Citrus bioflavonoids and sleep quality -
When using other components, eg. As extracts, the amount used must be adjusted accordingly in a manner known to those skilled in the art. Nachfolgend wird eine kurze Beschreibung der Abbildungen gegeben. The following is a brief description of the figures.
zeigt Änderungen der spektralen Leistungsdichte in vier Hirnregionen der Ratte nach Verabreichung von Kochsalz, Orangenextrakt, Hopfenextrakt, Baldrianextrakt Valeriana sowie einer Kombination dieser drei Pflanzenextrakte. Die x-Achse gibt die Frequenzbereiche nach der Fast Fourier Transformation der Daten an: von links nach rechts: delta, theta, alpha1, alpha2, beta1 und beta2.
Je höher die Leistungsdichte, umso tiefer ist der Schlaf. shows changes in the spectral power density in four brain regions of the rat after administration of saline, orange extract, hops extract, valerian extract Valeriana and a combination of these three plant extracts.
The x-axis indicates the frequency ranges after the Fast Fourier transformation of the data: from left to right: delta, theta, alpha1, alpha2, beta1 and beta2. The higher the power density, the deeper the sleep. zeigt den zeitlichen Verlauf der theta Wellen über 5 Stunden nach Verabreichung der einzelnen Extrakte in höherer Dosierung im Vergleich mit der Dreierkombination von Baldrian-, Hopfen- und Orangenextrakt bei der Ratte.
Die Ergebnisse zeigen, daß Orangenextrakt keine Eigenwirkung auf diese Frequenz hat, jedoch in Kombination mit den anderen beiden Extrakten bei gleicher Dosierung eine maximale Wirkung erreicht wird.
shows the time course of the theta waves over 5 hours after administration of the individual extracts in higher dosage compared with the triple combination of valerian, hops and orange extract in the rat. The results show that orange extract has no effect on this frequency, but in combination with the other two extracts at the same dosage maximum effect is achieved.
zeigt den zeitlichen Verlauf der beta1 Wellen über 5 Stunden nach Verabreichung der einzelnen Extrakte in höherer Dosierung im Vergleich mit der Dreierkombination von Baldrian-, Hopfen- und Orangenextrakt bei der Ratte. shows the time course of beta1 waves over 5 hours after administration of the individual extracts in higher dosage compared with the triple combination of valerian, hops and orange extract in the rat.
Je niedriger der SFx Wert auf der Ordinate, umso tiefer ist der Schlaf. Die Gegenwart von Orangenextrakt verbessert den Schlaf sowohl in Kombination mit Baldrian wie auch mit Hopfen. Die beste Wirkung zeigt die Dreierkombination, wie auch schon an der Ratte dokumentiert.
The lower the SFx value on the ordinate, the lower the sleep. The presence of orange extract improves sleep in combination with valerian as well as hops.
The best effect is shown by the triple combination, as already documented on the rat. zeigt eine Analyse der Zeit, die ein Patient bei einer definierten Schlaftiefe verbringt. Die hintere Balkenreihe zeigt Vergleichswerte von gesunden Probanden ohne Schlafstörungen.
Die Werte der Dreierkombination haben sich dabei deutlich in Richtung der Werte gesunder Probanden verschoben. Auch die Streuung der Daten nimmt im Vergleich zu Placebo ab. shows an analysis of the time a patient spends at a defined depth of sleep.
The back row of bars shows comparable values of healthy subjects without sleep disturbances. The values of the triple combination have shifted significantly in the direction of the values of healthy volunteers. The spread of data also decreases compared to placebo.
zeigt die Korrelation zwischen dem Surrogatparameter für Schlaftiefe, der auf der Basis der quantitativen EEG Auswertung validiert wurde und dem subjektiven Gefühl, gut geschlafen zu haben, erfasst mittels Fragebogen.
shows the correlation between the sleep depth surrogate parameter, which was validated on the basis of the quantitative EEG evaluation and the subjective feeling of having slept well, recorded by questionnaire.
