Trim 7 is the culmination of 30 years of work in the area of exercise and nutritional science. Trim 7 is specifically designed with 7 key ingredients that have been clinically proven to support weight loss in a human weight management trial. Other ingredients such as Co-Enzyme Q10, Alpha Lipoic Acid and Vitamin E are potent antioxidants that help combat damage incurred by fat accumulation.

The clinical trial showed that subjects who consumed Trim 7 for 3 months lost more weight than subjects on a placebo. Other products on the market focus on one or two natural ingredients and claim to be scientifically backed but do not have the clinical work to show that they are effective.

Read our article: How Trim 7 Will Benefit Your Weight Loss Journey. Buy 1 Get 1 Free! Key Benefits: Temporarily Boosts Metabolism: Includes natural plant extracts that temporarily increases your metabolism and reduces body fat.

Protects Metabolism: Includes antioxidants that protect against metabolic damage caused by dieting or extra body fat Increases Energy Levels: Temporarily reduces fatigue, promoting alertness and wakefulness.

In stock Trim 7 quantity. Buy 1 get 1 free. Description Reviews 6 Directions Ingredients FAQ Description. Customer Image Gallery. Jerry Romaniello. Karishma Bhaya. I researched other supplements and their research claims and I realized that Trim 7 would maintain my muscle mass not lose it.

The other brands I considered had larger weight loss but a large portion of it was muscle - not for me I have now finished 12 weeks of Trim 7 with regular moderate exercise and have lost 18 lbs - not lbs anymore 😊… just thought you might be interested… Only 10 pounds to go 😊 I will keep on taking half the recommended dose as the ingredients in Trim 7 have many other health benefits once I reach my goal.

Should only take about more weeks. I also believe taking a good supplement motivated me to make better food choices ie. Whole foods and lifestyle choices.

I changed little actually and Got these amazing results - I am a believer I've been using Trim7 for over 5 months now and I'm surprised at all the benefits this gives me! I take this before a run and it seems to give me that extra energy to dig deep on that steep hill.

Its also not bad to wake you up if you are having a groggy morning. I've also seen an improvement on the scale. I've been able to keep off as much as 12 lb! My success with Trim 7 was better than I had expected.

Throughout a 3-month period of daily walks, I lost 10lbs of body fat. I would highly recommend Trim 7 to those who have a few extra pounds they'd like to shed.

Cancel reply Write a review. Rating Rate… Perfect Good Average Not that bad Very poor. Review Comment. Directions Intended for adult consumption. Ingredients Alpha Lipoic Acid is a naturally occurring short-chain fatty acid commonly found in spinach, broccoli, potatoes and liver.

How it works: Enhances blood flow to muscles, increasing exercise capacity Protects cells from damage and inflammation related to excess weight Coenzyme Q10 is a naturally occurring antioxidant in the human body.

How it works: Supports and protects energy production in the body Stabilizes energy production, increasing the utilization of fat as an energy source Forskolin, or Coleus forskohlii, is an extract from the root of a plant in the mint family and is known to activate key pathways in the body.

How it works: Acts upon hormone and satiety regulation, thereby promoting weight loss Enhances fat breakdown processes in the body Green Coffee Bean Extract is derived from the unroasted seeds from the coffee plant, which preserves a host of health-boosting compounds, such as Chlorogenic Acid.

How it works: Reduces the reliance on sugar, promoting the use of fat as an energy source Limits the amount of carbs absorbed, lowering the amount of consumed calories Green Tea Extract is derived from the non-fermented and non-roasted camellia sinensis plant.

How it works: Protects energy generation processes and helps regulate the utilization of good and bad fat Increases metabolism, specifically utilizing fat to generate energy Vitamin E is one of the essential vitamins. How it works: Supports the immune system and prevents damage to cells Protects the body from inflammation caused by excess weight.

FAQ Why should I take Trim 7? How does it work? How often should I be taking Trim 7? How is Trim 7 different from other weight management products on the market? Headquarters Hamilton, ON L8N 3Z5 Canada. Customer Service Returns Shipping FAQ Contact.

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We will endeavour to improve your experience with our products. Check out our FAQ for more information. Shipping We currently ship our products anywhere within Canada. Purchases are typically processed and shipped within 48 hours.

