Citrus bioflavonoids for cardiovascular health -
The prevalence of cardiovascular disease CVD is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD.
Citrus flavonoids offer an impressive array of health-related benefits. In general, citrus flavonoids offer antioxidant, cell-protective, and anti-inflammatory properties. Since inflammation and oxidative stress play significant roles in the development of cardiovascular disease, it makes sense that an increased intake of citrus flavonoids could support a healthy cardiovascular system.
Ample research confirms the intake of citrus flavonoids is associated with improved cardiovascular outcomes.
Bioflavonoids are already utilized for the clinical treatment of cardiovascular disease by some healthcare providers since research shows they offer:.
Cardiovascular diseases include atherosclerosis hardening of the arteries , stroke, and other conditions. Several health concerns significantly contribute to the development of cardiovascular disease, including hypertension high blood pressure , hyperlipidemia hypercholesterolemia , diabetes, and obesity.
You will learn much more about the health conditions mentioned above and the evidence-based cardiovascular benefits of bioflavonoids in Part 2 of this blog series. This product is not intended to diagnose, treat, cure or prevent any disease. Chronic stress is a frequent underlying cause of low nutrient levels and health issues.
In fact, according to the World Health Organization WHO , approximately million people worldwide are affected by stress-related disorders. Fortunately, the consistent use of a synergistic blend of vitamins, minerals, and herbal extracts that nourish the adrenal glands could support a healthy stress response.
The common cold is the most frequent human illness. Genetics, stress, smoking, nutrient deficiencies, and strenuous physical training can increase the risk of catching a cold.
Modern research now confirms that supplemental vitamins, minerals, botanicals, and other natural remedies can decrease the severity and duration of the common cold. Summer is an opportune time to focus on health — the weather tends to be pleasant, which makes many people naturally feel like being more active and vigorous.
According to the research, supplementing with zinc, vitamin C, and citrus bioflavonoids together could support optimal testosterone levels, recovery from injuries, and athletic performance.
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Your cart. Close Cart. In addition to maintaining a healthy lifestyle, which includes: Not smoking Achieving a healthy weight Controlling blood sugar and cholesterol levels Treating high blood pressure Getting at least minutes of moderate-intensity physical activity a week Getting regular checkups 1 Research shows certain nutrients, botanicals, and other natural compounds also support a healthy heart.
What are Bioflavonoids? We hope you join us! References U. commemorates 57th consecutive American Heart Month in February. Published November 14, Accessed December 2, Mahmoud AM, Hernández Bautista RJ, Sandhu MA, et al. B eneficial Effects of Citrus Flavonoids on Cardiovascular and Metabolic Health.
Oxid Med Cell Longev. Research shows the role they play in promoting cardiovascular health , metabolism, healthy aging, and insulin sensitivity. Being powerful antioxidants, they prevent free radicals from wreaking havoc in the body, thereby positively impacting various aspects of health.
When oxygen levels are too high or too low, cells will react and produce reactive oxygen species ROS , which are known for being carcinogenic. Citrus flavonoids reduce the production of ROS, and the risk of developing chronic diseases such as cardiovascular diseases and diabetes.
Cardiovascular diseases are one of the most fatal diseases in the world today. WHO reports that in , the CVD-induced death toll was at In order to avoid such dire effects on life, it is important to lead a healthy lifestyle and support it with the right food, exercise, and avoiding harmful substances like tobacco and alcohol.
The right nutrition goes a long way in supporting good health too. Research states that citrus bioflavonoids have a positive effect on cardiovascular health.
Maintaining a diet that is rich in flavonoids has been observed to have a protective effect on cardiovascular health. It is interesting to note that in people at risk of chronic diseases due to heavy smoking and drinking, the protective effect was stronger.
Metabolic health, in the larger sense, refers to the efficiency with which our bodies generate and process energy. Glucose is one of the key precursors for energy production in the body. For metabolism to function properly, glucose levels need to be strictly controlled.
