Liver health and stress management -
In Julia's case, identifying and treating her liver disease not only reversed her mental health symptoms, it may have saved her life. Right now, unfortunately, millions of Americans are experiencing some of the same symptoms as Julia, suffering from the same invisible process of liver pathology, but not understanding the connection or getting the right treatment.
Anxiety , depression , mood swings, memory loss, sleep impairment, personality changes. If the above symptoms make you think "mental illness," then you may be overlooking a potential cause now affecting nearly half of American adults: fatty liver disease. This once-rare condition results primarily from factors such as excess body fat, poor dietary practices, and alcohol and substance abuse.
Although most people know about obesity and diabetes, far fewer have heard about fatty liver disease, their close metabolic cousin. And almost no one realizes how closely their liver health is connected to their mental health. The liver is a remarkable organ, both for its staggering contributions to our overall health and for its vast underappreciation by the general public see above figure.
Outside of specialized liver doctors—such as hepatologists and gastroenterologists—even most healthcare providers do not realize the hundreds of life-enabling functions the liver performs each day.
The liver is the ultimate domestic engineer, working to chemically neuter toxins in our blood before they infect our bodies. The organ functions as a nutritional warehouse for many essential vitamins and minerals and metabolizes medicines, alcohol, and other substances that would otherwise quickly jeopardize our existence.
The liver labors in these and many more roles in almost total obscurity, taking a relentless beating in the process of protecting us. Thankfully, the liver also just happens to be the organ equivalent of Wolverine—the fast-healing superhero mutant from the Marvel movies—in its ability to regenerate.
But even the marvelous liver has limits. Too much insulin, too much alcohol, or too much fructose, for example, and even the normally indomitable liver can no longer keep pace and begins to develop invasive fat within the liver tissue itself the liver, under normal conditions, contains only trace amounts of fat.
The first signs of liver disease are sometimes recognized by physicians in the form of chronically elevated triglycerides, results on liver function tests such as alanine aminotransferase ALT , or even by certain medical imaging procedures such as MRI and ultrasound. Caught early, fatty liver disease is treatable, frequently even reversible.
When these signs are missed, however, liver fat levels slowly progress, spiraling from the initial stages of inflammation to fibrosis and even cirrhosis. The latter cirrhosis stage is when the life-threatening process of liver failure ensues. As liver disease progresses across these stages, not only do many forms of physical illness become more likely, but symptoms of mental illness also increase.
As shown in Figure 2 above, liver disease can be a direct cause of mental health symptoms because a compromised liver cannot prevent toxins in the blood from reaching the brain. These unwelcome invaders then proceed to wreak havoc on a range of critical brain functions.
Concentration , memory, mood stability, and the ability to tolerate and respond to stress are just a few of the potential mental capacities that can be impaired when toxins begin accumulating in the brain. Sadly, fatty liver disease remains a silent epidemic in the U.
The bad news is that there are no medicines approved by the FDA for the treatment of fatty liver disease. Unlike high blood pressure, cholesterol, or glucose, there is no simple prescription drug for fatty liver disease. Instead, the most effective treatments for improving fatty liver disease and liver-induced mental health symptoms are behavioral.
Losing body fat—particularly abdominal area body fat—, reducing sugar and fructose intake, lowering insulin resistance through exercise, sleep, and stress management , and limiting or eliminating alcohol and certain medicines that can harm the liver in high quantities such as acetaminophen Tylenol , are some of the best ways to improve liver function particularly at early stages.
Unsurprisingly, stress also impacts other organs, such as the gut and liver. These are closely intertwined with stress because of the complex communication network between the brain and these organs. Also, stress can lead to inflammation in the liver and reduce its detoxification capacity.
Fatty Liver Disease: Chronic stress often causes unhealthy eating habits as a coping mechanism. This contributes to increased weight gain, which can lead to non-alcoholic fatty liver disease NAFLD.
NAFLD occurs when excessive fat builds up in the liver, leading to many other problems, such as inflammation and fibrosis. Altered Glucose Production: Cortisol triggers glucose production in the liver, providing a temporary source of extra energy during stressful encounters.
However, if stress is prolonged, it can cause increased glucose levels in the liver, contributing to insulin resistance and even type 2 diabetes. Inflammation and Liver Function: Chronic stress triggers inflammation all over the body, including the liver.
This impacts its capacity to remove toxins from the body and leads to tissue damage. As a result, the liver may struggle to process harmful substances, allowing toxins to build up. Overall, this can have detrimental effects on our entire health. Alcoholic Liver Disease: Many consume alcohol to cope with stress, which may lead to a vicious cycle of stress and health issues.
