Category: Health

Anthocyanins health benefits

Anthocyanins health benefits

This is a preview of subscription content, log Anthocyanin Joint support supplements an institution Anyhocyanins check access. Wu T, Yang L, Guo Anthocyanins health benefits, Zhang M, Liu R, Anthocyanins health benefits W Raspberry anthocyanin consumption prevents diet-induced benefihs by alleviating oxidative stress and modulating Sports training programs lipid metabolism. Users Crispy Pumpkin Seeds to obtain heqlth to reprint or Antocyanins any materials appearing on this site may contact us directly. How Do We Use the Information That You Provide to Us? The UK, Europe, US and Canada currently have no recommended daily reference intakes or toxicity levels for anthocyanins, when consumed from food. All brightly coloured fruit and vegetables contain plant pigments that play a key role in protecting our bodies. J Investig Dermatol — Article CAS PubMed Google Scholar Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, Varol M, Jain A, Khan MA, Sethi G Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements.

Anthocyanins health benefits -

Overall J, Bonney SA, Wilson M, Beermann A III, Grace MH, Esposito D, Lila MA, Komarnytsky S Metabolic effects of berries with structurally diverse anthocyanins. Paik SS, Jeong E, Jung SW, Ha TJ, Kang S, Sim S, Jeon JH, Chun MH, Kim IB Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N -methyl- N -nitrosourea.

Paixao J, Dinis TC, Almeida LM Malvidin O -glucoside protects endothelial cells up-regulating endothelial NO synthase and inhibiting peroxynitrite-induced NF-kB activation. Chem Biol Interact — Front Neurosci Pandey KB, Rizvi SI Plant polyphenols as dietary antioxidants in human health and disease.

Pang L, Lian X, Liu H, Zhang Y, Li Q, Cai Y, Ma H, Yu X Understanding diabetic neuropathy: focus on oxidative stress. Parichatikanond W, Pinthong D, Mangmool S Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin.

Parmar NS, Ghosh MN Protective effect of some bioflavonoids on the X-irradiation-induced increase in capillary permeability of rat intestine. Parra-Vargas M, Sandoval-Rodriguez A, Rodriguez-Echevarria R, Dominguez-Rosales JA, Santos-Garcia A, Armendariz-Borunda J Delphinidin ameliorates hepatic triglyceride accumulation in human hepg2 cells, but not in diet-induced obese mice.

Nutrients 10 8 Parry J, Su L, Moore J, Cheng Z, Luther M, Rao JN, Wang J-Y, Yu LL Chemical compositions, antioxidant capacities, and antiproliferative activities of selected fruit seed flours. Passeri V, Koes R, Quattrocchio FM New challenges for the design of high value plant products: stabilization of anthocyanins in plant vacuoles.

Front Plant Sci Pereira SR, Pereira R, Figueiredo I, Freitas V, Dinis TCP, Almeida LM Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries Vaccinium corymbosum L.

and 5-aminosalicylic acid in a TNBS-induced colitis rat model. Pergola C, Rossi A, Dugo P, Cuzzocrea S, Sautebin L Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. Nitric Oxide — Phaniendra A, Jestadi DB, Periyasamy L Free radicals: properties, sources, targets, and their implication in various diseases.

Indian J Clin Biochem. Pojer E, Mattivi F, Johnson D, Stockley CS The Case for Anthocyanin consumption to promote human health: a review. Compr Rev Food Sci Food Saf — Klin Monbl Augenheilkd — Poulose SM, Fisher DR, Larson J, Bielinski DF, Rimando AM, Carey AN, Schauss AG, Shukitt-Hale B Anthocyanin-rich Acai Euterpe oleracea Mart.

fruit pulp fractions attenuate inflammatory stress signaling in mouse brain bv-2 microglial cells. Prior RL, Wu X Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities. Free Radic Res — Probst Y A review of the nutrient composition of selected Rubus berries.

Nutr Food Sci — Putta S, Yarla NS, Kumar KE, Lakkappa DB, Kamal MA, Scotti L, Scotti MT, Ashraf GM, Rao BSB, Kumari DS et al Preventive and therapeutic potentials of anthocyanins in diabetes and associated complications.

Curr Med Chem — Qin L, Zhang J, Qin M Protective effect of cyanidin 3- O -glucoside on beta-amyloid peptide-induced cognitive impairment in rats. Qin S, Sun D, Mu J, Ma D, Tang R, Zheng Y Purple sweet potato color improves hippocampal insulin resistance via down-regulating SOCS3 and galectin-3 in high-fat diet mice.

Behav Brain Res — Ramirez-Tortosa C et al Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats. Free Radic Biol Med — Rasheed Z, Akhtar N, Anbazhagan AN, Ramamurthy S, Shukla M, Haqqi TM Polyphenol-rich pomegranate fruit extract POMx suppresses PMACI-induced expression of pro-inflammatory cytokines by inhibiting the activation of MAP Kinases and NF-kappaB in human KU cells.

J Inflamm Reddivari L, Vanamala J, Chintharlapalli S, Safe SH, Miller JJC Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways.

Reddy MK, Alexander-Lindo RL, Nair MG Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors.

Rehman SU, Shah SA, Ali T, Chung JI, Kim MO Anthocyanins reversed d-galactose-induced oxidative stress and neuroinflammation mediated cognitive impairment in adult rats.

