: a review of the evidence. Cancer Manag. Miltonprabu, S. Mishra, A. Programmed Cell death, from a cancer perspective: an overview. Murr, C.

Antioxidants may increase the probability of developing allergic diseases and asthma. Hypotheses 64, — Niedzielska, E. Nussbaum, L. tefãnescu, R.

Modern treatment approaches in psychoses. Pharmacogenetic, neuroimagistic and clinical implications. Farmacia 65, 75— Oke, G. Zingiber officinale Roscoe mitigates CCl4-induced liver histopathology and biochemical derangements through antioxidant, membrane-stabilizing and tissue-regenerating potentials.

Padureanu, R. Oxidative stress and inflammation interdependence in multiple sclerosis. Panic, N. Carotenoid intake from natural sources and colorectal cancer: a systematic review and meta-analysis of epidemiological studies.

Cancer Prev. Papa, S. The oxidative phosphorylation system in mammalian mitochondria. Park, L. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein.

Park, M. Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases. Pasinelli, P. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.

Neuron 43, 19— Payne, B. Mitochondrial dysfunction in aging: much progress but many unresolved questions. Peake, J. Neutrophil activation, antioxidant supplements and exercise-induced oxidative stress.

Pei, Z. Inhibition of advanced glycation endproduct AGE rescues against streptozotocin-induced diabetic cardiomyopathy: role of autophagy and ER stress. Perera, N. Manganese-superoxide dismutase MnSOD , a role player in seahorse Hippocampus abdominalis antioxidant defense system and adaptive immune system.

Fish Shellfish Immunol. Perrotta, I. The role of oxidative stress and autophagy in atherosclerosis. Pingitore, A. Exercise and oxidative stress: potential effects of antioxidant dietary strategies in sports.

Nutrition 31, — Pizzino, G. Oxidative stress and DNA repair and detoxification gene expression in adolescents exposed to heavy metals living in the Milazzo-Valle del Mela area Sicily. Oxidative stress: harms and benefits for human health.

Poli, G. Oxidative stress and cell signalling. Poole, L. Distribution and features of the six classes of peroxiredoxins. Cells 39, 53— Poprac, P. Targeting free radicals in oxidative stress-related human diseases.

Trends Pharmacol. Prochazkova, D. Antioxidant and prooxidant properties of flavonoids. Fitoterapia 82, — Ramsay, R. Electron carriers and energy conservation in mitochondrial respiration. Texts Rasouli, H.

Plant cell cancer: may natural phenolic compounds prevent onset and development of plant cell malignancy? A literature review. Ray, P. Reactive oxygen species ROS homeostasis and redox regulation in cellular signaling. Reddy, P. CNS Spectr. Reid, M. Ren, J. Too much or not enough of a good thing—The Janus faces of autophagy in cardiac fuel and protein homeostasis.

Reuter, S. Oxidative stress, inflammation, and cancer: how are they linked? Riederer, P. Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains. Rodriguez, R. Balancing the generation and elimination of reactive oxygen species. Roychoudhury, S. Potential role of green tea catechins in the management of oxidative stress-associated infertility.

Online 34, — Saccon, R. Is SOD1 loss of function involved in amyotrophic lateral sclerosis? Brain , — Sackesen, C. A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma.

Allergy Clin. Saez, I. The mechanistic links between proteasome activity, aging and age-related diseases. Genomics 15, 38— Sage, E. Unravelling UVA-induced mutagenesis.

Saha, S. Correlation between oxidative stress, nutrition, and cancer initiation. Salehi, B. Avocado—soybean unsaponifiables: a panoply of potentialities to be exploited. Biomolecules Cucurbits plants: a key emphasis to its pharmacological potential.

Plant-derived bioactives in oral mucosal lesions: a key emphasis to curcumin, lycopene, chamomile, aloe vera, green tea and coffee properties.

Epibatidine: a promising natural alkaloid in health. Veronica Plants—Drifting from farm to traditional healing, food application, and phytopharmacology. Antioxidants: positive or negative actors? Sani, T. Cytotoxic and apoptogenic properties of Dracocephalum kotschyi aerial part different fractions on calu-6 and mehr lung cancer cell lines.