Gezeigt werden Änderungen der beiden Parameter unter Berücksichtigung aller Nächte in Gegenwart der verschiedenen Extraktmischungen. Shown are changes of the two parameters considering all nights in the presence of the different extract mixtures.
Klinische Versuche an Patienten mit nachgewiesenen Schlafstörungen zeigen, daß die Kombination von Orangenextrakt mit Baldrianwurzelextrakt oder Hopfenextrakt beiden konventionellen Präparaten, d.
Baldrianwurzelextrakt oder Hopfenextrakt, allein gegeben in statistisch signifikanter Weise überlegen ist. Die beste Wirkung war bei Gabe einer Dreierkombination bestehend aus Baldrianwurzelextrakt, Hopfenextrakt und Orangenextrakt zu verzeichnen.
Clinical trials in patients with proven sleep disorders indicate that the combination of orange extract with valerian root extract or hop extract is superior to both conventional preparations, ie valerian root extract or hop extract, given in a statistically significant manner.
The best effect was when a combination of three valerian root extract, hops extract and orange extract was administered. The experiments were carried out with the orange extract "Hesperidina Farma" from Exquim S. The valerian extract used was a dry extract "Valeriane extractum hydroalcoholicum siccum Ph.
Der Anteil an Xanthohumol und Isoxanthohumol beträgt mind. Die Veränderungen der EEG-Frequenzen wurde nach Gabe von Salzlösung Kontrolle bzw. Placebo bzw.
oral von Orangenextrakt in verschiedenen Kombinationen mit anderen Extrakten bestimmt. The changes in the EEG frequencies were determined after administration of saline solution control or placebo or orally from orange extract in various combinations with other extracts.
Die Untersuchungen wurden analog der durch W. Dimpfel beschriebenen Methode Dimpfel W: Preclinical data base of pharmaco-specific rat EEG fingerprints Tele-Stereo-EEG. Eur J Med Res 8: — folgendermaßen durchgeführt: Sechs männlichen erwachsenen Fischer Ratten Tag-Nacht konvertiert wurden im Alter von 6 Monaten 4 bipolar konzentrische Elektroden zusammen mit einem Mikrostecker auf einer gemeinsamen Basisplatte implantiert.
Der Stecker diente der Aufnahme eines 4-Kanal-Senders zur telemetrischen Übertragung der aus frontalem Kortex, Hippocampus, Striatum und Formatio Reticularis abgeleiteten Feldpotentiale.
Die Unterteilung der Spektren in 6 verschiedene Frequenzbereiche erlaubte die Erfassung pharmako-spezifischer Veränderungen in Bezug auf die jeweils vor Applikation gemessenen Vorwerfe innerhalb dieser Frequenzbänder. The investigations were carried out analogously to the method described by W.
Dimpfel Dimpfel W: Preclinical data base of pharmaco-specific rat EEG fingerprints Tele-Stereo-EEG. Eur J Med Res 8: carried out as follows: Six male adult Fischer rats day-night converted were implanted at the age of 6 months 4 bipolar concentric electrodes together with a micro connector on a common base plate.
The plug was used to record a 4-channel transmitter for telemetric transmission of the field potentials derived from the frontal cortex, hippocampus, striatum and formatio reticularis. The signals were subjected to Fast Fourier Transformation in real time on a computer system "EEG Analysis" software, OS Science operating system, "LabTeam" lab computer from MediSyst, Linden, DE , and the power density spectra were each averaged over 60 minutes.
The subdivision of the spectra into 6 different frequency ranges allowed the detection of pharmaco-specific changes with respect to the pre-embrasures measured before each application within these frequency bands.
Zum Applikationsprotokoll der Präparate: die Präparate wurden oral 45 Minuten nach Beginn der Messungen Vorwert appliziert. Fünf Minuten später wurden die Messungen wieder gestartet, mindestens über die nächsten 5 Stunden kontinuierlich analysiert und in minütigen Perioden zusammengefaßt.
Die Testpräparate wurden in unterschiedlichen Kombinationen appliziert. Die experimentelle Serie wurde mit der Injektion von Salzlösung Kontrolle , die zu keiner auffälligen Änderung führte, begonnen.