An individual's metabolic health can be enhanced by making consistent choices that help maintain glucose levels within a normal and healthy range and reduce big swings in glucose levels. These choices can include selecting foods that do not cause large spikes in glucose, exercising, coping with stress better, consuming nutritious food, getting quality sleep, and staying away from toxins in the environment that disrupt metabolic function.
There is a correlation between poor metabolic health and impaired brain function, energy levels, memory, mood, skin health, fertility, and the risk of developing chronic diseases.
Now accepting phone orders Monday through Fardiovascular from am to pm Pacific,healtth Citrus bioflavonoids for cardiovascular health wait to hear from you! February is American Raspberry ketones benefits Month — the ideal time for you to focus on your cardiovascular health. InPresident Lyndon B. Johnson, who had personally experienced a heart attack, issued the first proclamation that recognized February as American Heart Month. All subsequent U. presidents have also declared February as American Heart Month.Bipflavonoids fruits are the main fruits of the Mediterranean diet and have been long recognized for their beneficial effects Ctrus human health. Observational studies have shown forr significant carriovascular between dietary flavonoid intake Caloric expenditure calculator reduced risk of cardiovascular and malignant diseases.
The beneficial effects of xardiovascular fruits Citrus bioflavonoids for cardiovascular health Citris health appear to be due to their high Cirrus in vitamins, minerals and fibers. In particular, the antioxidant and anti-inflammatory activities have been indicated as some of the mechanisms through which citrus fruits may thwart the development of chronic degenerative diseases bioflavonoidz as atherosclerosis and cancer.
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Adefegha SA. Functional foods and nutraceuticals cardiovascilar dietary Citrus bioflavonoids for cardiovascular health in chronic diseases; novel perspectives for health promotion and disease prevention.
J Diet Suppl ; Gentile D, Fornai M, Pellegrini C, cardiovasvular al. Dietary flr as a potential intervention to improve redox balance in obesity and related comorbidities: a review. Nutr Res Rev ; Dillard CJ, German JB. Phytochemicals: Energy-boosting ingredients and human health.
Habits for athletic longevity Citrus bioflavonoids for cardiovascular health Cardiovascuoar Agric ; Keys A.
Mediterranean diet and public health: Personal cardiovaxcular. Am J Clin Nutr ; Casas R, bioflaonoids E, Estruch R.
The immune protective effect of the Citrus bioflavonoids for cardiovascular health diet Citrus bioflavonoids for cardiovascular health chronic low fpr inflammatory diseases. Healtg Metab Immune Disord Drug Targets ; Tripoli E, Citrjs Guardia M, Giammanco S, et al, Citrus bioflavonoids for cardiovascular health.
Citrus flavonoids: molecular structure, healtj activity and nutritional Sodium intake and bone health A review. Food Cardiovascula ; Heapth KE, Tagliaferro AR, Bobilya DJ.
Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem ; Mulvihill EE, Burke AC, Huff MW. Citrus flavonoids as regulators of lipoprotein metabo-lism and atherosclerosis.
Annu Rev Nutr ; Rodríguez-García C, Sánchez-Quesada C, Gaforio JJ. Dietary flavonoids as cancer chemo-preventive agents: an updated review of human studies. Antioxidants ; Xu H, Luo J, Huang J, Wen Q. Flavonoids intake and risk of type 2 diabetes mellitus. A meta-analysis of prospective cohort studies.
Medicine ;e Hwang SL, Shih PH, Yen GC. Neuroprotective effects of citrus flavonoids. J Agric Food Chem ; Hardcastle AC, Aucott L, Reid DM, Macdonald HM. Associations between dietary flavonoid intakes and bone health in a Scottish population.
J Bone Miner Res ; Dietary flavonoids and risk of stroke in women. Stroke ; Di Majo D, La Guardia M, Leto G, et al. Flavonols and flavanols as modulators of xanthine oxidase and manganese superoxide dismutase activity.