The combination of alcohol and stress can be particularly damaging to the liver. Stress-induced heavy drinking contributes to alcoholic liver disease, causing liver inflammation, scarring cirrhosis , and even liver failure in severe cases.
Altered Lipid Metabolism: The liver deals with lipids, which include oils, fats and cholesterols. However, stress causes imbalances in lipid metabolism, affecting cholesterol levels and liver functions. This can lead to fatty liver disease as well as cardiovascular issues.
Irritable Bowel Syndrome IBS : Stress and gut health are clearly linked, and IBS is a common stress-induced gut condition.
Essentially, the complex connection between the gut and brain means that stress can easily increase gut sensitivity. Leaky Gut Syndrome: Ongoing stress weakens the intestinal barrier, contributing to gut permeability leaky gut syndrome.
In this state, the gut lining becomes far weaker, allowing toxins and harmful elements to enter the bloodstream. A good acid-base balance is an ongoing balancing act for our body. Especially after longer periods of heavy meat, fat and sugar consumption, our organism is ready for a nutrient-rich, alkaline-generating diet with fruits, vegetables, algae and herbs.
In addition, special preparations can also supply valuable base compounds. In addition to a healthy diet, sufficient fluid supply is required. At least two liters of liquid in the form of water or unsweetened organic herbal teas should be on the menu daily.
The hepatic wrap is considered a tried and tested home remedy. It improves the blood circulation of the liver and thus stimulates the liver processes. A small towel e. guest towel is immersed in hot salt water, squeezed and placed twice folded on the skin above the liver.
Physical activity not only keeps us fit, it also proves to be extremely useful when disposing of bodily contamination. In addition to cooling the body, sweat is used to remove salts and waste materials.
In addition, exercise stimulates the metabolism and thus also liver activity. It is naturally best for our liver to avoid harmful substances. Plant-based foods such as rice, vegetables or fruits, whether organic or not, should always be washed before consumption. We should walk or exercise away from busy roads in the fresh air and we should use natural variants for cosmetics and cleaning agents.
Long-term stress is not only a burden on our mind. In fact, our liver also suffers when we are stressed. It is therefore all the more important to let go not only physically, but also mentally. Relaxing alkaline baths, long walks or gentle yoga exercises, for example, help us to de-stress in everyday life and serve the purpose of holistic cleansing.
How often and for how long we should treat our liver to some time out depends on factors such as individual diet, lifestyle, pollution and predisposition.
However, an annual or semi-annual break definitely does this organ good in its detoxification mission. And free the liver: If we regularly consume alcohol, eat fat or take medication, we should treat this high performing organ more often to a regenerative break.
The liver always accepts with thanks such liver-friendly days, which are heavy in simple food and substances that support the liver. Herbal combination of proven artichoke, thistle, ginger and dandelion extracts.
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In the meantime, to ensure Liverr support, we are displaying the site without styles and JavaScript. An Mznagement Correction to this Lived was published on 09 December Calcium for bone health stress may have adverse syress effects stresss induce unhealthy behaviors, but the role of stress in the development of non-alcoholic fatty amnagement disease NAFLD is largely unexplored.
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In this large healty of healthy Korean men and women, perceived stress levels measured as PSI scores manayement positively associated managemsnt the wtress of NAFLD. The association Brown rice for cholesterol management significant even yealth adjustment for multiple Luver, behavioral, and metabolic managemenh.
To our knowledge, this is the first study to demonstrate a positive association Liver health and stress management perceived stress and NAFLD. Our findings support a possible relationship of perceived nealth Liver health and stress management NAFLD, warranting ehalth research into its underlying mechanism.
The association of tsress stress with Liver health and stress management and gealth abnormalities has been evaluated sterss prior studies A meta-analysis of longitudinal studies found that overall stress was associated with increasing adiposity In a prospective study of 6, healthy men and women, those with psychological distress as measured using the item version of the General Health Questionnaire, were 1.
Our study extends these findings by demonstrating an independent association between perceived stress and NAFLD, the liver manifestation of the metabolic syndrome and one of the most common chronic liver conditions worldwide. The mechanisms by which stress may contribute to NAFLD are not entirely known.
Stress is associated with increased HPA axis activity resulting in production of catecholamines and cortisol, both of which have been associated with NAFLD and insulin resistance Cortisol, directly or indirectly through insulin-mediated effects on adipose tissue, may induce visceral adiposity 19 and abnormalities of fatty acid metabolism Also, in a study of individuals who underwent dexamethasone challenge, hour urinary free cortisol excretion and serum cortisol levels were higher in NAFLD patients than in matched controls, and cortisol levels were closely associated with the severity of liver histology Additionally, the association of stress and NAFLD may be mediated by unhealthy behaviors.