Depending on your location, items will arrive within business days. Buy 1 Get 1 Trim 7 Free! Side effects: While green coffee beans have less caffeine than roasted coffee beans, you may still experience caffeine-related side effects , says Sopczak — like irritability, anxiety, jitteriness, headache, insomnia, and irregular heartbeat.

To be safe, green coffee extract should be avoided by people who are pregnant or breastfeeding , who have heart disease or high blood pressure, or who are taking anti-anxiety medication. How it works: Green tea extract is high in catechins, a type of antioxidant believed to assist weight loss by increasing the activity of norepinephrine , a hormone that helps burn fat while also making the body more effective at burning calories , says Sopczak.

The caffeine in green tea extract may also promote weight loss. What the research says: Results from studies on green tea extract for weight loss are mixed. According to a review of 15 studies totaling participants, two studies found green tea extract helped participants burn anywhere from However, it's worth noting these effects were most apparent when participants were also exercising.

Overall effectiveness: According to the National Center for Complementary and Integrative Health NCCIH , it has yet to be proven that green tea extracts can produce meaningful, sustainable weight loss. Plus, it's difficult to determine whether green tea extract is effective on its own or if the caffeine in the extract is what's driving studies' results.

Side effects: Green tea extract is generally well-tolerated, says Sopczak, but may cause symptoms like anxiety, sleeping problems, or irritability in people who are caffeine sensitive or who take large doses — above milligrams per day. How it works: More recent studies suggest that garcinia extract, which comes from a fruit native to Indonesia, can reduce a fat-producing enzyme called citrate lyase and increase levels of serotonin , thus potentially helping to reduce sugar cravings , says Sopczak — but most of these studies have been conducted in animals.

What the research says: A review of 17 clinical trials totaling subjects found garcinia cambogia had limited to no impact on weight loss. While a separate review found garcinia cambogia supplementation can lead to a small short-term weight reduction compared with a placebo, all of the studies examined had design weaknesses that likely affected the outcomes, the review's researchers reported.

Overall effectiveness: The NIH has concluded garcinia cambogia has "little to no effect" when it comes to weight loss. Side effects: Possible side effects associated with this supplement mainly include gastrointestinal symptoms like nausea and diarrhea but in rare cases, it's been linked to liver damage.

How it works: Glucomannan is a type of dietary fiber found in elephant yams. When it absorbs water in your gut, it swells up to times its initial size — and by taking up more room in your stomach, it's thought to help you feel more full so you eat fewer calories, says Sopczak.

What the research says: A study of overweight, otherwise healthy, subjects found those who took a glucomannan supplement lost more than those who took a placebo — about pounds over the course of five weeks.

However, other studies have failed to find a connection between glucomannan and weight loss. Overall effectiveness: According to the NIH , this supplement has little to no effect on weight loss.

Side effects: Glucomannan can cause bloating and gas , says Sopczak, and is not recommended for people with gut or esophageal disorders.

How it works: Conjugated Linoleic Acid CLA , a type of fat found in meat and dairy products, may reduce appetite, boost metabolism , and help with fat burning, says Sopczak. What the research says: A review of 18 studies found taking CLA was associated with losing 0.

Overall effectiveness: According to the NIH, CLA might help you lose a "very small amount" of weight as well as body fat. Side effects: CLA can cause some digestive side effects like constipation and diarrhea, and if taken over the long-term, Sopczak says it may increase your risk of fatty liver disease and insulin resistance.

How it works: Guar gum, a type of fiber extracted from guar beans, may help you feel fuller longer, thereby reducing how much you eat, says Sopczak. What the research says: A review of 20 trials found taking a guar gum supplement resulted in less than 1 pound of weight loss — and that the risk of adverse events like abdominal pain, diarrhea, gas, and cramps outweighed any potential benefits.

Overall effectiveness: The NIH has concluded that taking guar gum "probably doesn't" help you lose weight. Guar gum may help to control appetite, but this same effect could potentially be achieved without unpleasant side effects simply by eating more foods high in soluble fiber such as oats, barley, apples, and oranges.

Side effects: Guar gum may cause gastrointestinal symptoms or trigger an allergic reaction in some people, says Sopczak. How it works: Extract from the bitter orange fruit contains synephrine, a compound with stimulant effects believed to reduce appetite and increase fat burning.

