Int J Organ Anthocyanins and liver health Anthocynains. Participants were excluded if they 1 were unable to Immune-boosting exercise down on livr exam table, Anghocyanins were pregnant or unsure if pregnant at the time of their exam, or a urine could not be obtained to test for pregnancy, 3 had an implanted electronic medical device, or 4 were wearing a bandage or had lesions on the right side of their abdomen by the ribs where measurements would be taken. Anthocyanin is one of the subclasses that have anti-inflammatory and antioxidant activities.

Anthocyanins and liver health -

In addition, no significant correlation was observed between all flavonoid subtypes and the risk of liver fibrosis.

The protective effect of higher levels of anthocyanin was more significant in patients who were non-Hispanic whites, without diabetes mellitus and with hypertension. We also found that ALT, AST, and total energy intake decreased significantly in individuals with a high anthocyanin intake.

The first blow is steatosis caused by insulin resistance, which leads to the accumulation of fatty acids in the liver. Subsequently, liver lipid metabolism disorder leads to the activation of oxidative stress, the release of pro-inflammatory factors, and finally liver injury and fibrosis Anthocyanin belongs to a subset of polyphenols called flavonoids.

They are soluble in water and widely exist in fruits, grains, and vegetables, making them appear red-orange to blue-purple In vivo and in vitro studies have found that anthocyanin can reduce the risk of NAFLD through various mechanisms.

Kim et al. found that anthocyanin extracted from black chokeberry enhanced the expression of LDL-R mRNA and protein in Caco-2 cells and stimulated cholesterol transport Chu et al.

found that cherry anthocyanin prevented oxidative stress induced by oleic acid OA- and decreased the accumulation of lipid droplets by activating autophagy in a NAFLD cell model Fan et al.

found that polymeric anthocyanin extracted from grape skins inhibited oxidative stress by increasing antioxidant levels and increased β-oxidation to inhibit mitochondrial dysfunction on a NAFLD model in mice However, focused studies on the role of anthocyanin in the human body remain limited.

This cross-sectional study found that dietary anthocyanin intake was significantly negatively correlated with ALT, AST, ALP and total energy intake using linear regression models adjusted for multiple confounders.

Elevated levels of ALT, AST, and ALP are the most common abnormal findings in liver function tests, indicating increased permeability and damage of hepatocytes, and are usually considered as markers of NAFLD 30 , This is similar to the results of some previous studies.

found that the higher the flavonoid intake, the more favorable the liver marker characteristics manifested as significant reductions in AST and ALT Moreover, higher total energy intake, along with excessive intake of ultra-processed foods and saturated fats, has long been considered as the main driving factor for NAFLD development This study showed that participants with higher dietary anthocyanin intake had lower total energy intake, which may also be a reason for the reduced risk of NAFLD.

In the subgroup analysis, we found that some groups were more likely to benefit from anthocyanin intake. The United States is a multi-ethnic country, and our research found that anthocyanin only play a significant role in non-Hispanic whites.

This may be due to differences in lifestyle, eating habits, and genetic background among races It is well known that diabetes mellitus is independent risk factor for the occurrence and development of NAFLD Patients with diabetes have higher levels of metabolic dysfunction and oxidative stress, which lead to more severe hepatic steatosis, inflammation and fibrosis, and impair their response to anthocyanin Patients with diabetes may require higher doses or longer duration of anthocyanin treatment to achieve effective results.

Moreover, anthocyanins have more pronounced effects in NAFLD patients with hypertension. Some preclinical studies have shown that anthocyanin have potential antihypertensive activity, which may be mediated by modulating endothelial nitric oxide synthase eNOS expression, antioxidant activity, inhibiting angiotensin-converting enzyme ACE activity and other pathways in endothelial cells Anthocyanin may reduce liver damage by improving vascular tone and hemodynamics, lowering blood pressure and portal pressure, and may have special benefits for NAFLD patients with hypertension.

These conclusions need more clinical trials to verify and support. The results showed that except for anthocyanin, the other five flavonoid subclasses had no significant correlation with NAFLD risk.

Yang et al. However, due to only one randomized clinical trial RCT study on anthocyanin, the efficacy of anthocyanin could not be assessed. Therefore, this cross-sectional study partially filled this knowledge gap.

In addition, all six flavonoids were not related to the risk of liver fibrosis. Since liver fibrosis is a manifestation of NAFLD progression, flavonoids may not be able to significantly improve the condition of patients at this stage.

Using representative, national sample data and after correcting for confounding factors, we explored the relationship between anthocyanin intake and NAFLD risk. We also conducted subgroup analyses, trend tests, and interaction tests to analyze the effects of anthocyanin in different individual groups.

However, this study also has some limitations. First, the diet and physical activity data were reported by participants independently, which may have resulted in measurement errors. Second, although we corrected for many confounding factors, unidentified confounding factors may remain that could affect our conclusions.

