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The 8 Benefits of Alpha-Lipoic AcidAfonso V, Champy Alpha-lipoic acid and joint health, Mitrovic D, Collin P, Lomri Wcid Reactive oxygen species and superoxide dismutases: hoint in joint diseases.
Joint Bone Spine 74, Bhowmick K, Alpha-lipoic acid and joint health G, Game world fueling stop NS, Moideen Hwalth, Sheety HV Alpba-lipoic Free radical and antioxidant Nutrient-rich weight loss in rheumatoid arthritis.
Indian Journal of Heath 3, Capitanescu Energy boosting snacks, Simionescu C, Margaritesu C, Stepan A, Ciurea R Clinical and morphological aspects Alpha-lipiic sinovitis early rheumatoid aciid.
Current Jojnt Sciences Journal 37, Alpna-lipoic Chen L, Bao B, Wang N, Xie J, Joinnt W Pharmaceuticals 5, ad Dubey S and Adebajo AO Historical afid current axid on Vegan party food options Alpha-lipoic acid and joint health osteorthritis Apha-lipoic rheumatoid arthritis.
In: Reid DM Aplha-lipoic Miller CG eds. Clinical Trials in Rheumatoid Alpha-lipoic acid and joint health and Osteoarthritis, London, Springe, jealth Emery Respiratory health for seniors Pocket Reference to Early Rheumatoid Arthritis, London, Springer Healthcare, heatlh Golbidi S, Badran M, Increase athletic agility I Diabetes and alpha qcid acid.
Frontiers in Pharmacology 2, Haywood L and Walsh D Fasting and inflammation reduction Vasculature of the normal and arthritis synovial joint.
Histology and Histopathology Cellular and Molecular Biology 16, Henrotin Healrh, Alpha-lipoic acid and joint health P, Pujol JPL The role of reactive healtg species in homeostasis and Alpha-lipoic acid and joint health of cartilage.
Osteoarthritis and Cartilage 11, Yoga for weight loss Ishibashi T Micronutrients for young athletes hydrogen: new antioxidant Alpha-lipolc anti-inflammatory therapy for rheumatoid arthritis and related heqlth.
Current Pharmaceutical A,pha-lipoic 19, BCAA supplements online S, Mehta HC, Sood AK, Alpha-lipoic acid and joint health, Halth J Alpha-lipoic acid and joint health Antioxidant ane in rheumatoid arthritis and Alphx-lipoic of heaoth Alpha-lipoic acid and joint health.
Afid Chimica Acta Malemud CJ amd Intracellular healty pathways join rheumatoid arthritis. Journal of Clinical and Cellular Immunology 4, Koint P and Alpha-lipoic acid and joint health J Diagnosis heqlth rheumatoid arthritis at an early stage.
In: Bouysset M, Tourne Y, Tillmann K eds. Foot and Ankle in Rheumatoid Arthritis, Berlin, Springer-Verlag, p Mirshafiey A and Mohsenzadegan M The role of reactive oxygen species in immunopathogenesis of rheumatoid arthritis.
Iranian Journal of Allergy, Asthma and Immunology 4, Mirtaheri E, Gargari BP, Kolahi S, Dehghan P, Asghari-Jafarabadi M, Hajalilou M, Novin ZS, Abbasi MM Effects of alpha lipoic acid supplemetation on inflammatory biomarkers and matrix metalloproteinase-3 in rheumatoid arthritis patiens.
Journal of the American College of Nutrition 34, Mor A, Abramson SB, Pillinger MH The fibroblast-like synovial cell in rheumatoid arthritis: a key player in inflammation and joint destruction.
Clinical Immunology Orhan CE, Onal A, Uyanikgil Y, Ulker S Antihyperalgesic and antiallodynic effect of sirolimus in rat model of adjuvant arthritis. European Journal of Pharmacology Saxena R Arthritis as a disease of aging and changes in antioxidant status. In: Preedy VR ed.
Aging: Oxidative Stress and Dietary Antioxidants, London, Academic Press, p Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.
