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Anti-inflammatory effect of coffee with milk foundPolyphenols and anti-viral effects -
These compounds are known as natural by-products or secondary metabolites of plants, which are present in the daily diet and provide important benefits to the human body such as antioxidant, anti-inflammatory, anticancer, anti-allergic, antihypertensive and antiviral properties, among others. Plentiful evidence has been provided on the great potential of polyphenols against different viruses that cause widespread health problems.
As a result, this review focuses on the potential antiviral properties of some polyphenols and their action mechanism against various types of viruses such as coronaviruses, influenza, herpes simplex, dengue fever, and rotavirus, among others.
Also, it is important to highlight the relationship between antiviral and antioxidant activities that can contribute to the protection of cells and tissues of the human body. Yuan, X. Qu, J. Chen, G. Wang et al. Wang, L. Juang, J. Yang, L. Tai, M. Huang, Altern.
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Polyphenols are plant secondary metabolites and are commonly found in fruits, vegetables, food grains, seeds, flowers, tea, wine, honey and forages. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases.
A number of traditional plant derived folk medicines rich in polyphenols used from earliest times to cure disorders of the blood stream including blood pressure, antiviral effects, stomach disorders, antiseptic action, dressing of burns and inflammation and inhibition of direct acting mutagens.
Phenols and bioflavanoids are the major classes with antiviral activity against various diverse virus families such as retroviridae, hepadnaviridae, hespervirides, HIV virus, influenza virus, herpes simplex virus, dengue virus, polio virus etc. For antiviral activity presence of hydroxyl group and ester groups are necessary.
The phenolics with five and more hydroxyl groups and 3, 4, 5-three methoxy derivatives show anti-viral and anti-rabies activity while alkyl-esters of gallic acid gallates , epicathechin responsible for anti-herpetic activity.
These compounds represent novel leads, and future studies may allow the development of a pharmacologically acceptable antiviral agents or class of agents.
In this review, plant polyphenols as antiviral agent, different sites of its antiviral action, evaluation methods of its antiviral properties and various phenolic components isolated from plants with antiviral activities are outlined and discussed.
Rita Kapoor. Rajesh Naithani. World's Veterinary Journal Editor. The goal of this review was to highlight some plant species that have significant antiviral activity against DNA and RNA viruses in vitro and in vivo although more research is needed to address safety issues, drug interactions, and the possibility of using them in combination with other natural products.
Viral infection plays an important role in human and animal diseases. Although there have been advances in immunization and antiviral drugs, there is still a lack of protective vaccines and effective antiviral drugs in human and veterinary medicine. The lack of effective antivirals necessitates the search for new effective antiviral compounds.
Plants are naturally gifted at synthesizing antiviral compounds. They are rich sources of phytochemicals with different biological activities, including antiviral activities as a result of advanced analytical chemistry, standard virus assays, and development of standardization and extraction methods.
Plant extracts have a wide variety of active compounds, including flavonoids, terpenoids, lignans, sulphides, polyphenolics, coumarins, saponins, furyl compounds, alkaloids, polyines, thiophenes, proteins, and peptides.
Moreover, certain volatile oils have indicated a high level of antiviral activity. Replication, assembly, and release, as well as targeting virus host-specific interactions capable of inhibiting several viruses, could help the development of broad-spectrum antivirals for the prevention and control of viral pathogens.
The in vitro antiviral activities of Erythroxylum deciduum, Lacistema hasslerianum chodat , Xylopia aromatica, Heteropteris aphrodisiaca, Acacia nilotica gum arabic tree , Lippia graveolens Guettarda angelica Velvetseed , Prunus myrtifolia, and Symphyopappus plant extracts can inhibite viral replication, and interfer with the early stages of viral adsorption of DNA viruses.
However, Boesenbergia rotunda plant extracts have inhibited RNA viruses. A potent anti-SARS-CoV-2 inhibitor with B. rotunda extract and panduratin A after viral infection drastically suppresses SARS-CoV-2 infectivity in Vero E6 cells. Vijeta Prakash. Tomas Drevinskas.
The application of natural products for treatment and prevention of various diseases is becoming more important. Not only antibacterial natural preparations are being developed, but also antiviral natural products are investigated. There are two main problems in such investigations: i special chemical analysis and data analysis methods have to be used, ii not only antiviral effect has to be taken into account, but also cytotoxic and other unwanted effects.