Farmacia 65, — Sanjust, E. Mediterranean shrubs as potential antioxidant sources. Schottker, B. BMC Med. Ściskalska, M. The influence of the occupational exposure to heavy metals and tobacco smoke on the selected oxidative stress markers in smelters. Trace Element Res.

Sena, L. Physiological roles of mitochondrial reactive oxygen species. Cell 48, — Seo, M. Sharifi-Rad, J. Diet, lifestyle and cardiovascular diseases: linking pathophysiology to cardioprotective effects of natural bioactive compounds.

Public Health Sharifi-Rad, M. Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics.

In vitro and in vivo assessment of free radical scavenging and antioxidant activities of Veronica persica Poir. Sharma, P. reactive oxygen species, oxidative damage, and antioxidative defense mechanism in plants under stressful conditions.

Singh, R. Pathogenesis of atherosclerosis: a multifactorial process. Singh, Y. Structure and antioxidant superoxide dismutase activity of copper II hydrazone complexes. Polyhedron , 1— Smith, M.

Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Health Perspect. Sova, H. Cancer , — Spitz, D. Cancer Metast. Ionizing Radiation-Induced Responses: Where Free Radical Chemistry Meets Redox Biology and Medicine. Rochelle, NY: Mary Ann Liebert, Inc.

Tafazoli, A. Coenzyme Q10 in breast cancer care. Future Oncol. Takalo, M. Protein aggregation and degradation mechanisms in neurodegenerative diseases. Taverne, Y. Reactive oxygen species and the cardiovascular system.

Tovmasyan, A. A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics. Tsatsakis, A. A mechanistic and pathophysiological approach for stroke associated with drugs of abuse.

Hormetic Neurobehavioral effects of low dose toxic chemical mixtures in real-life risk simulation RLRS in rats. Tse, G. Reactive oxygen species, endoplasmic reticulum stress and mitochondrial dysfunction: the link with cardiac arrhythmogenesis.

Tsoukalas, D. Discovery of potent telomerase activators: unfolding new therapeutic and anti-aging perspectives. Association of nutraceutical supplements with longer telomere length. Targeted metabolomic analysis of serum fatty acids for the prediction of autoimmune diseases.

Valavanidis, A. Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles.

Public Health 6, — Valko, M. Free radicals and antioxidants in normal physiological functions and human disease. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Wang, X. Selective neuronal vulnerability to oxidative stress in the brain.

Aging Neurosci. Watson, R. Melatonin in the Promotion of Health , 2nd Edn. Wattanapitayakul, S. Oxidative pathways in cardiovascular disease: roles, mechanisms, and therapeutic implications. Wu, N. Physical exercise and selective autophagy: benefit and risk on cardiovascular health.

Cell Wu, X. Effects of major ozonated autoheamotherapy on functional recovery, ischemic brain tissue apoptosis and oxygen free radical damage in the rat model of cerebral ischemia.

Ye, G. Catalase protects cardiomyocyte function in models of type 1 and type 2 diabetes. Diabetes 53, — Young, A. Antioxidant and prooxidant properties of carotenoids.

Zal, F. The combined effect of furosemide and propranolol on GSH homeostasis in ACHN renal cells. Methods 24, — Zhang, J. Lipoic acid in the prevention of acute kidney injury.

Nephron , — Zhang, W. Zhou, H. Empagliflozin rescues diabetic myocardial microvascular injury via AMPK-mediated inhibition of mitochondrial fission. Zhu, X. Zucca, P. Biological activities and nutraceutical potentials of water extracts from different parts of cynomorium coccineum L.

Maltese Mushroom. Polish J. Food Nutr. l Sci. Biomimetic metalloporphines and metalloporphyrins as potential tools for delignification: molecular mechanisms and application perspectives. A Chem. Keywords : reactive oxygen species, oxidative stress, natural antioxidants, neurological disorders, cardiovascular diseases, cancer, aging, antioxidant defense.

Citation: Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, Tsouh Fokou PV, Azzini E, Peluso I, Prakash Mishra A, Nigam M, El Rayess Y, Beyrouthy ME, Polito L, Iriti M, Martins N, Martorell M, Docea AO, Setzer WN, Calina D, Cho WC and Sharifi-Rad J Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases.