The application protocol of the preparations: the preparations were administered orally 45 minutes after the start of the measurements pre-value. Five minutes later, measurements were restarted, continuously analyzed for at least the next 5 hours, and pooled into minute periods.
The test preparations were applied in different combinations. The experimental series was started with the injection of saline control , which did not lead to a noticeable change. Der statistische Vergleich der Versuche zu den Ergebnissen, die nach Gabe von Salzlösung gemessen wurde, erfolgte nach Wilcoxon, Mann and Whitney auf der Basis der Veränderungen innerhalb der einzelnen Frequenzbänder in allen Hirnregionen als Variablen.
The statistical comparison of the experiments to the results measured after administration of saline solution was made according to Wilcoxon, Mann and Whitney based on the changes within the individual frequency bands in all brain regions as variables.
Bei den Untersuchungen der Veränderungen der EEG-Frequenzen der Ratte wurde aber überraschenderweise im Vergleich zur alleinigen Gabe von Baldrianextrakt oder Hopfenextrakt eine deutlich stärkere Zunahme der theta und beta1 Wellen nach Kombination mit Orangenextrakt gefunden, die bei einer Behandlung von Schlafstörungen nützlich ist, da die Zunahme dieser Frequenzen mit der Schlaftiefe korreliert.
Surprisingly, however, in the studies of changes in EEG frequencies of the rat, a significantly greater increase in the theta and beta1 waves after combination with orange extract, which is useful in the treatment of sleep disorders, was found when compared to the sole administration of valerian extract or hop extract of these frequencies correlates with the depth of sleep.
Die Verabreichung von Orangenextrakt in Kombination mit Baldrianwurzelextrakt oder Hopfenextrakt führte zu stabilen Veränderungen der Leistungsdichte in allen Hirngebieten, vor allem während der dritten bis fünften Stunde nach Applikation siehe.
Administration of orange extract in combination with valerian root extract or hops extract resulted in stable changes in power density in all brain areas, especially during the third to fifth hour after application see. Die orale Verabreichung von Extraktkombinationen als Einzeldosis führte zu Veränderungen der elektrischen Hirnaktivität bei den Testtieren, die denen während des Schlafes ähnelten.
Insbesondere ist dies überraschend, da die Präparate am Morgen, d. nach der Nachtruhe verabreicht wurden. Oral administration of extract combinations as a single dose resulted in changes in brain electrical activity in test animals similar to those during sleep.
In particular, this is surprising because the preparations in the morning, d. were administered after sleep. Die zeigt die zeitabhängigen Veränderungen der theta EEG Frequenzen nach oraler Verabreichung verschiedener Dosierungen von Orangenextrakt, Baldrianwurzelextrakt und Hopfenextrakt allein sowie als Dreierkombination.
In früheren Versuchen konnte gezeigt werden, daß vor allem die theta und beta1 Wellen des EEG die Schlaftiefe repräsentieren Dimpfel W, Hofmann H-C Mehrdimensionale Dokumentation des Schlafes auf der Grundlage der Frequenzanalyse.
In Mayer G Hrgs. Jahrbuch Schlafmedizin Deutschland MMV Verlag, München. Obwohl der Orangenextrakt bei alleiniger Gabe keine Erhöhung der theta Frequenzen bewirkt, ist zu erkennen, daß die trotz hoher Dosis ebenfalls nur geringe Wirkung von Baldrianwurzelextrakt oder Hopfenextrakt bei der Einzelapplikation durch die Kombination von Orangenextrakt, Baldrianwurzelextrakt und Hopfenextrakt massiv überboten wird und damit eine größere Schlaftiefe erreicht wird.
Zudem ist in der Kombination nur die halbe Dosis beider klassischen Extrakte vorhanden, was auf eine Potenzierung durch den Orangenextrakt schließen läßt. The shows the time-dependent changes in the theta EEG frequencies after oral administration of various doses of orange extract, valerian root extract and hops extract alone, and as a triplicate combination.