J Ayurveda Integr Med. Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, Stampfer MJ Prospective study of alcohol consumption and risk of coronary disease in men.

Lancet — Rodrigo KA, Rawal Y, Renner RJ, Schwartz SJ, Tian Q, Larsen PE, Mallery SR Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Rodriguez-Mateos A, Istas G, Boschek L, Feliciano RP, Mills CE, Boby C, Gomez-Alonso S, Milenkovic D, Heiss C Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics.

J Gerontol A Biol A — Rosenblat M, Hayek T, Aviram M Anti-oxidative effects of pomegranate juice PJ consumption by diabetic patients on serum and on macrophages. Atherosclerosis — Rouher F, Sole P, Offret G, Bernard JA Demonstration by adaptoelectroretinography of the action of a cyanidin on nocturnal vision.

Sadilova E, Stintzing Florian C, Carle R Anthocyanins, colour and antioxidant properties of eggplant Solanum melongena L. and violet pepper Capsicum annuum L.

peel extracts. Z für Naturforsch — Salehi B, Sharifi-Rad J, Cappellini F, Reiner Z, Zorzan D, Imran M, Sener B, Kilic M, El-Shazly M, Fahmy NM et al The therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action.

Front Pharmacol — Saric A, Sobocanec S, Balog T, Kusic B, Sverko V, Dragovic-Uzelac V, Levaj B, Cosic Z, Macak Safranko Z, Marotti T Improved antioxidant and anti-inflammatory potential in mice consuming sour cherry juice Prunus cerasus cv.

Plant Foods Hum Nutr Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.

Seeram NP, Schutzki R, Chandra A, Nair MG Characterization, quantification, and bioactivities of anthocyanins in Cornus species. Serafino A, Sinibaldi-Vallebona P, Lazzarino G, Tavazzi B, Rasi G, Pierimarchi P, Andreola F, Moroni G, Galvano G, Galvano F et al Differentiation of human melanoma cells induced by cyanidin O -β-glucopyranoside.

FASEB J — Seymour E, Lewis SK, Urcuyo-Llanes DE, Tanone I, Kirakosyan A, Kaufman PB Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet. Seymour EM, Tanone II, Urcuyo-Llanes DE, Lewis SK, Kirakosyan A, Kondoleon MG, Kaufman PB, Bolling SF et al Blueberry intake alters skeletal muscle and adipose tissue peroxisome proliferator-activated receptor activity and reduces insulin resistance in obese rats.

Shah SA, Amin FU, Khan M, Abid MN, Rehman SU, Kim TH, Kim MW, Kim MO Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain. J Neuroinflamm Shah SA, Yoon GH, Kim MO Protection of the developing brain with anthocyanins against ethanol-induced oxidative stress and neurodegeneration.

Sharma P, McClees SF, Afaq F Pomegranate for prevention and treatment of cancer: an update. Shi M, Mathai ML, Xu G, McAinch AJ, Su XQ The effects of supplementation with blueberry, cyanidin O -β-glucoside, yoghurt and its peptides on obesity and related comorbidities in a diet-induced obese mouse model.

Shih P-H, Wu C-H, Yeh C-T, Yen G-C Protective effects of anthocyanins against amyloid β-peptide-induced damage in neuro-2A cells. Shih P-H, Yeh C-T, Yen G-C Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells.

Food Chem Toxicol — Shih P-H, Yeh C-T, Yen G-C Anthocyanins induce the activation of phase-II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. Shim SH, Kim JM, Choi CY, Kim CY, Park KH Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma.

Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K et al Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity.

Nat Med — Singh PP, Chandra A, Mahdi F, Roy A, Sharma P Reconvene and reconnect the antioxidant hypothesis in human health and disease. Indian J Clin Biochem — Singletary KW, Jung KJ, Giusti M Anthocyanin-rich grape extract blocks breast cell DNA damage.

Skates E, Overall J, DeZego K, Wilson M, Esposito D, Lila MA, Komarnytsky S Berries containing anthocyanins with enhanced methylation profiles are more effective at ameliorating high fat diet-induced metabolic damage.

Skemiene K, Liobikas J, Borutaite V Anthocyanins as substrates for mitochondrial complex I—protective effect against heart ischemic injury.

FEBS J — Skrovankova S, Sumczynski D, Mlcek J, Jurikova T, Sochor J Bioactive compounds and antioxidant activity in different types of berries.

Smith MAL, Marley KA, Seigler D, Singletary KW, Meline B Bioactive properties of wild blueberry fruits. Sole P, Rigal D, Peyresblanques J Effects of cyaninoside chloride and Heleniene on mesopic and scotopic vision in myopia and night blindness.

J Fr Ophtalmol — Song H, Wu T, Xu D, Chu Q, Lin D, Zheng X a Dietary sweet cherry anthocyanins attenuates diet-induced hepatic steatosis by improving hepatic lipid metabolism in mice.

Biochim Biophys Acta Mol Basis Dis — Antioxidants Stintzing FC, Stintzing AS, Carle R, Frei B, Wrolstad RE Color and antioxidant properties of cyanidin-based anthocyanin pigments.

Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol — Strathearn KE, Yousef GG, Grace MH, Roy SL, Tambe MA, Ferruzzi MG, Wu QL, Simon JE, Lila MA, Rochet JC Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinsons disease.