The selected plants belonged to families: i Lamiaceae, ii Asteraceae and iii Fabaceae. Most cytotoxic were Agastache foeniculum Pursh. and Salvia officinalis L. Juan Carlos Carmona-Hernandez. Polyphenols are attributed to multiple biological activities that providenutritional and therapeutical benefits.
The present paper is a descriptive review focused on polyphenolic chemical structural aspects contributing to explain biological and biochemical functions offered by these phytochemicals. Element conformation differences, ring modifications, the presence of specific functional groups, and the tridimensional chemical arrangement are fundamental to explain specific effects presented by polyphenols.
The anti-oxidant and anti-inflammatory actions of polyphenols suggest that basic chemical reactions and element re-organization are important in understanding their function, well-known polyphenols such as quercetin, curcumin, and catechin have been evaluated in multiple studies.
Moreover, anti-bacterial and anti-viral activities have been proven to be dependent on hydroxylation, methoxylation, and alkylation of several polyphenol ring components. Polyphenols extracted from tea, Maria Teresa Sciortino. Viral infections are responsible for several chronic and acute diseases in both humans and animals.
Despite the incredible progress in human medicine, several viral diseases, such as acquired immunodeficiency syndrome, respiratory syndromes, and hepatitis, are still associated with high morbidity and mortality rates in humans.
Natural products from plants or other organisms are a rich source of structurally novel chemical compounds including antivirals. Indeed, in traditional medicine, many pathological conditions have been treated using plant-derived medicines.
Thus, the identification of novel alternative antiviral agents is of critical importance. In this review, we summarize novel phytochemicals with antiviral activity against human viruses and their potential application in treating or preventing viral disease.
International Journal of Current Science Research and Review. Urmistha Sarkar. Antiviral is such as an agent, defined as used to treat the targeted virus, or vaccine to produce an antibody against the virus. It gives a proactive therapeutic effect. On the other hand, there is a long traditional use of herbal medicine in the medical platform.
The herbal medicine is ornamented with a wide therapeutic window and its side effect is less. The synthetic drug sometimes invites some adverse effects, which is more important that is it occurs more frequently. This gives the opportunity to the researchers to get the noble drug based on the herbal formulation.
This review reveals the many herbal plants with their use against the specific virus with the experimental method, based on the knowledge of the Indian traditional system of medicine. The recent database shows the growing research with the herbal medicine, with their therapeutics, especially this time of the society, suffering from the covid Coronavirus disease , because the doctors have no other options except qamar ahmed.
Exploration of the traditional medicinal plants is essential for drug discovery and development for various pharmacological targets. Various phytochemicals derived from medicinal plants were extensively studied for antiviral activity.
This review aims to highlight the role of medicinal plants against viral infections that remains to be the leading cause of human death globally. Antiviral properties of phytoconstituents isolated from 45 plants were discussed for five different types of viral infections.
The experimental values, such as IC50, EC50, CC50, ED50, TD50, MIC, and SI of the active compounds, were compiled and discussed to determine their potential. Among the plants mentioned, 11 plants showed the most promising medicinal plants against viral infections.
Sambucus nigra and Clina paulina bermejo. David McKoskey. Gustavo Henrique. Aster Ati. Beatriz Monteiro. Alejandro Viloria. Gianluca Nazzaro. mohamed mahmoud gad. Reinaldo P D Souza.
Mohamad Suhendri. Sandra Baquedano Jer. Joseph Verbalis. Aziz Tuncer. Alba Avila. Yureiny Ducuara González. Christopher P Atwood. daniel jeronimo. Ellyn King. Yusman Syaukat. Muhammad usama. Log in with Facebook Log in with Google. Remember me on this computer. Enter the email address you signed up with and we'll email you a reset link.
Need an account? Click here to sign up. Download Free PDF. Antiviral activity of plant polyphenols. Anjoo Kamboj JPR Solutions. See Full PDF Download PDF. Related Papers. Download Free PDF View PDF. Dietary Components and Immune Function Antiviral Activity of Phytochemicals: A Current Perspective.
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Anjoo Kamboj et al. R College of Pharmacy, VV Nagar, Gujarat, India 3 G. S College of Pharmacy, Yamuna Nagar, Haryana, India Received on; Revised on: ; Accepted on ABSTRACT Polyphenols are plant secondary metabolites and are commonly found in fruits, vegetables, food grains, seeds, flowers, tea, wine, honey and forages.