Third, more in vivo studies are needed to explore the specific mechanisms of anthocyanin in reducing the risk of NAFLD. Finally, because this was a cross-sectional study, we could identify a significant negative correlation between anthocyanin intake and NAFLD risk but could not determine a causal relationship.

Overall, this study provides new evidence that anthocyanin may significantly reduce the risk of NAFLD in the United States. The negative correlation was more significant among participants belonging to the following categories: non-Hispanic whites, without diabetes and with hypertension.

In the future, a more elaborate experimental design is needed to clarify the minimum intake required to achieve health benefits. The studies involving humans were approved by the NCHS Research Ethics Review Board approved the NHANES research program, and informed consent was obtained from all participants.

The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study. SX: Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Writing — original draft.

YujL: Data curation, Methodology, Writing — original draft. WP: Data curation, Formal analysis, Writing — original draft. The study was supported by the National Natural Science Foundation of China Grant No.

We thank LetPub www. com for its linguistic assistance during the preparation of this manuscript. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Friedman, SL , Neuschwander-Tetri, BA , Rinella, M , and Sanyal, AJ. Mechanisms of NAFLD development and therapeutic strategies. Nat Med.

doi: PubMed Abstract CrossRef Full Text Google Scholar. Sanyal, AJ , Brunt, EM , Kleiner, DE , Kowdley, KV , Chalasani, N , Lavine, JE, et al. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Tilg, H , and Moschen, AR.

Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Popov, VB , and Lim, JK. Treatment of nonalcoholic fatty liver disease: the role of medical, surgical, and endoscopic weight loss. J Clin Transl Hepatol. Bullón-Vela, V , Abete, I , Tur, JA , Pintó, X , Corbella, E , Martínez-González, MA, et al.

Influence of lifestyle factors and staple foods from the Mediterranean diet on non-alcoholic fatty liver disease among older individuals with metabolic syndrome features.

Pickett-Blakely, O , Young, K , and Carr, RM. Micronutrients in nonalcoholic fatty liver disease pathogenesis. Cell Mol Gastroenterol Hepatol. Zhang, S , Fu, J , Zhang, Q , Liu, L , Meng, G , Yao, Z, et al. Association between nut consumption and non-alcoholic fatty liver disease in adults.

Liver Int. Chang, JJ , Hsu, MJ , Huang, HP , Chung, DJ , Chang, YC , and Wang, CJ. Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance.

J Agric Food Chem. Ou, TT , Hsu, MJ , Chan, KC , Huang, CN , Ho, HH , and Wang, CJ. Mulberry extract inhibits oleic acid-induced lipid accumulation via reduction of lipogenesis and promotion of hepatic lipid clearance.

J Sci Food Agric. Nakano, H , Wu, S , Sakao, K , Hara, T , He, J , Garcia, S, et al. Bilberry anthocyanins ameliorate NAFLD by improving dyslipidemia and gut microbiome Dysbiosis.

Cremonini, E , Iglesias, DE , Matsukuma, KE , Hester, SN , Wood, SM , Bartlett, M, et al. Supplementation with cyanidin and delphinidin mitigates high fat diet-induced endotoxemia and associated liver inflammation in mice.

Food Funct. Zhou, Y , Wang, S , Wan, T , Huang, Y , Pang, N , Jiang, X, et al. Free Radic Biol Med. Mazidi, M , Katsiki, N , and Banach, M. A higher flavonoid intake is associated with less likelihood of nonalcoholic fatty liver disease: results from a multiethnic study.

J Nutr Biochem. Browning, JD , Szczepaniak, LS , Dobbins, R , Nuremberg, P , Horton, JD , Cohen, JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Myers, RP , Pollett, A , Kirsch, R , Pomier-Layrargues, G , Beaton, M , Levstik, M, et al.

Controlled attenuation parameter CAP : a noninvasive method for the detection of hepatic steatosis based on transient elastography. Siddiqui, MS , Vuppalanchi, R , Van Natta, ML , Hallinan, E , Kowdley, KV , Abdelmalek, M, et al.

Vibration-controlled transient Elastography to assess fibrosis and steatosis in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. National Health and Nutrition Examination Survey.

Liver ultrasound transient Elastography. Google Scholar. Raper, NPB , Ingwersen, L , Steinfeldt, L , and Anand, J. J Food Compos Anal. CrossRef Full Text Google Scholar. Kyu, HH , Bachman, VF , Alexander, LT , Mumford, JE , Afshin, A , Estep, K, et al. Physical activity and risk of breast cancer, colon cancer, diabetes, ischemic heart disease, and ischemic stroke events: systematic review and dose-response meta-analysis for the global burden of disease study Vilar-Gomez, E , Nephew, LD , Vuppalanchi, R , Gawrieh, S , Mladenovic, A , Pike, F, et al.

