Caffeine and liver health -
For example, in Finland and Japan instant coffee is the most popular type, and inverse associations with CLD outcomes have been reported in both those countries [ 23 , 26 ]. A meta-analysis of three studies reported inverse associations between decaffeinated coffee and HCC, though smaller in magnitude compared to caffeinated coffee [ 6 ].
A cohort study in the United States reported a lower risk of death from CLD among drinkers of two cups of decaffeinated coffee each day compared to none, even after adjustment for caffeinated coffee intake [ 9 ]. The observation of a protective effect of decaffeinated coffee is highly relevant to the development of a coffee-based intervention for preventing CLD onset or progression.
Caffeine intolerance may limit increases in coffee consumption, and thus decaffeinated coffee may be a preferable alternative. Given its well know safety profile and cheap cost, coffee has potential as widely accessible lifestyle intervention, even in low to middle-income countries.
A limitation is the observational cohort design, which cannot infer causation. There was a single timepoint of coffee consumption, and volumes and preferred types may have changed over the follow-up period. Cup sizes may also have varied. However, misclassification of coffee consumption would have pushed the effect size towards null and not explain our results.
There was also no data on ex-coffee drinkers, which may be relevant to reverse causation, as is discussed below. In addition, there may have been differences in chemical composition between coffees within the same type e. due to different processes for decaffeination.
The risk of confounding was reduced by making adjustments for baseline covariates, but these may have been assessed inaccurately or changed during follow-up. In relation to alcohol consumption, a key CLD risk factor, the assumptions used to convert drinks into units, such as the volume and alcohol content of each beverage, may have been inaccurate.
In addition, imputation of alcohol units was not used for missing data. The HRs adjusted for weekly units were similar to those adjusted for alcohol consumption frequency. While there may have been some residual confounding from alcohol, it is unlikely that this alone is responsible for the findings of this study.
Bias may have been introduced from incomplete adjustment for socio-economic status using Townsend deprivation index scores rather than individual level socioeconomic variables e. education [ 12 ].
This would have exaggerated the effect sizes because deprivation was associated with CLD and non-coffee drinkers were more deprived than coffee drinkers. There were small differences in proportions of ethnicities in the non-coffee drinking reference group compared to the coffee drinking groups.
Prevalence and aetiology of CLD is known to vary between ethnic groups [ 27 ], and this would have introduced bias if not fully accounted for by binary adjustment for white or other ethnicity.
The results were also not adjusted for waist circumference, which may be related to metabolic syndrome independently of BMI, or prediabetes. Other CLD risk factors not adjusted for included chronic infection with hepatitis B or C, though prevalence of these conditions was likely low in this UK volunteer cohort.
Some cases and non-cases may have been misclassified because of inaccuracies in the coded data used to ascertain outcomes.
Participants with an associated ICD code K nonalcoholic steatohepatitis, which corresponds to K While this assumption may have led to under-ascertainment of CLD cases, the risk of bias was likely small given the similar associations of all coffee types with CLD and CLD or steatosis.
Reverse causation was addressed by excluding diagnosed CLD at baseline. The presence of undiagnosed cases might have exaggerated the effect sizes if CLD resulted in coffee intolerance, and it was not possible to identify previous coffee drinkers in our non-coffee drinker category.
However, the protective effect of coffee was robust to exclusion of CLD outcomes in the first five years of follow-up, suggesting that any effect of reverse causation was small. It was not possible to fully assess the effects of very high levels of coffee consumption as the numbers of events in these categories were low.
Dose-response meta-analyses report protective effects up to around 5 cups each day with increasing uncertainty thereafter [ 6 , 7 ]. The results of this study may be limited by the demographics of the voluntary UK Biobank Cohort, who were predominantly white and likely over-representative of those from higher socio-economic groups.
As such, the findings may not generalise to populations with a very different ethnic and socio-economic composition. Confidence in the veracity of the observed inverse associations of coffee consumption with CLD outcomes is increased by several factors. These include the magnitude and significance of the effect sizes and the presence of a dose response.
In addition, residual confounding was likely to have led to underestimation of the effect sizes given that the adjusted HRs were generally larger in magnitude and significance than the unadjusted HRs, indicating coffee drinkers had a greater overall burden of known CLD risk factors.
There is biological plausibility of a protective effect of coffee against CLD outcomes. Caffeine is a non-selective antagonist of the A2aA receptor, activation of which stimulates collagen production by hepatic stellate cells, the primary mediators of fibrosis [ 28 , 29 ].