Biochimica et Biophysica Acta BBA -General Subjects Snekhalatha U, Anburajan M, Venkatraman B, Menaka M Zeitschrift für Rheumatologie 4, Stadtman ER and Berlett BS Reactive oxygen-mediated protein oxidation in aging and disease.
In: Gilbert DL and Colton CA eds. Reactive Oxygen Species in Biology Systems: An Interdisciplinary Approach, New York, Kluwer Academic Publishers, p Wahl K and Schuna AA Rheumatoid arthritis. In: Dipiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM eds.
Pharmacotherapy: A Pathophysiologic Approach, New York, Mc Graw Hill, p Waldburger J and Firestein GS Signaling pathways in rheumatoid arthritis. In: Tak P ed. New Therapeutic Targets in Rheumatoid Arthritis, Switzerland, Birkhauser Verlag, p Zhang R and Ren K Animal models of inflammatory pain.
In: Ma C and Zhang J eds. Animal Models of Pain, London, Humana Press, p Quick jump to page content. Home Archives Vol. Selvi Megawati. Mahardian Rahmadi.
Imam Susilo. Junaidi Khotib Junaidi-k ff. id Primary Contact. Article Sidebar. Submitted 26 July Accepted 26 July Published 8 August Read Counter : Download : Main Article Content Abstract Rheumatoid arthritis RA is an autoimmune diseases which is characterized by chronic inflammation of the synovial tissue in joints.
ALA was administered orally once a day for 7 days at 30, 60 and mg doses a week after CFA injection. The severity of arthritis was evaluated by joint diameter and latency time on thermal stimulation. Joint diameter and latency time on thermal stimulation will measured on day 0, 3, 5, 7, 10, 12 and Measurement of malondialdehyde MDA level in plasma was performed using thiobarbituric acid TBA method to assess lipid peroxidation.
Histology of joint was examined by microscope following hematoxylin-eosin staining. Measurement of MDA in CFA group and ALA group had no significant difference. Histological staining indicated that the recovery of the synovial membranes of joint in ALA group had no effect.
Results indicated that ALA has the effect to suppress the development of inflammation in RA but not through oxidative stress pathway. How to Cite. Megawati, S.
: Alpha-lipoic acid and joint health| Alpha-Lipoic Acid – Diabetes + Nerve Pain + Weight Support | Shay, K. First, PαLA was prepared by a reaction between αLA with diethyl ether. Biochimica et Biophysica Acta BBA -General Subjects , Snekhalatha U, Anburajan M, Venkatraman B, Menaka M Neuropathic pain is the medical term used to describe the pain, numbness, and abnormal sensations caused by nerve damage. RAW cells were further examined by CLSM Figure 5C. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Drug Deliv. |
| Publication types | It sort of crept up on me. So now Hewlth have spinal pain and Neuropathy pain. Iman Vitamins Halal Melatonin Gummies 2. Read full return policy. In: Ma C and Zhang J eds. KolahiP. |
| Polyethylene Glycol-grafted poly alpha-lipoic acid-dexamethasone nanoparticles for osteoarthritis | What is ad feedback? Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential. Diabetol Metab Syndr. Free radical and antioxidant status in rheumatoid arthritis. com About Us Style Guide. Alpha-lipoic acid has been studied for other benefits, including:. |
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Sleep Support, Halal, delayed sleep support, Non-Habit Forming. Brief content visible, double tap to read full content. Full content visible, double tap to read brief content. Help others learn more about this product by uploading a video!
Important information Directions For adults, take one 1 capsule daily, preferably with a meal. Legal Disclaimer Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
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There was a problem filtering reviews right now. Please try again later. Verified Purchase. A neurologist recommended this to help with my diabetic neuropathy foot pain.
I take it in the evenings and it helps tremendously with foot pains and cramping during the night. This works as good as the brand I first bought for much more money at Walgreens. It has also helped a friend who suffers from plantar fasciitis.