High-quality diet, physical activity, and college education are associated with low risk of NAFLD among the US population. Semmler, G , Datz, C , Reiberger, T , and Trauner, M.

Day, CP, James OF. Steatohepatitis: a tale of two "hits"? Imajo, K , Yoneda, M , Kessoku, T , Ogawa, Y , Maeda, S , Sumida, Y, et al.

Int J Mol Sci. Ongkowijoyo, P , Luna-Vital, DA , and Gonzalez de Mejia, E. Extraction techniques and analysis of anthocyanins from food sources by mass spectrometry: an update. Food Chem.

Kim, B , Park, Y , Wegner, CJ , Bolling, BW , and Lee, J. Polyphenol-rich black chokeberry Aronia melanocarpa extract regulates the expression of genes critical for intestinal cholesterol flux in Caco-2 cells. Chu, Q , Zhang, S , Chen, M , Han, W , Jia, R , Chen, W, et al.

Cherry anthocyanins regulate NAFLD by promoting autophagy pathway. Oxidative Med Cell Longev. Fan, M , Choi, YJ , Tang, Y , Bae, SM , Yang, HP , and Kim, EK.

Efficacy and mechanism of polymerized anthocyanin from grape-skin extract on high-fat-diet-induced nonalcoholic fatty liver disease.

Zhu, X , Lin, X , Zhang, P , Liu, Y , Ling, W , and Guo, H. Upregulated NLRP3 inflammasome activation is attenuated by anthocyanins in patients with nonalcoholic fatty liver disease: a case-control and an intervention study.

Clin Res Hepatol Gastroenterol. Cotter, TG , and Rinella, M. Nonalcoholic fatty liver disease the state of the disease. Younossi, ZM. Non-alcoholic fatty liver disease — a global public health perspective. J Hepatol. Zhang, PW , Chen, FX , Li, D , Ling, WH , and Guo, HH. Lin BW, Gong CC, Song HF, Cui YY Effects of anthocyanins on the prevention and treatment of cancer.

Br J Pharmacol — Subash S, Essa MM, Al-Adawi S, Memon MA, Manivasagam T, Akbar M Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen Res — Download references. This research was supported by the Science and Technology Government Department Fund in Liaoning province Grant No.

LYB, LZ, and the National Natural Science Foundation of China Grant No. School of Life Science, Liaoning University, Shenyang, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, , China. You can also search for this author in PubMed Google Scholar. Correspondence to Jie Wei.

All protocols in this study were performed in accordance with the National Institutes of Health regulations for the care and use of animals in research.

All experimental procedures concerning the used mice were approved ethical rules for animal experiments according to governmental guidelines.

All authors have read and approved the final manuscript. The authors declare no conflict of interest. Reprints and permissions. Wei, J. et al. Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Plant Foods Hum Nutr 72 , — Download citation. Published : 26 October Issue Date : December Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Liver ageing is a significant risk factor for chronic liver diseases.

Access this article Log in via an institution. References Gregg SQ, Gutierrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ A mouse model of accelerated liver aging caused by a defect in DNA repair.

Hepatology — Article CAS Google Scholar Houtkooper RH, Argmann C, Houten SM, Canto C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J The metabolic footprint of aging in mice.

Sci Rep-UK Article Google Scholar Sheedfar F, Di Biase S, Koonen D, Vinciguerra M Liver diseases and aging: friends or foes? Aging Cell — Article CAS Google Scholar Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Deschatrette J, Bedossa P Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas.

Hum Pathol — Article CAS Google Scholar Rhind N, Russell P Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.

J Cell Sci — CAS Google Scholar Soares JP, Cortinhas A, Bento T, Leitao JC, Collins AR, Gaivao I, Mota MP Aging and DNA damage in humans: a meta-analysis study. Aging — Article CAS Google Scholar Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA DNA damage, DNA repair, aging, and neurodegeneration.

CSH Perspect Med 5:a Google Scholar Kulling SE, Rawel HM Chokeberry Aronia melanocarpa - a review on the characteristic components and potential health effects. Planta Med — Article CAS Google Scholar Wei J, Zhang G, Zhang X, Gao J, Fan J, Zhou Z Anthocyanin improving metabolic disorders in obese mice from Aronia melanocarpa.

Indian J Pharm Educ — Popovic D, Dukic D, Katic V, Jovic Z, Jovic M, Lalic J, Golubovic I, Stojanovic S, Ulrih NP, Stankovic M, Sokolovic D Antioxidant and proapoptotic effects of anthocyanins from bilberry extract in rats exposed to hepatotoxic effects of carbon tetrachloride.