These compounds represent novel leads, and future studies may allow the development of a pharmaco- logically acceptable antiviral agents or class of agents. KEYWORDS: Polyphenols, antiviral, structure activity, mechanism of action.
According to one estimate, antiviral activity present in medicinal plants are still not known. Among several other ailments, viral infections, particularly infections action, including antiviral effects by either inhibiting the formation of viral associated with human immune deficiency virus type-1 HIV-1 and newly DNA or RNA or inhibiting the activity of viral reproduction.
Acute and cell, and that viral diseases can only be diagnosed and recognized after it is too recurrent viral infections are distributed worldwide and cause wide range of late for effective treatment. In the first case, an effective antiviral agent must diseases from mild to severe and in some cases they may become life threat- prevent completion of the viral growth cycle in the infected cell without ening in immunocompromised patients.
Diseases caused by these viruses are difficult to tackle with the help of plication of the virus particles and this may be a point of attack by a specific available antiviral drugs because widespread use of these drugs has shown inhibitor. In order to circumvent the problem of viral resistance, develop- The present review will project a view on antiviral activity of polyphenols, ment of new antiviral products with mechanism of action are very much a class of natural products; different sites of their antiviral action, evaluation required.
A number of traditional plants derived folk medicines rich in polyphe- methods of its antiviral properties and various phenolic components isolated nols used from earliest times to cure disorders of the blood stream including from plants with antiviral activities are outlined and discussed.
blood pressure, antiviral effects, stomach disorders, antiseptic action, dress- ing of burns and inflammation and inhibition of direct acting mutagens. So polyphenols are one of the important constituents of both human pounds, alkaloids, polyines, thiophenes, proteins and peptides have been and animal diets.
identified having potential as a novel antiviral agents. Some volatile essential oils of commonly used culinary herbs, spices and herbal teas have also They are widely distributed in plants and are responsible for color develop- exhibited a high level of antiviral activity.
However, in most of the pharmaco- ment, pollination and protection against UV radiation and pathogens. They also contribute to the color and astringency of some foods.
an abundance of fruits and vegetables contain a large quantity of polyphenols Anjoo Kamboj are protective against a variety diseases particularly cardiovascular disease Chandigarh College of Pharmacy, and cancer. The basic structural feature of polyphe- The knowledge of absorption, biodistribution and metabolism of polyphe- nolic compounds includes range of substances that possess an aromatic ring nols is partial and incomplete, yet it is sufficient to state that in general, some bearing one or more hydroxyl substituent.
The structure of natural polyphe- polyphenols are bioactive compounds that are absorbed from the gut in their nols varies from simple molecules, such as phenolic acids C6-C1 , Biofla- native or modified form.
They are subsequently metabolized with products vonoid C6-C3-C6 , to highly polymerized compounds such as condensed detected in plasma that retain at least part of the antioxidant capacity and tannins. Major classes of polyphenolic compounds found in the plants then excreted.
on the detection of quercetin after the consumption of onions, tea, and apple juice. They metabolites rutin and quercetin metabolites retain antioxidant activity, such have been reported to posses many useful properties, including antioxi- as the ability of quercetin and isorhamnetin to inhibit copper induced LDL dant,[12] and anti-radical activity, chelation of metal ion, modulation of some oxidation.
against various diverse virus families such as retroviridae, hepadnaviridae, hespervirides,[37] HIV Human immune deficiency virus virus, influenza Table 1: Major classes of polyphenolic compounds in the plants. virus, herpes simplex virus, dengue virus, polio virus, diarrhea virus etc.
Bioflavanoids are one of the major class of polyphenols has important anti- Number Basic Class Examples viral activity such as quercetin, kaempferol, rutin. It has been found that of carbon skeleton flavonols are more active than flavones against herpes simplex virus type-1 atoms and HIV virus.
Synergism has also been reported between flavonoids and other antiviral agents. Benzoquinones 2,6-Dimethoxybenzoquinone Apigenin also enhances the antiviral activity of acyclovir against these vi- 7 C6-C1 Phenolic acids Gallic, salicylic ruses. paraascorbic acid, quer- Phenylacetic acids p-Hydroxyphenylacetic cetin, kaempferol, morin, galagenin, apigenin, naringenin, chrysin, luteolin, 9 C6-C3 Hydroxycinnamic acids Caffeic, ferulic analgin, rosmarinic acid and various gallates of phenolic acid.