I was just told by my doctor to start taking Alpha Lipoic Acid for a condition I am suffering from. When I went to the pharmacy to get some I was flabbergasted by the high price they were charging. Doctors do not understand people on limited funds.
There was no way I was going to pay that price. I did not give up. I surfed the net and found "We Like Vitamins". Thank you "We Like Vitamins"! Size: Count Pack of 1 Verified Purchase. Keeps me in complete balance. Twelve years ago I was diagnosed with Parkinson's Disease.
The reason I mention that fact is because of the side affects associated with that ailment. The first thing that happened was I became unable to exercise properly. Before the diagnosis I was running four times a week and at least twice a week in the gym weight training.
It took about two years before I was forced to give up all exercise and shortly after began gaining weight. A lot of weight. Fortunately I hooked up with a nutritionist and learned to eat less and healthier.
Unfortunately, not before I was diagnosed with Diabetes and was placed on Insulin. The second complication was Spinal Stenosis which caused quite a bit of pain. I ended up calling the number you see advertised on TV and went with not one but two so called non invasive surgeries.
The end result was the surgeries didn't work and the only other option other than Opioids, was Steroid injections which my body rejected and caused the Diabetes to go out of control. As everyone now knows Opioid medication isn't the answer either and was placed on a well thought out NSAID therapy.
For those who don't know what that is Nonsteroidal anti-inflammatory drugs. Aspirin being the most common. I was fortunate to have this medicine work and the pain relief was pretty good but on occasion had the Opioids as back up. Just about two years ago my doctor of over thirty years retired and I found a new physician who was sympathetic to my pain.
After a full physical and many blood tests as well as a consult with a Pain Management group he accepted me into his practice.
The first thing he did was to take away the NSAID medication as my blood work came back showing kidney failure. Not more than a month past when I awoke with a new problem. My feet and fingers felt like they were on fire and became numb some of the time.
Diagnosis was Diabetic Peripheral Neuropathy and it seemed as it was getting worse every day. Another Pain Management consult and I was placed on Lyrica. The starting dose was Mg and after a few months was increased to Mg.
The pain didn't go away completely but was greatly reduced. Things certainly were getting better. I felt so well I was actually looking forward to waking up and planning a full day of activities.
What I didn't recognize was the amount of sleep I was getting, the heavy weight gain and the amount of tears running down my face and for no reason. My daughter did notice something not right and contacted my doctor who immediately brought me in and of course reduced the Lyrica dosage until I was completely off the medication.
It didn't take long before the pain came back. So now I have spinal pain and Neuropathy pain. On the next office visit, three months later, the doctor's Physician Assistant sat with me and we chatted about the possibility of a complete new approach to helping with the pain. The minute she said " Vitamin Therapy " I chuckled but she wasn't laughing with me.
It's called Holistic Medicine she told me. Healing that considers the whole person. Body, mind, spirit and wellness. A proper balance in life. Now I'm just about seventy years old and as the saying goes, you can't teach an old dog new tricks, was pretty much my philosophy.
So after some additional research on her end and some understanding on my end we discussed a treatment of Alpha Lipoic Acid and a Vitamin B- Complex.
Not available in the States as prescription it is available at Vitamin specialty stores and drug stores and of course here at Amazon. On June 28th I received a bottle of Mg Alpha Lipoic Acid and a bottle of Nature Made Super B Complex.
The B Complex was horrible smelling and made me gag but the Alpha Lipoic Acid had no odor nor taste and being a capsule very easy to swallow.
Now the dosage recommended by the Manufacturer is Mg but the Physician's Assistant started me on Mg. Its been just over two weeks now and I can honestly state there is improvement in the foot and finger pain.
It's not completely gone but it definitely has been reduced. The plan now is to see how much further the pain can be reduced. If and once the pain is eliminated the dosage will be reduced to Mg. It sort of crept up on me. I was so involved with the foot and finger pain I really didn't recognize the back pain was reduced.
It was while sitting in front of my computer for over three hours without too much discomfort I became aware. I would usually be looking to stretch out after about an hour.