Int J Food Sci Nutr ; Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci ; Croft KD.
The chemistry and biological effects of flavonoids and phenolic acids. Ann NY Acad Sci ; Yusof S, Ghazali HM, King GS. Naringin content in local citrus fruits. Caristi C, Bellocco E, Gargiulli C, et al. Flavone-di-C-glycosides in citrus juices from Southern Italy.
Tsiokanos E, Tsafantakis N, Termentzi A, et al. Phytochemical characteristics of bergamot oranges from the Ionian islands of Greece: A multianalytical approach with emphasis in the distribution of neohesperidose flavanones.
Ooghe WC, Detavernier CM. Detection of the addition of Citrus reticulata and hybrids to Citrus sinensis by flavonoids. Narayana KR, Reddy MS, Chaluvadi MR, Krishna DR.
Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol ; Verma ML, Sharma S, Saini R, et al. Chapter 3-Bioflavonoids: Synthesis, functions and biotechnological applications.
Biotechnological Product Bioact Comp ; Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Scient World J ; Feng X, Li Y, Brobbey M, et al.
Insights into the intestinal bacterial metabolism of flavonoids and the bioactivities of their microbe derived ring cleavage metabolites.
Drug Metab Rev ; Nielsen IL, Chee WS, Poulsen L, et al. Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial.
J Nutr ; Kanaze FI, Bounartzi MI, Georgarakis M, Niopas, I. Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects.
Eur J Clin Nutr ; Lin SP, Hou YC, Tsai SY, et al. Tissue distribution of naringenin conjugated metabolites following repeated dosing of naringin to rats. Biomedicine ; Ekalu A, Habila JH. Flavonoids: isolation, characterization, and health benefits. Beni Suef Univ J Basic Appl Sci ; Burda S, Oleszek W.
Antioxidant and antiradical activities of flavonoids. Di Majo D, Giammanco M, La Guardia M, et al. Flavanones in citrus fruit: structure antioxidant activity relationships.
Food Res Int ; Benavente-García O, Castillo J. Update on uses and properties of Citrus flavonoids: new findings in anticancer, cardiovascular, and antiinflammatory activity. Sichel G, Corsaro C, Scalia M, et al. Free Radic Biol Med ; Di Majo D, La Neve L, La Guardia M, et al.
The influence of two different pH levels on the antioxidant properties of flavonols, flavanols, phenolic acids and aldehyde compounds analysed in synthetic wine and in a phosphate buffer.
J Food Compost Anal ; Rapisarda P, Tomaino A, Lo Cascio R, et al. Effec-tiveness as influenced by phenolic content of fresh orange juices.
: Citrus bioflavonoids for cardiovascular health| Citrus Flavonoids in Preventing Cardiovascular Diseases | SpringerLink | The Impact of Flavonols on Cardiovascular Risk. Cell Biochem Funct. Chronic stress is a frequent underlying cause of low nutrient levels and health issues. Inflammation is a complex process that includes many inflammatory mediators such as iNOS inducible nitric oxide synthase and cyclooxygenase-2 COX-2 , which enhance the nitric oxide level and prostaglandins. Calprotectin is an abundant neutrophil protein, and its presence in the stool indicates neutrophilic infiltration into the gut lumen, which is associated with severe inflammation. |
| Citrus Bioflavonoids -Support Blood Sugar Levels & Heart Health - 60 Vegetable Capsules | Flavonoids, thyroid iodide bioflavonlids and thyroid cancer-a review. Isoflavones that are known to have an Citrus bioflavonoids for cardiovascular health on health include daidzein, genistein, and glycitein. Neurology — Quality assessment Authors ASK and OA separately assessed the quality of the work, with any differences settled by discussion. J Agr Food Chem ; |