What the research says: A review of 23 studies totaling about participants found nine of the studies showed that synephrine may cause an increase in metabolic rate, suggesting it may be beneficial in weight management.

However, researchers said well-controlled, longer-term studies involving only bitter orange extract are needed since about two-thirds of subjects also consumed caffeine, which may have impacted results. Overall effectiveness: While bitter orange extract may slightly suppress appetite and increase how many calories you burn, the NIH says the word is still out on whether it can actually help you lose weight.

Research on the potentially harmful effects of bitter orange is inconclusive — some studies found bitter orange raised heart rate and blood pressure , while others found it didn't have cardiovascular effects at common doses up to milligrams.

How it works: The active ingredient in ephedra, an herb that comes from an evergreen shrub, is a known stimulant that may increase your metabolic rate, thus helping you to burn more calories and ultimately lose weight.

What the research says: A review of nine studies totaling overweight or obese participants found products containing ephedrine were associated with around 4. Overall effectiveness: Researchers have struggled to discern the effectiveness of ephedra since there aren't any long-term studies and most studies have also included caffeine , which is known to support weight loss.

Ultimately, the risks of these supplements seem to far outweigh the potential benefits. Side effects: The FDA banned this highly controversial supplement in because it can increase heart rate and blood pressure , and in rare cases, cause heart attack , stroke , or even death.

How it works: Chitosan is a sugar mainly derived from the outer skeletons of crustaceans. According to Sopczak, it is said to turn into a gel-like substance in the stomach which then binds to fat in the intestines , but evidence of this is inconclusive. What the research says: A review of 14 trials totaling 1, overweight or obese subjects found chitosan supplements slightly reduced body weight — by about 2.

Overall effectiveness: According to the NIH , chitosan does not bind to nearly enough fat to result in significant weight loss. Side effects: Chitosan is generally considered safe , but Sopczak says possible side effects include upset stomach, nausea, bloating, and constipation.

How it works: The mineral chromium is believed to increase lean muscle mass while reducing body fat. It also helps insulin perform properly , which Sopczak says helps the body process carbs, fat, and protein more effectively.

What the research says: A review of nine trials with a total of participants found overweight and obese adults who took chromium picolinate a supplemental form of chromium lost an average of about 2.

Researchers determined this amount of weight loss was of "debatable clinical relevance" and that more "reliable evidence" is needed to verify the efficacy of these supplements.

Overall effectiveness: The NIH says chromium may help you lose a "very small amount" of body weight and fat. Less than 2. Side effects: In supplement form, high doses of chromium can interfere with insulin and other diabetes medications.

This supplement should also be avoided by those with kidney or liver problems , or with anemia. Kidney damage, worsened depression or anxiety, and irregular heartbeat have been reported in rare cases. People with liver or kidney problems , or people with anemia, should not take chromium without first talking to their doctor.

While there's a chance some of these supplements — like green coffee extract, CLA, and chromium — may help support your weight loss efforts, Kumar says there still aren't enough randomized controlled trials to prove they result in significant, sustained weight loss on their own.

Experts agree none of these products will work miracles without healthy changes to your diet and exercise habits. Because of the potential for interactions with medications and side effects, you should always talk to your health care provider before trying any of these supplements.

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These products are not intended to diagnose, treat, cure or prevent any disease. View Favorites. Home Products Supplements By Health Need. By Category Minerals Boron Calcium Iron Liquid Minerals Magnesium Multi Mineral Potassium Selenium Silica Zinc.

By Category Vitamins Multi-Vitamin Vitamin A Vitamin B Vitamin C Vitamin D Vitamin E Vitamin K. This week trial used Xanthigen, a dietary supplement containing brown seaweed extract and pomegranate-seed oil [ ]. Compared to the placebo group, those receiving Xanthigen lost significantly more body weight by the end of the trial mean loss of 6.

The safety of fucoxanthin has not been thoroughly evaluated in humans. Although participants using Xanthigen in the clinical trial described above reported no adverse effects [ ], further investigation of the safety and potential side effects of fucoxanthin at various levels of intake is required.