It is definitely helping. Now I'm not going to state the supplement will be helpful to everyone. Medicine, not prescribed nor supplement, works that way. There is also the fact that I have just started using this supplement.
I'm hoping for complete elimination of all pain but I'm very acceptive to what it has brought so far. Soon after I started writing this review I began my independent research of The Alpha Lipoic Acid. The facts are quite interesting. This treatment has been very popular in Europe.
Germany, England and France are still investigating the use of the supplement. In England it's the first treatment physicians turn to for not only Diabetic pain but as a treatment for lower back pain, Dementia, control of sugar levels in Diabetes and other ailments.
I would suggest anyone considering the use of the supplement to do their own research. There is so much available. In addition, taking into account the functional disability-associated obesity in RA patients, if an agent has also potential lowering effects on weight, it will be noteworthy to be studied as an adjuvant therapy in RA.
Given the drug side effects Wood et al. Use this link to get back to this page. Effects of alpha-lipoic acid supplementation on clinical status and anthropometric indices in women with rheumatoid arthritis. Authors: B. Pourghasem Gargari , S. Kolahi , P. Dehghan , A. Khabbazi and E. Date: Feb. From: Current Topics in Nutraceutical Research Vol.
Finally, using an LSM CLSM microscope Carl Zeiss, Jena, Germany with a eyepiece objective lens, microscopic images of cell uptake were obtained. For FCM analysis, activated RAW Following that, the medium was removed, and the cells were washed three times with PBS, digested with trypsin, and centrifuged for 5 minutes to collect the cells.
Finally, they were suspended in μL PBS, and the fluorescence intensity of cell uptake was measured using a Guava EasyCyte 12 flow cytometer Millipore, Billerica, MA, United States.
The concentration in the medium containing DXM was from 0. Following that, The expression of proinflammatory cytokines were determined by enzyme-linked immunosorbent assay ELISA in activated RAW RAW After 24 h, IL-1β, TNF-α, and IL-6 levels in the supernatants were determined using ELISA kits Spark ® multimode microplate reader, TECAN, Switzerland.
Louis, MO, United States of America in mice Chung et al. The successful induction of OA was confirmed by significantly reducing the load-bearing and withdrawal point stimulus thresholds of the hind paw Bove et al. Mice without OA induction were used as a negative control.
The OA knee was tested by intraarticular injection in each group. Day zero was the first day of treatment. All groups were given treatments every 4 days until the mice were put down at the end of the third week. The knee joint was harvested and treated for further analysis after the animals were killed.
Next, the decalcified specimens were buried in paraffin and cut into 5 μm sections. Knee specimens were also used to assess the shape of the knee and to measure skeletal characteristics with Micro CT. All results are presented as the means ± standard deviations, and the important statistical data were analyzed using one-way ANOVA in the GraphPad Prism Software GraphPad Software Inc.
As shown in Figure 2A , PαLA was synthesized by ring-opening polymerization of the aLA monomer at 80°C. The structure of PαLA was confirmed by 1 H NMR. The mPEG-g-PαLA polymer was created by esterifying the hydroxyl group of mPEG with the carboxyl group of PαLA and coupling the mPEG with the PαLA side chain.
As shown in Figure 2B , the positions of the proton peaks H, I, and J of polymer mPEG-g-PαLA in the 1 H NMR spectrum indicate that mPEG has successfully connected with the P αLA side group. In addition, the structure of the product was analyzed by gel permeation chromatography GPC. The peak time of GPC in Figure 2C is In summary, this means that mPEG successfully connects to the side chain of PαLA.
FIGURE 2. A Polymerization of αLA and 1 H NMR spectra of PαLA DMSO-D6 B 1 H NMR spectra of PαLA DMSO-D6 of mPEG-g-PαLA DMSO.
C GPC analysis of DMF phase of mPEG-g-PαLA. The Rh of NP PPLA measured by DLS was Due to the amphiphilic properties of polymers, drug delivery efficiency is improved. And can maintain the shaped structure for a long time. FIGURE 3. A Sizes of NP PPLA measured by DLS and TEM images of NP PPLA.