Brain Res — Su X, Griffin J, Xu J, Ouyang P, Zhao Z, Wang W Identification and quantification of anthocyanins in purple-fleshed sweet potato leaves. Heliyon 5:e Sumner MD, Elliott-Eller M, Weidner G, Daubenmier JJ, Chew MH, Marlin R, Raisin CJ, Ornish D Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease.

AM J Cardiol — Sun H, Zhang P, Zhu Y, Lou Q, He S Antioxidant and prebiotic activity of five peonidin-based anthocyanins extracted from purple sweet potato Ipomoea batatas L.

Sci Rep Tan L, Yang HP, Pang W, Lu H, Hu YD, Li J, Lu SJ, Zhang WQ, Jiang YG Cyanidin O -galactoside and blueberry extracts supplementation improves spatial memory and regulates hippocampal ERK expression in senescence-accelerated mice. Biomed Environ Sci — Thiraphatthanavong P, Wattanathorn J, Muchimapura S, Thukham-mee W, Lertrat K, Suriharn B The combined extract of purple waxy corn and ginger prevents cataractogenesis and retinopathy in streptozotocin-diabetic rats.

Thiraphatthanavong P et al Preventive effect of Zea mays L. purple waxy corn on experimental diabetic cataract. BioMed Res Int Tian L, Tan Y, Chen G, Wang G, Sun J, Ou S, Chen W, Bai W Metabolism of anthocyanins and consequent effects on the gut microbiota.

Toufektsian M-C, De Lorgeril M, Nagy N, Salen P, Donati MB, Giordano L Chronic dietary intake of plant-derived anthocyanins protects the rat heart against ischemia-reperfusion injury. Traustadottir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM Tart cherry juice decreases oxidative stress in healthy older men and women.

Tsuda T, Horio F, Uchida K, Aoki H, Osawa T Dietary cyanidin 3- O - β -D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. Tsuda T, Ueno Y, Kojo H, Yoshikawa T, Osawa T Gene expression profile of isolated rat adipocytes treated with anthocyanins.

Biochim Biophys Acta — Tsuda T, Ueno Y, Yoshikawa T, Kojo H, Osawa T Microarray profiling of gene expression in human adipocytes in response to anthocyanins. Turck P, Fraga S, Salvador I, Campos-Carraro C, Lacerda D, Bahr A, Ortiz V, Hickmann A, Koetz M, Bello-Klein A et al Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension.

Turner K, Fischer JG, Grider A, Hargrove J, Tokarev J Anthocyanins increase antioxidant enzyme activity in ht adenocarcinoma cells by martha. MsC Thesis, Athens, Georgia, USA. Ulla A, Mohamed MK, Sikder B, Rahman AT, Sumi FA, Hossain M, Reza HM, Rahman GMS, Alam MA Coenzyme Q10 prevents oxidative stress and fibrosis in isoprenaline induced cardiac remodeling in aged rats.

BMC Pharmacol Toxicol — Ullah R, Khan M, Shah SA, Saeed K, Kim MO Natural antioxidant anthocyanins—a hidden therapeutic candidate in metabolic disorders with major focus in neurodegeneration.

Nutritions Valensi P, Behar A, Attalah M, Cohen-Boulakia F, Pariès J, Attali JR Increased capillary filtration of albumin in diabetic patients-relation with gender, hypertension, microangiopathy, and neuropathy.

Valensi P, Cohen-Boulakia F, Attali JR, Behar A Changes in capillary permeability in diabetic patients. Clin Hemorheol Micro — Valenza A, Bonfanti C, Pasini ME, Bellosta P Anthocyanins function as anti-inflammatory agents in a Drosophila model for adipose tissue macrophage infiltration.

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol — van Velden DP, Mansvelt EPG, Troup GJ Red wines good, white wines bad? Redox Rep — Varadinova MG, Docheva-Drenska DI, Boyadjieva NI Effects of anthocyanins on learning and memory of ovariectomized rats.

Menopause — Varma SD, Kinoshita JH Inhibition of lens aldose reductase by flavonoids—their possible role in the prevention of diabetic cataracts. Vendrame S, Klimis-Zacas D Anti-inflammatory effect of anthocyanins via modulation of nuclear factor-kappaB and mitogen-activated protein kinase signaling cascades.

Wallace TC, Giusti MM Anthocyanins. Adv Nutr — Wang L-S, Stoner GD Anthocyanins and their role in cancer prevention. Williamson G, Sies H, Heber D, Keen CL, Macdonald IA, Actis-Gorreta L, Momma TY, Ottaviani JI, Holt RR, Schroeter H et al Functional foods for health promotion: state-of-the-science on dietary flavonoids, extended abstracts from the 12th Annual Conference on Functional Foods for Health Promotion, April Woodward G, Kroon P, Cassidy A, Kay C Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples.

Worsztynowicz P, Napierała M, Białas W, Grajek W, Olkowicz M Pancreatic α-amylase and lipase inhibitory activity of polyphenolic compounds present in the extract of black chokeberry Aronia melanocarpa L. Process Biochem — Wu T, Jiang Z, Yin J, Long H, Zheng X a Anti-obesity effects of artificial planting blueberry Vaccinium ashei anthocyanin in high-fat diet-treated mice.