Garcinia cambogia is a fruit-bearing tree that grows throughout Asia, Africa, and the Polynesian islands [ ]. The pulp and rind of its fruit contain high amounts of hydroxycitric acid HCA , a compound that has been proposed to inhibit lipogenesis, increase hepatic glycogen synthesis, suppress food intake, and reduce weight gain [ 6 , 15 , , , ].

Studies in rats have found that Garcinia cambogia suppresses food intake and inhibits weight gain [ 3 ]. In humans, however, the evidence on whether Garcinia cambogia or HCA is effective for weight loss is conflicting, and any effects it has appear to be small [ 6 , 17 , ].

In one randomized, placebo-controlled trial, 89 women who were mildly overweight mean BMI Women receiving Garcinia cambogia lost significantly more weight 3. However, Garcinia cambogia did not alter appetite, and the study produced no evidence that the supplement affected feelings of satiety.

Participants in both groups lost weight, but the between-group weight-loss differences were not statistically significant. HCA also had no effect on body fat loss. A review and meta-analysis of 12 randomized controlled trials with a total of participants examined the effects of Garcinia cambogia on weight loss [ ].

Therefore, the effect of Garcinia cambogia on body weight remains uncertain. The reported adverse effects of Garcinia cambogia and HCA are generally mild and include headache, nausea, upper respiratory tract symptoms, and gastrointestinal symptoms [ , , ].

However, dietary supplements containing Garcinia cambogia have been implicated in three cases of mania, which might have been caused by the serotonergic activity of HCA [ ]. Symptoms included grandiosity an unrealistic sense of superiority , irritability, pressured speech, and decreased need for sleep.

Reports have also described 10 cases of liver toxicity, resulting in one death and two liver transplants, in people taking products containing Garcinia cambogia [ 43 , ]. In most of these cases, the products contained other botanical ingredients and minerals as well, so the toxicity cannot be definitively attributed to Garcinia cambogia.

Because all clinical trials of Garcinia cambogia and HCA have been short, its long-term safety is unknown. Glucomannan is a soluble dietary fiber derived from konjac root Amorphophallus konjac that can absorb up to 50 times its weight in water [ 16 ].

Like guar gum, glucomannan has been proposed to increase feelings of satiety and fullness and prolong gastric emptying by absorbing water in the gastrointestinal tract [ 16 , , ]. It might also reduce fat and protein absorption in the gut [ 16 ].

Glucomannan appears to have beneficial effects on blood lipids and glucose levels [ ], but its effects on weight loss are inconsistent. At the end of the study, glucomannan produced significantly greater weight loss mean loss of 2. In another study conducted in the United States, supplementation with glucomannan 3.

Eight weeks of glucomannan supplementation 1. The authors of a systematic review of six randomized controlled trials with a total of participants concluded that 1. Similarly, a meta-analysis of eight trials that included participants found that glucomannan did not significantly affect weight loss compared to placebo [ ].

The authors of an older meta-analysis of 14 studies designed primarily to investigate glucomannan's effect on lipid and blood glucose levels concluded that 1.

Little is known about the long-term safety of glucomannan. Glucomannan appears to be well tolerated for short-term use, with minor adverse effects, including belching, bloating, loose stools, flatulence, diarrhea, constipation, and abdominal discomfort [ , , , ].

The use of tablet forms of glucomannan was reported to be associated with seven cases of esophageal obstruction in — in Australia [ 99 ]. Users should therefore be cautious when taking glucomannan tablets.

Powdered and capsule forms have not been associated with this effect [ ]. The seeds or beans of the coffee plant Coffea arabica, Coffea canephora, Coffea robusta are green until they are roasted.

Compared to roasted beans, green coffee beans have higher levels of chlorogenic acid. Green coffee extract, probably because of its chlorogenic acid content, inhibits fat accumulation in mice and humans by regulating adipogenesis. Green coffee extract also modulates glucose metabolism [ ], perhaps by reducing glucose absorption in the gut [ ].

Green coffee beans contain caffeine see section on caffeine above [ ], although decaffeinated forms are available [ 16 ]. In mice, green coffee bean extract in combination with a high-fat diet significantly reduced body weight gain and fat mass [ , ].

Only a few clinical trials have examined the effects of green coffee bean extract on weight loss in humans, and all were of poor methodological quality. The researchers concluded that green coffee bean extract has a moderate but significant effect on body weight mean weight loss of 2.