However, in the present study as well as in previous studies [ 6 ] decaffeinated coffee was also protective. Alternative active ingredients in coffee may include chlorogenic acid, kahweol and cafestol, which protect against liver fibrosis in animal studies [ 30 , 31 ].
Kahweol and cafestol are present in highest concentrations in ground coffee, which was most protective. Given the protective effects of the different coffee types with varying composition, there may be a complex relationship involving more than one active ingredient.
This study provides evidence of a protective effect of all types of coffee including decaffeinated against CLD outcomes. These findings are significant given the paucity of effective preventative and treatment strategies for CLD, especially in low to medium income countries, where the burden of CLD is highest.
Further work is now needed to replicate these findings using more robust methods, including Mendelian randomisation with a more powerful set of genetic variants to estimate coffee consumption than available previously.
Randomised trials should then investigate the efficacy of a coffee-based intervention in those at risk of CLD or its complications. Sepanlou SG, Safiri S, Bisignano C, Ikuta KS, Merat S, Saberifiroozi M, et al. The global, regional, and national burden of cirrhosis by cause in countries and territories, — a systematic analysis for the Global Burden of Disease Study Lancet Gastroenterol Hepatol.
Spearman CW, Sonderup MW. Health disparities in liver disease in sub-Saharan Africa. Liver Int. Article PubMed Google Scholar. Tsochatzis EA, Bosch J, Burroughs AK. Liver cirrhosis.
Lancet London, England. Article Google Scholar. Ponte S. Regulation, markets and consumption in the global coffee chain. World Dev ;— Ludwig IA, Clifford MN, Lean MEJ, Ashihara H, Crozier A. Coffee: biochemistry and potential impact on health. Food Funct.
Article CAS PubMed Google Scholar. Kennedy OJ, Roderick P, Buchanan R, Fallowfield JA, Hayes PC, Parkes J. Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose-response meta-analysis.
BMJ Open. Article PubMed PubMed Central Google Scholar. Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis.
Aliment Pharmacol Ther. Kennedy OJ, Roderick P, Poole R, Parkes J. Coffee, caffeine and non-alcoholic fatty liver disease? Ther Adv Gastroenterol. Article CAS Google Scholar. Setiawan VW, Wilkens LR, Lu SC, Hernandez BY, Le Marchand L, Henderson BE. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort.
Urgert R, van der Weg G, Kosmeijer-Schuil TG, van de Bovenkamp P, Hovenier R, Katan MB. Levels of the cholesterol-elevating Diterpenes Cafestol and Kahweol in various coffee brews.
J Agric Food Chem. UK Biobank. About UK Biobank. Accessed 13 June Mackenbach JP. Health and deprivation. Inequality and the North: by P. Townsend, P. Phillimore and A. Beattie eds. Croom Helm Ltd, London, pp. Health Policy New York. UK Data Service. Accessed 8 May Textor J, van der Zander B, Gilthorpe MS, Liskiewicz M, Ellison GT.
Int J Epidemiol. Lv Y-B, Gao X, Yin Z-X, Chen H-S, Luo J-S, Brasher MS, et al. Revisiting the association of blood pressure with mortality in oldest old people in China: community based, longitudinal prospective study.
Therneau T. A package for survival analysis in R. R Package Version. Google Scholar. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology STROBE statement: guidelines for reporting observational studies.
J Clin Epidemiol. Ding J, Zhang Y. Associations of coffee consumption with the circulating level of alanine aminotransferase and aspartate aminotransferase.
A meta-analysis of observational studies. J Am Coll Nutr. Liu F, Wang X, Wu G, Chen L, Hu P, Ren H, et al. Coffee consumption decreases risks for hepatic fibrosis and cirrhosis: a meta-analysis. PLoS One. Article CAS PubMed PubMed Central Google Scholar.
Wijarnpreecha K, Thongprayoon C, Thamcharoen N, Panjawatanan P, Cheungpasitporn W. Association of coffee consumption and chronic kidney disease: a meta-analysis. Int J Clin Pract. Wijarnpreecha K, Thongprayoon C, Ungprasert P. Impact of caffeine in hepatitis C virus infection: a systematic review and meta-analysis.
Eur J Gastroenterol Hepatol. During the study period, the sample contained 3, diagnoses of chronic liver disease, 5, cases of chronic liver disease or fatty liver disease, and cases of hepatocellular carcinoma.
There were deaths from chronic liver disease. For people who drank coffee from ground beans, the reduction in risk was even greater. A limitation of the study is that its sample consisted of white individuals from higher socioeconomic backgrounds, so its findings may not be universally applicable.