During the development of OA, activated macrophages are relevant to the unregulated expression of matrix metalloproteinases MMPs , proinflammatory cytokines, and other tissue-degrading enzymes Bondeson et al. It has been reported that matrix metalloproteinases break ester bonds Xia et al.
Figure 4 depicts the results. When the pH is 7. The amount of DXM released increased significantly as the concentration of H 2 O 2 in the release medium increased. FIGURE 4. When activated RAW In contrast, activated RAW showed an extremely low fluorescence signal.
NP PPLA or non-LPS-activated RAW Was applied to 7 cells. RAW cells were further examined by CLSM Figure 5C. DAPI nuclei were blue and Dio fluorescence was green. Dio is a lipophilic membrane dye that can only be diffused laterally into cells, staining the entire cell membrane gradually.
Green fluorescence surrounds blue fluorescence, indicating that the released Dio enters the cell, and green fluorescence intensity increases significantly over time. The results were consistent with the FCA results.
FIGURE 5. A FCA of RAW The average fluorescence intensity of Dio at each time point was detected. B FCA of RAW The average fluorescence intensity of Dio at each time point was detected C Confocal scanning microscope images of RAW PPLA was non-toxic to RAW αLA, a natural antioxidant synthesized in the human body, does not affect RAW In addition, the poor solubility of DXM may be responsible for the decreased inhibition of RAW This may be due to the endocytosis of nanoparticles by macrophages.
FIGURE 6. The MIA model is the most successful and frequent OA model, and its pathological characteristics are very similar to human OA Pomonis et al. OA mice were injected with drugs of each group at a weight of kg every 4 days.
Mice without OA induction were set as a control group. The degree of articular cartilage destruction, extracellular matrix loss, and changes in inflammatory cytokines IL-1β, IL-6, and TNF-α was measured after treatment.
FIGURE 7. Proinflammatory cytokines expressed by macrophages have been shown to play an important role in the early stages of OA and in promoting disease progression Blanco et al.
Inhibiting the release of proinflammatory cytokines in OA tissue therefore can effectively reduce the degree of cartilage damage Agarwal et al. Next, we evaluated the knee bone structure of OA mice by Micro CT. FIGURE 8. It also revealed good stability under physiological conditions.
Finally, synovial inflammation was reduced in the OA mice model, and cartilage destruction and bone loss were inhibited, which was closer to the knee joint of the control mice.
At present, the research on drug delivery, targeting, controlled release and other aspects is the forefront of drug delivery systems. In this study, drug delivery nanoparticles were prepared by simple and easy methods, achieving a more stable drug controlled release, which has a certain anti osteoarthritis effect, providing a certain reference for the development of more efficient drug delivery systems in the future.
The animal study was reviewed and approved by the Animal Ethics Committee of Jilin University. DsL, ZJ, YC, YX and JL contributed to conception and design of the study. ZJ, YC, YX, LiS performed the experiments. LS, YC, DbL and DsL analyzed data and interpreted results of experiments.
JL and YX provided resources. JL and DsL supervised the study. YC and LS wrote the original draft, ZJ, DbL, JL, YX reviewed and edited it. All authors contributed to manuscript revision and approved the submitted version.
This study supported by the Jilin Province Science and Technology Development Plan Project Grant No. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.
Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Agarwal, R.
Alpha-lipoic acid Alpha-lipoic acid and joint health an antioxidant made by ioint body. It is found in acjd cell, where Alpha-lipoic acid and joint health helps turn Multivitamin with iron into Alphq-lipoic. Antioxidants attack "free radicals," waste products created when the body turns food into energy. Free radicals cause harmful chemical reactions that can damage cells, making it harder for the body to fight off infections. They also damage organs and tissues. Other antioxidants work only in water such as vitamin C or fatty tissues such as vitamin E.
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Meiner Meinung nach ist es nicht logisch