The authors of another small clinical trial claimed to show a benefit of green coffee bean extract for weight loss [ ], but the study was strongly criticized by the FTC for having several critical flaws in its design [ , ]. Two of the three study authors subsequently retracted the journal publication.

Green coffee bean extract appears to be well tolerated, but its safety has not been rigorously studied. Reported adverse effects include headaches and urinary tract infections [ ]. The caffeine naturally present in green coffee beans acts as a stimulant and can cause adverse effects, depending on the dose and whether it is combined with other stimulants see section on caffeine above.

Green tea Camellia sinensis is a popular beverage consumed worldwide that has several purported health benefits [ ]. Green tea is present in some dietary supplements, frequently in the form of green tea extract.

The active components of green tea that are associated with weight loss are caffeine see section on caffeine above and catechins, primarily epigallocatechin gallate EGCG , which is a flavonoid [ 41 , ].

A typical brewed cup of green tea has about — mg catechins [ ] and 45 mg caffeine. It has been suggested that green tea and its components might reduce body weight by increasing energy expenditure and fat oxidation, reducing lipogenesis, and decreasing fat absorption [ 41 , ].

Green tea might also decrease carbohydrate digestion and absorption [ ]. Available green tea extracts cover the range from minimally processed tea leaves to highly processed, manufactured concentrates of single constituents, such as EGCG.

The authors of a meta-analysis of six randomized controlled trials with a total of 98 participants found that caffeine alone or in combination with catechins significantly increases energy expenditure in a dose-dependent fashion compared with placebo [ ].

This effect might be important for maintaining weight loss by helping counteract the decrease in metabolic rate that can occur during weight loss. Catechins combined with caffeine also significantly increase fat oxidation, but caffeine alone does not.

Other human research indicates that EGCG alone does not increase resting metabolic rate, fat oxidation, or the thermic effect of feeding the increase in metabolic rate associated with the digestion and absorption of food [ , ].

Taken together, these findings suggest that green tea catechins and caffeine might act synergistically [ 41 , , ]. Several human studies have examined the effects of green tea catechins on weight loss and weight maintenance.

A Cochrane Review analyzed the results from 14 randomized controlled trials of green tea preparations in a total of 1, participants with overweight or obesity [ ]. The trials lasted from 12 to 13 weeks, and doses of green tea catechins ranged from to 1, mg; in 10 of the 14 trials, the green tea preparations contained caffeine.

Green tea supplementation reduced body weight by a mean of 0. However, when the authors analyzed the six studies that were conducted outside of Japan where study methodologies were less heterogeneous than in the Japanese studies , they found no statistically significant difference in weight loss for green tea compared to placebo.

The authors reported that green tea catechins combined with caffeine over a median of 12 weeks modestly yet significantly reduced body weight by a mean of 1.

Only two studies in this meta-analysis examined the effects of green tea catechins alone. Their results suggest that green tea catechins alone do not affect body weight or other anthropometric measurements.

A meta-analysis of 11 randomized controlled trials found that people who took EGCG combined with caffeine for 12—13 weeks lost a mean of 1.

In , EFSA examined health claims related to green tea and concluded that "a cause and effect relationship has not been established between the consumption of catechins including EGCG from green tea … and contribution to the maintenance or achievement of a normal body weight" [ ].

Taken together, the findings of these studies suggest that if green tea is an effective weight-loss aid, any effect it has is small and not likely to be clinically relevant [ , ]. No adverse effects have been reported from the consumption of green tea as a beverage [ ].

For green tea extract, most reported adverse effects are mild to moderate, and they include nausea, constipation, abdominal discomfort, and increased blood pressure [ ]. Toxicology studies in rats and mice show that green tea extract does not cause cancer but does cause nonneoplastic lesions in many areas of the body, including the nose, liver, and bone marrow [ ].

Other evidence in mice shows that high doses of catechins cause liver toxicity. There is also increasing evidence in humans that green tea extract might cause liver damage, though the underlying mechanism is not well understood [ ].

An analysis of 1, postmenopausal women participating in the Minnesota Green Tea Trial found that women who consumed green tea extract containing 1, mg total catechins including mg EGCG and Consumption of some green tea extracts—primarily ethanolic extracts of green tea—has also been linked to liver damage in at least 50 case reports since [ 43 , ].