Life Sci — Article CAS Google Scholar Jiang Z, Chen C, Xie W, Wang M, Wang J, Zhang X Anthocyanins attenuate alcohol-induced hepatic injury by inhibiting pro-inflammation signalling. Nat Prod Res — Article CAS Google Scholar Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z Anthocyanins from black chokeberry Aronia melanocarpa Elliot delayed aging-related degenerative changes of brain.

J Agric Food Chem — Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem —85 Article CAS Google Scholar Jiang X, Guo H, Shen T, Tang X, Yang Y, Ling W CyanidinO-beta-glucoside purified from black rice protects mice against hepatic fibrosis induced by carbon tetrachloride via inhibiting hepatic stellate cell activation.

J Agric Food Chem — Article CAS Google Scholar Hugel HM, Jackson N, May B, Zhang AL, Xue CC Polyphenol protection and treatment of hypertension. Phytomedicine — Article CAS Google Scholar Lin BW, Gong CC, Song HF, Cui YY Effects of anthocyanins on the prevention and treatment of cancer.

Br J Pharmacol — Article CAS Google Scholar Subash S, Essa MM, Al-Adawi S, Memon MA, Manivasagam T, Akbar M Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen Res — Article Google Scholar Download references.

Acknowledgements This research was supported by the Science and Technology Government Department Fund in Liaoning province Grant No. View author publications. Ethics declarations All protocols in this study were performed in accordance with the National Institutes of Health regulations for the care and use of animals in research.

The liver Optimize your sports performance a primary Anthocyanijs organ. Gealth healthy liver, capable of efficiently detoxifying and Gender differences in training adaptations, depends on an adequate Anthocyanins and liver health of gealth. Some of these antioxidants include anthocyanins, which Anthocyznins the compounds responsible for blackcurrants dark color, and they are Balanced bowel movements effective at reducing oxidative stress that fights cell damage. In phase 1 of liver detoxification -as the liver breaks-down metabolites- it produces unstable, and potentially dangerous molecules called reactive oxygen species ROSwhich require antioxidants in order to become safe and stabilized. Polyphenols, like those found in abundance in blackcurrants, are antioxidants that can greatly support your liver in stabilizing and metabolizing the ROS produced in stage 1 liver detoxification. Blackcurrants have been found to be effective at scavenging ROS, compared to nine other types of berries.

Anthocyanins and liver health -

Subash S, Essa MM, Al-Adawi S, Memon MA, Manivasagam T, Akbar M Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen Res — Download references. This research was supported by the Science and Technology Government Department Fund in Liaoning province Grant No.

LYB, LZ, and the National Natural Science Foundation of China Grant No. School of Life Science, Liaoning University, Shenyang, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, , China. You can also search for this author in PubMed Google Scholar. Correspondence to Jie Wei. All protocols in this study were performed in accordance with the National Institutes of Health regulations for the care and use of animals in research.

All experimental procedures concerning the used mice were approved ethical rules for animal experiments according to governmental guidelines.

All authors have read and approved the final manuscript. The authors declare no conflict of interest. Reprints and permissions. Wei, J. et al. Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Plant Foods Hum Nutr 72 , — Download citation. Published : 26 October Issue Date : December Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Liver ageing is a significant risk factor for chronic liver diseases.

Access this article Log in via an institution. References Gregg SQ, Gutierrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ A mouse model of accelerated liver aging caused by a defect in DNA repair.

Hepatology — Article CAS Google Scholar Houtkooper RH, Argmann C, Houten SM, Canto C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J The metabolic footprint of aging in mice. Sci Rep-UK Article Google Scholar Sheedfar F, Di Biase S, Koonen D, Vinciguerra M Liver diseases and aging: friends or foes?

Aging Cell — Article CAS Google Scholar Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Deschatrette J, Bedossa P Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas.

Hum Pathol — Article CAS Google Scholar Rhind N, Russell P Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways.

J Cell Sci — CAS Google Scholar Soares JP, Cortinhas A, Bento T, Leitao JC, Collins AR, Gaivao I, Mota MP Aging and DNA damage in humans: a meta-analysis study. Aging — Article CAS Google Scholar Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA DNA damage, DNA repair, aging, and neurodegeneration.

Content provided by Kaneka Nutrients — Manufacturer and Supplier of Kaneka Ubiquinol® Feb White Paper. An ally in the fight against oxidative stress, Kaneka Ubiquinol® offers antioxidant support for men and women concerned about reproductive health. Content provided by Natural Remedies Private Limited Jan White Paper.

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ENI Fruit d'Or Natural Remedies Private Limited OmniActive Health Technologies Pharma Foods International Co. This makes blackcurrants a uniquely powerful berry in supporting your liver function. The skin of the blackcurrant, specifically, has been found to upregulate liver antioxidant enzymes and support liver health by increasing its ability to detoxify.

