Participants were aaging on Creatine supplementation and aging sit-to-stand test, 1 RM bench press and leg Weight loss support groups, isometric hand-grip supplementtaion, tandem gait test, and upper and lower body Cretine tests Calorie intake for muscle gain to and following supplementation with 0. Future research is required to directly compare higher and lower frequencies with and without creatinine. Aging and Skeletal Muscle Adaptations At the cellular level sarcopenia is best described as a gradual loss of type II muscle fibers with a concurrent increase in intramuscular fat storage[ 27 ].

Creatine supplementation and aging -

While these results are exciting, they are somewhat recent and we expect to better know the effects of creatine on brain function in the near future. There is even now compelling evidence that creatine supplementation can help mitigate the symptoms of, or even help prevent, concussion. There are many different formulas used for creatine dosing, but one common strategy is as follows:.

Think of the loading dose as an initial boost to jumpstart your muscle creatine levels. After that boost, all you need is to maintain your high levels of creatine, and continuing to take high doses has no added benefit which is why it is not recommended.

Whilst the loading period is popular, it is likely that a low dose taken daily g will ultimately prove just as effective, and with less likelihood for side effects, which commonly occur during the loading phase.

Andy Reed at the Banff Sport Medicine clinic says he adds 5g to his morning coffee as a creative way to get his daily dose Importantly, almost all research about creatine is in the form of creatine monohydrate , so the benefits and risks of any other forms of creatine are not clear.

The only consistent effect is that there is sometimes unexpected weight gain 2. This tends to come from water weight, meaning water is added to the muscles alongside the creatine.

This occurs more frequently during the high dose loading period. Any other risks or case studies of adverse effects that come up in popular media have been refuted by rigorous scientific reports 2.

Creatine also has promising cognitive benefits including benefits to memory. The recommended dose begins with a short loading phase followed by a smaller-dose maintenance phase, but it is likely that daily low doses in the range of g for most adults will provide just as much benefit.

Desmond Young , Masters of Science, Faculty of Kinesiology, Sport, and Recreation, University of Alberta. Candow DG, Forbes SC, Kirk B, Duque G. Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults.

Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.

J Int Soc Sports Nutr. Kreider R, Jung Y. Creatine supplementation in exercise, sport, and medicine. J Exerc Nutr Biochem. Devries M, Phillips S. Creatine Supplementation during Resistance Training in Older Adults—A Meta-analysis. Med Sci Sports Exerc. Stares A, Bains M. The Additive Effects of Creatine Supplementation and Exercise Training in an Aging Population: A Systematic Review of Randomized Controlled Trials.

Journal of Clinical Medicine. McMorris T, et al. Creatine supplementation and cognitive performance in elderly individuals. Aging, Neuropsychology, and Cognition. Dolan E. Beyond muscle: The effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury.

European Journal of Sport Science. Trexler ET, et al. Creatine and caffeine: Considerations for concurrent supplementation. International Journal of Sport Nutrition and Exercise Metabolism. Simon DK, et al.

Caffeine and progression of Parkinson's disease: A deleterious interaction with creatine. Clinical Neuropharmacology. Mayo Clinic Press Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Mayo Clinic on Incontinence - Mayo Clinic Press Mayo Clinic on Incontinence The Essential Diabetes Book - Mayo Clinic Press The Essential Diabetes Book Mayo Clinic on Hearing and Balance - Mayo Clinic Press Mayo Clinic on Hearing and Balance FREE Mayo Clinic Diet Assessment - Mayo Clinic Press FREE Mayo Clinic Diet Assessment Mayo Clinic Health Letter - FREE book - Mayo Clinic Press Mayo Clinic Health Letter - FREE book.

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PLoS Med. Quan, Y, Xin, Y, Tian, G, Zhou, J, and Liu, X. Mitochondrial ROS-modulated mtDNA: a potential target for cardiac aging. Oxidative Med Cell Longev. Schulz, TJ, Zarse, K, Voigt, A, Urban, N, Birringer, M, and Ristow, M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress.