Indeed, perceived stress has been described as a negative affective state in which individuals engage in unhealthy lifestyles including smoking and alcohol use as coping mechanism Similar to previous studies 2122we found that study participants with higher stress levels were more likely to current smokers, moderate drinkers, and less likely to perform vigorous exercise than participants with lower stress levels.
However, the association between perceived stress levels and NAFLD persisted even after adjusting for smoking, alcohol use and physical activity, suggesting that other pathways are implicated in this association. The association between perceived stress levels and NAFLD in our study was stronger in men versus womenand in obese participants versus non-obese participants.
Stress responses can differ by sex. Compared to women, men were more likely to engage in unhealthy lifestyles such as consuming alcohol or smoking 2324 or in aggressive strategies 25 to cope with stress. Moreover, men have greater acute HPA and autonomic responses to standard performance-related psychosocial stressors such as public speaking and arithmetic tasks compared to women This greater sympathoadrenal responsiveness in men compared to women 27 may explain the sex-interaction that we observed in our study.
Additionally, we also found that the stronger relationship between stress and NAFLD in obese participants. Adipose tissue actively produces and releases adipokines with direct effects on glucose and fat metabolism 28 as well as interleukin-6 and tumor necrosis factor-alpha which can be involved in NAFLD.
It is thus possible that stress is more likely to result in NAFLD in this metabolic milieu. Further mechanistic studies, however, are needed to understand the differences in stress responses in by gender and by obesity levels.
Our study had some limitations. First, we used a cross-sectional design and therefore could not establish temporal relationships or infer causality. However participants were asked to complete the survey questionnaire prior to getting the ultrasonographic results.
Second, we used US-detected fatty liver as the study outcome, as histological confirmation or MR spectroscopy 2930 are unfeasible in studies of this magnitude. US, however, has an acceptable degree of diagnostic accuracy for steatosis 31 and is widely used clinically and in population-based studies 29 Furthermore, this type of measurement error is non-differential and likely to result in an underestimation of the association between perceived stress and NAFLD.
Third, stress assessment was based on self-report and also subject to measurement error, which would tend to attenuate the observed associations even further. Fourth, the test-retest reliability of PSI score was not available in our study population.
We cannot exclude the misclassification of PSI score, NAFLD and other covariates using single measurement. Additionally, we cannot exclude the possibility of some unmeasured or residual confounding in the association between PSI score and prevalent NAFLD. Finally, our results were based on a sample of relatively healthy, young and middle-aged, educated Koreans, and might not be generalizable to other age- and ethnic populations.
Our study also had several strengths. Measurements in the Kangbuk Samsung Cohort Study were obtained by trained personnel using standardized data collection procedures and protocols.
We had information on a large number of NAFLD risk factors and were able to adjust for them in multivariable models and, because of the large sample size, we had sufficient power to examine the association across a number of pre-specified clinically relevant subgroups.
Additionally, our exposure variable, perceived stress, was measured using a culturally validated tool. Biological markers of stress measure the activation of specific pathways in the stress response 33while perceived stress, as measured in our study, also captures information regarding stress appraisal In summary, in this large population study of apparently healthy men and women, higher perceived stress was significantly associated with a higher prevalence of NAFLD independent of established risk factors.
Our study extends an increasing body of research showing that stress may have adverse metabolic consequences and adds NAFLD to the list of health concerns associated with stress. Prospective studies and interventional trials focused the impact of stress management on metabolic abnormalities and NAFLD are warranted.
The Kangbuk Samsung Cohort Study is a cohort study of Korean men and women 18 years of age or older who underwent a comprehensive annual or biennial health examination at the Kangbuk Samsung Hospital Health Screening Centers in Seoul and Suwon, South Korea In South Korea, all employees are required to participate in annual or biennial health screening exams, offered free of charge under the Industrial Safety and Health Law.
The remaining participants purchased screening exams out of pocket voluntarily at the health exam center. Since participants could meet more than one exclusion criteria, the number of eligible participants wasThe final study sample includedparticipants.
If a participant had more than one screening exam with a stress questionnaire and US during the study period, only the first exam was included in the analysis. PSI scores were modeled as restricted cubic splines with knots at the 5 th35 th65 th and 95 th percentiles of the sample distribution.