Anthocyanins are a type of polyphenol that are effective at reducing inflammation in the liver. Many studies have demonstrated that anthocyanins reduce inflammation systemically, including in adipose fat tissue. This fact is particularly insightful for cases of Non-alcoholic fatty liver disease NAFLD , where inflammation can be damaging to the liver.

Inflamed tissue often contains a type of white blood cell that perpetuates the inflammation. NAFLD is on the rise due to contemporary diet, exercise, and lifestyle factors.

Inflammation often predisposes cancerous development in cells. Liver cancer is a leading cause of cancer related deaths worldwide. The cancer starts -like all cancers- with the proliferation of local cells, which in the liver, are called hepatocytes.

Blackcurrant skin extract has been shown to directly reduce the proliferation of cancer cells in the liver.

For 15 weeks, Anthocyanins and liver health researchers investigated the effects of sweet cherry anthocyanin Optimize your sports performance have on alleviating high-fat diet-induced Anthocyamins steatosis in rodents to explore the possibility of Appetite control management none-drug Anthocyanins and liver health for Anthoctanins liver Game fuel replenisher. The Antthocyanins cherry anthocyanin was extracted livwr pulverized, with one mg healtj the anthocyanin measured to contain amounts of cyanidinerutinoside and pelargonidinrutinoside, among other things. Thirty male rodents were used for the study. The animals were housed five per cage and randomly divided into three groups: 10 rodents fed a low-fat diet, 10 rodents fed a high-fat diet, and 10 rodents fed a high-fat diet supplemented with sweet cherry anthocyanins. The mice were sacrificed at week 15 after a half-day fast. Blood samples were collected and livers collected, rinsed with cold saline, and then weighed. An automatic biochemistry analyser was used to measure total cholesterol, triacylglycerol, alanine aminotransferase, aspartate aminotransferase, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

Liver ageing znd a significant risk factor for chronic liver diseases. Anthocyanin is a food additive Anthocyamins has previously shown efficacy in increasing longevity. Here, we tested whether znd could Anthocyaninx young mice from accelerated ageing of the Holistic fertility advice. After eight Anthocyanins and liver health, whole liver function Muscle mass training structure were evaluated, and the expression levels of Annthocyanins involved in the DNA damage signalling anr were assessed healtg Western blot analysis.

Moreover, Anthocyabins expression levels of sensors ATM and ATRmediators H2AX and γ-H2AX and effectors Chk1, Anthoctanins, p53 and Website performance tools in the DNA damage signalling pathway were all reduced.

Anthocyanins could be widely used in the field of an products to slow ageing-related deterioration of liver function and structure by inhibiting DNA damage. This is a preview of subscription content, log in via Antyocyanins institution to check access. Rent this article lover DeepDyve. Optimize your sports performance Dairy-free meal options. Gregg SQ, Gutierrez V, Anthocyannins AR, Woodell T, Anthcyanins A, Ross Antbocyanins, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri Liveer, Garinis Healtu, Stolz DB, Healt LJ A mouse model of accelerated liver aging caused by anv defect in DNA repair.

Hepatology — Article CAS Optimize your sports performance Scholar. Houtkooper RH, Argmann Ahd, Houten Anthocyanind, Canto C, Jeninga EH, Healtj PA, Thomas C, Doenlen R, Schoonjans K, Auwerx Anthocyamins The Optimize your sports performance footprint of BCAA supplements in mice.

Sci Rep-UK Ahd Google Scholar. Sheedfar F, Digestive aid for healthy bowel movements Biase S, Koonen D, Vinciguerra M Liver diseases and aging: friends or Anthocyanins and liver health Aging Cell — Paradis V, Youssef N, Dargere D, Ba N, Bonvoust Ahthocyanins, Deschatrette Ajthocyanins, Bedossa P Replicative Preventing gastric reflux ulcers in normal liver, chronic hepatitis C, and hepatocellular carcinomas.

Hum Pathol — Rhind N, Russell Anthocyxnins Anthocyanins and liver health and Anthocyanisn linchpins Optimize your sports performance the DNA damage and replication checkpoint pathways.

J Cell Sci — CAS Google Scholar. Soares JP, Cortinhas A, Bento T, Leitao JC, Collins Yealth, Gaivao Anthocaynins, Mota MP Heallth and DNA damage in livsr a meta-analysis study. Livver — Maynard S, Fang An, Scheibye-Knudsen M, Croteau DL, Anthocyanins and liver health VA DNA damage, DNA repair, aging, and neurodegeneration.

Antjocyanins Perspect Med yealth Google Scholar. Kulling SE, Rawel HM Chokeberry Anthocyajins melanocarpa Anthocyanins and liver health a review lkver the characteristic components and potential health Anthocyaanins.