Cell Metab. Wyss, M, and Kaddurah-Daouk, R. Creatine and creatinine metabolism. Physiol Rev. Mills, S, Candow, DG, Forbes, SC, Neary, JP, Ormsbee, MJ, and Antonio, J. Effects of creatine supplementation during resistance training sessions in physically active young adults.

Reid, MB. Invited review: redox modulation of skeletal muscle contraction: what we know and what we don't.

J Appl Physiol. Green, LC, Ruiz de Luzuriaga, K, Wagner, DA, Rand, W, Istfan, N, Young, VR, et al. Nitrate biosynthesis in man.

del Campo Cervantes, JM, Cervantes, MHM, and Torres, RM. Effect of a resistance training program on sarcopenia and functionality of the older adults living in a nursing home. J Nutr Health Aging. Bloomer, RJ, Schilling, BK, Karlage, RE, Ledoux, MS, Pfeiffer, RF, and Callegari, J.

Effect of resistance training on blood oxidative stress in Parkinson disease. Med Sci Sports Exerc.

Meng, S-J, and Yu, L-J. Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci. Stefani, GP, Nunes, RB, Dornelles, AZ, Alves, JP, Piva, MO, Domenico, MD, et al. Effects of creatine supplementation associated with resistance training on oxidative stress in different tissues of rats.

J Int Soc Sports Nutr. Rahimi, R. Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise.

J Strength Cond Res. Brzycki, M. Strength testing—predicting a one-rep max from reps-to-fatigue. Candow, DG, Zello, GA, Ling, B, Farthing, JP, Chilibeck, PD, McLeod, K, et al. Comparison of creatine supplementation before versus after supervised resistance training in healthy older adults.

Res Sports Med. Candow, DG, Forbes, SC, and Vogt, E. Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults. Exp Gerontol. Ware, JE Jr, and Sherbourne, CD. The MOS item short-form health survey SF : I. Conceptual framework and item selection.

Med Care. Alikhani, S, and Sheikholeslami-Vatani, D. Oxidative stress and anti-oxidant responses to regular resistance training in young and older adult women. Geriatr Gerontol Int. Bouzid, MA, Hammouda, O, Matran, R, Robin, S, and Fabre, C.

Low intensity aerobic exercise and oxidative stress markers in older adults. Takahashi, M, Miyashita, M, Kawanishi, N, Park, J-H, Hayashida, H, Kim, H-S, et al. Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults. Eur J Appl Physiol.

Soares, JP, Silva, AM, Oliveira, MM, Peixoto, F, Gaivão, I, and Mota, MP. Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes.

Ghahremani Moghadam, M, and Hejazi, K. Effects of eight weeks of aerobic exercise on markers of oxidative stress in elderly women. Med Lab J. Padilha, CS, Ribeiro, AS, Fleck, SJ, Nascimento, MA, Pina, FL, Okino, AM, et al.

Effect of resistance training with different frequencies and detraining on muscular strength and oxidative stress biomarkers in older women. Janssen, I.

The epidemiology of sarcopenia. Clin Geriatr Med. Kingsley, MI, Cunningham, D, Mason, L, Kilduff, LP, and McEneny, J.

Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress. Candow, DG, Forbes, SC, Chilibeck, PD, Cornish, SM, Antonio, J, and Kreider, RB. Effectiveness of creatine supplementation on aging muscle and bone: focus on falls prevention and inflammation.

J Clin Med. Deminice, R, Rosa, FT, Franco, GS, Jordao, AA, and de Freitas, EC. Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Citation: Amiri E and Sheikholeslami-Vatani D The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults.