Logistic regression models were adjusted for age, sex, study center, education, marital status, year of visit, smoking, vigorous exercise, alcohol, body mass index, systolic blood pressure, total and HDL cholesterol, triglycerides, and fasting glucose.
The Institutional Ethics Committee of the Kangbuk Samsung Hospital approved this study. The Ethics Committee waived the requirement of informed consent because de-identified data routinely collected during health screening visits was used.
All methods were carried out in accordance with relevant guidelines and regulations. Perceived stress was assessed using the short version of the Perceived Stress Inventory PSIa validated stress questionnaire developed for the evaluation of perceived stress in the general Korean population by the Korean Center for Disease Control The questionnaire was developed based on the Stress-induced Cognition Scale 38the Stress Response Inventory 39 and the Perceived Stress Questionnaire The questionnaire consists of 9 items in 3 domains tension, depression and anger and uses a 1—5 Likert response scale.
Perceived stress was defined as the total sum of all Likert items in the questionnaire PSI scoreand ranged from 9 to 45 with higher scores indicating increased stress. The test-retest correlation and Cronbach α for internal consistency of the original PSI were 0.
PSI scores were categorized in quintiles as there are no clinically established cut-offs. Abdominal US were performed by eleven experienced radiologists who were all unaware of the study aims Images were captured in a standard fashion with the patient in the supine position with the right arm raised above the head.
An ultrasonographic diagnosis of fatty liver was defined as the presence of a diffuse increase of fine echoes in the liver parenchyma compared with the kidney or spleen parenchyma The inter- and intra-observer reliability of fatty liver diagnoses were very high kappa statistics of 0.
At the screening visit, demographic characteristics, smoking status, alcohol consumption, physical activity, medical history, and medication use were collected through standardized self-administered questionnaires.
Education was categorized into less than high school, high school or technical college, and university or above. Marital status was categorized into unmarried, married, separated, divorced or widowed. Height and weight were measured by trained nurses with the participants wearing a light weight hospital gown and no shoes.
: Liver health and stress management| What are liver enzymes? | It is Grape Face Mask Recipes to consult Liveg Liver health and stress management professional if any of these symptoms are present, as early intervention can managemfnt further liver damage strees improve outcomes. Additionally, we hralth found that the stronger relationship between stress and NAFLD in obese participants. This can lead to the accumulation of fat in the liver, inflammation, and ultimately, liver damage. Explore how LivPure enhances liver wellness here. Have a query? Non-alcoholic fatty liver disease NAFLD as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches. |
| This might be related & helpful! | Digestive Liver health and stress management, physiological characteristics, and rumen bacterial community of Holstein managemennt steers in response to three nutrient density diets abd fattening manxgement advanced. Abdominal Body fat calipers measurement were performed by eleven experienced radiologists who were all unaware of the study aims Overall, this can have detrimental effects on our entire health. Supplementary table. Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease. Milk thistle, for example, contains a compound called silymarin, which has antioxidant and anti-inflammatory effects that can help protect liver cells from damage. |
| Stress as a Potential Driver for MASLD? | These stress hormones serve a specific purpose in acute stress situations, allowing our body to adapt and survive. However, problems arise when the stress is chronic or ongoing, leading to prolonged exposure to cortisol. Chronic stress is linked to premature ageing, heart conditions, weight gain, hair loss, and reduced life expectancy. Unsurprisingly, stress also impacts other organs, such as the gut and liver. These are closely intertwined with stress because of the complex communication network between the brain and these organs. Also, stress can lead to inflammation in the liver and reduce its detoxification capacity. Fatty Liver Disease: Chronic stress often causes unhealthy eating habits as a coping mechanism. This contributes to increased weight gain, which can lead to non-alcoholic fatty liver disease NAFLD. NAFLD occurs when excessive fat builds up in the liver, leading to many other problems, such as inflammation and fibrosis. Altered Glucose Production: Cortisol triggers glucose production in the liver, providing a temporary source of extra energy during stressful encounters. However, if stress is prolonged, it can cause increased glucose levels in the liver, contributing to insulin resistance and even type 2 diabetes. Inflammation and Liver Function: Chronic stress triggers inflammation all over the body, including the liver. This impacts its capacity to remove toxins from the body and leads to tissue damage. As a result, the liver may struggle to process harmful substances, allowing toxins to build up. Overall, this can have detrimental effects on our entire health. Alcoholic Liver Disease: Many consume alcohol to cope with stress, which may lead to a vicious cycle of stress and health issues. The combination of alcohol and stress can be particularly damaging to the liver. Stress-induced heavy