Reported Phenylpropenes Myristicin, eugenol antiviral phenolics acting on specific types of virus is enumerated in table 2 Coumarins Umbelliferone, aesculetin and 3. Isocoumarins Bergenon Chromones Eugenin Table 2. Plant Phenolics with Antiviral Activity 10 C6-C4 Naphthoquinones Juglone, plumbagin S.
Types of virus Antiviral Phenolics References 13 C6-C1-C6 Xanthones Mangiferin 14 C6-C2-C6 Stilbenes Resveratrol 1 Rabies virus Quercetin, Quercetrin, Rutin 40 Anthraquinones Emodin 2.
Para influenza virus Quercetin, Rutin 41 15 C6-C3-C6 Flavonoids Quercetin, cyanidin 2 Herpes virus type -1 Galangin, Quercetin, 42 Isoflavonoids Genistein Kempferol, apigenin, chrysin 18 C6-C3 2 Lignans Pinoresinol 4.
Potato virus Quercetin, Rutin, Morin 43 Neolignans Eusiderin 5. Influenza virus Quercetin, Rutin 44 30 C6-C3-C6 2 Biflavonoids Amentoflavone 6. Herpes virus type - 2 Quercetin, chrysin 45 n C6-C3 n Lignins 7. Respiratory syncytial virus Quercetin, Naringin 46 C6 n Catechol melanins 8. Immuno-deficiency virus Apigenin , Caffeic acid 47,48 C6-C3-C6 n Flavolans 9 Azesky virus Quercetin, quercetrin, 49 Condensed Tannins Morin, Apigenin, Luteolin 10 Polio virus Quercetin 50 Polyphenols might interfere in several of the steps that lead to the develop- 11 Mango virus Quercetin 51 ment of malignant tumors, inactivating carcinogens, inhibiting the expression 12 Pseudorabies virus Quercetin 52 of mutant genes and the activity of enzymes involved in the activation of Dengue virus Ellagic acid, Rutin, Quercetin 53 procarcinogens and activating enzymatic systems involved in the detoxifica- Human cytomegalovirus Kaempferol, chrysin 54,55, tion of xenobiotics.
Sindabis virus Catechin 59 Journal of Pharmacy Research Vol. This results from the very Virus envelope is an outer lipoprotein bilayer membrane, which most vi- fact that the synthesis of viral proteins is not without the involvement of ruses possess.
Though some viruses contain lipid as part of a complex the nucleic acids and vice versa. However, the viral proteins present further outer layer, these are not usually regarded as enveloped unless a bilayer unit unique opportunities for antiviral drug attack both as viral structural pro- membrane structure is clearly demonstrable.
Enveloped viruses mostly bud teins as well as the functional proteins and enzymes. The mechanisms for through the host cell membrane leaving the cell intact and acquiring the the biosynthesis of viral coat proteins resemble the synthesis of normal cell envelope from the host cell membrane and with similar composition.
The proteins on the polyribosomes.
Fruits, Endurance interval workouts, spices, and herbs are a potential Sports nutrition for weight management of phenolic acids and polyphenols. These compounds are Polyphenols and anti-viral effects as Polhphenols by-products or secondary metabolites of plants, Polyphebols are present effectss the daily diet anti-iral provide important Polyphenkls to the human body such Sports nutrition for weight management antioxidant, anti-inflammatory, anticancer, anti-allergic, antihypertensive and antiviral properties, among others. Plentiful evidence has been provided on the great potential of polyphenols against different viruses that cause widespread health problems. As a result, this review focuses on the potential antiviral properties of some polyphenols and their action mechanism against various types of viruses such as coronaviruses, influenza, herpes simplex, dengue fever, and rotavirus, among others. Also, it is important to highlight the relationship between antiviral and antioxidant activities that can contribute to the protection of cells and tissues of the human body. Laurent Lebrun : Connect Polyphenols and anti-viral effects Lowering cholesterol with plant sterols to contact the contributor. Documentation EN French FR. Sign in. Poltphenols Loading Author Efrects multi-criteria Efects multi-criteria Author: Sports nutrition for weight management name Author: Last name Author: First name Author: middle name Author: funding institution Author: IdHal string Author: function Author: personID integer Author: funding institution identifier Author: Structure identifier Thesis director Publisher Scientific editor Series editor Add. Search using SolR syntax. Search using SolR syntax Run the search.
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