In previous experiments it could be shown, that above all the theta and beta1 waves of the EEG represent the sleep depth Dimpfel W, Hofmann HC Multidimensional documentation of sleep on the basis of the frequency analysis Mayer G Hrgs Yearbook Sleep Medicine Germany MMV Verlag, Munich , Although the orange extract when administered alone does not cause an increase in the theta frequencies, it can be seen that, in spite of the high dose, the valerian root extract also has only a slight effect or hop extract in the single application by the combination of orange extract, valerian root extract and hops extract massively outbid and thus a greater sleep depth is achieved.
In addition, in the combination only half the dose of both classic extracts is present, which suggests a potentiation by the orange extract. Ähnliches trifft für die für die Schlaftiefe wichtige beta1 Frequenz zu. Wie in dargestellt übertrifft die Wirkung der Kombination die Wirkung beider Einzelextrakte deutlich, wobei Orangenextrakt allein keine Wirkung erkennen läßt.
The same applies to the sleep depth important beta1 frequency. As in the effect of the combination clearly exceeds the effect of both single extracts, with orange extract alone showing no effect.
Diese Wirkung konnte bei Schlaf-gestörten Patienten bestätigt werden. Nachdem der auf der Basis der theta und beta Frequenzen definierte spektrale Frequenzindex Apparatus for determining sleep staging: US Pat.
Zweierkombinationen mit Orangenextrakt während einer Nacht bestimmt worden war, ergab sich eine erheblich größere Schlaftiefe für die Dreierkombination im Vergleich zu beiden Zweierkombinationen Es wurden immer dieselben Patienten im Abstand von mehreren Tagen untersucht.
Das Ergebnis der Studie ist in dokumentiert. This effect was confirmed in sleep-disordered patients. After the spectral index of frequencies defined on the basis of the theta and beta frequencies Apparatus for determining sleep staging: US Pat.
The result of the study is in documented. Betrachtet man darüber hinaus, wie viel Zeit die Patienten innerhalb einer jeweils bestimmten Schlaftiefe verbracht haben, ergibt sich eine klare Überlegenheit der Dreierkombination im Vergleich zu Placebo.
Dies ist in dokumentiert. Gleichzeitig ist ersichtlich, wie die Wirkung der Dreierkombination sich dem gesunden Schlaf nähert. Aus der Erkenntnis, das Orangenextrakt die für Schlaftiefe repräsentativen Parameter signifikant beeinflußt, muß geschlossen werden, daß der Zusatz von Orangenextrakt den Schlaf von Patienten deutlich bessert, was bislang unbekannt und auch nicht zu vermuten war.
In addition, considering how much time the patients spent within each particular sleep depth, the triple combination is clearly superior to placebo. This is in documented.
At the same time it can be seen how the effect of the triple combination approaches healthy sleep. From the finding that orange extract significantly affects the parameters representative of sleep depth, it must be concluded that the addition of orange extract significantly improves the sleep of patients, which was previously unknown and could not be assumed.
Die bereits anhand einer früheren Studie publizierte Korrelation Dimpfel W, Hoffmann H-C, Schober F, Todorova A Validation of an EEG-derived spectral frequency index SFx for continuous monitoring of sleep depth in humans. Eur J Med Res ; 3: — konnte auch in dieser Studie wieder belegt werden, wie in erkennbar ist.
Daher muß auf Grund dieser Ergebnisse angenommen werden, daß eine Kombination pflanzlicher Schlafmittel mit Orangenextrakt zu einem hochpotenten Naturheilmittel zur Behandlung von Schlafstörungen mit geringem Nebenwirkungspotential führen wird.
The validity of the "spectral frequency index" SFx surrogate parameter evaluated and patented using the EEG record is also substantiated by the correlation analysis between the change in the SFx and the subjective quality of sleep recorded in a questionnaire.
The correlation already published on the basis of an earlier study Dimpfel W, Hoffmann HC, Schober F, Todorova A Validation of an EEG-derived spectral frequency index SFx for continuous monitoring of sleep depth in humans.