drinking contributes to alcoholic liver disease, causing liver inflammation, scarring cirrhosis , and even liver failure in severe cases. Altered Lipid Metabolism: The liver deals with lipids, which include oils, fats and cholesterols. However, stress causes imbalances in lipid metabolism, affecting cholesterol levels and liver functions. This can lead to fatty liver disease as well as cardiovascular issues. Irritable Bowel Syndrome IBS : Stress and gut health are clearly linked, and IBS is a common stress-induced gut condition. Essentially, the complex connection between the gut and brain means that stress can easily increase gut sensitivity. Leaky Gut Syndrome: Ongoing stress weakens the intestinal barrier, contributing to gut permeability leaky gut syndrome. In this state, the gut lining becomes far weaker, allowing toxins and harmful elements to enter the bloodstream. All of this can lead to inflammation and worse health conditions. Microbiome Imbalance: Our gut microbiome comprises an incredible community of microorganisms in our digestive tract. Having a healthy microbiome is absolutely essential for optimal gut health and function. This means our gut microbiome needs to be balanced, free from overgrowths and able to support diverse bacteria. However, constant stress disturbs the balance of gut bacteria, causing immunity and digestive issues. Gastroesophageal Reflux Disease GERD : This occurs when our stomach acid continually flows back into the oesophagus, leading to irritation and heartburn. Stress can cause and intensify GERD by increasing stomach acid production and relaxing the muscle that usually prevents acid reflux. Functional Dyspepsia: Those with this condition experience ongoing discomfort in the upper abdomen without having any underlying physical problems. Changes noticed in liver function tests should be reviewed by a physician to find the cause and manage the condition. Do you feel tired and drained out all the time? This can be chronic fatigue and a clear indicator that the liver is under stress. The liver feels stressed as the body works very hard to repair the damages. As the body works overtime, it can stress the other organs too and therefore; it results in tiredness. It is best to get your liver checked at this point. Is your urine darker than usual? If yes, then you may not be drinking enough water, and it may cause your stools to be darker too. It could also have blood spots in it. But if you start drinking water and these change, then all is well. If not, seek medical help right away. The culture of fast foods these days is slowly damaging the liver due to non alcoholic fatty liver disease,Avoiding refined sugar and fast food diet,eating before dusk helps a lot in prevention of fat accumulation in liver which can allay liver stress symptoms by promoting weight loss. Mood swings occur when we are unhappy or stressed. So, when the liver is stressed, it can disturb our emotional health. Emotions like anger, impatience, irritability and depression are common symptoms when the liver is in distress. Worse, it can affect your decision-making abilities and cause brain fog. It may even result in aggression and nasty outburst. A stressed liver impacts the overall body functions — it may cause ringing in the ears, insomnia, dizziness, blurry vision, allergies, no sex drive, internal or intestinal bleeding, sensitivities to chemicals, PMS, drastic weight loss and spider veins. Another warning sign of liver distress is little to no interest in food. Loss of appetite is always a sign of some underlying health condition and should never be ignored. Although irregular sleep pattern is a common occurrence amongst millennials due to a stressed lifestyle, a study found that liver cirrhosis was responsible for unusual sleep patterns in many patients. When you are suffering internally from liver fatigue internally, the organs are incapable of detoxing the blood. When toxins are not timely removed from the blood, it leads to hepatic encephalopathy which is a kind of build-up in the brain triggering memory loss. Hepatic encephalopathy could also make it difficult for you to concentrate. When you have liver cirrhosis, it gradually develops in your body, replacing the healthy liver tissue with damaged ones. This inhibits blood flow from the lever and makes it difficult for the organ to function properly. Experts believe that when you develop nonalcoholic fatty liver disease your palms start to turn red an outward indicator of the distress inside of you. This means an excess fat build-up in the liver cells of people who do not even look at a bottle of alcohol. Another warning sign of the nonalcoholic fatty liver disease is the appearance of enlarged breasts in mem. This happens due to excess growth of the gynecomastia tissues as a result of testosterone and estrogen discord. Another sign of unexplained liver disease is the sudden swelling in regions around your ankles and legs. Experiencing chills is often a natural response of the body when the mercury drops or when you are developing a fever. However, if none of this fits the bill for your sudden and regular chills it could indicate cholestasis during liver disease. If you have faced any of these symptoms or are unsure as you encounter some of them, do seek medical help. Consult your doctor today or a liver specialist. Also, it is best to make regular health check-ups a habit. Also Read: What Does Liver Pain Feel Like? Symptoms and Possible Conditions Explained. The reader should consult a registered medical practitioner to determine the appropriateness of the information and before consuming any medication. |
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