Biochemist Prof. The long-term risk and benefit in the study was so small, said Prof. You know what? It is of note that the study does not delve into the mechanics of why coffee is so beneficial to the liver. Adhami said that as a result of this study, he anticipates randomized controlled clinical trials that test various coffee molecules against liver disease.
This would be especially valuable in countries with lower income and worse access to healthcare and where the burden of chronic liver disease is highest. Many people worry that drinking coffee may cause cancer. This is because roasted coffee beans contain acrylamide.
Learn more here. Decaffeinated coffee, or decaf, is similar to regular coffee but contains very little caffeine. Research suggests that drinking decaf is not harmful….
Scientists have conducted a lot of research into the effects of caffeine in people with depression. This article explains the research and lists other…. Researchers from China have found an association between high dietary niacin vitamin B3 consumption and lower risk of all-cause and….
The report provides evidence that: Regularly drinking moderate amounts of coffee may prevent liver cancer — the World Health Organisation has recently confirmed this reduced risk after reviewing more than 1, studies in humans Coffee also lowers the risk of other liver conditions including fibrosis scar tissue that builds up within the liver and cirrhosis Drinking coffee can slow the progression of liver disease in some patients Beneficial effects have been found however the coffee is prepared — filtered, instant and espresso However, it is important to remember that although drinking coffee may protect you from developing liver disease and can in addition help those who already have some degree of liver damage — the key messages for good liver health remain reducing the amount of alcohol we drink, eating a good diet, drinking plenty of water, doing regular exercise and keeping to a healthy weight.
Useful Links Perk up your liver coffee morning Cirrhosis and liver disease Keeping a healthy weight Looking after yourself FAQs A well-balanced diet Back to diet and liver disease. Support us Hold a coffee break event with friends, family or colleagues. Find out more.
Raise vital funds and be kind to your liver at the same time!
Coffee contains hundreds Caffiene chemical Caffeine and liver health liveg comes in several ilver, and according to a recent study, Cafdeine a protective effect on liveg liver, no matter what the type. A recent report said all types of coffee—ground, instant, caffeinated, or decaffeinated—are protective against chronic liver diseaseOptimal nutrient timing problem Muscle preservation for preventing muscle atrophy is increasing worldwide. The study, published last month in BMC Public Healthwas conducted by researchers who noted that previous studies have indicated that drinkers of caffeinated coffee and, to a lesser extent, decaf drinkers appear to be somewhat shielded from hepatocellular carcinoma HCCcirrhosis and nonalcoholic fatty liver disease. In this report, they sought to determine the effects of different types of coffee, which contains hundreds of chemical compounds. The authors, from the Universities of Southampton and Edinburgh, studied UK Biobank data onparticipants who had a history of coffee consumption. They were followed over a median of In recent years, coffee has emerged Cafreine a liber ally in the battle against wnd Caffeine and liver health liver disease NAFLDa Caffeibe marked by the accumulation anr fat in the liver Cafceine to healtj Caffeine and liver health consumption. Research studies have unveiled Pet dander promising link between coffee consumption and a reduced risk of developing NAFLD, shedding light on the multifaceted benefits it offers for liver health. The liver, a vital organ responsible for various metabolic processes, is susceptible to damage from factors such as poor diet, obesity and sedentary lifestyles, which contribute to the onset and progression of NAFLD. Amidst this health landscape, coffee stands out as a potential shield, exhibiting several mechanisms that positively influence liver function and combat NAFLD. It enhances the breakdown of fat by activating enzymes involved in fat metabolism.
Caffeine and liver health -
Consuming around two to three cups of coffee per day has been associated with a significantly lower prevalence of NAFLD compared to non-coffee drinkers. Nevertheless, individual responses may vary, and moderation remains key, as excessive caffeine intake can lead to adverse effects such as increased heart rate and anxiety.
Studies suggest that regular coffee consumption may reduce the risk of liver cirrhosis, a late-stage liver disease characterised by irreversible scarring.
Additionally, coffee intake has been linked to a decreased risk of liver cancer, possibly due to its anti-inflammatory and antioxidant effects. But here are some cautionary notes. Watch out for the amount of sugar in your coffee. Consult healthcare professionals, especially if you have pre-existing medical conditions, on medications that might interact with caffeine.
The relationship between coffee and liver health continues to be an intriguing area of research, promising new insights into combating liver diseases.