Eur J Med Res ; 3: was again demonstrated in this study, as in is recognizable. Therefore, based on these results, it must be assumed that a combination of herbal sleeping tablets with orange extract will result in a highly potent natural remedy for the treatment of sleep disorders with low side effect potential.
Eur J Med Res ; 3: — Dieser neue Parameter, als spektraler Frequenzindex SFx bezeichnet, erfaßt die Schlaftiefe kontinuierlich und somit auch die gleitenden Übergänge der ca. Dadurch werden u. auch alle Aufwachvorgänge, die bekanntlich zu wenig erholsamen Schlaf führen, automatisch mit erfaßt und ausgewertet.
Eur J Med Res ; 3: This new parameter, referred to as the spectral frequency index SFx , continuously records the depth of sleep and thus also the sliding transitions of the individual sleep phases lasting about 90 minutes. As a result, among other things, all wake-up procedures, which are known to lead to less restful sleep, automatically detected and evaluated.
A double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using the electrohypnogram. Eur J Med Res ; — Eur J Med Res ; Die vorgenannten Beispiele dienen der Erläuterung der Erfindung, ohne daß die Erfindung jedoch auf die speziell beschriebenen Ausführungsformen beschränkt sein soll.
The above examples serve to illustrate the invention, but without the invention being limited to the specifically described embodiments. Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen.
Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen. This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader.
The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions. Zitierte Patentliteratur Cited patent literature. Zitierte Nicht-Patentliteratur Cited non-patent literature.
Effective date : Der IUAPC-Name von Hesperidin ist 2S 6-O- 6-Desoxy-α-L-mannopyranosyl -β-D-glucopyranosyl oxy -2,3-dihydrohydroxy 3-hydroxymethoxyphenyl -4Hbenzopyranon CAS-Nummer entsprechend der Summenformel C 28 H 34 O 15 und der allgemeinen Strukturformel:.
Wirkstoffkombinationen nach Anspruch 1, dadurch gekennzeichnet, daß sie Hesperidin in Form eines Pflanzenextrakts, bevorzugt eines Zitrusfruchtextrakts, insbesondere in Form von Orangenextrakt enthalten.
Active substance combinations according to Claim 1, characterized in that they contain hesperidin in the form of a plant extract, preferably a citrus fruit extract, in particular in the form of orange extract. Wirkstoffkombinationen nach Anspruch 3, dadurch gekennzeichnet, daß der pflanzliche Wirkstoff in Form eines Pflanzenextrakts eingesetzt wird.
Active substance combinations according to Claim 3, characterized in that the herbal active ingredient is used in the form of a plant extract.
Schlafmittel oder Nahrungsergänzungsmittel nach Anspruch 5, dadurch gekennzeichnet, daß sie Hesperidin in Form eines Pflanzenextrakts, bevorzugt eines Zitrusfruchtextrakts, insbesondere in Form von Orangenextrakt enthalten.
Sleep aid or dietary supplement according to claim 5, characterized in that it contains hesperidin in the form of a plant extract, preferably a citrus fruit extract, in particular in the form of orange extract.
Kombination nach Anspruch 9, dadurch gekennzeichnet, daß sie von bis mg Orangenextrakt, insbesondere von bis mg enthält. Combination according to claim 9, characterized in that it contains from to mg of orange extract, in particular from to mg.
Kombination nach Anspruch 9 oder 10, dadurch gekennzeichnet, daß sie von 50 bis mg Hopfenextrakt, insbesondere von bis mg enthält. Combination according to claim 9 or 10, characterized in that it contains from 50 to mg hops extract, in particular from to mg.
Kombination nach einem der Ansprüche 9—11, dadurch gekennzeichnet, daß sie von bis mg Baldrianwurzelextrakt, insbesondere von bis mg enthält. Combination according to any one of Claims , characterized in that it contains from to mg valerian root extract, in particular from to mg.
Schlafmittel oder Nahrungsergänzungsmittel nach einem der Ansprüche 5—7 oder 13, dadurch gekennzeichnet, daß sie zur oralen Verabreichung hergerichtet sind. Sleep aid or dietary supplement according to any one of claims or 13, characterized in that they are prepared for oral administration.