Int J Food Sci Nutr — Wu T, Yang L, Guo X, Zhang M, Liu R, Sui W Raspberry anthocyanin consumption prevents diet-induced obesity by alleviating oxidative stress and modulating hepatic lipid metabolism.

Wu T, Yin J, Zhang G, Long H, Zheng X b Mulberry and cherry anthocyanin consumption prevents oxidative stress and inflammation in diet-induced obese mice.

Xu J-W, Ikeda K, Yamori Y Cyanidin O -glucoside regulates phosphorylation of endothelial nitric oxide synthase. Yamahara J, Mibu H, Sawada T, Fujimura H, Takino S, Yoshikawa M Biologically active principles of crude drugs.

Antidiabetic principles of Corni Fructus in experimental diabetes induced by streptozotocin. J Pharm Soc Jpn — Yang Z, Zhai W Identification and antioxidant activity of anthocyanins extracted from the seed and cob of purple corn Zea mays L. Innov Food Sci Emerg Technol — Yaribeygi H, Sathyapalan T, Atkin SL, Sahebkar A Molecular mechanisms linking oxidative stress and diabetes mellitus.

Yawadio R, Tanimori S, Morita N Identification of phenolic compounds isolated from pigmented rices and their aldose reductase inhibitory activities. You Q, Chen F, Wang X, Luo PG, Jiang Y Inhibitory effects of muscadine anthocyanins on alpha-glucosidase and pancreatic lipase activities.

Youdim KA, Martin A, Joseph JA Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Youdim KA, McDonald J, Kalt W, Joseph JA Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults.

Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D Berry anthocyanins as novel antioxidants in human health and disease prevention. Zdarilova A, Svobodova AR, Chytilova K, Simanek V, Ulrichova J Polyphenolic fraction of Lonicera caerulea L. fruits reduces oxidative stress and inflammatory markers induced by lipopolysaccharide in gingival fibroblasts.

Zhang H, Guo J, Mao L, Li Q, Guo M, Mu T, Zhang Q, Bi X Up-regulation of miRp is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins.

Zhang H, Xu Z, Zhao H, Wang X, Pang J, Li Q, Yang Y, Ling W a Anthocyanin supplementation improves anti-oxidative and anti-inflammatory capacity in a dose—response manner in subjects with dyslipidemia. Redox Biol Zhang Q, Gonzalez de Mejia E, Luna-Vital D, Tao T, Chandrasekaran S, Chatham L, Juvik J, Singh V, Kumar D a Relationship of phenolic composition of selected purple maize Zea mays L.

genotypes with their anti-inflammatory, anti-adipogenic and anti-diabetic potential. Zhang X, Wei J, Tian J, Li N, Jia L, Shen W, Cui J b Enhanced anthocyanin accumulation of immature radish microgreens by hydrogen-rich water under short wavelength light.

Sci Hortic — Zhang Y, Jayaprakasam B, Seeram NP, Olson LK, DeWitt D, Nair MG Insulin secretion and cyclooxygenase enzyme inhibition by cabernet sauvignon grape skin compounds.

Zhang Y, Meng Q, Yin J, Zhang Z, Bao H, Wang X b Anthocyanins attenuate neuroinflammation through the suppression of MLK3 activation in a mouse model of perioperative neurocognitive disorders.

Brain Res Zhang Y, Vareed SK, Nair MG Human tumor cell growth inhibition by nontoxic anthocyanidins, the pigments in fruits and vegetables. Life Sci — Zhang Z-c, Zhou Q, Huangfu G-y, Wu Y, Zhang J-l c Anthocyanin extracts of lingonberry Vaccinium vitis-idaea L. attenuate serum lipids and cholesterol metabolism in HCD-induced hypercholesterolaemic male mice.

Zhao X, Feng P, He W, Du X, Chen C, Suo L, Liang M, Zhang N, Na A, Zhang Y The prevention and inhibition effect of anthocyanins on colorectal Cancer. Curr Pharm Des — Zhu F Anthocyanins in cereals: composition and health effects.

Zhu F, Cai Y-Z, Yang X, Ke J, Corke H Anthocyanins, hydroxycinnamic acid derivatives, and antioxidant activity in roots of different chinese purple-fleshed sweetpotato genotypes. Zhu Y, Sun H, He S, Lou Q, Yu M, Tang M, Tu L Metabolism and prebiotics activity of anthocyanins from black rice Oryza sativa L.

in vitro. PLoS ONE. Download references. Nahar gratefully acknowledges the financial support of the European Regional Development Fund - Project ENOCH No. Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh.

Ashraful Alam, Priota Islam, Nusrat Subhan, Md. School of Agricultural and Wine Sciences, Charles Sturt University, Locked Bag , Wagga Wagga, NSW, , Australia.

Centre for Natural Products Discovery CNPD , School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool, L3 3AF, UK. You can also search for this author in PubMed Google Scholar. MAA, SDS and NS planned for the review.

MAA, PI, MMR and NS made the literature collection and preliminary draft manuscript. FK, GEB and LN critically expanded the draft manuscript and checked the correctness of the references.

MAA, NS and SDS made the tables and pictorial diagram. MAA, NS, GEB and SDS critically reviewed the whole manuscript. All author approved the final version of this manuscript. Correspondence to Nusrat Subhan.

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Potential health benefits of anthocyanins in oxidative stress related disorders. Phytochem Rev 20 , — Download citation. Received : 06 September Accepted : 17 April Published : 08 May Issue Date : August Anyone you share the following link with will be able to read this content:.

Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Abstract Anthocyanins are naturally occurring water-soluble plant pigments belonging to the flavonoids chemical class.

Access this article Log in via an institution. References Abo El-Ella DM, Bishayee A Chapter 6 - The epigenetic targets of berry anthocyanins in cancer prevention. Academic Press, pp — Chapter Google Scholar Afaq F, Malik A, Syed D, Maes D, Matsui MS, Mukhtar H a Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign.

Photochem Photobiol —45 Article CAS PubMed Google Scholar Afaq F, Saleem M, Krueger CG, Reed JD, Mukhtar H b Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.

Int J Cancer — Article CAS PubMed Google Scholar Afaq F, Syed DN, Malik A, Hadi N, Sarfaraz S, Kweon MH, Khan N, Zaid MA, Mukhtar H Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human hacat keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis.

J Investig Dermatol — Article CAS PubMed Google Scholar Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, Varol M, Jain A, Khan MA, Sethi G Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements.

Biomolecules Article CAS PubMed Central Google Scholar Ahmadiani N, Sigurdson GT, Robbins RJ, Collins TM, Giusti MM Solid phase fractionation techniques for segregation of red cabbage anthocyanins with different colorimetric and stability properties. Food Res Int — Article CAS PubMed Google Scholar Ahmet I, Spangler E, Shukitt-Hale B, Joseph JA, Ingram DK, Talan M Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats.

PLoS ONE 4:e Article PubMed PubMed Central CAS Google Scholar Akkarachiyasit S, Charoenlertkul P, Yibchok-Anun S, Adisakwattana S Inhibitory activities of cyanidin and its glycosides and synergistic effect with acarbose against intestinal alpha-glucosidase and pancreatic alpha-amylase.

Int J Mol Sci — Article CAS PubMed PubMed Central Google Scholar Alam MA Anti-hypertensive effect of cereal antioxidant ferulic acid and its mechanism of action. Front Nutr Article PubMed PubMed Central CAS Google Scholar Alam MA, Subhan N, Hossain H, Hossain M, Reza HM, Rahman MM, Ullah MO Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity.

Nutr Metab Article CAS Google Scholar Al-Awwadi NA, Araiz C, Bornet A, Delbosc S, Cristol J-P, Linck N, Azay J, Teissedre P-L, Cros G Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats.

J Agric Food Chem — Article CAS PubMed Google Scholar Aloud BM, Raj P, McCallum J, Kirby C, Louis XL, Jahan F, Yu L, Hiebert B, Duhamel TA, Wigle JT et al Cyanidin 3- O -glucoside prevents the development of maladaptive cardiac hypertrophy and diastolic heart dysfunction in week-old spontaneously hypertensive rats.

Food Funct — Article CAS PubMed Google Scholar Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW et al Isolation and characterization of polyphenol type-a polymers from cinnamon with insulin-like biological activity. J Agric Food Chem —70 Article CAS PubMed Google Scholar Anderson RA, Polansky MM Tea enhances insulin activity.

J Agric Food Chem — Article CAS PubMed Google Scholar Andriambeloson E, Magnier C, Haan-Archipoff G, Lobstein A, Anton R, Beretz A, Stoclet JC, Andriantsitohaina R Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta.

J Nutr — Article CAS PubMed Google Scholar Anggraini T, Wilma S, Syukri D, Azima F Total phenolic, anthocyanin, catechins, DPPH radical scavenging activity, and toxicity of Lepisanthes alata Blume Leenh. Int J Food Sci Article PubMed PubMed Central CAS Google Scholar Aoki H, Kuze N, Kato Y Anthocyanins isolated from purple corn Zea mays L.

Nutr Cancer — Article CAS PubMed PubMed Central Google Scholar Arevstrom L, Bergh C, Landberg R, Wu H, Rodriguez-Mateos A, Waldenborg M, Magnuson A, Blanc S, Frobert O Freeze-dried bilberry Vaccinium myrtillus dietary supplement improves walking distance and lipids after myocardial infarction: an open-label randomized clinical trial.

Nutr Res —22 Article PubMed CAS Google Scholar Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K et al Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.

Biochem Biophys Res Commun — Article CAS PubMed Google Scholar Atalay M, Gordillo G, Roy S, Rovin B, Bagchi D, Bagchi M, Sen CK Anti-angiogenic property of edible berry in a model of hemangioma.

FEBS Lett — Article CAS PubMed Google Scholar Augusti KT, Daniel RS, Cherian S, Sheela CG, Nair CR Effect of leucopelargonin derivative from Ficus bengalensis Linn. Indian J Med Res —86 CAS PubMed Google Scholar Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H et al Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.

Clin Nutr — Article CAS PubMed Google Scholar Azzini E, Vitaglione P, Intorre F, Napolitano A, Durazzo A, Foddai MS, Fumagalli A, Catasta G, Rossi L, Venneria E et al Bioavailability of strawberry antioxidants in human subjects.

Br J Nutr — Article CAS PubMed Google Scholar Badshah H, Kim TH, Kim MO Protective effects of anthocyanins against amyloid beta-induced neurotoxicity in vivo and in vitro. Neurochem Int —59 Article CAS PubMed Google Scholar Bagchi D, Sen CK, Bagchi M, Atalay M Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula.