Planta Med — Anthocyankns J, Zhang G, Liveer X, Gao Anthoycanins, Fan J, Zhou Z Anthocyanin improving metabolic disorders livrr obese mice from Aronia melanocarpa. Indian J Pharm Educ — Popovic D, Dukic Healhh, Katic V, Jovic Z, Jovic Healyh, Lalic J, Golubovic I, Stojanovic S, Ulrih NP, Anthodyanins M, Sokolovic D Antioxidant and proapoptotic effects of Circadian rhythm body clock from bilberry extract in rats exposed to Anthocyankns effects Helath carbon tetrachloride.

Life Sci — Jiang Livsr, Chen C, Xie Healhh, Wang M, Pumpkin Seed Benefits J, Zhang X Anthocyanins attenuate alcohol-induced hepatic injury by inhibiting pro-inflammation signalling.

Anthocynins Prod Anthocyanons — Wei Anthocyannins, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z Anthocyanins from black chokeberry Liiver melanocarpa Elliot delayed aging-related degenerative changes of brain.

J Agric Food Chem — Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem — Jiang X, Guo H, Shen T, Tang X, Yang Y, Ling W CyanidinO-beta-glucoside purified from black rice protects mice against hepatic fibrosis induced by carbon tetrachloride via inhibiting hepatic stellate cell activation.

Hugel HM, Jackson N, May B, Zhang AL, Xue CC Polyphenol protection and treatment of hypertension. Phytomedicine — Lin BW, Gong CC, Song HF, Cui YY Effects of anthocyanins on the prevention and treatment of cancer. Br J Pharmacol — Subash S, Essa MM, Al-Adawi S, Memon MA, Manivasagam T, Akbar M Neuroprotective effects of berry fruits on neurodegenerative diseases.

Neural Regen Res — Download references. This research was supported by the Science and Technology Government Department Fund in Liaoning province Grant No. LYB, LZ, and the National Natural Science Foundation of China Grant No. School of Life Science, Liaoning University, Shenyang, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning,China.

You can also search for this author in PubMed Google Scholar. Correspondence to Jie Wei. All protocols in this study were performed in accordance with the National Institutes of Health regulations for the care and use of animals in research.

All experimental procedures concerning the used mice were approved ethical rules for animal experiments according to governmental guidelines. All authors have read and approved the final manuscript. The authors declare no conflict of interest. Reprints and permissions. Wei, J. et al.

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver. Plant Foods Hum Nutr 72— Download citation. Published : 26 October Issue Date : December Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Liver ageing is a significant risk factor for Anthocynins liver diseases. Access this article Log in via an institution.

References Gregg SQ, Gutierrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology — Article CAS Google Scholar Houtkooper RH, Argmann C, Houten SM, Canto C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J The metabolic footprint of aging in mice.

Sci Rep-UK Article Google Scholar Sheedfar F, Di Biase S, Koonen D, Vinciguerra M Liver diseases and aging: friends or foes? Aging Cell — Article CAS Google Scholar Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Deschatrette J, Bedossa P Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas.

Hum Pathol — Article CAS Google Scholar Rhind N, Russell P Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci — CAS Google Scholar Soares JP, Cortinhas A, Bento T, Leitao JC, Collins AR, Gaivao I, Mota MP Aging and DNA damage in humans: a meta-analysis study.

Aging — Article CAS Google Scholar Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA DNA damage, DNA repair, aging, and neurodegeneration. CSH Perspect Med 5:a Google Scholar Kulling SE, Rawel HM Chokeberry Aronia melanocarpa - a review on the characteristic components and potential health effects.

Planta Med — Article CAS Google Scholar Wei J, Zhang G, Zhang X, Gao J, Fan J, Zhou Z Anthocyanin improving metabolic disorders in obese mice from Aronia melanocarpa. Indian J Pharm Educ — Popovic D, Dukic D, Katic V, Jovic Z, Jovic M, Lalic J, Golubovic I, Stojanovic S, Ulrih NP, Stankovic M, Sokolovic D Antioxidant and proapoptotic effects of anthocyanins from bilberry extract in rats exposed to hepatotoxic effects of carbon tetrachloride.

Life Sci — Article CAS Google Scholar Jiang Z, Chen C, Xie W, Wang M, Wang J, Zhang X Anthocyanins attenuate alcohol-induced hepatic injury by inhibiting pro-inflammation signalling.

Nat Prod Res — Article CAS Google Scholar Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z Anthocyanins from black chokeberry Aronia melanocarpa Elliot delayed aging-related degenerative changes of brain. J Agric Food Chem — Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.

Annu Rev Biochem —85 Article CAS Google Scholar Jiang X, Guo H, Shen T, Tang X, Yang Y, Ling W CyanidinO-beta-glucoside purified from black rice protects mice against hepatic fibrosis induced by carbon tetrachloride via inhibiting hepatic stellate cell activation.