DEA DEA1 en. EPA EPA1 en. DEA1 true DEA1 en. DEA Ceased DEA1 en. EPA1 en. DEA1 en. for medical use or for use in treatment of sleeping disorders. USA en. EPB1 en. Dimpfel W, Hoffmann H-C, Schober F, Todorova A Validation of an EEG-derived spectral frequency index SFx for continuous monitoring of sleep depth in humans.
Dimpfel W, Hoffmann H-C, Schober F, Todorova A: Validation of an EEG-derived spectral frequency index SFx for continuous monitoring of sleep depth in humans. Dimpfel W: Preclinical data base of pharmaco-specific rat EEG fingerprints Tele-Stereo-EEG.
Eur J Med Res 8: FERNÁNDEZ, S. et al. Garg A, Garg S, Zaneveld LJD, Singla AK Chemistry and Pharmacology of the Citrus Bioflavonoid Hesperidin. GUZMAN-GUTIERREZ, S.
L:, NAVARETTE, A. JP A abstract. DOKIDX [online], [recherchiert am In: DEPATIS und Englisch-Übersetzung aus DEPATIS. MARTINEZ, M. Mayer G Hrgs. WOA1 en. Method and substances for releasing a growth factor from endothelial cells, growth factor released in accordance with said method and use of same.
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Purchase options and add-ons. Brand Nature's Life Item Form Tablet Primary Supplement Type Vitamin C Diet Type Vegetarian Flavor Lemon. About this item Tri-Complex — A hardworking antioxidants supplement, Nature's Life Lemon Bioflavonoids provide mg of citrus bioflavonoids and mg each of Hesperidin and Rutin — the perfect trifecta for antioxidant support.
Flavonoids to the Rescue — Polyphenols naturally found in lemons and other citrus fruits, bioflavonoids support cellular health by helping to neutralize free radicals and may help the body absorb and utilize all-important Vitamin C. GMP Certified — GMP stands for Good Manufacturing Practice, and it ensures that all the products we make — including our bioflavonoids supplements — follow stringent quality standards.
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Vitamin C. Vitamin C, Sodium. Lemon Bioflavonide. Immune Support. Main - Quercetin, Citrus Bioflavonoid Complex, Rutin.
See supplement facts for full list of ingredients. Citrus Bioflavonoid Complex. Other Ingredients: Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Stearic Acid, Silica, Vegetable Glycerin.
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There was a problem filtering reviews right now. Please try again later. Size: Count Pack of 1 Verified Purchase. These really work. This supplement is the real deal. What I mean by that is not that it necessarily will help your particular health issues, but that it is in fact a lemon bioflavonoid supplement, not a cheap imitation or a "citrus" bioflavonoid supplement primarily derived from other sources.
The reason this is important is that for the conditions for which most people are advised take bioflavonoids, the flavanone that's actually providing the benefit is something called eriocitrin eriodictyol 7-rutinosidealso, also called eriodictyol glycoside , which is most abundant in lemon rinds.
Other citrus fruits contain very little eriocitrin by comparison. Eriocitrin is believed to widen the tiny capillaries in the inner ear and to moderate inflammation caused by histamines. It's also been found to reduce lipid levels in animal studies. So if it's eriocitrin that you need, then you specifically want lemon bioflavonoids, not "citrus" bioflavonoids, which may contain very little eriocitrin.
Or more to the point: If you are trying to clear up Eustachian tube problems resulting in tinnitus or hearing loss, Meniere's disease, balance problems, or other inner ear issues; and if you have been told by your doctor or other health-care professional to try taking bioflavonoids; then I suggest that either these tablets or the same company's mg tablets would be a good choice.
Not all companies' supplements are what they claim to be. These ones are. Regarding lemon bioflavonoids in general, they're very potent. They should be considered a medication and need to be taken at the correct dosage. In fact, these 1, mg tablets may actually be too potent for you.
Bioflavonoids really need to be taken twice a day preferably with the morning and evening meals because of the way they're metabolized, but the resulting 2, mg daily dose may be too much for you.