| ♡ Heart-Healthy Bioflavonoids ♡ - Part 2 – InterPlexus | Liu RH Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr S—S. Liu Y, Heying E, Tanumihardjo SA History, global distribution, and nutritional importance of citrus fruits. Compr Rev Food Sci Food Saf — Majed BH, Khalil RA Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Pharmacol Rev — Mendis S, Puska P, Norrving B Global atlas on cardiovascular disease prevention and control. World Health Organization, Geneva, pp 2— Morand C, Dubray C, Milenkovic D et al Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Okwu DE Citrus fruits: a rich source of phytochemicals and their roles in human health. Int J Chem Sci — Pérez-Jiménez J, Fezeu L, Touvier M et al Dietary intake of polyphenols in French adults. Peterson JJ, Beecher GR, Bhagwat SA et al a Flavanones in grapefruit, lemons, and limes: a compilation and review of the data from the analytical literature. J Food Compos Anal S74—S Peterson JJ, Dwyer JT, Beecher GR et al b Flavanones in oranges, tangerines mandarins , tangors, and tangelos: a compilation and review of the data from the analytical literature. J Food Compos Anal S66—S Reshef N, Hayari Y, Goren C, Boaz M, Madar Z, Knobler H Antihypertensive effect of sweetie fruit in patients with stage I hypertension. Am J Hypertens — Rizza S, Muniyappa R, Iantorno M Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab Scalbert A, Johnson IT, Saltmarsh M Polyphenols: antioxidants and beyond. Am J Clin Nutr 81 1 S—S. Tomas-Barberen FA, Clifford MN, Tomas-Barberan FA, Clifford MN Flavanones, chalcones and dihydrochalcones—nature, occurrence and dietary burden. J Sci Food Agric — Article Google Scholar. Turner J, Belch JJF, Khan F Current concepts in assessment of microvascular endothelial function using laser doppler imaging and iontophoresis. Trends Cardiovasc Med — Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res — CAS PubMed Google Scholar. Zygmunt K, Faubert B, MacNeil J, Tsiani E Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK. Biochem Biophys Res Commun — Download references. Department of Pharmaceutical Technology, Faculty of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia. Department of Chemistry, Faculty of Science, International Islamic University Malaysia, Kuantan, Pahang, Malaysia. Department of Chemistry, Universiti Pendidikan Sultan Idris, Tanjung Malim, Perak, Malaysia. Department of Pharmacy, Islamic University of Indonesia, Yogyakarta, Indonesia. You can also search for this author in PubMed Google Scholar. Correspondence to Muhammad Taher. Department of Biotechnology, East West First Grade College, Bengaluru, Karnataka, India. Reprints and permissions. Taher, M. Citrus Flavonoids in Preventing Cardiovascular Diseases. In: Swamy, M. eds Plant-derived Bioactives. Springer, Singapore. Published : 28 June Publisher Name : Springer, Singapore. Print ISBN : Online ISBN : eBook Packages : Biomedical and Life Sciences Biomedical and Life Sciences R0. Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Policies and ethics. Skip to main content. Abstract Citrus , belonging to the family of Rutaceae is a genus of the flowering plants and shrubs. Keywords Citrus Biological properties Phytochemical Hesperidin Naringin. Buying options Chapter EUR eBook EUR Softcover Book EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions. References Actis-Goretta L, Ottaviani JI, Fraga CG Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 60 36 — Article CAS PubMed Google Scholar Cobbold CA, Sherratt JA, Maxwell SRJ Lipoprotein oxidation and its significance for atherosclerosis: a mathematical approach. Am J Clin Nutr — Article PubMed Google Scholar FAO Citrus Fruit Statistics Food Agric Organ U N 53 Google Scholar Go AS, Mozaffarian D, Roger VL, et al Heart Disease and Stroke Statistics Update: a report from the American Heart Association Google Scholar Grassi D, Desideri G, Croce G et al Flavonoids, vascular function and cardiovascular protection. pp — Google Scholar Jayaraman