Public Health. Received: 06 October ; Accepted: 28 March ; Published: 02 May Copyright © Amiri and Sheikholeslami-Vatani. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

No use, distribution or reproduction is permitted which does not comply with these terms. vatani uok. Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Top bar navigation. About us About us. Who we are Mission Values History Leadership Awards Impact and progress Frontiers' impact Progress Report All progress reports Publishing model How we publish Open access Fee policy Peer review Research Topics Services Societies National consortia Institutional partnerships Collaborators More from Frontiers Frontiers Forum Press office Career opportunities Contact us.

Sections Sections.

Creatine monohydrate aand a supplement that is commonly used by athletes Creaitne Creatine supplementation and aging to improve muscle Crreatine and size. However, recent studies have Weight loss support groups that aing may have Fat burners for body recomposition effects on our bodies, particularly on lipofuscin accumulation and sarcopenia. Lipofuscin is Creatine supplementation and aging pigment that accumulates Creatinf our cells over time and is associated with cellular aging and dysfunction. It is particularly prevalent in the heart, liver, and muscles. Studies have shown that creatine supplementation can reduce lipofuscin accumulation in muscle cells, which may help prevent age-related muscle dysfunction. In a study published in the Journal of Clinical Endocrinology and Metabolism, researchers investigated the effect of creatine supplementation on muscle function in older adults. The researchers found that creatine supplementation significantly improved muscle function in older adults and reduced the amount of lipofuscin in muscle cells.

Creatine supplementation and aging -

Gender differences in resistance-training-induced myofiber hypertrophy among older adults. J Gerontol A Biol Sci Med Sci. PubMed Abstract CrossRef Full Text Google Scholar. Fehrenbach, E, and Northoff, H. Free radicals, exercise, apoptosis, and heat shock proteins.

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Prediction of mycoplasma hominis proteins targeting in mitochondria and cytoplasm of host cells and their implication in prostate cancer etiology.

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Mitochondrial ROS-modulated mtDNA: a potential target for cardiac aging. Oxidative Med Cell Longev. Schulz, TJ, Zarse, K, Voigt, A, Urban, N, Birringer, M, and Ristow, M.

Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. Wyss, M, and Kaddurah-Daouk, R.

Creatine and creatinine metabolism. Physiol Rev. Mills, S, Candow, DG, Forbes, SC, Neary, JP, Ormsbee, MJ, and Antonio, J. Effects of creatine supplementation during resistance training sessions in physically active young adults.

Reid, MB. Invited review: redox modulation of skeletal muscle contraction: what we know and what we don't. J Appl Physiol. Green, LC, Ruiz de Luzuriaga, K, Wagner, DA, Rand, W, Istfan, N, Young, VR, et al.

Nitrate biosynthesis in man. del Campo Cervantes, JM, Cervantes, MHM, and Torres, RM. Effect of a resistance training program on sarcopenia and functionality of the older adults living in a nursing home. J Nutr Health Aging. Bloomer, RJ, Schilling, BK, Karlage, RE, Ledoux, MS, Pfeiffer, RF, and Callegari, J.

Effect of resistance training on blood oxidative stress in Parkinson disease. Med Sci Sports Exerc. Meng, S-J, and Yu, L-J. Oxidative stress, molecular inflammation and sarcopenia. Int J Mol Sci. Stefani, GP, Nunes, RB, Dornelles, AZ, Alves, JP, Piva, MO, Domenico, MD, et al.

Effects of creatine supplementation associated with resistance training on oxidative stress in different tissues of rats. J Int Soc Sports Nutr. Rahimi, R. Creatine supplementation decreases oxidative DNA damage and lipid peroxidation induced by a single bout of resistance exercise.

J Strength Cond Res. Brzycki, M. Strength testing—predicting a one-rep max from reps-to-fatigue. Candow, DG, Zello, GA, Ling, B, Farthing, JP, Chilibeck, PD, McLeod, K, et al. Comparison of creatine supplementation before versus after supervised resistance training in healthy older adults.

Res Sports Med. Candow, DG, Forbes, SC, and Vogt, E. Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults. Exp Gerontol. Ware, JE Jr, and Sherbourne, CD. The MOS item short-form health survey SF : I. Conceptual framework and item selection.