In , the U. Pharmacopeia USP systematically reviewed the safety of green tea products [ ]. The USP noted that problems are more likely when green tea extract is taken on an empty stomach and, therefore, advises taking green tea extracts with food to minimize the possible risk of liver damage.

Other researchers and medical experts advise using dietary supplements containing green tea extract only with caution [ ]. Guar gum is a soluble dietary fiber derived from seeds of the Indian cluster bean Cyamopsis tetragonolobus [ 16 , ]. Guar gum is present in certain dietary supplements and is an ingredient in some food products, especially gluten-free baked goods, because it helps bind and thicken these products.

Like glucomannan, guar gum is purported to promote weight loss by acting as a bulking agent in the gut; delaying gastric emptying; increasing feelings of satiety; and, theoretically, decreasing appetite and food intake [ 16 , ].

However, guar gum does not appear to enhance weight loss. In a meta-analysis of 20 randomized, double-blind, placebo-controlled trials that statistically pooled data from 11 trials, Pittler and colleagues evaluated the effects of guar gum for body weight reduction in a total of adults [ ].

Trial participants included people with hypercholesterolemia, hyperlipidemia, or type 1 or type 2 diabetes; menopausal women; and healthy volunteers. Compared with placebo, guar gum had no significant effect on weight loss.

The authors concluded that guar gum is not effective for body weight reduction. Reported adverse effects for guar gum are primarily gastrointestinal and include abdominal pain, flatulence, diarrhea, increased number of bowel movements, nausea, and cramps [ , , ]. Case reports indicate that guar gum can cause severe esophageal and small-bowel obstruction if taken without sufficient fluid [ , ].

However, these reports were about a guar gum product that is no longer available [ ]. In their meta-analysis, Pittler and colleagues concluded that given the adverse effects associated with the use of guar gum, the risks of taking it outweigh its benefits [ ].

Hoodia gordonii is a succulent plant that grows in the Kalahari Desert of southern Africa. The San people have traditionally used hoodia as an appetite suppressant during long hunts. This anecdotal evidence, combined with results of a few animal studies indicating that hoodia reduces food intake [ ], led to the widespread marketing of hoodia as a weight-loss supplement in the United States in the early s.

Scientists have not determined the exact mechanism whereby hoodia might suppress appetite. A glycoside commonly called P57, which may have central nervous system activity [ ], is widely believed to be the main active ingredient, although not all researchers agree [ 16 , ]. Despite its popularity as a weight-loss supplement, very little scientific research on hoodia has been conducted in humans [ ].

Compared to placebo, hoodia extract had no significant effect on energy intake or body weight. Hoodia has been reported to cause significant increases in heart rate and blood pressure [ ]. It also raises bilirubin and alkaline phosphatase levels which may indicate impaired liver function , although the clinical significance of these findings is unclear because hoodia has not been reported to affect levels of other liver enzymes.

Other side effects include headache, dizziness, nausea, and vomiting. In the past, some hoodia products were found to contain little or no hoodia [ ]. The human microbiota, which outnumber human cells by up to fold, have myriad roles in human health [ , ]. Although microbes are found throughout the human body, the vast majority inhabit the colon.

The gut microbiota play an important role in nutrient and energy extraction from food. Research in mice suggests that the gut microbiota affect not only use of energy from the diet but also energy expenditure and storage within the host [ ].

Whether these effects translate to humans is unknown. However, manipulating the gut microbiota has been proposed as a method to prevent or treat obesity in humans, and probiotics might provide a way to accomplish this.

Probiotics are in foods, such as some yogurts, as well as dietary supplements. The many different genera of probiotics include Lactobacillus, Streptococcus, and Bifidobacterium, which all have widely varying effects in the body [ , ].

Much of the research on probiotics and its influence on the gut microbiota and obesity has been in mice, and the results have been promising. For example, probiotic supplementation reduced body weight gain and fat accumulation in obese mice fed a high-fat diet [ ].

In humans, however, results of clinical trials that assessed the impact of probiotics on obesity-related endpoints have been inconsistent. In another randomized clinical trial, daily supplementation with 3. However, among the 77 female participants, the Lactobacillus supplementation did significantly reduce body weight after 12 weeks loss of 1.