As scientists delve deeper into this complex relationship, coffee might just prove to be not only a morning pick-me-up but also a powerful elixir safeguarding our liver. BCCI secretary Jay Shah stresses that all centrally contracted players must participate in domestic red ball tournaments upon request from selectors, coach, and captain.
However, the national cricket academy's guidance will be taken into consideration for players with physical limitations.
News Health and Wellness Why drinking coffee twice a day can protect your liver Premium. Written by Dr Priyanka Rohatgi November 20, IST.
Follow Us. Listen to this article Why drinking coffee twice a day can protect your liver. How does coffee shield the liver?
How much coffee is safe according to studies? Tags: Coffee. Post Comment. Jay Shah says centrally contracted players will have to play domestic red-ball cricket. Sports Updated: February 15, IST. View all shorts. India vs England Live Score, 3rd Test: Rohit Sharma and Co take on ENG at Rajkot; Toss, Playing XI updates 3 mins ago.
PM Modi UAE Visit Live Updates: PM Modi holds bilateral talks in Doha 47 mins ago. Farmers Protest Live Updates: Farm leaders' meeting with Central ministers tomorrow as Punjab-Haryana border remains tense 10 hours ago.
Mumbai News Live Updates: BJP, Shinde Sena choose Ashok Chavan, Milind Deora as Rajya Sabha poll candidates days after Cong exit 10 hours ago. Entertainment Teri Baaton Mein Aisa Uljha Jiya: Kriti Sanon's return to form shouldn't be overlooked as just another mainstream performance.
Entertainment The New Look review: Lavish Apple series revisits Dior and Chanel's origins, but works better as a WW II thriller.
The study, from researchers at the Universities of Southampton and Edinburgh in the United Kingdom, appears in the journal BMC Public Health. Worldwide, liver disease causes 2 million deaths annually, with 1 million people dying from complications of cirrhosis and another from viral hepatitis and hepatocellular carcinoma.
According to the study, the area most profoundly affected by liver disease is sub-Saharan Africa. Central and South America, Eastern Europe, and Southeast Asia follow. Liver disease risk factors include consuming alcohol , having overweight , and having diabetes.
Medical News Today spoke with Cleveland Clinic transplant hepatologist Dr. The authors of the study analyzed the UK Biobank health data of , people, following them for an average of Coffee drinkers consumed caffeinated, decaffeinated, ground, and instant coffee. During the study period, the sample contained 3, diagnoses of chronic liver disease, 5, cases of chronic liver disease or fatty liver disease, and cases of hepatocellular carcinoma.
There were deaths from chronic liver disease. For people who drank coffee from ground beans, the reduction in risk was even greater. A limitation of the study is that its sample consisted of white individuals from higher socioeconomic backgrounds, so its findings may not be universally applicable.
Biochemist Prof. The long-term risk and benefit in the study was so small, said Prof. You know what? It is of note that the study does not delve into the mechanics of why coffee is so beneficial to the liver.
Adhami said that as a result of this study, he anticipates randomized controlled clinical trials that test various coffee molecules against liver disease. This would be especially valuable in countries with lower income and worse access to healthcare and where the burden of chronic liver disease is highest.
Many people worry that drinking coffee may cause cancer. This is because roasted coffee beans contain acrylamide. Learn more here. Decaffeinated coffee, or decaf, is similar to regular coffee but contains very little caffeine.
Research suggests that drinking decaf is not harmful…. Scientists have conducted a lot of research into the effects of caffeine in people with depression. This article explains the research and lists other….
Researchers from China have found an association between high dietary niacin vitamin B3 consumption and lower risk of all-cause and…. Learn about cost and Generlac, financial and insurance assistance, ways to lower long-term costs, and more.
Hey live, coffee heapth — perk up! Caffeone you know that your daily cup of coffee Muscle preservation for preventing muscle atrophy halth fewcan impact your liver health? For Caffeine and liver health, the effects Roasted garlic recipes coffee consumption on the liver have been widely studied. The incidence of liver disease is at an all-time high in Canada. To learn more about coffee and your liver, call our National Help Line at or send us an email at clf liver. If you respond and have not already registered, you will receive periodic updates and communications from Canadian Liver Foundation.
Sehr gut, ich dachte als auch.
Ihre Mitteilung, einfach die Anmut
die Auswahl bei Ihnen schwer
Ich tue Abbitte, dass sich eingemischt hat... Mir ist diese Situation bekannt. Man kann besprechen. Schreiben Sie hier oder in PM.
JA, diese verständliche Mitteilung