R, Subramani S, Sheik Abdullah SH, Udaiyar M Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlidemic in streptozotocin-induced diabetic rats. Flavonoids intake and risk of type 2 diabetes mellitus. A meta-analysis of prospective cohort studies. Medicine ;e Hwang SL, Shih PH, Yen GC. Neuroprotective effects of citrus flavonoids. J Agric Food Chem ; Hardcastle AC, Aucott L, Reid DM, Macdonald HM. Associations between dietary flavonoid intakes and bone health in a Scottish population. J Bone Miner Res ; Dietary flavonoids and risk of stroke in women. Stroke ; Di Majo D, La Guardia M, Leto G, et al. Flavonols and flavanols as modulators of xanthine oxidase and manganese superoxide dismutase activity. Int J Food Sci Nutr ; Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci ; Croft KD. The chemistry and biological effects of flavonoids and phenolic acids. Ann NY Acad Sci ; Yusof S, Ghazali HM, King GS. Naringin content in local citrus fruits. Caristi C, Bellocco E, Gargiulli C, et al. Flavone-di-C-glycosides in citrus juices from Southern Italy. Tsiokanos E, Tsafantakis N, Termentzi A, et al. Phytochemical characteristics of bergamot oranges from the Ionian islands of Greece: A multianalytical approach with emphasis in the distribution of neohesperidose flavanones. Ooghe WC, Detavernier CM. Detection of the addition of Citrus reticulata and hybrids to Citrus sinensis by flavonoids. Narayana KR, Reddy MS, Chaluvadi MR, Krishna DR. Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol ; Verma ML, Sharma S, Saini R, et al. Chapter 3-Bioflavonoids: Synthesis, functions and biotechnological applications. Biotechnological Product Bioact Comp ; Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. Scient World J ; Feng X, Li Y, Brobbey M, et al. Insights into the intestinal bacterial metabolism of flavonoids and the bioactivities of their microbe derived ring cleavage metabolites. Drug Metab Rev ; Nielsen IL, Chee WS, Poulsen L, et al. Bioavailability is improved by enzymatic modification of the citrus flavonoid hesperidin in humans: a randomized, double-blind, crossover trial. J Nutr ; Kanaze FI, Bounartzi MI, Georgarakis M, Niopas, I. Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects. Eur J Clin Nutr ; Lin SP, Hou YC, Tsai SY, et al. Tissue distribution of naringenin conjugated metabolites following repeated dosing of naringin to rats. Biomedicine ; Ekalu A, Habila JH. Flavonoids: isolation, characterization, and health benefits. Beni Suef Univ J Basic Appl Sci ; Burda S, Oleszek W. Antioxidant and antiradical activities of flavonoids. Di Majo D, Giammanco M, La Guardia M, et al. Flavanones in citrus fruit: structure antioxidant activity relationships. Food Res Int ; Benavente-García O, Castillo J. Update on uses and properties of Citrus flavonoids: new findings in anticancer, cardiovascular, and antiinflammatory activity. Sichel G, Corsaro C, Scalia M, et al. Free Radic Biol Med ; Di Majo D, La Neve L, La Guardia M, et al. The influence of two different pH levels on the antioxidant properties of flavonols, flavanols, phenolic acids and aldehyde compounds analysed in synthetic wine and in a phosphate buffer. J Food Compost Anal ; Rapisarda P, Tomaino A, Lo Cascio R, et al. Effec-tiveness as influenced by phenolic content of fresh orange juices. Di Majo D, La Guardia M, Crescimanno M, et al. In-fluence of flavonoids on the transmembrane electron transport: study ex vivo. Di Majo D, La Guardia M, Di Sclafani E, et al. Influence of quercetin and luteolin on the activity of the catalase: Study ex vivo about erythrocytes in smokers and non-smokers. J Biol Res ; Maleki SJ, Crespo JF, Cabanillas B. Anti-inflammatory effects of flavonoids. Rathee P, Chaudhary H, Rathee S, et al. Mechanism of action of flavonoids as anti-inflammatory agents: a review. Allergy Drug Targets , 8, Manthey JA, Guthrie N, Grohmann K. Biological properties of citrus flavonoids pertaining to cancer and inflammation. Curr Med Chem ; Da Silva EJA, Oliveira AS, Lapa AJ. Pharmacological evaluation of the antiinflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice. J Pharm Pharmacol ; Sakata K, Hirose Y, Qiao Z, et al. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett ; Lin N, Sato T, Takayama Y, et al. Novel anti inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages. Biochem Pharmacol ; Huxley RR, Neil HAW. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Alam MA, Subhan N, Rahman MM, et al. Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action. Adv Nutr ; Fuhrman B, Aviram M. Flavonoids protect LDL from oxidation and attenuate atherosclerosis. Curr Opin Lipidol ; Naderi GA, Asgary S, Sarraf-Zadegan GN, Shirvany H. Antioxidant effect of flavonoids on the susceptibility of LDL oxidation. Mol Cell Biochem ; Mahmoud AM, Hernández Bautista RJ, Mansur A, et al. Beneficial effects of citrus flavonoids on cardiovascular and metabolic health. Oxid Med Cell Longev ; Kurowska EM, Borradaile NM, Spence JD, Carroll KK. Hypocholesterolemic effects of dietary citrus juices in rabbits. Nutr Res ; Kim HK, Jeong TS, Lee MK, et al. Lipid lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. Clin Chim Acta ; Chtourou Y, Fetoui H, Jemai R, et al. Naringenin reduces cholesterol induced hepatic inflammation in rats by modulating matrix metalloproteinases-2, 9 via inhibition of nuclear factor κB pathway. Eur J Pharmacol ; Kurowska EM, Manthey JA. Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet induced hypercholesterolemia. Park HJ, Jung UJ, Cho SJ, et al. Lee S, Park YB, Bae KH, et al. Cholesterol lowering activity of naringenin via inhibition of 3- hydroxymethylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase in rats. Ann Nutr Metab ; Lee MK, Moon SS, Lee SE, et al. Naringenin 7-O-cetyl ether as inhibitor of HMG-CoA reductase and modulator of plasma and hepatic lipids in high cholesterol-fed rats. Bioorg Med Chem ; Chanet A, Milenkovic D, Deval C, et al. Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice. Lee CH, Jeong TS, Choi YK, et al. Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VCAM-1 and MCP-1 in high cholesterol-fed rabbits. Biophys Res Commun ; Lee S, Lee CH, Moon SS, et al. Naringenin derivatives as anti-atherogenic agents. Bioorg Med Chem Lett ; Mulvihill EE, Assini JM, Sutherland BG, et al. Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high fat-fed low density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol ; Oboh G, Bello FO, Ademosun AO. Hypocholesterolemic properties of grapefruit Citrus paradisii and shaddock Citrus maxima juices and inhibition of angiotensinconverting enzyme activity. J Food Drug Anal ; Angelone T, Pasqua T, Di Majo D, et al. Distinct signalling mechanisms are involved in the dissimilar myocardial and coronary effects elicited by quercetin and myricetin, two red wine flavonols. Nutr Metab Cardiovasc Dis ; Mink PJ, Scrafford CG, Barraj LM, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr ;85; Aptekmann NP, Cesar TB. Long-term orange juice consumption is associated with low LDL-cholesterol and apolipoprotein B in normal and moderately hypercholesterolemic subjects. Lipids Health Dis ; Yamada T, Hayasaka S, Shibata Y, et al. Frequency of citrus fruit intake is associated with the incidence of cardiovascular disease: the Jichi Medical School cohort study. J Epidemiol ; Gorinstein S, Caspi A, Libman I, et al. Red grapefruit positively influences serum triglyceride level in patients suffering from coronary atherosclerosis: studies in vitro and in humans. J Agr Food Chem ; Miwa Y, Yamada M, Sunayama T, et al. Effects of glucosyl hesperidin on serum lipids in hyperlipidemic subjects: preferential reduction in elevated serum triglyceride level. J Nutr Sci Vitaminol ; Miwa Y, Mitsuzumi H, Sunayama T, et al. Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low density lipoprotein metabolic abnormality. Jung UJ, Kim HJ, Lee JS, et al. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clin Nutr ; Roza JM, Xian-Liu Z, Guthrie N. Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Altern Ther Health Med ; Reshef N, Hayari Y, Goren C, et al. Antihypertensive effect of sweetie fruit in patients with stage I hypertension. Am J Hypertens ; Morand C, Dubray C, Milenkovic D, et al. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Rizza S, Muniyappa R, Iantorno M, et al. Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing in-flammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab ; Benavente-Garcìa O, Castillo J, Marin FR, et al. Uses and properties of citrus flavonoids. Manach C, Regerat F, Texier O, et al. Bioavailability, metabolism and physiological impact of 4-oxo-flavonoids. Van Wauwe J, Goossens J. Effects of antioxidants on cyclooxygenase and lipoxygenase activities in intact human platelets: Comparison with indomethacin and ETYA. Prostaglandins ; Tzeng SH, Ko WC, Ko FN, Teng CM. Inhibition of platelet aggregation by some flavonoids. Thromb Res ; Alcaraz MJ, Ferrandiz ML. Modification of arachidonic metabolism by flavonoids. J Ethnopharmacol ; Reyes-Farias M, Carrasco-Pozo C. The anticancer effect of quercetin: Molecular implications in cancer metabolism. Int J Mol Sci ; Aghajanpour M, Nazer MR, Obeidavi Z, et al. Functional foods and their role in cancer prevention and health promotion: a comprehensive review. Am J Cancer Res ; Rawson NE, Ho CT, Li S. Efficacious anticancer property of flavonoids from citrus peels. Food Sci Human Wellness ; Shimoi K, Masuda S, Furogori M, et al. Radioprotective affect of antioxidative flavonoids in c-ray irradiated mice. Carcinogenesis ; Jeon SM, Bok SH, Jang MK, et al. Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci ; Heo HY, Lee SJ, Kwon CH, et al. Anticlastogenic effects of galangin against bleomycin-induced chromosomal aberrations in mouse spleen lymphocytes. Mut Res ; |
| Citrus Bioflavonoids: Benefits and Safety in Dietary Supplements | The robust cardiovasscular of the citrus bioflavonoid complex Citrus bioflavonoids for cardiovascular health the AIP cardiovasscular less than 0. Hypertension, smoking, biotlavonoids, obesity, physical inactivity, cardiovsscular, and alcohol bioflavonoidw are factors that increase the Citrus bioflavonoids for cardiovascular health of stroke. Please Note: The articles on this database are automatically generated by our AI system. Check for updates. Data extraction The authors ASK and OA independently re-checked all eligible RCTs and extracted the following information. Cholesterol lowering activity of naringenin via inhibition of 3- hydroxymethylglutaryl coenzyme A reductase and acyl coenzyme A: cholesterol acyltransferase in rats. EPI Miyamoto S, Yasui Y, Tanaka T, et al. |
| Citrus Bioflavonoids -Support Blood Sugar Levels & Heart Health - 60 V – HealthyHey Nutrition | Biophys Res Commun ; An Overview on Citrus aurantium L. The dietary flavonoids present in citrus fruits include hesperidin, hesperetin, naringin, naringenin, diosmin, quercetin, rutin, nobiletin, tangeretin, and many others. The participants were divided into three groups that consumed mL of juice daily for twelve weeks. After four weeks of treatment, the participants experienced significant reductions in total cholesterol, LDL, and triglyceride levels. Dauchet L, Amouyel P, Dallongeville J Fruit and vegetable consumption and risk of stroke: A meta-analysis of cohort studies. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. |
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