Biochem Mosc —80 Article CAS Google Scholar Bakuradze T, Tausend A, Galan J, Maria-Groh IA, Berry D, Tur JA, Marko D, Richling E Antioxidative activity and health benefits of anthocyanin-rich fruit juice in healthy volunteers.

Free Radic Res 53 sup 1 — Article CAS PubMed Google Scholar Barnes MJ, Perry BG, Hurst RD, Lomiwes D Anthocyanin-rich New Zealand blackcurrant extract supports the maintenance of forearm blood-flow during prolonged sedentary sitting.

Front Nutr Article PubMed PubMed Central CAS Google Scholar Barton M, Cosentino F, Brandes RP, Moreau P, Shaw S, Luscher TF Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin.

Hypertension — Article CAS PubMed Google Scholar Basu A, Rhone M, Lyons TJ Berries: emerging impact on cardiovascular health. Nutr Rev — Article PubMed Google Scholar Bhatt S, Nagappa AN, Patil CR Role of oxidative stress in depression.

Drug Discov Today — Article CAS PubMed Google Scholar Bell DR, Gochenaur K Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol — Article CAS PubMed Google Scholar Bell L, Williams CM A pilot dose—response study of the acute effects of haskap berry extract Lonicera caerulea L.

Eur J Nutr — Article CAS PubMed Google Scholar Bernatoniene J, Kopustinskiene DM The role of catechins in cellular responses to oxidative stress.

Molecules Article PubMed Central CAS Google Scholar Bertuglia S, Malandrino S, Colantuoni A Effects of the natural flavonoid delphinidin on diabetic microangiopathy.

Arzneimittel-Forsch — CAS Google Scholar Bhaswant M, Shafie SR, Mathai ML, Mouatt P, Brown L Anthocyanins in chokeberry and purple maize attenuate diet-induced metabolic syndrome in rats.

Nutrition —31 Article CAS PubMed Google Scholar Blesso CN Dietary anthocyanins and human health. Anticancer Res — CAS PubMed Google Scholar Bomser J, Madhavi D, Singletary K, Smith M In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med — Article CAS PubMed Google Scholar Bonesi M, Leporini M, Tenuta MC, Tundis R The Role of anthocyanins in drug discovery: recent developments.

Curr Drug Discov Technol — Article CAS PubMed Google Scholar Borkowski T, Szymusiak H, Gliszczyńska-Świgło A, Rietjens IMCM, Tyrakowska B Radical scavenging capacity of wine anthocyanins is strongly pH-dependent. J Agric Food Chem — Article CAS PubMed Google Scholar Bouayed J, Bohn T Exogenous antioxidants—double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses.

Oxid Med Cell Longev — Article PubMed PubMed Central Google Scholar Brandstetter H, Grams F, Glitz D, Lang A, Huber R, Bode W, Krell H-W, Engh RA The 1. J Biol Chem — Article CAS PubMed Google Scholar Broncel M, Kozirog M, Duchnowicz P, Koter-Michalak M, Sikora J, Chojnowska-Jezierska J Aronia melanocarpa extract reduces blood pressure, serum endothelin, lipid, and oxidative stress marker levels in patients with metabolic syndrome.

Nutrients Article CAS PubMed Central Google Scholar Burton-Freeman B, Sandhu A, Edirisinghe I Chapter 35—Anthocyanins. Academic Press, Boston, pp — Chapter Google Scholar Carluccio Maria A, Siculella L, Ancora Maria A, Massaro M, Scoditti E, Storelli C, Visioli F, Distante A, De Caterina R Olive oil and red wine antioxidant polyphenols inhibit endothelial activation.

Arterioscler Thromb Vasc Biol — Article PubMed CAS Google Scholar Chang J-J, Hsu M-J, Huang H-P, Chung D-J, Chang Y-C, Wang C-J Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance.

J Agric Food Chem — Article CAS PubMed Google Scholar Chang Y-C, Huang H-P, Hsu J-D, Yang S-F, Wang C-J Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells. Toxicol Appl Pharmacol — Article CAS PubMed Google Scholar Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L Inflammatory responses and inflammation-associated diseases in organs.

Oncotarget — Article PubMed PubMed Central Google Scholar Chen L, Jiang B, Zhong C, Guo J, Zhang L, Mu T, Zhang Q, Bi X Chemoprevention of colorectal cancer by black raspberry anthocyanins involved the modulation of gut microbiota and SFRP2 demethylation. Carcinogenesis — Article CAS PubMed Google Scholar Chen PN, Chu SC, Chiou HL, Chiang CL, Yang SF, Hsieh YS Cyanidin 3- O -glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo.

Nutr Cancer — Article CAS PubMed Google Scholar Chen PN, Kuo WH, Chiang CL, Chiou HL, Hsieh YS, Chu SC Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chem Biol Interact 3 — Article CAS PubMed Google Scholar Chen S, Zhou H, Zhang G, Meng J, Deng K, Zhou W, Wang H, Wang Z, Hu N, Suo Y Anthocyanins from Lycium ruthenicum Murr.

J Agric Food Chem — Article CAS PubMed Google Scholar Chen Y-F, Shibu M, Fan M, Chen M-C, Viswanadha V, Lin Y-L, Lai C-H, Lin K-H, Ho T-J, Kuo W-W et al Purple rice anthocyanin extract protects cardiac function in STZ-induced diabetes rat hearts by inhibiting cardiac hypertrophy and fibrosis.