Another recent systematic review and meta-analysis of 15 randomized controlled trials in individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight by 0.

However, these effects were small and of questionable clinical significance. The most recent systematic review and meta-analysis, which included 19 randomized trials in 1, participants, found that supplementation with probiotics or synbiotics products containing both probiotic organisms and prebiotic sugars, which microorganisms in the gastrointestinal tract use as metabolic fuel reduced waist circumference slightly by 0.

The findings from another meta-analysis of 14 trials in adults, 5 trials in children, and 12 trials in 1, infants suggested that probiotics promote an average loss of 0. Taken together, these results indicate that the effects of probiotics on body weight and obesity might depend on several factors, including the probiotic strain, dose, and duration as well as certain characteristics of the user, including age, sex, and baseline body weight.

Additional research is needed to understand the potential effects of probiotics on body fat, body weight, and obesity in humans.

Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts. For these reasons, the common probiotic species—such as Lactobacillus species acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius and Bifidobacterium species adolescentis, animalis, bifidum, breve, and longum —are unlikely to cause harm [ ].

Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia fungi in the blood , or infections that result in severe illness [ , ].

For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation advises restricting probiotic use to the strains and indications that have proven efficacy [ ]. Pyruvate is a three-carbon compound that is generated in the body through glycolysis [ ].

Pyruvate is also available as a dietary supplement, frequently in the form of calcium pyruvate. Researchers have suggested that pyruvate enhances exercise performance and reduces body weight and body fat, possibly by increasing lipolysis and energy expenditure [ 6 , , ].

Only a few studies have examined the effects of pyruvate supplementation in humans. Although some of these studies suggest that pyruvate decreases body weight and body fat, others do not.

At the end of the trial, the pyruvate group had significant decreases in body weight mean loss of 1. In the placebo group, these measurements did not change significantly compared to baseline. However, a double-blind, placebo-controlled trial in 23 women who were overweight mean BMI The authors of a systematic review and meta-analysis of six randomized controlled trials in a total of participants concluded that 5—30 g pyruvate for 3—6 weeks reduces body weight by a mean of 0.

However, the authors noted that the methodological quality of all trials is weak, preventing them from drawing firm conclusions. The safety of pyruvate has not been rigorously studied. Pyruvate might also increase LDL levels and decrease HDL levels [ , ].

Additional research is needed to better understand the safety and possible side effects of this compound. Raspberry ketone is the primary aroma compound found in red raspberries Rubus idaeus , and it is added to some foods as a flavoring agent [ 16 , ].

In vitro and animal studies suggest that raspberry ketone might help prevent weight gain by increasing fatty acid oxidation, suppressing lipid accumulation, and inhibiting pancreatic lipase activity [ 16 ].

Although it has been touted on the Internet and national television as an effective way to burn fat, little evidence exists to support this claim.

In mice fed a high-fat diet, raspberry ketone supplementation reduced food intake and body weight compared to the same diet without raspberry ketone [ ]. Only one randomized controlled trial has examined the effects of a dietary supplement containing raspberry ketone on weight loss.

This product contained 2, mg of a proprietary blend of raspberry ketone, caffeine, bitter orange, ginger, garlic, cayenne, L-theanine, and pepper extract along with B-vitamins and chromium.

During the 8-week study, participants followed a calorie-restricted diet approximately calories less per day than estimated needs and engaged in moderate exercise 60 minutes 3 days per week. Compared to the placebo group, those receiving METABO lost significantly more body weight mean loss of 1.

However, 25 of the 70 participants dropped out of the study, and results were reported for only the 45 participants who completed the study i. Furthermore, the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone.

Typical diets provide only a few mg of raspberry ketone a day. Doses contained in dietary supplements typically range from to 1, mg, and the safety of such doses has never been evaluated in humans [ ].

Participants in the METABO study described above had no serious adverse effects [ ]. However, additional research on raspberry ketone is needed to better understand its safety and side effects. Vitamin D, which is fat soluble, is present in a few foods, such as fatty fish, cheese, egg yolks, and vitamin D-fortified milk.

It is also available in many dietary supplements, and humans synthesize it naturally when their skin is exposed to sunlight. Vitamin D promotes calcium absorption in the gastrointestinal tract and is needed for proper bone growth and remodeling [ 56 ].