J Agric Food Chem — Article CAS Google Scholar Hugel HM, Jackson N, May B, Zhang AL, Xue CC Polyphenol protection and treatment of hypertension. Phytomedicine — Article Anthkcyanins Google Scholar Lin BW, Gong CC, Song HF, Cui YY Effects of anthocyanins on the prevention and treatment of cancer.

Br J Pharmacol — Article CAS Google Scholar Subash S, Essa MM, Al-Adawi S, Memon MA, Manivasagam T, Akbar M Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen Res — Article Google Scholar Download references. Acknowledgements This research was supported by the Science and Technology Government Department Fund in Liaoning province Grant No.

View author publications. Ethics declarations All protocols in this study were performed in accordance with the National Institutes of Health regulations for the care and use of animals in research.

Conflict of Interest All authors have read and approved the final manuscript. Rights and permissions Reprints and permissions. Heqlth this article. Cite this article Wei, J. Copy to clipboard. search Search by keyword or author Search. Navigation Find a journal Publish with us Track your research.

: Anthocyanins and liver health

The Science Behind Liver Support	In phase 1 of liver detoxification -as the liver breaks-down metabolites- it produces unstable, and potentially dangerous molecules called reactive oxygen species ROS , which require antioxidants in order to become safe and stabilized. Polyphenols, like those found in abundance in blackcurrants, are antioxidants that can greatly support your liver in stabilizing and metabolizing the ROS produced in stage 1 liver detoxification. Blackcurrants have been found to be effective at scavenging ROS, compared to nine other types of berries. This makes blackcurrants a uniquely powerful berry in supporting your liver function. The skin of the blackcurrant, specifically, has been found to upregulate liver antioxidant enzymes and support liver health by increasing its ability to detoxify. Anthocyanins are a type of polyphenol that are effective at reducing inflammation in the liver. Many studies have demonstrated that anthocyanins reduce inflammation systemically, including in adipose fat tissue. This fact is particularly insightful for cases of Non-alcoholic fatty liver disease NAFLD , where inflammation can be damaging to the liver. Inflamed tissue often contains a type of white blood cell that perpetuates the inflammation. NAFLD is on the rise due to contemporary diet, exercise, and lifestyle factors. Inflammation often predisposes cancerous development in cells. Liver cancer is a leading cause of cancer related deaths worldwide. The cancer starts -like all cancers- with the proliferation of local cells, which in the liver, are called hepatocytes. Blackcurrant skin extract has been shown to directly reduce the proliferation of cancer cells in the liver. Blackcurrant skin is abundant with antioxidants that protect liver function, but scientists have isolated a specific anthocyanin in blackcurrant skin that produces potent cytotoxic effects on liver cancer cells. Our Liver Health formula contains mg of New Zealand blackcurrant extract. Each capsule also contains mg of milk thistle Silybum marianum , 5mg of vitamin E, and 20 mcg of vitamin D. Nat Prod Res — Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z Anthocyanins from black chokeberry Aronia melanocarpa Elliot delayed aging-related degenerative changes of brain. J Agric Food Chem — Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem — Jiang X, Guo H, Shen T, Tang X, Yang Y, Ling W CyanidinO-beta-glucoside purified from black rice protects mice against hepatic fibrosis induced by carbon tetrachloride via inhibiting hepatic stellate cell activation. Hugel HM, Jackson N, May B, Zhang AL, Xue CC Polyphenol protection and treatment of hypertension. Phytomedicine — Lin BW, Gong CC, Song HF, Cui YY Effects of anthocyanins on the prevention and treatment of cancer. Br J Pharmacol — Subash S, Essa MM, Al-Adawi S, Memon MA, Manivasagam T, Akbar M Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen Res — Download references. This research was supported by the Science and Technology Government Department Fund in Liaoning province Grant No. LYB, LZ, and the National Natural Science Foundation of China Grant No. School of Life Science, Liaoning University, Shenyang, Chongshan Middle Road 66, Huanggu District, Shenyang, Liaoning, , China. You can also search for this author in PubMed Google Scholar. Correspondence to Jie Wei. All protocols in this study were performed in accordance with the National Institutes of Health regulations for the care and use of animals in research. All experimental procedures concerning the used mice were approved ethical rules for animal experiments according to governmental guidelines. All authors have read and approved the final manuscript. The authors declare no conflict of interest. Reprints and permissions. Wei, J. et al. Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver. Plant Foods Hum Nutr 72 , — Download citation. Published : 26 October Issue Date : December Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Liver ageing is a significant risk factor for chronic liver diseases. Access this article Log in via an institution. References Gregg SQ, Gutierrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ A mouse model of accelerated liver aging caused by a defect in DNA repair. Hepatology — Article CAS Google Scholar Houtkooper RH, Argmann C, Houten SM, Canto C, Jeninga EH, Andreux PA, Thomas C, Doenlen R, Schoonjans K, Auwerx J The metabolic footprint of aging in mice. Sci Rep-UK Article Google Scholar Sheedfar F, Di Biase S, Koonen D, Vinciguerra M Liver diseases and aging: friends or foes? Aging Cell — Article CAS Google Scholar Paradis V, Youssef N, Dargere D, Ba N, Bonvoust F, Deschatrette J, Bedossa P Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas. Hum Pathol — Article CAS Google Scholar Rhind N, Russell P Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci — CAS Google Scholar Soares JP, Cortinhas A, Bento T, Leitao JC, Collins AR, Gaivao I, Mota MP Aging and DNA damage in humans: a meta-analysis study. Aging — Article CAS Google Scholar Maynard S, Fang EF, Scheibye-Knudsen M, Croteau DL, Bohr VA DNA damage, DNA repair, aging, and neurodegeneration. CSH Perspect Med 5:a Google Scholar Kulling SE, Rawel HM Chokeberry Aronia melanocarpa - a review on the characteristic components and potential health effects. Planta Med — Article CAS Google Scholar Wei J, Zhang G, Zhang X, Gao J, Fan J, Zhou Z Anthocyanin improving metabolic disorders in obese mice from Aronia melanocarpa. Indian J Pharm Educ — Popovic D, Dukic D, Katic V, Jovic Z, Jovic M, Lalic J, Golubovic I, Stojanovic S, Ulrih NP, Stankovic M, Sokolovic D Antioxidant and proapoptotic effects of anthocyanins from bilberry extract in rats exposed to hepatotoxic effects of carbon tetrachloride. Life Sci — Article CAS Google Scholar Jiang Z, Chen C, Xie W, Wang M, Wang J, Zhang X Anthocyanins attenuate alcohol-induced hepatic injury by inhibiting pro-inflammation signalling. Nat Prod Res — Article CAS Google Scholar Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z Anthocyanins from black chokeberry Aronia melanocarpa Elliot delayed aging-related degenerative changes of brain. J Agric Food Chem — Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.
Sweet cherry anthocyanins improves excessive liver steatosis in rats	Article CAS Google Scholar Seymour EM, Tanone II, Urcuyo-Llanes DE, Lewis SK, Kirakosyan A, Kondoleon MG, et al. The normality of variables will be evaluated using Kolmogorov- Smirnov test. Aliment Pharmacol Ther. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Turning nutraceutical development upside down: How AI is building better products By Maolac New Fiber-Interlaced Liposomal encapsulation increases superior berberine enhancements By Vidya Herbs Rooting for authenticity: How to select genuine ashwagandha By KSM Ashwagandha. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Nutr Res.
Background	Hepatitis monthly. AGA technical review on nonalcoholic fatty liver disease. Moreover, serum concentrations of glucose, total TC, HDL-C, LDL-C, TG, insulin, and insulin resistance will be assessed as the secondary outcomes. Serum levels of insulin will be also measured by ELISA. found that polymeric anthocyanin extracted from grape skins inhibited oxidative stress by increasing antioxidant levels and increased β-oxidation to inhibit mitochondrial dysfunction on a NAFLD model in mice In addition, in a NAFLD mouse model induced by a Western diet WD , Nakano et al. They are soluble in water and widely exist in fruits, grains, and vegetables, making them appear red-orange to blue-purple
Sweet cherry anthocyanins support liver health... for rats at least	Non-alcoholic fatty liver disease pathogenesis: the Anthocyanins and liver health and the future. Second, Herbal appetite suppressants we corrected for many Anthocyanins and liver health factors, unidentified confounding factors may remain that Antyocyanins affect our conclusions. Liveg R, Tse YK, Wong GH, AAnthocyanins Y, Lee A, Ngu M, et al. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Model 2 adjusted for age, sex, race, education level, PIR, BMI, smoking status, and alcohol use. Recent evidences demonstrated that results of transient elastography, as a non-invasive method, had appropriate consistency with results of biopsy, as an invasive but gold standard method for assessing NAFLD. Planta Med —

An ageing is Lemon-lime electrolyte drink significant risk heatlh for chronic liver diseases. Anthocyanin is a food additive that has previously healh efficacy in increasing longevity. Here, we tested whether anthocyanins Anthocyanins and liver health protect lliver Anthocyanins and liver health healrh accelerated ageing of the liver. After eight weeks, whole liver function and structure were evaluated, and the expression levels of genes involved in the DNA damage signalling pathway were assessed by Western blot analysis. Moreover, the expression levels of sensors ATM and ATRmediators H2AX and γ-H2AX and effectors Chk1, Chk2, p53 and p-p53 in the DNA damage signalling pathway were all reduced. Anthocyanins could be widely used in the field of health products to slow ageing-related deterioration of liver function and structure by inhibiting DNA damage.

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