J Nutr Biochem — Article CAS PubMed Google Scholar Cherian S, Kumar RV, Augusti KT, Kidwai JR Antidiabetic effect of a glycoside of pelargonidin isolated from the bark of Ficus bengalensis Linn. Indian J Biochem Bio — CAS Google Scholar Chiu L-W, Zhou X, Burke S, Wu X, Prior RL, Li L The purple cauliflower arises from activation of a MYB transcription factor.

Plant Physiol — Article CAS PubMed PubMed Central Google Scholar Cho J, Kang JS, Long PH, Jing J, Back Y, Chung KS Antioxidant and memory enhancing effects of purple sweet potato anthocyanin and cordyceps mushroom extract. Arch Pharm Res — Article CAS PubMed Google Scholar Chun OK, Chung S-J, Claycombe KJ, Song WO Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.

J Nutr — Article CAS PubMed Google Scholar Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, Pober JS, Wick TM, Konkle BA, Schwartz BS et al Endothelial cells in physiology and in the pathophysiology of vascular disorders.

Blood CAS PubMed Google Scholar Cohen-Boulakia F, Valensi PE, Boulahdour H, Lestrade R, Dufour-Lamartinie J-F, Hort-Legrand C, Behar A In vivo sequential study of skeletal muscle capillary permeability in diabetic rats: effect of anthocyanosides.

Metabolism — Article CAS PubMed Google Scholar Cook MD, Sandu BAK, Joyce PJP Effect of New Zealand blackcurrant on blood pressure, cognitive function and functional performance in older adults. J Nutr Gerontol Geriatr — Article PubMed Google Scholar Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ, Marczylo TH Effect of cyanidin O -glucoside and an anthocyanin mixture from bilberry on adenoma development in the ApcMin mouse model of intestinal carcinogenesis—Relationship with tissue anthocyanin levels.

Anthocyanin-rich red cabbage Brassica oleracea L. extract attenuates cardiac and hepatic oxidative stress in rats fed an atherogenic diet. J Sci Food Agric. Graf D, Seifert S, Jaudszus A, Bub A, Watzl B.

Anthocyanin-rich juice lowers serum cholesterol, leptin, and resistin and improves plasma fatty acid composition in Fischer rats.

PLoS One. Wang LS, Stoner GD. Anthocyanins and their role in cancer prevention. Cancer Lett. Wang LS, Hecht SS, Carmelia SG, et al. Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev Res Phila. Lim S, Xu J, Kim J, et al.

Role of anthocyanin-enriched purple-fleshed sweet potato p40 in colorectal cancer prevention. Rossi M, Garavello W, Talamini R, et al. Flavonoids and the risk of oral and pharyngeal cancer: a case-control study from Italy.

Cancer Epidemiol Biomarkers Prev. Bosetti C, Bravi F, Talamini R, et al. Flavonoids and prostate cancer risk: a study in Italy. Nutr Cancer. Bode U, Hasan C, Hulsmann B, Fleischhack G.

Recancostat compositum therapy does not prevent tumor progression in young cancer patients. Klin Padiatr. Wang LS, Sardo C, Rocha CM, et al. Effect of freeze-dried black raspberries on human colorectal cancer lesions. Presented at: AACR Special Conference in Cancer Research: Advances in Colon Cancer Research; November , ; Cambridge, MA.

Thomasset S, Berry DP, Cai H, et al. Pilot study of oral anthocyanins for colorectal cancer chemoprevention. Spencer JP. The impact of fruit flavonoids on memory and cognition. Br J Nutr. Youdim KA, Shukitt-Hale B, Joseph JA. Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system.

Free Radic Biol Med. Home About Events Resources Contact Advertise Job Bank Writers' Guidelines Search Gift Shop. Great Valley Publishing Company Valley Forge Road Valley Forge, PA Copyright © Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs.

When it comes to anthocyanin supplements, there are no guidelines for recommended dosage. More research is needed to establish safe dosage information for all people. There is also no Dietary Reference Intake DRI for anthocyanins from food. However, a joint committee comprising the Food and Agriculture Organization of the United Nations FAO and the World Health Organization WHO has established 2.

However, this recommendation applies to anthocyanins from grape skin extracts, not anthocyanins in general. The committee found this to be a safe, nontoxic dose. If necessary, your healthcare provider can help determine the right anthocyanin dose for you.

You may be more likely to experience side effects if you take a dose of anthocyanins that is too high. However, anthocyanins are generally considered safe, especially when consumed through food.

Reports of anthocyanin toxicity or overdose have not been made. Anthocyanins have also been labeled as having low to no toxicity.

Regardless, it's still important to be safe and only use anthocyanin supplements as directed. You should also only consume anthocyanins through food in normal amounts.

Anthocyanins may interact with certain nutrients and medications. Some research suggests that anthocyanins interfere with various enzymes and protein transporters responsible for helping the body absorb some nutrients, like thiamine and folic acid.

Anthocyanins may also affect enzymes or transporters needed to metabolize certain medications. Unfortunately, anthocyanin interactions are not well-documented or understood. It is also important that you carefully read the ingredients list and nutrition facts panel of a supplement. This will ensure you know which ingredients are in the product and how much of each ingredient is included in the supplement.