Observational studies indicate that greater body weights are associated with lower vitamin D status, and individuals with obesity frequently have marginal or deficient circulating levels of vitamin D [ ].

Nevertheless, the association between vitamin D and obesity raises the question of whether increasing vitamin D concentrations might reduce body weight [ , ]. Despite the association between low vitamin D levels and obesity, scientific evidence does not support a cause-and-effect relationship.

The authors commented that the cause of this finding might have been stored vitamin D in body fat and skeletal muscle that was released during weight loss. However, according to a meta-analysis of 12 vitamin D supplementation trials including 5 in which body composition measurements were primary outcomes , vitamin D supplements without calorie restriction did not affect body weight or fat mass compared to placebo [ ].

Overall, the available research suggests that consuming higher amounts of vitamin D or taking vitamin D supplements does not promote weight loss. Vitamin D toxicity can cause anorexia, weight loss, polyuria, and heart arrhythmias. It can also raise calcium blood levels, which can cause vascular and tissue calcification.

White kidney bean or bean pod Phaseolus vulgaris is a legume that is native to Mexico, Central America, and South America and is cultivated worldwide [ ]. Phaseolus vulgaris extract is an ingredient in some weight-loss dietary supplements marketed as carbohydrate- or starch-absorption blockers.

Laboratory research indicates that Phaseolus vulgaris extract inhibits alpha-amylase activity, so experts have hypothesized that the plant interferes with the breakdown and absorption of carbohydrates in the gastrointestinal tract [ 16 , ].

Read on to find out which ones can help you shed excess weight and keep it off. These vitamins are essential for a fully functioning metabolism. The main function of the B vitamins is to help your body metabolize carbohydrates , proteins , and fats , and to use the stored energy in food.

Thiamine B-1 , for example, helps the body cells convert carbohydrates into energy. This makes losing weight even harder. Food sources: You can find B vitamins in a range of foods.

Good sources include:. Tip: In general, dietary supplements containing all eight B vitamins are known as B-complex vitamins. They can easily be found in stores or online. Try it: Shop for vitamin B supplements. Vitamin D is critical to a healthy immune system. Your body can get all the vitamin D it needs courtesy of the sun.

Getting enough vitamin D from food is difficult, so supplements are often recommended. Adequate levels of vitamin D may also help prevent depression, according to some research.

A positive attitude is also fundamental for an effective diet. Researchers have noticed lower-than-normal levels of serum vitamin D in obese people. The exact role of vitamin D in weight loss is still unclear. A study found that overweight and obese adults taking calcium and vitamin D supplements lost significantly more stomach fat than people not taking any supplements.

Food sources: While the sun is the best source of vitamin D, you can also get this vitamin from food , especially fortified foods. Tip: You might want to consider taking a vitamin D supplement if you spend most of your days indoors.

Try it: Shop for vitamin D supplements. Iron plays a role in helping your body create energy from nutrients. Iron helps carry oxygen to all of the cells in your body, including your muscles.

This, in turn, helps them burn fat. Too little iron can lead to iron deficiency anemia , which is one of the most common nutritional deficiencies in the United States. Women who experience heavy menstrual periods and people who frequently donate blood are more prone to iron deficiency.

Your body absorbs the type of iron found in meat better than the iron that comes from a plant-based source. Not a meat eater? Eating iron-rich foods along with a source of vitamin C, like strawberries or tomatoes , can help improve absorption.

Tip: Take iron supplements with food and add extra fiber to your diet, as iron supplements can be constipating. Try it: Shop for iron supplements. Magnesium is necessary for energy production in the body.

This mineral acts as a cofactor in more than enzyme systems. These systems are responsible for a wide range of reactions in the body, including:. Dietary surveys of people in the United States regularly show that magnesium intakes are too low.

Tip: Very high doses of magnesium from supplements or medications often result in diarrhea. Try it: Shop for magnesium supplements. Green tea is thought to increase energy expenditure and fat oxidation, and to reduce fat production and absorption. The extract of this popular beverage is known to contain powerful flavonoid antioxidants known as catechins.

Green tea also contains a healthy dose of caffeine. An analysis of six controlled clinical trials found that caffeine alone, or in combination with catechins, significantly increased energy expenditure when compared to placebo.