So ask your doctor. The same company has a mg version that might be a better choice for you. Some of the side effects of overdose include insomnia, vivid or bizarre dreams, diarrhea, dizziness, pounding in the ears, and swelling of the joints, among others. So if you're silly enough to take these tablets without asking your doctor first, and if you experience any of those side effects, then you're probably taking too much.
As for me, I'm not a doctor. I'm not even very smart. I've just been studying and using herbal supplements, in addition to conventional medicine, with my doctors' advice and supervision, for more than 40 years. In fact, I suggest that you not believe a damn thing I say until you run it by your doctor or health care provider.
But if your doctor or health care provider does in fact suggest a bioflovanoid supplement for whatever's ailing you, then I suggest that you try this one. I've been using bioflavonoids for a few years now, and this product is at a great price point vs.
the mg in each pill. They definitely work, and I can actually feel them kick in about 20 minutes after I take them. I tend to take two at once with my other vitamins. I originally got these after reading studies that found bioflavonoids help with hemorrhoids.
They absolutely do. They reduce the pain of them, make them go away quicker, and even reduce the frequency of them coming back. Taking one or two a day, every day, and I essentially don't get hemorrhoids any more.
When I forget, they do come back. If you suffer from hemorrhoids, these are a god-send. The other side benefit I found, as a male, comes from the fact that bioflavonoids directly affect the circulatory system. To put it bluntly, take pills and these will beat Viagra. I'm 29, and if I take at once, for the next 10 hours or so, it's like I'm 12 again.
Gust of wind I don't have erectile dysfunction or any real problems, but I absolutely notice a nearly immediate increase in ability to get erect, the hardness of the erection, a greater ability to control ejaculation, slightly increased pleasure, and the psychological benefit of having my body working sexually like it did year ago.
If you have erectile dysfunction, or just want to have some more fun and you will, seriously , give these a shot. You don't have to take pills at once, if you just take the one or two daily that is recommended, you'll still get some fun southern side effects.
After taking 3 tablets a day for 2 weeks, I can honestly said this has significantly helped to minimize annoying effects of Tinnitus, aka "ringing in the ears. Even worse, after 15 minutes or so of listening to music on a good audio system, the hiss evolved into a sizzling echo sound around each musical note.
In addition to essential micronutrients such as vitamin Coenzyme Q supplementation, citrus fruits Coenzyme Q supplementation a considerably rich Athletic recovery formula of non-essential xnd compounds, in particular flavanones xleep form a sub-set of the flavonoid group. Bioflavonoidd, results from Managing insulin levels studies, although limited in number, appear to support Citrus bioflavonoids and sleep quality preclinical sleeep, with improvements in cognitive performance and disease risk observed across healthy and disease states. In addition, there should be further exploration of citrus polyphenols to establish therapeutic efficacy, particularly in the context of well-designed human interventions. A varied and balanced diet, rich in plant-derived material fruit and vegetablesis widely regarded as optimal for maintaining overall health and wellbeing. Unfortunately, typical modern dietary preferences are increasingly skewed in favor of nutrient poor, calorie dense, ultra-processed food choices. Plant bioactives such as polyphenolic compounds have shown potential in negating the metabolic disease process Chiva-Blanch and Badimon, Warning: Do not use if safety seal is broken or bioflaovnoids. Keep out of Citrus bioflavonoids and sleep quality of children. Qualuty your licensed health care practitioner informed when using this product. Bioflavonoids act as antioxidants, may help support blood vessel health and circulation and and the proper absorption and utilization of Vitamin C. Lemon Bioflavonoid, Hesperidin Complex, Rutin Complex.
Ist so auch es kommt vor:)
Nach meiner Meinung irren Sie sich. Geben Sie wir werden besprechen. Schreiben Sie mir in PM.
Ich entschuldige mich, aber meiner Meinung nach lassen Sie den Fehler zu. Ich kann die Position verteidigen. Schreiben Sie mir in PM, wir werden umgehen.
Sie lassen den Fehler zu. Geben Sie wir werden besprechen. Schreiben Sie mir in PM, wir werden reden.