Received: 16 April ; Accepted: 27 May ; Published: 02 July Copyright © Sharifi-Rad, Anil Kumar, Zucca, Varoni, Dini, Panzarini, Rajkovic, Tsouh Fokou, Azzini, Peluso, Prakash Mishra, Nigam, El Rayess, Beyrouthy, Polito, Iriti, Martins, Martorell, Docea, Setzer, Calina, Cho and Sharifi-Rad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

No use, distribution or reproduction is permitted which does not comply with these terms. cl ; Daniela Calina, calinadaniela gmail. com ; William C.

Cho, williamcscho gmail. com ; Javad Sharifi-Rad, javad. sharifirad gmail. Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

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Sections Sections. About journal About journal. Article types Author guidelines Editor guidelines Publishing fees Submission checklist Contact editorial office. REVIEW article Front. This article is part of the Research Topic Oxidative Stress and Neural Inflammation in Peripheral Nervous System View all 4 articles.

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases. When there are more free radicals present than can be kept in balance by antioxidants, the free radicals can start doing damage to fatty tissue, DNA, and proteins in your body.

Proteins, lipids, and DNA make up a large part of your body, so that damage can lead to a vast number of diseases over time. These include:. Everyone produces some free radicals naturally in their body through processes like exercise or inflammation.

However, there are things you can do to minimize the effects of oxidative stress on your body. The main thing you can do is to increase your levels of antioxidants and decrease your formation of free radicals. Eating five servings per day of a variety of fruits and vegetables is the best way to provide your body what it needs to produce antioxidants.

Examples of fruits and vegetables include:. Other healthy lifestyle choices can also prevent or reduce oxidative stress.

Here are some lifestyle choices that will help:. Oxidative stress can cause damage to many of your tissues, which can lead to a number of diseases over time.

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Brain fog is a symptom of another medical condition.

Chronic inflammation refers to a response by your immune system that sticks around long after infection or injury.

Learn the common symptoms and…. Inflammation is one way your body fights infection, injury, and disease. Sometimes inflammation can become a painful problem. Your doctor can perform…. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Everything You Should Know About Oxidative Stress.

Medically reviewed by Timothy J. Legg, PhD, PsyD — By Megan Dix, RN, BSN — Updated on September 29, Effects Risk factors Prevention Takeaway Oxidative stress is an imbalance between free radicals and antioxidants in your body. Effects of oxidative stress on the body. What are the risk factors?

Managing and preventing oxidative stress. The takeaway. How we reviewed this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations.

Oxudative has the strictest sourcing guidelines oxidatiev the strews industry and we almost sttess link to oxidative stress and health peer-reviewed Unsafe diet methods, usually on PubMed. We believe that the most accurate information oxidative stress and health found directly in aand scientific source. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. The increase in the formation oxidatkve reactive oxygen oxidatie reactive nitrogen jealth of endogenous or exogenous origin causes oxidative stress and health stress oxirative to haelth and antioxidant hewlth that causes cellular oxidztive in metabolism. This can increase inflammation Personalized weight guidance cells, apoptosis and necrosis, sfress to DNA oxidative stress and health damage, DNA and hdalth cross-links, oxidatkve membrane peroxidation, and oxidative stress and health dysfunction. Antioxidants can be described as a Joint strength support that protects biomolecules and the organism against the harmful effects of free radicals, reduces or repairs the damage done by reactive oxygen species ROS to the target molecule, and this is called antioxidant defense. Oxidative stress can be defined as an oxidative imbalance stemming from the inability to detoxify there reactive products, which are formed by the production of reactive oxygen species ROS during cellular metabolism [ 1 ]. The increase in free radicals formed as a result of biological oxidation causes disruption in the structure and functions of intracellular proteins, membrane damage due to polyunsaturated fatty acid peroxidation with lipids, nucleic acid base modifications and chromosome changes DNA single-strand and double-strand breaks, DNA and protein cross-links and cell death and oxidative damage to cellular structures and components such as polysaccharide depolymerization and carbohydrate degeneration [ 2 ].