Med Care. Alikhani, S, and Sheikholeslami-Vatani, D. Oxidative stress and anti-oxidant responses to regular resistance training in young and older adult women. Geriatr Gerontol Int. Bouzid, MA, Hammouda, O, Matran, R, Robin, S, and Fabre, C. Low intensity aerobic exercise and oxidative stress markers in older adults.

Takahashi, M, Miyashita, M, Kawanishi, N, Park, J-H, Hayashida, H, Kim, H-S, et al. Low-volume exercise training attenuates oxidative stress and neutrophils activation in older adults.

Eur J Appl Physiol. Soares, JP, Silva, AM, Oliveira, MM, Peixoto, F, Gaivão, I, and Mota, MP. Effects of combined physical exercise training on DNA damage and repair capacity: role of oxidative stress changes.

Ghahremani Moghadam, M, and Hejazi, K. Effects of eight weeks of aerobic exercise on markers of oxidative stress in elderly women. Med Lab J. Padilha, CS, Ribeiro, AS, Fleck, SJ, Nascimento, MA, Pina, FL, Okino, AM, et al. Effect of resistance training with different frequencies and detraining on muscular strength and oxidative stress biomarkers in older women.

Janssen, I. The epidemiology of sarcopenia. Clin Geriatr Med. Kingsley, MI, Cunningham, D, Mason, L, Kilduff, LP, and McEneny, J. Role of creatine supplementation on exercise-induced cardiovascular function and oxidative stress.

Candow, DG, Forbes, SC, Chilibeck, PD, Cornish, SM, Antonio, J, and Kreider, RB. Effectiveness of creatine supplementation on aging muscle and bone: focus on falls prevention and inflammation.

J Clin Med. Deminice, R, Rosa, FT, Franco, GS, Jordao, AA, and de Freitas, EC. Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans. Citation: Amiri E and Sheikholeslami-Vatani D The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults.

Public Health. Received: 06 October ; Accepted: 28 March ; Published: 02 May Copyright © Amiri and Sheikholeslami-Vatani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY. The use, distribution or reproduction in other forums is permitted, provided the original author s and the copyright owner s are credited and that the original publication in this journal is cited, in accordance with accepted academic practice.

No use, distribution or reproduction is permitted which does not comply with these terms. vatani uok. Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. Top bar navigation. About us About us. Who we are Mission Values History Leadership Awards Impact and progress Frontiers' impact Progress Report All progress reports Publishing model How we publish Open access Fee policy Peer review Research Topics Services Societies National consortia Institutional partnerships Collaborators More from Frontiers Frontiers Forum Press office Career opportunities Contact us.

Sections Sections. About journal About journal. Article types Author guidelines Editor guidelines Publishing fees Submission checklist Contact editorial office. ORIGINAL RESEARCH article Front. Public Health , 02 May This article is part of the Research Topic Active and Healthy Aging and Quality of Life: Interventions and Outlook for the Future View all 53 articles.

The role of resistance training and creatine supplementation on oxidative stress, antioxidant defense, muscle strength, and quality of life in older adults.

Introduction The production of free radicals increases from the fourth decade of life onwards, and the amount of antioxidant enzymes such as superoxide dismutase SOD and glutathione peroxidase GPX decreases 1.

Materials and methods 2. Ethical considerations Before the start of the study, a meeting session was held to coordinate and explain the objectives of the project and to mention the possible risks and benefits for the participants.

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This study compared the effects of different creatine supplementation Weight loss support groups, independent supplenentation resistance training, on aging muscle sjpplementation and functionality. Keto chicken breast was Weight loss support groups significant increase over time for muscle strength Leg press: CR-H pre Short-term creatine supplementation, independent of dosage and resistance training, has no effect on aging muscle performance or tasks of functionality. This is a preview of subscription content, log in via an institution to check access. Rent this article via DeepDyve.