For best practice, please speak with your healthcare provider regarding the potential for interactions between anthocyanins and any other supplements or medications you take. Anthocyanin supplements should be stored in a cool, dry place.

Keep them out of direct sunlight. Foods containing anthocyanins should be stored normally. To ensure proper shelf life, always keep supplements in their original bottle or packaging. You should also keep anthocyanins out of the reach of pets and children to prevent accidental ingestion.

Discard all supplements once they reach their expiration date. Various supplements have been researched for similar uses to anthocyanins.

These include:. Talk with your healthcare provider about which supplement is best for you. Anthocyanins contain antioxidant properties, which means they can act like antioxidants.

In fact, many of the reported health benefits of anthocyanins are thought to be due to antioxidant activity. Antioxidants scavenge for potentially harmful free radicals in the body. Anthocyanins are a type of water-soluble flavonoid.

Flavonoids are a type of phytochemical, which are compounds found in many plant foods. Flavonoids are said to contain antioxidant, anti-inflammatory, and even anticarcinogenic properties.

Anthocyanins are a class of polyphenols. Polyphenols are found in many plant foods and contain various health benefits. Polyphenols are thought to be beneficial for heart health and may help treat other conditions like insulin resistance and inflammation.

Although supplements are available, the best way to get anthocyanins is through food. A food-first approach to anthocyanins ensures better absorption and utilization of nutrients.

However, supplements may be necessary in certain cases. Anthocyanins are found in many plant foods, most of which are fruits or vegetables.

Plants that are rich in anthocyanins include:. Some foods, like baked goods, dairy products, and beverages may even be fortified with anthocyanins. You can also purchase anthocyanin-rich supplements, including tart cherry extract, blueberry extract , bilberry extract , and black raspberry extract.

Fruits, vegetables, beans, and grains that are deep red, purple, or blue are generally rich in anthocyanins. You can also buy berry-based, anthocyanin-rich dietary supplements. Anthocyanin supplements are mostly available as various berry extracts. These may come in the form of capsules, soft gels, tablets, or gummies.

Keep in mind that supplements containing anthocyanins typically have additional nutrients and ingredients. If you choose to take an anthocyanin supplement, you should also note that supplements are not regulated in the United States as strictly as drugs and conventional food products.

Because of this, they can vary in quality and may contain ingredients you may not want. To better ensure quality and purity, look for products that have been independently certified by ConsumerLab, USP, or NSF International.

Certification doesn't mean that supplements are safe or effective but that they contain the ingredients listed on the product label and in the advertised amounts. Anthocyanins are natural pigments in certain plants that give them their purple, blue, or red color.

Anthocyanins are rich in antioxidants and other bioactive ingredients that may offer health benefits. Anthocyanin-rich foods are highly nutritious and an excellent part of a well-balanced diet, but it is still unknown if anthocyanin supplements provide any true benefits.

If you're thinking about taking an anthocyanin supplement, talk with your healthcare provider first. Remember that supplements cannot cure or prevent any health condition and that nothing beats nutrition from whole food sources. Khoo HE, Azlan A, Tang ST, Lim SM.

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits. Food Nutr Res. Mattioli R, Francioso A, Mosca L, Silva P. Anthocyanins: a comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases.

Liu J, Zhou H, Song L, et al. Anthocyanins: promising natural products with diverse pharmacological activities. Xu L, Tian Z, Chen H, Zhao Y, Yang Y. Anthocyanins, anthocyanin-rich berries, and cardiovascular risks: systematic review and meta-analysis of 44 randomized controlled trials and 15 prospective cohort studies.

Many benrfits are healh aware Anthocyanins health benefits the benefits fruits and vegetables Calorie counting and nutrition tracker, but few may know the actual names and types of the disease-fighting compounds they contain that are so important for Anthocyannins health. Anthocyanins, hralth particular group Crispy Pumpkin Seeds compounds, are one of the more Anthocyanins health benefits 6, members of the flavonoid family of polyphenol phytochemicals found in various plant foods. Anthocyanin pigments have been used in folk medicine for generations, but only recently the specific pharmacological properties of these compounds have been isolated and studied. But laboratory research as well as studies in animals and humans have suggested that anthocyanins may play important roles in helping reduce the risk of cardiovascular disease CVDcognitive decline, and cancer. An Overview Anthocyanins are plentiful in plant foods, providing the bright red-orange to blue-violet colors of many fruits and vegetables. Crispy Pumpkin Seeds Anthoyanins naturally wakefulness and sleep quality water-soluble Anyhocyanins pigments Anthocyanijs to the Antyocyanins chemical healh. The red, blue and purple Crispy Pumpkin Seeds of leaves, flowers and Anthocyanis of plants confirm that they are rich sources of anthocyanins. Anthocyanins health benefits in vivo and in vitro studies reveal that anthocyanins have different health beneficial effects such as antioxidant, antidiabetic, anti-inflammatory, anti-obesity, antihypertensive and anticancer properties. Major benefits of anthocyanin administration are owing to their potent anti-inflammatory and antioxidant activities. Recent investigations have revealed that anti-inflammatory activities of anthocyanins follow the inhibitory pathways of NF-кB-mediated decline of inflammatory cytokines production. Inhibition of the anti-inflammatory pathways also influences the modulation of arteriolar disorders and cardiovascular complications due to anthocyanin administration.

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